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Why त्रिकाल संध्या ? Why specific time bound rituals?
Why waking up in ब्रह्ममुहूर्त?
Why prayers at specific time?
Why morning & evening आरती?

genes

We have genes which can protect us against any life-causing situations provided we know how to instruct them timely otherwise they are useless. Timing is everything, to our genes. If our education & upbringing inspire us to mock early riser and insult timely routine, live like in hazy manner, no one but we are at losing end. Loss of life in certain cases.

Insulting biological clocks not only hampers body but also invite diseases. Crime against gifted human form!

In most of the tissues, gene transcription peaked in the early morning and late afternoon and quieted in the evening after dinner, around bedtime. With 81.7 percent of protein-coding genes experiencing a rhythmic effect, this timing mechanism is far more widespread than previously suspected.

—> Gene transscription is at high peak in morning and late afternoon. So last meal must be taken before sunset. No more stress to body and mind at night by most complex digestion process.

Respect biological clocks and in return देव & ऋषि गण residing in our body, controlling genes, will bless us great healthy life! There is still time, go back to roots. I say, blindly follow rituals followed by your grand-parents! Yes, blindly! There are enough evidences to convey perfection of legacy given to us as Sanatana dharma followers!

Never research to doubt rituals to reject them.Follow timeless wisdom and research only to strentghen our understanding!

Old posts:

दिनचर्या and Modern Inflammatory Epidemics

Research : GUT Microbes controls circadian clocks

Research: Not just enough sleep, timely sleep!

Panchang and Body cycles


Research


Timing is everything, to our genes

Salk scientists discover critical gene activity follows a biological clock, affecting diseases of the brain and body

To everything there is a season. This saying applies to many human endeavors, but new research shows it’s even true on the molecular level. A Salk Institute study published in the journal Science on February 8, 2018, found that the activity of nearly 80 percent of genes follows a day/night rhythm in many tissue types and brain regions.

While scientists have long known that many tissues follow these cycles, called circadian rhythms, this is the most comprehensive study connecting timing to gene transcription (the process of copying DNA into RNA to guide protein assembly).

“This is the first time a reference map of daily gene expression has been established,” says Satchidananda Panda, a professor in Salk’s Regulatory Biology Laboratory and senior author on the paper. “It’s a framework to understand how circadian disruption causes diseases of the brain and body, such as depression, Crohn’s disease, IBD, heart disease or cancer. This will have huge impact on understanding the mechanisms or optimizing cures for at least 150 diseases.”

Using RNA sequencing, the research team tracked gene expression in dozens of different non-human primate tissues every 2 hours for 24 hours. The team found that each tissue contained genes that were expressed at different levels based on the time of day. However, the number of these “rhythmic” genes varied by tissue type, from around 200 in pineal, mesenteric lymph nodes, bone marrow and other tissues to more than 3,000 in prefrontal cortex, thyroid, gluteal muscle and others. In addition, genes that were expressed most often tended to show more rhythmicity, or variability by time.

Of the 25,000 genes in the primate genome, nearly 11,000 were expressed in all tissues. Of those (which mostly govern routine cellular functions, such as DNA repair and energy metabolism), 96.6 percent were particularly rhythmic in at least one tissue, varying drastically by when they were sampled.

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