We have saying: Those who sleep early and wake up early, are Heroes. They receive strength, intellect, knowledge and wealth. Their body remains in bliss.

But our so called educated and rational flock make fun of it and says: If this is true, all milkmen and newspaper vendors should be wealthy!

Claps! Good joke! 😀

What you miss in this silly argument is noteworthy.

Shifting sleep cycle affects immune response, sleep quality

Late? Forever
Late? Forever


ब्राह्मे मुहूर्ते बुध्येत स्वस्थो रक्षाऽथमायुषः|

तत्र सर्वाघशान्त्यर्थं स्मरेद्धि मधुसूदनम्||

अर्थात् स्वस्थ व्यक्ति को अपनी जीवन-रक्षा के लिए प्रातः काल ब्रह्ममुहूर्त में उठना चाहिए।

Those who want to protect life, should wake up in the early morning (4 AM) and spend time in self-realization.

ब्राह्मे मुहूर्त उत्तिष्ठेतस्वस्थो रक्षार्थमायुष : ।

Brahm muhurt = 96 minutes before sunrise. Adjust your routine accordingly.

ब्राह्मे मुहूर्ते बुध्येत धर्मार्थांचानुचिंतयेत।

कायक्लेषाँष्च तन्मूलान्वेदतत्तवार्थमेव च॥ (मनु. 4/92)

प्रत्येक मनुष्य को ब्रह्ममुहूर्त में उठकर धर्म और अर्थ का चिंतन करना तथा शरीर के रोग और उनके कारणों का विचार करना एवं वेद के रहस्यों का भी विचार-चिंतन करना चाहिए।

What do we have now?

Everyday different wake up time. Mostly after sunrise. 🙂 Job forces to alter sleep as per shift!


Read this research.


Shifting sleep cycle affects sleep quality, immune response

Shifting sleep cycle affects sleep quality, immune response

Most sleep research focuses on the effects of sleep deprivation or the overall amount of sleep an animal needs. This is generally referred to as sleep’s homeostatic process, which is driven by sleepiness or “sleep pressure.”

The work by Karatsoreos and his colleagues – published in the journal Brain, Behavior and Immunity – is a rare look into the circadian process, a brain-driven clock that controls the rhythms of various biological processes, from digestion to blood pressure, heart rate to waking and sleeping. The cycle is found in most everything that lives more than 24 hours, including plants and single-celled organisms.

Research into the system has significant implications for modern living, write Karatsoreos and his coauthors, as “disruption of the circadian clock is nearly ubiquitous in our modern society” due to nighttime lighting, shift work, jet lag and even the blue-tinged light emitted by cell phones and tablets.

Typically, sleep researchers have a hard time studying sleep deprivation and the circadian cycle separately, as a change in one usually affects the other. However, Karatsoreos and his colleagues saw their model did not affect an animal’s total sleep, giving them a unique look into the effects on the timing of the sleeping-waking cycle.

The researchers used mice whose body clocks run at about 24 hours – much like our own – and housed them in a shorter 20-hour day. This forced their biological clocks out of sync with the light-dark cycle. After four weeks, the researchers injected the mice with lipopolysaccharide, a molecule found in bacteria that can make an animal sick without being contagious.

Environmental disruption of the circadian clock leads to altered sleep and immune responses in mouse

In mammals, one of the most salient outputs of the circadian (daily) clock is the timing of the sleep–wake cycle. Modern industrialized society has led to a fundamental breakdown in the relationship between our endogenous timekeeping systems and the solar day, disrupting normal circadian rhythms. We have argued that disrupted circadian rhythms could lead to changes in allostatic load, and the capacity of organisms to respond to other environmental challenges. In this set of studies, we apply a model of circadian disruption characterized in our lab in which mice are housed in a 20 h long day, with 10 h of light and 10 h of darkness. We explored the effects of this environmental disruption on sleep patterns, to establish if this model results in marked sleep deprivation. Given the interaction between circadian, sleep, and immune systems, we further probed if our model of circadian disruption also alters the innate immune response to peripheral bacterial endotoxin challenge. Our results demonstrate that this model of circadian disruption does not lead to marked sleep deprivation, but instead affects the timing and quality of sleep. We also show that while circadian disruption does not lead to basal changes in the immune markers we explored, the immune response is affected, both in the brain and the periphery. Together, our findings further strengthen the important role of the circadian timing system in sleep regulation and immune responses, and provide evidence that disrupting the circadian clock increases vulnerability to further environmental stressors, including immunological challenges.