Pick up any text book of Ayurveda and there will be greater emphasis of time of the day. Tithi and Prahar play vital role in our life. Prescriptions to do certain activity at certain time is mandatory. When it comes to food, sleep and exercise, more stringent rules to align these actions with time of the day.

Never mind! We don’t care! We all have little arrogant educated self within. So we ignore such prescriptions. What do we invite ? Inflammatory epidemics!

From the standpoint of health and chronic diseases, inflammation certainly appears to be the scourge of humankind. Inflammation is not, however, considered to be a disease. This is in spite of the fact that a variety of processes that are associated with inflammation are fundamental to the cause of many chronic diseases. From Cardiovascular to cancer, root is in benign inflammation ignored for prolonged duration.

As per this research, anti-inflammatory action of a biological clock protein could prevent the onset of fulminant hepatitis, by alleviating symptoms and increasing survival rates.


Could the Biological Clock Be a Key Ally in the Fight Against Inflammatory Disease?

Fulminant hepatitis is a serious disease which leads to rapid deterioration of tissue and liver function in the patient, associated with blood coagulation disorders and irreparable brain damage. Although fulminant hepatitis can be caused by different factors, overdose with medications containing acetaminophen continues to be the main cause of the disease. Accumulation of acetaminophen in the body can cause cellular stress, which gives rise to an abnormal immune system response. This is expressed by excessive inflammation, which destroys hepatocytes and the liver. Until now, no specific treatment for fulminant hepatitis has been identified, and the only solution is liver transplant within 24 hours following onset of symptoms. Researchers from Inserm, Institut Pasteur de Lille and Université de Lille are focusing on the mechanisms underlying inflammation specifically in fulminant hepatitis, with a view to identifying potential avenues of treatment.

Fulminant hepatitis is not the only disease involving the circadian molecular mechanism inhibited by Rev-erbα. Other diseases such as peritonitis, diabetes or even atherosclerosis display a similar imbalance in the inflammatory response due to the abnormal accumulation of toxins in the body. Inserm researcher Hélène Duez affirms that: “the results of this study could open up new prospects in preventing these diseases. They also offer new avenues for researchers, notably in terms of potential improvements in quality of life and longevity among patients suffering from chronic inflammatory disease.”