Gut Microbes - Depression — Gut Microbes – Depression

Inflammation is your body’s first line of defense against infection and injury. This process normally shuts down after healing occurs.
But trouble can arise when the inflammation process gets stuck “on” and doesn’t know when to stop.
Then inflammation can turn on your body, attacking healthy cells, blood vessels, and tissues instead of protecting them.
This is called chronic or systemic inflammation.
You can develop chronic inflammation anywhere in the body — including the brain.
Unlike the inflammation of an injury or arthritis, brain inflammation doesn’t cause pain since the brain has no pain receptors.
But that doesn’t mean it’s not there, causing hidden damage to your most vital organ.

As per this[1] research, depression is linked to brain inflammation.

As per this[2] research, Gut microbes protects against brain inflammation.

Antibiotics, Highly acidic processed food, chemical ingredients – We are daily waging war against our friends. 🙁

And we complain about Alzheimer, Parkinson’s, Aggression, Autism, Asthma, Suicides, Dumb, Zombiness… 🙁 That is what we deserve.
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[1] http://archpsyc.jamanetwork.com/article.aspx?articleid=2091919

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

Elaine Setiawan, PhD^1,2; Alan A. Wilson, PhD^1,2,3; Romina Mizrahi, MD, PhD^1,2,3,4; Pablo M. Rusjan, PhD^1,2; Laura Miler, HBSc^1,2; Grazyna Rajkowska, PhD⁵; Ivonne Suridjan, HBSc^1,2,4; James L. Kennedy, MD^1,2,3,4; P. Vivien Rekkas, PhD^1,2; Sylvain Houle, MD, PhD^1,2,3; Jeffrey H. Meyer, MD, PhD, FRCPC^1,2,3,4

The neuroinflammatory hypothesis of major depressive disorder is supported by several main findings. First, in humans and animals, activation of the immune system causes sickness behaviors that present during a major depressive episode (MDE), such as low mood, anhedonia, anorexia, and weight loss. Second, peripheral markers of inflammation are frequently reported in major depressive disorder. Third, neuroinflammatory illnesses are associated with high rates of MDEs. However, a fundamental limitation of the neuroinflammatory hypothesis is a paucity of evidence of brain inflammation during MDE. Translocator protein density measured by distribution volume (TSPO V_T) is increased in activated microglia, an important aspect of neuroinflammation.

[2] http://today.duke.edu/2015/07/wormsonthebrain

Gut Worms Protect Babies’ Brains From Inflammation

What’s in mom’s gut could help protect her baby’s brain

According to what scientists call the “Biome Depletion Theory,” some autoimmune and inflammation-related diseases may be the result of too few of the life forms that once lived in and on the body — particularly gut worms — rather than too many.

Tapeworms, roundworms and other wormy companions have inhabited the warm wet folds of animal intestines for more than 100 million years, bathing in a constant supply of food and nutrients.

Over millions of years of co-existence, the theory goes, the immune system learned to tolerate these live-in guests, and eventually adapted to work with worms in mind.

The theory is that now, with worms gone from our guts, the body’s natural defenses can spiral out of control.

“Our bodies are essentially an ecosystem,” said Duke immunologist and study co-author William Parker.

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

Gut Worms Protect Babies’ Brains From Inflammation

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