I hope we understand this. Right age pregnancy followed by at least 6 months feeding is not only critical for child but equally critical for mother’s health.
A large international study shows that breastfeeding is associated with a lower risk of developing an aggressive form of breast cancer called hormone-receptor negative. This new combined evidence shows the risk was reduced by up to 20% in women who breastfed.
All working mothers : Work and career can wait for another year, your health cannot. Take care. If required, take Paid Time Offs or Leaves without pay. It is not worth to ignore this duty with good health as return.
Breastfeeding and breast cancer risk by receptor status—a systematic review and meta-analysis
Background Breastfeeding is inversely associated with overall risk of breast cancer. This association may differ in breast cancer subtypes defined by receptor status, as they may reflect different mechanisms of carcinogenesis. We conducted a systematic review and meta-analysis of case–control and prospective cohort studies to investigate the association between breastfeeding and breast cancer by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status.
Design We searched the PubMed and Scopus databases and bibliographies of pertinent articles to identify relevant articles and used random-effects models to calculate summary odds ratios (ORs) and 95% confidence intervals (CIs).
Results This meta-analysis represents 27 distinct studies (8 cohort and 19 case–control), with a total of 36 881 breast cancer cases. Among parous women, the risk estimates for the association between ever (versus never) breastfeeding and the breast cancers negative for both ER and PR were similar in three cohort and three case–control studies when results were adjusted for several factors, including the number of full-term pregnancies (combined OR 0.90; 95% CI 0.82–0.99), with little heterogeneity and no indication of publication bias. In a subset of three adjusted studies that included ER, PR, and HER2 status, ever breastfeeding showed a stronger inverse association with triple-negative breast cancer (OR 0.78; 95% CI 0.66–0.91) among parous women. Overall, cohort studies showed no significant association between breastfeeding and ER+/PR+ or ER+ and/or PR+ breast cancers, although one and two studies (out of four and seven studies, respectively) showed an inverse association.
Conclusions This meta-analysis showed a protective effect of ever breastfeeding against hormone receptor-negative breast cancers, which are more common in younger women and generally have a poorer prognosis than other subtypes of breast cancer. The association between breastfeeding and receptor-positive breast cancers needs more investigation.
You might not cook with it, but you almost certainly eat or use palm oil.
Palm oil is the most widely consumed vegetable oil on the planet, and it is in about half of all packaged products sold in the supermarket. While palm oil is the most efficient source of vegetable oil, its rapid expansion threatens some of the planet’s most important and sensitive habitats.
Many products that use palm oil aren’t clearly labeled. Palm oil and its derivatives can appear under many names, including:
Do we realize the havoc we invite @ Indonesia by increasing demand of palm oil?
The establishment of vast monoculture oil plam plantations has a number of environmental impacts.
The two most serious are:
large-scale forest conversion
loss of critical habitat for endangered species
Other impacts include:
soil & water pollution
What can I do personally or at family level?
Reduce palm oil usage. Google and find out different use of palm oil.
This was about Environmental Cancer!
Recent study finds that it also helps spreading cancer in body!
GROUND-BREAKING EVIDENCE THAT CANCER SPREAD IS INCREASED BY A HIGH FAT DIET AS RESEARCHERS DISCOVER NEW CANCER-SPREADING PROTEIN
A study partly funded by UK charity Worldwide Cancer Research and headed by Professor Salvador Aznar Benitah, at the Institute for Research in Barcelona (IRB) have identified for the first time a specific protein called CD36 on cancer cells which have the ability to metastasize (spread). CD36, found in the cell membranes of tumour cells, is responsible for taking up fatty acids. This unique CD36 activity and dependence on fatty acids distinguishes metastasis-initiating cells from other tumour cells. The work was published today in the leading scientific journal Nature.
They went on to test a specific saturated fatty acid called palmitic acid – a major component of animal and vegetable fats and present at high levels in palm oil which is used in many house hold products from peanut butter and processed food to toothpaste. The researchers treated human oral tumours with palmitic acid for two days then injected them into mice fed a standard diet. The team observed that all the mice with CD36 developed cancer spread compared to only half when not treated with palmitic acid.
“In mice inoculated with human tumour cells, there appears to be a direct link between fat intake and an increase in metastatic potential through CD36. More studies are needed to unravel this intriguing relationship, above all because industrialised countries are registering an alarming increase in the consumption of saturated fats and sugar,” warns Professor Benitah. “Fat is necessary for the function of the body, but uncontrolled intake can have an effect on health, as already shown for some tumours such as colon cancer, and in metastasis, as we demonstrate here.”
Targeting metastasis-initiating cells through the fatty acid receptor CD36
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44bright cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36+ metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36+ metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.
5 Chemicals in your food cause cancer, DNA damage, cell damage
Thank moronic farming!
At present, India is the largest producer of pesticides in Asia. The Indian Pesticide Industry with 82000+ MT of production. $3.8 billion in the year 2011 that produces even those pesticides which are banned in the developed countries. 12th for the usage of pesticides!
Only 2% to 3% pesticides used is utilized for the purpose it is designed, the rest persists in soil and water causing environmental pollution leading to toxicity.
Theorists, established science (academia) fanatics, armchair intellectuals – Do they even realize the havoc created by this?
No. Idiots are busy in researching how much less plants can consume so that their food is less toxic. 😀 Classic error of reductionist outlook. Looking things in compartments and missing the whole!
Make in India! 😀
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC) on 3–10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos.
The herbicide glyphosate and the insecticides malathion and diazinon were classified as probably carcinogenic to humans (Group 2A). The insecticides tetrachlorvinphos and parathion were classified as possibly carcinogenic to humans (Group 2B).
But still modern Indian ostrich scientists, their fanatic followers, govt of India, and all science lunatics, will wait for epidemic like situation to conclude that yes, these chemical farming is foolish idea! Remember Endosulfan?
Loonies will say: WHO is paid agent of CIA. France agency on cancer is paid agent 😀 😀
One such fanatic asked me: “What is the proof that your traditional farming way is safe?” 😀 😀 कुतर्की! I am alive is the proof! I see farmers dying around by your moron ways!
And also I was titled as greedy businessman who wants to sell organic so that I am against chemical farming! 😀 😀
God save humanity from science loonies! Pump this food in your kids’ veins and wait for disaster!
We cut short feeding duration for petty things like career, beauty and money.
We also don’t have access to ethically procured A2 milk from lovable mother Gau.
Mother’s milk has HAMLET. Cow’s raw milk has BAMLET.
Both can control cancerous nature of the cell.
And we cry increasing numbers of cancer cases. 🙁
“Breast-feeding has also been reported to protect against development of immunological diseases, such as allergy (Ahmed & Fuchs, 1997; Saarinen & Kajosaari, 1995), infantile diabetes mellitus (Gerstein, 1994; Mayer et al., 1988) and inflammatory gastrointestinal disease (Koletzko et al., 1989). These results imply that factors in milk may help optimise the function of the immune system and regulate cell populations that results in les risk of tumor development and less risk for abberant immunity in the rapidly growing neonatal intestinal tract.”
“These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.”
To date several studies have addressed the ability of HAMLET to kill tumor cells in vivo. Early attempts in mouse models were thwarted as we realized that serum (especially serum albumin) induces a partial inactivation of HAMLET based on binding to the fatty acid in HAMLET. The attempts that have since been done have addressed topical or mucosal administration of HAMLET.
Walter Fischer, then in Bergen, Norway, used HAMLET in a model where tumor tissue from patients with glioblastomas were transplanted under the skull of rats. In this model one dose of HAMLET was infused in the brain through a pump and tissue was tested for apoptosis induction and the rats were monitored for survival. HAMLET treatment delayed death of the rats and the most important finding was that when investigating the brain tissue they found that apoptosis was only induced in tumor cells, no healthy brain cells were affected (Fischer Cancer Res 2004). This indicated what we already know in vitro, that the protein only attacks tumor cells, and indicated that little side effects may be expected should this be used for treatment purposes. Walter, now in Copenhagen, Denmark, is currently planning a patient study in patients with glioblastomas.
In a second study, Lotta Gustafsson together with Irene Leijonhufvud conducted a study on benign papilloma virus warts. Papillomas are a benign tumor form where the skin cells are transformed by virus infection and the hypothesis was that this transformation may make them susceptible to HAMLET treatment. A population of individuals having a major problem with recurrent warts were treated topically with HAMLET and it was found that HAMLET was effective in eliminating warts and that this effect had a long lasting effect (Gustafsson NEJM 2004).
Recently, Anki Mossberg together with Bjorn Wullt performed a study on 9 patients with transitional bladder carcinomas (tumor of the urinary bladder) (Mossberg Int J Cancer 2007). They instilled HAMLET in the bladder of patients in the week preceding surgery and evaluated the tumor morphology by endoscopic photography and apoptosis-induction in biopsy tissue. They found that a reduction in tumor size was seen in 8 of 9 patients and that apoptosis was detected in the tumor tissue but not in the adjacent healthy tissue, indicating that HAMLET is specifically tumorigenic also in vivo. This study was followed up by a study in mice (Mossberg, J Urol, 2010) using the MB49 bladder carcinoma model. In this model they showed a delay in tumor development when HAMLET was instilled in the bladder.
In a study from 2014 Puthia et al (Gut January issue, 2014) it wa shown that HAMLET could be used to prevent and treat colon cancer in APC/Min-mice. HAMLET was given perorally and showed a reduced progression of tumor growth and an increased survival when given as a prophylaxis and reduction of established tumors when given as treatment. HAMLEt accumulated only in tumor tissue and only healthy cells were observed to be apoptotic.
BAMLET activates a lysosomal cell death program in cancer cells.
A complex of human alpha-lactalbumin and oleic acid (HAMLET) was originally isolated from human milk as a potent anticancer agent. It kills a wide range of transformed cells of various origins while leaving nontransformed healthy cells largely unaffected both in vitro and in vivo. Importantly, purified alpha-lactalbumins from other mammals form complexes with oleic acid that show biological activities similar to that of HAMLET. The mechanism by which these protein-lipid complexes kill tumor cells is, however, largely unknown. Here, we show that complex of bovine alpha-lactalbumin and oleic acid (BAMLET), the bovine counterpart of HAMLET, kills tumor cells via a mechanism involving lysosomal membrane permeabilization. BAMLET shows potent cytotoxic activity against eight cancer cell lines tested, whereas nontransformed NIH-3T3 murine embryonic fibroblasts are relatively resistant. BAMLET accumulates rapidly and specifically in the endolysosomal compartment of tumor cells and induces an early leakage of lysosomal cathepsins into the cytosol followed by the activation of the proapoptotic protein Bax. Ectopic expression of three proteins known to stabilize the lysosomal compartment, i.e. heat shock protein 70 (Hsp70), Hsp70-2, and lens epithelium-derived growth factor, confer significant protection against BAMLET-induced cell death, whereas the antiapoptotic protein Bcl-2, caspase inhibition, and autophagy inhibition fail to do so. These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.
Ghee is medicine but modern doctors blame it for all life style diseases. They even prescribe ban at home.
Well, urban dwellers disconnected from Gau based villages must not consume ghee available in their super markets. It is indeed deadly.
But this does not mean all variety of ghee is bad. Rural India is where we can find ideal case studies. A study on a rural population in India showed a significantly lower prevalence of coronary heart disease in men who consumed higher amounts of ghee.
“Asian Indians previously had a low incidence of coronary heart disease and for generations had been using ghee in their cooking, which is low in PUFAs such as linoleic acid and arachidonic acid. The epidemic of coronary heart disease in India began two to three decades ago when traditional fats were replaced by oils rich in linoleic and arachidonic acid, as well as trans fatty acids which comprise 40% of vanaspati. Adulteration of commercially prepared ghee with vanaspati is also prevalent in India.”
Ghee prepared from desi Gau’s milk by churning is an elixir. If you can avail it, get it at any cost! Yes, at any cost! It will be cheaper than your medical bills. 😛 Be wise, at least health-wise. 😉
Association of dietary ghee intake with coronary heart disease and risk factor prevalence in rural males.
To determine the association between intake of dietary fat, specifically Indian ghee, and prevalence of coronary heart disease (CHD) and risk factors as study was undertaken on a rural population in Rajasthan. Total community cross-sectional survey was done using a physician administered questionnaire; 1982 males aged 20 years and more were studied. The dietary questionnaire focused on the amount and type of fat consumed. Staple dietary fat in this area is mustard/rapeseed oil and Indian ghee. To define the role of ghee, the average amount consumed in a month was determined; 782 males (39%) consumed 1 kg or more ghee per month (group 1) and 1200 (61%) consumed less than 1 kg per month (group 2). To elicit details of fatty acid composition of the diet consumed, detailed dietary history was acquired from a random 460 (23%) males; 220 from group 1 and 240 from group 2. Group 1 males were significantly younger, more literate and had more weight and body-mass index. This group consumed significantly more calories, saturated and mono-unsaturated fats while the consumption of polyunsaturated fats was similar in the two groups. Fatty acid intake analysis showed that group 1 males consumed more mono-unsaturated (n-9) fatty acids than group 2. Intake of polyunsaturated n-3 and n-6 fatty acids was similar. There was significantly lower prevalence of CHD in men who consumed > kg ghee per month (odds ratio = 0.23, 95% confidence limits 0.18-0.30, p < 0.001). Multivariate analysis confirmed this association (p < 0.001). The prevalence of hypertension and other coronary risk factors was similar in the two groups.
So your doctor asks you to stop having Ghee and start having Soyabean oil. Right?
Well, study suggests contradictory findings. You should actually stop eating genetically modified Soya oil and start consuming ethically procured desi Gau’s ghee (*What is it?).
As per this study:
“Dietary cow ghee compared to soybean oil downregulates the enzyme activities responsible for carcinogen activation in liver and upregulates carcinogen detoxification activities in liver and mammary tissues.”
*Ethically procured desi Gau’s ghee is produced by Gau shala that treats Gau as mother, never tortures her by hormone injections, processed food, allows calves to have milk as much they want, allows Gau to live freely and graze green grass daily.
Effects of cow ghee (clarified butter oil) & soybean oil on carcinogen-metabolizing enzymes in rats.
INTERPRETATION & CONCLUSIONS:
Our findings show that dietary cow ghee compared to soybean oil downregulates the enzyme activities responsible for carcinogen activation in liver and upregulates carcinogen detoxification activities in liver and mammary tissues.
[Based on reading late Dr M L Kothari’s cancer research]
Cancer is not a disease, but a biological event programmed by cells. The ticks of this event were started way back in past before symptoms are surfaced. The inception of cancer-starts as a very small, silent event that tardily marches over several years to the stage of being detected.
This initial event programmed by cell is due to several reasons. Some of them physiological and some psychological. Our body cells are themselves individual unique organisms with individual identity. They forget own identity to support larger existence i.e. your body. So they selflessly work day and night, perform own duty towards Nation (your body). It is Nation’s (body or “I” that govern body) reciprocal duty to provide stress-free life to each cell. Mentally stress-free life for cell is possible when “I” do not live life under any mental stress. Physically stress-free life for each cell is possible when “I” eat nutrient-rich, less-toxic or non-toxic food which can provide continuous support to each cell’s biological need. “I” also need to take care of vital Prana (force that keep the communication between “I” and each cell proper. Prana can be maintained by Prayer, meditation, exercise.
Now since our modern life expect us to live with stressful life, junk food devoid of nutrients and full of toxins, Genetically modified food, lack of exercise and prayer, wifi, mobile towers etc; so cancerous events are triggered in almost all of us. Only when the tolerance level of cells is passed, cells disconnect with identity of “I” and start living selfish life. So for their individual existence, they proliferate out of control. One fine day, tumor is detected.
So what is solution? Removing tumor is cancer treatment? No it is just a self-satisfaction of modern medicine that they can control cancer. They cannot as cancer is inherent nature of each cell. Until stress is controlled, cancer is not treated.
Treatment is not perfect if it does not restore cell identity and connect it again with you, your “I”. If you remove tumor from X position, it will resurface again at some other place. This is because canceribility (ability to disconnect from body and grow separately i.e. Ego of cell) is inherent nature of all cells. It is not treated. It can be treated when we take rest. When we remove stress. When we start eating healthy food. When we live more socially active life. When we live more jovial and smiling life.
Every human being genetically possesses the cancerability of tissues. Such cancerability, as a biologic feature, is normally distributed. All humans can, thus, develop cancer, yet only a fixed percentage (20%) of them does. This is dependent on the fact that to express cancerability, a human being must cross a certain threshold of physical, mental stress. This is the reason you sometimes see relatively healthy person inflicted by cancer and a chain smoker living cacer-free life 🙂.
Take care. Take care of your body very well. Love and nurture each cell of your body daily by right food, right exercise, faith in self, faith in God/almighty/mother nature.
At first, the researchers assumed that genes would shut down shortly after death, like the parts of a car that has run out of gas. What they found instead was that hundreds of genes ramped up. Although most of these genes upped their activity in the first 24 hours after the animals expired and then tapered off, in the fish some genes remained active 4 days after death.
Many of these postmortem genes are beneficial in emergencies; they perform tasks such as spurring inflammation, firing up the immune system, and counteracting stress. Other genes were more surprising. “What’s jaw-dropping is that developmental genes are turned on after death,” Noble says. These genes normally help sculpt the embryo, but they aren’t needed after birth. One possible explanation for their postmortem reawakening, the researchers say, is that cellular conditions in newly dead corpses resemble those in embryos. The team also found that several genes that promote cancer became more active. That result could explain why people who receive transplants from the recently deceased have a higher risk of cancer, Noble says. He and his colleagues posted their results on the preprint server bioRxiv last week, and Noble says their paper is undergoing peer review at a journal.
Autophagy is news for Nobel prize and suddenly there is world-focus on this word! This particular phenomenon is not new for us in India. This is well-understood concept in Ayurveda. Ojovisramsa is impairment in distribution of Ojas. Ojas is a immunological factor.
“Ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture.”
This post is about Ginger triggered Autophagy!
Ginger truly does top the list of effective natural home remedies.
Being used throughout history by different cultures around the world, ginger harnesses an incredible healing power proven for a host of ailments. The spice is packed with essential nutrients and rejuvenating compounds.
While ginger has been shown to help countless ‘minor’ problems such as an upset stomach, amazingly the health benefits of ginger also include combating cancer more effectively than pharmaceutical cancer drugs.
इमां खनाम्योषधिं वीरुधं बलवत्तमाम् । ऋग्वेद: सूक्तं १०.१४५
“What I dig is very potent herb to increase strength.”
Excuse my faulty translation but there are interesting dots to connect.
1) शारीरिक & प्राणिक बल are necessary to earn पुरुषार्थ (धर्म,अर्थ,काम,मोक्ष) and perform our duties towards the Universe with least errors.
2) In my understanding, when grown in soil nurtured and kindled with Prana(प्राण) by gobar, mutra and butter milk of Desi Gau, Vegetables from कंद वर्ग (the ones that we dig) grows in the epicenter of rich Pranic environment. And this Prana is not Raw Prana like other vegetables and fruits get from the Sun by photosynthesis and external environment. It is digested Prana or churned prana. Churning prana makes its potency manifold. So they are full of प्राणिक बल. Since they are the roots, they have most possible essence of all physical nutrients.
3) कंद वर्ग’s vegetables is main food for ऋषि पञ्चमी. That means, to nurture the ऋषि अंश settled at our subtle senses can realize their full potential with the help of कंद वर्ग.
4) In most cases, you dig them only when they plant completes its life cycle. For example, I dig my turmeric only when all its leaves are dried and gone.
Keep an eye on seasonal कंद वर्ग vegetables and include them in your meals. Of course, nothing worth without Gau mata.
जामवंत के बचन सुहाए। सुनि हनुमंत हृदय अति भाए॥
तब लगि मोहि परिखेहु तुम्ह भाई। सहि दुख कंद मूल फल खाई॥
Now read on about Ginger and Autophagy! 🙂
6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death
Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. The spheroids were generated from adherent breast cancer cells. 6-shogaol was effective in killing both breast cancer monolayer cells and spheroids at doses that were not toxic to noncancerous cells. The percentages of CD44+CD24–/low cells and the secondary sphere content were reduced drastically upon treatment with 6-shogaol confirming its action on CSCs. Treatment with 6-shogaol caused cytoplasmic vacuole formation and cleavage of microtubule associated protein Light Chain3 (LC3) in both monolayer and spheroid culture indicating that it induced autophagy. Kinetic analysis of the LC3 expression and a combination treatment with chloroquine revealed that the autophagic flux instigated cell death in 6-shogaol treated breast cancer cells in contrast to the autophagy inhibitor chloroquine. Furthermore, 6-shogaol-induced cell death got suppressed in the presence of chloroquine and a very low level of apoptosis was exhibited even after prolonged treatment of the compound, suggesting that autophagy is the major mode of cell death induced by 6-shogaol in breast cancer cells. 6-shogaol reduced the expression levels of Cleaved Notch1 and its target proteins Hes1 and Cyclin D1 in spheroids, and the reduction was further pronounced in the presence of a γ-secretase inhibitor. Secondary sphere formation in the presence of the inhibitor was also further reduced by 6-shogaol. Together, these results indicate that the inhibitory action of 6-shogaol on spheroid growth and sustainability is conferred through γ-secretase mediated down-regulation of Notch signaling. The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment.
Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
Zerumbone, a natural monocyclic sesquiterpene, is the main component of the tropical plant Zingiber zerumbet Smith. Zerumbone induced antiproliferative and apoptotic effects against PC-3 and DU-145, two human hormone-refractory prostate cancer (HRPC) cell lines. Zerumbone inhibited microtubule assembly and induced an increase of MPM-2 expression (specific recognition of mitotic proteins). It also caused an increase of phosphorylation of Bcl-2 and Bcl-xL, two key events in tubulin-binding effect, indicating tubulin-binding capability and mitotic arrest to zerumbone action. Furthermore, zerumbone induced several cellular effects distinct from tubulin-binding properties. First, zerumbone significantly increased, while paclitaxel (as a tubulin-binding control) decreased, Mcl-1 protein expression. Second, paclitaxel but not zerumbone induced Cdk1 activity. Third, zerumbone other than paclitaxel induced Cdc25C downregulation. The data suggest that, in addition to targeting tubulin/microtubule, zerumbone may act on other targets for signaling transduction. Zerumbone induced mitochondrial damage and endoplasmic reticulum (ER) stress as evidenced by the loss of mitochondrial membrane potential and upregulation of GRP-78 and CHOP/GADD153 expression. Zerumbone induced an increase of intracellular Ca(2+) levels, a crosstalk marker between ER stress and mitochondrial insult, associated with the formation of active calpain I fragment. It induced apoptosis through a caspase-dependent way and caused autophagy as evidenced by dramatic LC3-II formation. In summary, the data suggest that zerumbone is a multiple targeting compound that inhibits tubulin assembly and induces a crosstalk between ER stress and mitochondrial insult, leading to apoptosis and autophagy in HRPCs.
Don’t panic if you have taken in past. Avoid in future and take measures to reverse the effect in body by living stress-free life.
I have been vocal against idiotic Pill obsession. Mindless birth control pills in your young age will invite grave danger in menopausal age. Not only obesity but also diabetes, cancer and hormonal disorders.
It is grave mistake on govt side to promote contraceptives as birth control tools.
Not only females, newborns also suffer due to pills. Early in fetal life, nutrient deficiencies may result in severe impairments. For example, folate. Or as popularly known as : B Vitamin. Pill obsession will make your child devoid of folate in growth period as mother’s folate level reduces due to pill-intake.
Take care. Spread awareness. Save Nation.
ACCORDING TO A LOT OF DOCTORS:
Got acne? Take the pill.
Got PMS? Take the pill.
Got irregular cycles? Take the pill.
Don’t want to get pregnant? Take the pill.
All thanks parents’ pre-planning sexual indulgence and avoidance of progeny by modern pills. Folate is a vitamin that may become depleted with the use of birth control pills. Aside from the long list of potential side effects birth control pills can deplete important nutrients. These nutrients include: Vitamin B2, Vitamin B6, Vitamin B12, Folic Acid, Vitamin C, Magnesium and Zinc.
Once the pills become regular bedroom utility, body start denying absorption of nutrients. No matter how sophisticated supplements you take.
Such information is never passed-on to teens and young married couples. And so sex becomes pleasure machine for them. Instant, handy and under control. What a toxic delusion! 🙁🙁 And and top of that Idiot Chetan Bhagat tribe cry for porn freedom rights!! Ghor Kaliyug !! 🙁🙁
Little is known about whether contemporary hormonal contraception is associated with an increased risk of breast cancer.
We assessed associations between the use of hormonal contraception and the risk of invasive breast cancer in a nationwide prospective cohort study involving all women in Denmark between 15 and 49 years of age who had not had cancer or venous thromboembolism and who had not received treatment for infertility. Nationwide registries provided individually updated information about the use of hormonal contraception, breast-cancer diagnoses, and potential confounders.
Among 1.8 million women who were followed on average for 10.9 years (a total of 19.6 million person-years), 11,517 cases of breast cancer occurred. As compared with women who had never used hormonal contraception, the relative risk of breast cancer among all current and recent users of hormonal contraception was 1.20 (95% confidence interval [CI], 1.14 to 1.26). This risk increased from 1.09 (95% CI, 0.96 to 1.23) with less than 1 year of use to 1.38 (95% CI, 1.26 to 1.51) with more than 10 years of use (P=0.002). After discontinuation of hormonal contraception, the risk of breast cancer was still higher among the women who had used hormonal contraceptives for 5 years or more than among women who had not used hormonal contraceptives. Risk estimates associated with current or recent use of various oral combination (estrogen–progestin) contraceptives varied between 1.0 and 1.6. Women who currently or recently used the progestin-only intrauterine system also had a higher risk of breast cancer than women who had never used hormonal contraceptives (relative risk, 1.21; 95% CI, 1.11 to 1.33). The overall absolute increase in breast cancers diagnosed among current and recent users of any hormonal contraceptive was 13 (95% CI, 10 to 16) per 100,000 person-years, or approximately 1 extra breast cancer for every 7690 women using hormonal contraception for 1 year.
The risk of breast cancer was higher among women who currently or recently used contemporary hormonal contraceptives than among women who had never used hormonal contraceptives, and this risk increased with longer durations of use; however, absolute increases in risk were small. (Funded by the Novo Nordisk Foundation.)
Cancer cell? What is it? There is nothing like cancer cell. Body cells are your Annamaya footprints. Your own identity. There is nothing called cancer cell. Cancer cells – they are nothing but your normal body cells behaving cancerously.
Cancer is a behavior. Uncontrolled behavior to rebel against the self. Rebel because you being Pati (Protector) of the Ayodhya (Body) is not performing duties well.
Cancer can be treated. Suppressing cancer symptoms is not cancer treatment. Revive cellular confidence. Be happy. Be cheerful. Be more social. Live in the lap of mother nature.
Cricket is a societal cancer. So even if you are a great person but still associated with Cricket, you are responsible for cancer. I don’t see such persons with high respect.
I am long distance runner and despite crossing 30, I still can beat teen athletes in 100 m sprints. Occasionally, I play football. In my teen age, I played cricket too.
My yardstick to evaluate Cricket as cancer is because of my understanding of word क्रीडा.
Cricket is light years far to fit in word ‘क्रीडा’ (Cricket being hopelessly laggard entertainment cannot fit in my understanding of क्रीडा ) but it is very close to word ‘कीड़ा’ (insects – mafias, corrupts, criminals chewing this Nation) of the society. As a leader, as a political party with difference, as a youngster, I would never ever embrace it.
And someone doing it, it is fate of the Nation, party and an individual. God bless.
Many friends ask me, why Indians used to live short life despite having rich Ayurvedic knowledge?
“Short life span was not pan-India observation. It was limited to British ruled area. And it is because Indians under British lived slave’s life. Slaves live under stress. Stress accelerates aging. Stress kills. Many remote villages unaffected by British rule, did have long life span as it is observed now”
👆 Work stress = Cancer or TB any chronic disease
Good Morning. Read it. Slow down. Our mindless race to achieve something (which many don’t realize) virtual (career, growth, money) beyond our capacity induces stress. This does not mean we don’t pursue our goals. It only mean, pursue without generating stress on body and mind. Stress , as I shared with friends often, is root cause of inflammation and inflammation a root cause of cancer. This research proves my hypothesis about stress.
Prolonged exposure to work-related stress thought to be related to some cancers
For men, prolonged exposure to work-related stress has been linked to an increased likelihood of lung, colon, rectal, and stomach cancer and non-Hodgkin lymphoma. The findings are among the results obtained by researchers at INRS and Université de Montréal who conducted the first study to assess the link between cancer and work-related stress perceived by men throughout their working life. The research results were recently published in Preventive Medicine.
On average, the study participants had held four jobs, with some holding up to a dozen or more during their working lifetime. Significant links to five of the eleven cancers considered in the study were revealed. These links were observed in men who had been exposed to 15 to 30 years of work-related stress, and in some cases, more than 30 years. A link between work-related stress and cancer was not found in participants who had held stressful jobs for less than 15 years.
The most stressful jobs included firefighter, industrial engineer, aerospace engineer, mechanic foreman, and vehicle and railway-equipment repair worker. For the same individual, stress varied depending on the job held. Researchers were able to document changes in perceived work-related stress.
The study also shows that perceived stress is not limited to high work load and time constraints. Customer service, sales commissions, responsibilities, the participant’s anxious temperament, job insecurity, financial problems, challenging or dangerous work conditions, employee supervision, interpersonal conflict, and a difficult commute were all sources of stress listed by the participants.
“One of the biggest flaws in previous cancer studies is that none of them assessed work-related stress over a full working lifetime, making it impossible to determine how the duration of exposure to work-related stress affects cancer development. Our study shows the importance of measuring stress at different points in an individual’s working life,” explain the authors of the study.
The results obtained raise the question of whether chronic psychological stress should be viewed as a public health issue. But these results are as yet unsubstantiated because they are based on a summary assessment of work-related stress for a given job. There is now a need for epidemiological studies based on reliable stress measurements, repeated over time and that take all sources of stress into account.