Cancer

Cancer

Business of Cancer Screening

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It is height of fear vending by modern medical technology to detect disease that now normal biological events are termed as disease symptoms.

img src: http://prostatecancer911.com/wp-content/uploads/2015/03/ProstateCancerDiagnosis.jpg
img src: http://prostatecancer911.com/wp-content/uploads/2015/03/ProstateCancerDiagnosis.jpg
PSA test
PSA test

For example prostate cancer (PSA screening or prostate-specific antigen screening) prescribed by doctors as yearly check up for men above age 50. It is normal that with growing age, prostate size increases gradually. I bet, 90% aged men diagnosed for early prostate cancer symptoms were having normal conditions. But due to modern medical technological arrogance, they were terms as cancerous and hence operated.

Unnecessary surgical stress. Unnecessary hospital stress. Unnecessary antibiotic attack. Financial stress. Family under stress. Major havoc for life without any reason. Just for the sake of sheer arrogance of technological feet.

USA is waking up and correcting mistakes. Will Indian doctor learn? Genuine doctors will. Business minded won’t. You take care 🙂

Reference: http://www.cancer.gov/types/prostate/psa-fact-sheet

Factory Food (Processed Food) and Cancer

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AminoAcids

I shared it before. It is game of Prana. Amino Acids with their unique shape promoting feature, triggers many biological events, including cancer.

Cutting out certain amino acids – the building blocks of proteins – from the diet of mice slows tumour growth and prolongs survival, according to new research* published in Nature.

Researchers at the Cancer Research UK Beatson Institute and the University of Glasgow found that removing two non-essential amino acids – serine and glycine – from the diet of mice slowed the development of lymphoma and intestinal cancer.

Serine?

Yeah! the meat, beef, dairy products like cheese etc.
And so called vegan diet – almonds, asparagus, chickpea, cow pea, flax-seed, lentils, sesame seed, walnut and soy beans.

glycine ?

Again meat!! Glycine is a conditional/non-essential amino acid found in bone broth, meat, poultry, eggs, dairy products and certain beans and veggies.


Research


Amino acids in diet could be key to starving cancer

http://www.medicilon.com/201742415371-2/

Cancer cells have an unnatural appetite for certain amino acids—nonessential amino acids that healthy cells produce themselves, usually in amounts sufficient for ordinary metabolism. If cancer cells are denied these amino acids, they are weakened. They grow and proliferate more slowly. It is possible, moreover, that they could be more vulnerable to conventional cancer treatments, such as chemotherapy and radiotherapy.

Gut Bacteria (Pranic Footprint-प्राणमय कोष) controls speed of tumor growth

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I have shared it many times that the ultimate way of cancer prevention is to restore Prana in body. It is lack of prana/blockage of Nadi, that causes cancer.

Gut Bacteria, like any other body organ, is manifestation of Prana. And they being non-organ self of body, play critical role in well-being of body organs.

We can prevent cancer easily. Even cancer management is also less painful compare to modern chemo and radiation torture.

Three fundamental source of Prana for restoration

  1. Raw Prana from the Sun
  2. Churned Prana from Desi cow’s milk and ghee
  3. Food grown on the soil replenished by raw and churned prana (Sun light, cow dung, urine, milk, butter milk)

GUTBacteria


Research


Gut Bacteria Determine Speed of Tumor Growth in Pancreatic Cancer

https://nyulangone.org/press-releases/gut-bacteria-determine-speed-of-tumor-growth-in-pancreatic-cancer

The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells.

These are the findings of a study conducted in mice and in patients with pancreatic ductal adenocarcinoma (PDA), a form of cancer that is usually fatal within two years. Led by researchers at NYU School of Medicine, Perlmutter Cancer Center, and NYU College of Dentistry, the study published online March 22 in Cancer Discovery, a journal of the American Association for Cancer Research (AACR).

Specifically, the study found that removing bacteria from the gut and pancreas by treating mice with antibiotics slowed cancer growth and reprogrammed immune cells to again “take notice” of cancer cells. Oral antibiotics also increased roughly threefold the efficacy of checkpoint inhibitors, a form of immunotherapy that had previously failed in pancreatic cancer clinical trials, to bring about a strong anti-tumor shift in immunity.

Experiments found that in patients with PDA, pathogenic gut bacteria migrate to the pancreas through the pancreatic duct, a tube that normally drains digestive juices from the pancreas into the intestines. Once in the pancreas, this abnormal bacterial mix (microbiome) gives off cellular components that shut down the immune system to promote cancer growth, say the authors.

Cancer and Death : Two Biological events

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Would you call ‘Death’ as disease? No, right? Death is not a disease. It is biological event. Similarly, cancer is also a biological event. Sometimes, it surfaces on life early. Most of the times, it does in last stage of life. Game of circadian clocks. Time driven events.

diagram-showing-how-cancer-cells-keep-on-reproducing-to-form-a-tumour_0

Cancer is a property of each cell. It is the faulty clock that leads to cell into Cancer pathway than Cell Death pathway.

We all take birth with a probability of normal cells turned cancer cells.

Once you die, the cells in your body think that you are an embryo….so all the genes which remain up in embryo (and that never again become active in your life time after birth) become active again.

Body cells also think that there is something wrong, that’s why there is no signal of cell proliferation, development etc. So, the cells start expressing the genes that are generally overexpressed during cancer. I.e. signal is given to cell to proliferate (multiply).

People who get organ donation from dead body are more prone to cancers. This is explanation!!
Or in other words, Cancer is a sign of early death or rapid aging.

 


Research


http://www.scripps.edu/news/press/2016/20161116lamia.html

TSRI Researchers Show How Circadian ‘Clock’ May Influence Cancer Pathway

A new study led by scientists at The Scripps Research Institute (TSRI) describes an unexpected role for proteins involved with our daily “circadian” clocks in influencing cancer growth.

The research, published recently in the journal Molecular Cell, suggests that disruptions in circadian rhythms might leave levels of an important cancer-linked protein, called cMYC, unchecked.

“This appears to have big implications for the connection between circadian rhythms and cancer,” said TSRI biologist Katja Lamia, senior author of the study.

There is growing evidence that shift work and frequent jet lag can raise a person’s risk of cancer, suggesting a link between daily rhythms and cell growth. “We know this connection exists, but we haven’t known why,” said Lamia.

The researchers focused on proteins called cryptochromes, which evolved from bacterial proteins that sense light and repair DNA damage caused by sunlight. In humans, these proteins, called CRY1 and CRY2, regulate our circadian clocks, which influence what times of day we become tired, hungry and much more.

Using cells from mouse models, the researchers demonstrated that deleting the gene that expresses CRY2 reduced the cells’ ability to degrade a protein called cMYC. Without CRY2 keeping cMYC at normal levels, the researchers saw increased cell proliferation—similar to the abnormal growth seen in cancers.

Further studies of protein structures suggested that CRY2 is a key player in a process to “mark” cMYC for degradation. The researchers said it is significant that this process occurs after gene transcription—once the proteins are already produced—rather than during transcription, as in many other cryptochrome functions.

“This is a function of a circadian protein that has never been seen before,” said TSRI Research Associate Anne-Laure Huber, who served as first author of the study.

The researchers say more studies are needed to confirm this connection between circadian clocks and cancer in human tissues.

In addition to Lamia and Huber, authors of the study, “CRY2 and FBXL3 Cooperatively Degrade c-MYC,” were Stephanie J. Papp, Alanna B. Chan, Sabine D. Jordan, Anna Kriebs and Madelena Nguyen of TSRI; Emma Henriksson of TSRI and Lund University; Martina Wallace and Christian M. Metallo of the University of California, San Diego; and Zhizhong Li of the Genomics Institute of the Novartis Research Foundation and Novartis Institutes for Biomedical Research.

This study was supported by the National Institutes of Health (grants DK090188, DK097164, CA188652 and NIGMS P41-GM103311), the Searle Scholars Program through the Kinship Foundation, the Sidney Kimmel Foundation, the Lung Cancer Research Foundation, the Swedish Research Council, the Deutsche Forschungsgemeinschaft and the American Heart Association (grant 15POST22510020).

 

 

Microbes and Cruciferous Vegetables : Cancer Cure

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It confirms once more that:

  1. the inflamed organs end into cancer
  2. Prana heals (Here, in form of microbes that releases chemical to stop the cancer proliferation signals

Cruciferos-Vegetable


Research


With these special bacteria, a broccoli a day can keep the cancer doctor away

Colorectal cancer is one of the most common cancers in the world, especially the developed world. Although the 5-year survival rates for earlier stages of this cancer are relatively good, at later stages survival goes down and the risk of cancer recurrence goes up considerably.

At the heart of this cancer-targeting system is an engineered form of E. coli Nissle, a harmless type of bacteria found in the gut. Using genetic techniques, the team engineered the bacteria into a probiotic that attached to the surface of colorectal cancer cells and secreted an enzyme to convert a substance found in cruciferous vegetables (like broccoli) into a potent anticancer agent. The idea was for the cancer cells in the vicinity to take up this anticancer agent and be killed. Normal cells cannot do this conversion, nor are they affected by the toxin, thus the system should be targeted only to colorectal cancer cells.

True enough, the mixture of engineered probiotics with a broccoli extract or water containing the dietary substance killed more than 95% of colorectal cancer cells in a dish. Moreover, the mixture had no effect on cells from other types of cancer such as breast and stomach cancer. Strikingly, the probiotics-veggie combination reduced tumour numbers by 75% in mice with colorectal cancer. Also, the tumours that were detected in these mice were 3 times smaller than those in control mice which were not fed with the mixture.

https://www.nature.com/articles/s41551-017-0181-y

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432495/

Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been extensively studied due to its apparent health-promoting properties in disease and limited toxicity in normal tissue. Recent Studies: Recent identification of a sub-population of tumor cells with stem cell-like self-renewal capacity that may be responsible for relapse, metastasis, and resistance, as a potential target of the dietary compound, may be an important aspect of sulforaphane chemoprevention. Evidence also suggests that sulforaphane may target the epigenetic alterations observed in specific cancers, reversing aberrant changes in gene transcription through mechanisms of histone deacetylase inhibition, global demethylation, and microRNA modulation. Critical Issues: In this review, we discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound. Sulforaphane possesses the capacity to intervene in multistage carcinogenesis through the modulation and/or regulation of important cellular mechanisms. The inhibition of phase I enzymes that are responsible for the activation of pro-carcinogens, and the induction of phase II enzymes that are critical in mutagen elimination are well-characterized chemopreventive properties. Furthermore, sulforaphane mediates a number of anticancer pathways, including the activation of apoptosis, induction of cell cycle arrest, and inhibition of NFκB. Future Directions: Further characterization of the chemopreventive properties of sulforaphane and its capacity to be selectively toxic to malignant cells are warranted to potentially establish the clinical utility of the dietary compound as an anti-cancer compound alone, and in combination with clinically relevant therapeutic and management strategies. Antioxid. Redox Signal. 22, 1382–1424.

Ginger :10000 times more effective than Chemotherapy

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Ginger Cancer

What is cancer cell?

Some dirty cell of your body? No. This body is wonderful gift. Nature does not act dirty. You and me do. Cancer cell is ordinary cell with cancerous tendency. Such tendency is expected due to cellular level stress. This stress is due to mental stress, physical stress (Food, water, air pollution) and environmental stress. Prolonged stress.

No cell loves to act cancerously. If you help them reduce local and global stress, they prefer to live happy life for you.

Cancer stem cells is a step before Cancer Cells. Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse.

It is shown by this research paper that Ginger compounds act against CSCs and inhibits them.

So is this the solution? No! Why should we even invite cancer? Prevention is always better than cure. Having ginger in diet can help but more than that stress-free life is more important! The root of all sicknesses start with weak mind!

Beware! Ginger and Turmeric are found 10000 times more effective than Chemotherapy. Now, we will have flood industrial farming of ginger and turmeric. That will follow genetically modified Ginger and Turmeric. That is how species are destroyed by Idiot science.


Research


6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137614

Abstract

Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. The spheroids were generated from adherent breast cancer cells. 6-shogaol was effective in killing both breast cancer monolayer cells and spheroids at doses that were not toxic to noncancerous cells. The percentages of CD44+CD24/low cells and the secondary sphere content were reduced drastically upon treatment with 6-shogaol confirming its action on CSCs. Treatment with 6-shogaol caused cytoplasmic vacuole formation and cleavage of microtubule associated protein Light Chain3 (LC3) in both monolayer and spheroid culture indicating that it induced autophagy. Kinetic analysis of the LC3 expression and a combination treatment with chloroquine revealed that the autophagic flux instigated cell death in 6-shogaol treated breast cancer cells in contrast to the autophagy inhibitor chloroquine. Furthermore, 6-shogaol-induced cell death got suppressed in the presence of chloroquine and a very low level of apoptosis was exhibited even after prolonged treatment of the compound, suggesting that autophagy is the major mode of cell death induced by 6-shogaol in breast cancer cells. 6-shogaol reduced the expression levels of Cleaved Notch1 and its target proteins Hes1 and Cyclin D1 in spheroids, and the reduction was further pronounced in the presence of a γ-secretase inhibitor. Secondary sphere formation in the presence of the inhibitor was also further reduced by 6-shogaol. Together, these results indicate that the inhibitory action of 6-shogaol on spheroid growth and sustainability is conferred through γ-secretase mediated down-regulation of Notch signaling. The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment.

 

 

Cow Milk, BAMLET and Cancer Prevention

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Cow Milk Cancer

We cut short feeding duration for petty things like career, beauty and money.
We also don’t have access to ethically procured A2 milk from lovable mother Gau.

Mother’s milk has HAMLET. Cow’s raw milk has BAMLET.

Both can control cancerous nature of the cell.

And we cry increasing numbers of cancer cases. 🙁

“Breast-feeding has also been reported to protect against development of immunological diseases, such as allergy (Ahmed & Fuchs, 1997; Saarinen & Kajosaari, 1995), infantile diabetes mellitus (Gerstein, 1994; Mayer et al., 1988) and inflammatory gastrointestinal disease (Koletzko et al., 1989). These results imply that factors in milk may help optimise the function of the immune system and regulate cell populations that results in les risk of tumor development and less risk for abberant immunity in the rapidly growing neonatal intestinal tract.”

 

“These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.”


Research


Breast-feeding, HAMLET, and cancer

http://www.acsu.buffalo.edu/~andersh/research/milkcancer.asp

HAMLETs effect against tumors in vivo

To date several studies have addressed the ability of HAMLET to kill tumor cells in vivo. Early attempts in mouse models were thwarted as we realized that serum (especially serum albumin) induces a partial inactivation of HAMLET based on binding to the fatty acid in HAMLET. The attempts that have since been done have addressed topical or mucosal administration of HAMLET.

Walter Fischer, then in Bergen, Norway, used HAMLET in a model where tumor tissue from patients with glioblastomas were transplanted under the skull of rats. In this model one dose of HAMLET was infused in the brain through a pump and tissue was tested for apoptosis induction and the rats were monitored for survival. HAMLET treatment delayed death of the rats and the most important finding was that when investigating the brain tissue they found that apoptosis was only induced in tumor cells, no healthy brain cells were affected (Fischer Cancer Res 2004). This indicated what we already know in vitro, that the protein only attacks tumor cells, and indicated that little side effects may be expected should this be used for treatment purposes. Walter, now in Copenhagen, Denmark, is currently planning a patient study in patients with glioblastomas.

In a second study, Lotta Gustafsson together with Irene Leijonhufvud conducted a study on benign papilloma virus warts. Papillomas are a benign tumor form where the skin cells are transformed by virus infection and the hypothesis was that this transformation may make them susceptible to HAMLET treatment. A population of individuals having a major problem with recurrent warts were treated topically with HAMLET and it was found that HAMLET was effective in eliminating warts and that this effect had a long lasting effect (Gustafsson NEJM 2004).

Recently, Anki Mossberg together with Bjorn Wullt performed a study on 9 patients with transitional bladder carcinomas (tumor of the urinary bladder) (Mossberg Int J Cancer 2007). They instilled HAMLET in the bladder of patients in the week preceding surgery and evaluated the tumor morphology by endoscopic photography and apoptosis-induction in biopsy tissue. They found that a reduction in tumor size was seen in 8 of 9 patients and that apoptosis was detected in the tumor tissue but not in the adjacent healthy tissue, indicating that HAMLET is specifically tumorigenic also in vivo. This study was followed up by a study in mice (Mossberg, J Urol, 2010) using the MB49 bladder carcinoma model. In this model they showed a delay in tumor development when HAMLET was instilled in the bladder.

In a study from 2014 Puthia et al (Gut January issue, 2014) it wa shown that HAMLET could be used to prevent and treat colon cancer in APC/Min-mice. HAMLET was given perorally and showed a reduced progression of tumor growth and an increased survival when given as a prophylaxis and reduction of established tumors when given as treatment. HAMLEt accumulated only in tumor tissue and only healthy cells were observed to be apoptotic.


BAMLET activates a lysosomal cell death program in cancer cells.

https://www.ncbi.nlm.nih.gov/pubmed/20053771

A complex of human alpha-lactalbumin and oleic acid (HAMLET) was originally isolated from human milk as a potent anticancer agent. It kills a wide range of transformed cells of various origins while leaving nontransformed healthy cells largely unaffected both in vitro and in vivo. Importantly, purified alpha-lactalbumins from other mammals form complexes with oleic acid that show biological activities similar to that of HAMLET. The mechanism by which these protein-lipid complexes kill tumor cells is, however, largely unknown. Here, we show that complex of bovine alpha-lactalbumin and oleic acid (BAMLET), the bovine counterpart of HAMLET, kills tumor cells via a mechanism involving lysosomal membrane permeabilization. BAMLET shows potent cytotoxic activity against eight cancer cell lines tested, whereas nontransformed NIH-3T3 murine embryonic fibroblasts are relatively resistant. BAMLET accumulates rapidly and specifically in the endolysosomal compartment of tumor cells and induces an early leakage of lysosomal cathepsins into the cytosol followed by the activation of the proapoptotic protein Bax. Ectopic expression of three proteins known to stabilize the lysosomal compartment, i.e. heat shock protein 70 (Hsp70), Hsp70-2, and lens epithelium-derived growth factor, confer significant protection against BAMLET-induced cell death, whereas the antiapoptotic protein Bcl-2, caspase inhibition, and autophagy inhibition fail to do so. These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.


Raw Milk Fights Cancer? Who is Hamlet and Bamlet?

Raw Milk Fights Cancer? Who is Hamlet and Bamlet?

Milk Protein Kills Cancer Cells and Antibiotic-Resistant Bacteria

Milk Protein Kills Cancer Cells and Antibiotic-Resistant Bacteria

Live in joint family, reduce cancer risk

joint family

What more proofs and positive points you need to realize value of joint family system? Living in like-minded community, where joint family is smallest possible unity, you not only live life stress-free, you also grow kids strong and healthy.

Thanks to our brainwashed generation, now more and more married couple wish to live life separately. For them, parents are burden and they can’t really adjust with cousins and siblings. 12 mental stools are doing their job.

शोकः क्रोधश्च लोभश्च कामो मोहः परासुता।
ईर्ष्या मानो विचिकित्सा कृपासूया जुगुप्सता॥
द्वादश्ौते बुद्धिनाशहेतवो मानसा मलाः।

– इति कालिकापुराणे १८ अध्यायः

शोक,क्रोध्,लोभ,काम,मोह,परपीडन,द्वेश्,अहंकार,संशय,घृणा,दोषरोपन,परनिन्दा

These mental stools are in base of any modern disease. Joint family system can keep check on them. In turn, it will help to live stress-free healthy life.

Besides mental check by elderly in family, joint family system serve whole gamut of pro-life bio-markers to all in family, legacy of past 7 generations, strengthening immune system far better than living in nuclear setup.

Read on the research.


Research


Larger Families Reduce Cancer Risk

Families with many children have a lower risk of cancer. Greater family size reduces the risk not only in women but also in men, a global study using data from 178 countries by the University of Zurich and the Adelaide Medical School has found.

Correlation between family size and cancer risk

The study suggests that family size, as determined by the number of children born to a mother during her lifetime, and size of household have a strong negative correlation with the incidence of all cancer types, independent of the person’s age. The larger the family, the less frequently certain types of cancer occur, including brain, bladder, lung, stomach, breast, ovarian colorectal and cervical cancers as well as melanoma. The protective effects of family size are stronger for males than for females.

It has been known before that female-specific cancers such as breast or ovarian cancer depend on the number of pregnancies – the more pregnancies a woman has had, the less likely she is to develop cancer. Surprisingly, this new study shows the protective effects of family size on cancer incidence were even greater among men than among women and a large number of non-reproduction-related cancers are involved.

Protective aspects of family life

The fact that cancer risk among men depends on their partners’ fertility and on household size might seem remarkable, but it can be explained. Family life, though it can be stressful in some ways, creates a special emotional environment which can have a positive effect on the overall resistance to diseases – and thus also protects family members from developing cancer.

Humans have been adapting to living in classical family structures, i.e. two parents and children, for some four million years. The practice of collaborative parenting, where both the father and the mother participate in child care, has been one of the first specifically human traits to evolve.  The study now suggests that family members supporting each other in keeping a healthy lifestyle may also provide protection against cancer.

https://www.media.uzh.ch/en/Press-Releases/2018/Cancer-Risk.html

Prana heals : UCLA research suggests that Gut Microbes Prevents Cancer

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But we eat mindless acidic food so that bacteria can hardly reach GUT via digestive track.
We kill mouth bacteria by using toothpaste.
We kill them by handwash and soaps.
We hardly spend physically active time under the sun.
Our food lack supporting nutrition so that bacteria can travel and stabilize at Gut.
Mindless usage of antibiotics.
 
And then we are shocked by sudden increase in cancer cases! 😉
 
As a society, unless we correct our priorities, we will celebrate Cancer hospitals as human success milestones. 😛 😀
Microbes = Prana
Prana is an ultimate healer.
mirror daily_b39500c1cb938cbba99dc02f3fed73fd
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Research
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UCLA research suggests that gut bacteria could help prevent cancer

https://www.uclahealth.org/news/ucla-research-suggests-that-gut-bacteria-could-help-prevent-cancer

“It is not invasive and rather easy to do,” he said.

Over millions of years, gut bacteria have evolved into both good and bad types: The good ones have anti-inflammatory properties and the bad ones promote inflammation. The human body typically contains about 10 trillion bacterial cells, compared with only 1 trillion human cells.

Schiestl and his colleagues isolated a bacterium called Lactobacillus johnsonii 456, which is the most abundant of the beneficial bacteria, and which has some pretty useful applications outside of medicine. “Since it is a Lactobacillus strain, it makes excellent yogurt, kefir, kombucha and sauerkraut.”

In the UCLA study the bacterium reduced gene damage and significantly reduced inflammation — a critical goal because inflammation plays a key role in many diseases, including cancer, neurodegenerative diseases, heart disease, arthritis and lupus, and in the aging process.

Previous research led by Schiestl presented the first evidence of a relationship between intestinal microbiota and the onset of lymphoma, a cancer that originates in the immune system. The new study explains how this microbiota might delay the onset of cancer, and suggests that probiotic supplements could help keep cancer from forming.

For both studies, Schiestl and his team used mice that had mutations in a gene called ATM, which made them susceptible to a neurologic disorder called ataxia telangiectasia. The disorder, which affects 1 in 100,000 people, is associated with a high incidence of leukemia, lymphomas and other cancers.

The mice were divided into two groups — one that was given only anti-inflammatory bacteria and the other that received a mix of inflammatory and anti-inflammatory microbes that typically co-exist in the intestines.

In the Cancer Research paper, Schiestl and his team showed that in the mice with more of the beneficial bacteria, the lymphoma took significantly longer to form.

In the new study, the researchers analyzed the metabolites — molecules produced by the gut’s natural metabolic action — in the mice’s urine and feces. The scientists were surprised to find that the mice that were receiving only the beneficial microbiota produced metabolites that are known to prevent cancer. Those mice also had more efficient fat and oxidative metabolism, which the researchers believe might also lower the risk for cancer.

Among the other results, in the mice receiving only the good bacteria, lymphoma formed only half as quickly as it did in the other mice. In addition, mice with the good bacteria lived four times longer and had less DNA damage and inflammation.

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis

Abstract

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151190

Intestinal microbiota play a significant role in nutrient metabolism, modulation of the immune system, obesity, and possibly in carcinogenesis, although the underlying mechanisms resulting in disease or impacts on longevity caused by different intestinal microbiota are mostly unknown. Herein we use isogenic Atm-deficient and wild type mice as models to interrogate changes in the metabolic profiles of urine and feces of these mice, which are differing in their intestinal microbiota. Using high resolution mass spectrometry approach we show that the composition of intestinal microbiota modulates specific metabolic perturbations resulting in a possible alleviation of a glycolytic phenotype. Metabolites including 3-methylbutyrolactone, kyneurenic acid and 3-methyladenine known to be onco-protective are elevated in Atm-deficient and wild type mice with restricted intestinal microbiota. Thus our approach has broad applicability to study the direct influence of gut microbiome on host metabolism and resultant phenotype. These results for the first time suggest a possible correlation of metabolic alterations and carcinogenesis, modulated by intestinal microbiota in A-T mice.

Viral Infection : Sign of resilience, sign of life : Zika Virus kills Cancer cells

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Zika Cancer
I am not doctor but based on study and observation, I once told to my friends group that viral infections are indicators of healthy immune system. Don’t avoid them. Just take care of soothing and fast recovery.
 
Cancer is a stage indicating death. The last bastion for death to take over this body. Even dead-body flourishes like cancer after death. Difference between cancer and death is, presence of life/prana with body.
Old notes on : viral infections
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Research
———–

Zika virus kills brain cancer stem cells

Virus potentially could be used to treat deadly disease

While Zika virus causes devastating damage to the brains of developing fetuses, it one day may be an effective treatment for glioblastoma, a deadly form of brain cancer. New research from Washington University School of Medicine in St. Louis and the University of California San Diego School of Medicine shows that the virus kills brain cancer stem cells, the kind of cells most resistant to standard treatments.

The findings suggest that the lethal power of the virus – known for infecting and killing cells in the brains of fetuses, causing babies to be born with tiny, misshapen heads – could be directed at malignant cells in the brain. Doing so potentially could improve people’s chances against a brain cancer – glioblastoma – that is most often fatal within a year of diagnosis.

medicine.wustl.edu/news/zika-virus-kills-brain-cancer-stem-cells/

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