Cancer

Cancer

Ginger, Autophagy and Cancer Treatment : Science of Prana

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ginger-root-benefits
ginger-root-benefits

Autophagy is news for Nobel prize and suddenly there is world-focus on this word! This particular phenomenon is not new for us in India. This is well-understood concept in Ayurveda. Ojovisramsa is impairment in distribution of Ojas. Ojas is a immunological factor.

“Ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture.”

This post is about Ginger triggered Autophagy!

Ginger truly does top the list of effective natural home remedies.

Being used throughout history by different cultures around the world, ginger harnesses an incredible healing power proven for a host of ailments. The spice is packed with essential nutrients and rejuvenating compounds.

While ginger has been shown to help countless ‘minor’ problems such as an upset stomach, amazingly the health benefits of ginger also include combating cancer more effectively than pharmaceutical cancer drugs.

इमां खनाम्योषधिं वीरुधं बलवत्तमाम् । ऋग्वेद: सूक्तं १०.१४५
“What I dig is very potent herb to increase strength.”

Excuse my faulty translation but there are interesting dots to connect.

1) शारीरिक & प्राणिक बल are necessary to earn पुरुषार्थ (धर्म,अर्थ,काम,मोक्ष) and perform our duties towards the Universe with least errors.

2) In my understanding, when grown in soil nurtured and kindled with Prana(प्राण) by gobar, mutra and butter milk of Desi Gau, Vegetables from कंद वर्ग (the ones that we dig) grows in the epicenter of rich Pranic environment. And this Prana is not Raw Prana like other vegetables and fruits get from the Sun by photosynthesis and external environment. It is digested Prana or churned prana. Churning prana makes its potency manifold. So they are full of प्राणिक बल. Since they are the roots, they have most possible essence of all physical nutrients.

3) कंद वर्ग’s vegetables is main food for ऋषि पञ्चमी. That means, to nurture the ऋषि अंश settled at our subtle senses can realize their full potential with the help of कंद वर्ग.

4) In most cases, you dig them only when they plant completes its life cycle. For example, I dig my turmeric only when all its leaves are dried and gone.

Keep an eye on seasonal कंद वर्ग vegetables and include them in your meals. Of course, nothing worth without Gau mata.

जामवंत के बचन सुहाए। सुनि हनुमंत हृदय अति भाए॥
तब लगि मोहि परिखेहु तुम्ह भाई। सहि दुख कंद मूल फल खाई॥

Now read on about Ginger and Autophagy! 🙂


Research


6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137614

Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. The spheroids were generated from adherent breast cancer cells. 6-shogaol was effective in killing both breast cancer monolayer cells and spheroids at doses that were not toxic to noncancerous cells. The percentages of CD44+CD24/low cells and the secondary sphere content were reduced drastically upon treatment with 6-shogaol confirming its action on CSCs. Treatment with 6-shogaol caused cytoplasmic vacuole formation and cleavage of microtubule associated protein Light Chain3 (LC3) in both monolayer and spheroid culture indicating that it induced autophagy. Kinetic analysis of the LC3 expression and a combination treatment with chloroquine revealed that the autophagic flux instigated cell death in 6-shogaol treated breast cancer cells in contrast to the autophagy inhibitor chloroquine. Furthermore, 6-shogaol-induced cell death got suppressed in the presence of chloroquine and a very low level of apoptosis was exhibited even after prolonged treatment of the compound, suggesting that autophagy is the major mode of cell death induced by 6-shogaol in breast cancer cells. 6-shogaol reduced the expression levels of Cleaved Notch1 and its target proteins Hes1 and Cyclin D1 in spheroids, and the reduction was further pronounced in the presence of a γ-secretase inhibitor. Secondary sphere formation in the presence of the inhibitor was also further reduced by 6-shogaol. Together, these results indicate that the inhibitory action of 6-shogaol on spheroid growth and sustainability is conferred through γ-secretase mediated down-regulation of Notch signaling. The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment.

 

Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.

https://www.ncbi.nlm.nih.gov/pubmed/26246051

Zerumbone, a natural monocyclic sesquiterpene, is the main component of the tropical plant Zingiber zerumbet Smith. Zerumbone induced antiproliferative and apoptotic effects against PC-3 and DU-145, two human hormone-refractory prostate cancer (HRPC) cell lines. Zerumbone inhibited microtubule assembly and induced an increase of MPM-2 expression (specific recognition of mitotic proteins). It also caused an increase of phosphorylation of Bcl-2 and Bcl-xL, two key events in tubulin-binding effect, indicating tubulin-binding capability and mitotic arrest to zerumbone action. Furthermore, zerumbone induced several cellular effects distinct from tubulin-binding properties. First, zerumbone significantly increased, while paclitaxel (as a tubulin-binding control) decreased, Mcl-1 protein expression. Second, paclitaxel but not zerumbone induced Cdk1 activity. Third, zerumbone other than paclitaxel induced Cdc25C downregulation. The data suggest that, in addition to targeting tubulin/microtubule, zerumbone may act on other targets for signaling transduction. Zerumbone induced mitochondrial damage and endoplasmic reticulum (ER) stress as evidenced by the loss of mitochondrial membrane potential and upregulation of GRP-78 and CHOP/GADD153 expression. Zerumbone induced an increase of intracellular Ca(2+) levels, a crosstalk marker between ER stress and mitochondrial insult, associated with the formation of active calpain I fragment. It induced apoptosis through a caspase-dependent way and caused autophagy as evidenced by dramatic LC3-II formation. In summary, the data suggest that zerumbone is a multiple targeting compound that inhibits tubulin assembly and induces a crosstalk between ER stress and mitochondrial insult, leading to apoptosis and autophagy in HRPCs.

 

 

Cell Phone Radiation and Cancer

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CancerCellphone

When the technology is not safe in controlled environment, imagine the havoc it will create in country like India where rampant loopholes runs across all levels of tech implementations.

We are passing through toxic clouds of EMF.

❝ The unsettling findings are the result of a US$25 million study by the National Toxicology Program (NTP) – a division of the National Institutes of Health (NIH) – which has been underway for the past 2.5 years.
Although a full report on the study is not yet finished, the NTP has released its partial results early.
The research studied rats to determine whether the radio-frequency (RF) radiation emitted by mobile phones can cause cancer. To do so, pregnant rats were placed in special chambers. Once their pups were born, they were treated with RF radiation for approximately nine hours per day. ❞


News


The radiation received by rats was “not very different” from what humans are exposed to when they use mobile phones, said Chris Portier, a former associate director of the NTP and the person who commissioned the study, as cited by Mother Jones.

As researchers increased the intensity of the radiation, the incidence of cancer in the rats also increased. The highest level of radiation was five to seven times as strong as what humans typically receive while using a mobile phone.

I think this is a game changer,” Portier said. “We seriously have to look at this issue again in considerable detail.”

https://www.rt.com/usa/344640-mobile-phones-cancer-radiation/

Cancer and Death : Two Biological events

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Would you call ‘Death’ as disease? No, right? Death is not a disease. It is biological event. Similarly, cancer is also a biological event. Sometimes, it surfaces on life early. Most of the times, it does in last stage of life. Game of circadian clocks. Time driven events.

diagram-showing-how-cancer-cells-keep-on-reproducing-to-form-a-tumour_0

Cancer is a property of each cell. It is the faulty clock that leads to cell into Cancer pathway than Cell Death pathway.

We all take birth with a probability of normal cells turned cancer cells.

Once you die, the cells in your body think that you are an embryo….so all the genes which remain up in embryo (and that never again become active in your life time after birth) become active again.

Body cells also think that there is something wrong, that’s why there is no signal of cell proliferation, development etc. So, the cells start expressing the genes that are generally overexpressed during cancer. I.e. signal is given to cell to proliferate (multiply).

People who get organ donation from dead body are more prone to cancers. This is explanation!!
Or in other words, Cancer is a sign of early death or rapid aging.

 


Research


http://www.scripps.edu/news/press/2016/20161116lamia.html

TSRI Researchers Show How Circadian ‘Clock’ May Influence Cancer Pathway

A new study led by scientists at The Scripps Research Institute (TSRI) describes an unexpected role for proteins involved with our daily “circadian” clocks in influencing cancer growth.

The research, published recently in the journal Molecular Cell, suggests that disruptions in circadian rhythms might leave levels of an important cancer-linked protein, called cMYC, unchecked.

“This appears to have big implications for the connection between circadian rhythms and cancer,” said TSRI biologist Katja Lamia, senior author of the study.

There is growing evidence that shift work and frequent jet lag can raise a person’s risk of cancer, suggesting a link between daily rhythms and cell growth. “We know this connection exists, but we haven’t known why,” said Lamia.

The researchers focused on proteins called cryptochromes, which evolved from bacterial proteins that sense light and repair DNA damage caused by sunlight. In humans, these proteins, called CRY1 and CRY2, regulate our circadian clocks, which influence what times of day we become tired, hungry and much more.

Using cells from mouse models, the researchers demonstrated that deleting the gene that expresses CRY2 reduced the cells’ ability to degrade a protein called cMYC. Without CRY2 keeping cMYC at normal levels, the researchers saw increased cell proliferation—similar to the abnormal growth seen in cancers.

Further studies of protein structures suggested that CRY2 is a key player in a process to “mark” cMYC for degradation. The researchers said it is significant that this process occurs after gene transcription—once the proteins are already produced—rather than during transcription, as in many other cryptochrome functions.

“This is a function of a circadian protein that has never been seen before,” said TSRI Research Associate Anne-Laure Huber, who served as first author of the study.

The researchers say more studies are needed to confirm this connection between circadian clocks and cancer in human tissues.

In addition to Lamia and Huber, authors of the study, “CRY2 and FBXL3 Cooperatively Degrade c-MYC,” were Stephanie J. Papp, Alanna B. Chan, Sabine D. Jordan, Anna Kriebs and Madelena Nguyen of TSRI; Emma Henriksson of TSRI and Lund University; Martina Wallace and Christian M. Metallo of the University of California, San Diego; and Zhizhong Li of the Genomics Institute of the Novartis Research Foundation and Novartis Institutes for Biomedical Research.

This study was supported by the National Institutes of Health (grants DK090188, DK097164, CA188652 and NIGMS P41-GM103311), the Searle Scholars Program through the Kinship Foundation, the Sidney Kimmel Foundation, the Lung Cancer Research Foundation, the Swedish Research Council, the Deutsche Forschungsgemeinschaft and the American Heart Association (grant 15POST22510020).

 

 

Ginger :10000 times more effective than Chemotherapy

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Ginger Cancer

What is cancer cell?

Some dirty cell of your body? No. This body is wonderful gift. Nature does not act dirty. You and me do. Cancer cell is ordinary cell with cancerous tendency. Such tendency is expected due to cellular level stress. This stress is due to mental stress, physical stress (Food, water, air pollution) and environmental stress. Prolonged stress.

No cell loves to act cancerously. If you help them reduce local and global stress, they prefer to live happy life for you.

Cancer stem cells is a step before Cancer Cells. Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse.

It is shown by this research paper that Ginger compounds act against CSCs and inhibits them.

So is this the solution? No! Why should we even invite cancer? Prevention is always better than cure. Having ginger in diet can help but more than that stress-free life is more important! The root of all sicknesses start with weak mind!

Beware! Ginger and Turmeric are found 10000 times more effective than Chemotherapy. Now, we will have flood industrial farming of ginger and turmeric. That will follow genetically modified Ginger and Turmeric. That is how species are destroyed by Idiot science.


Research


6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137614

Abstract

Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. The spheroids were generated from adherent breast cancer cells. 6-shogaol was effective in killing both breast cancer monolayer cells and spheroids at doses that were not toxic to noncancerous cells. The percentages of CD44+CD24/low cells and the secondary sphere content were reduced drastically upon treatment with 6-shogaol confirming its action on CSCs. Treatment with 6-shogaol caused cytoplasmic vacuole formation and cleavage of microtubule associated protein Light Chain3 (LC3) in both monolayer and spheroid culture indicating that it induced autophagy. Kinetic analysis of the LC3 expression and a combination treatment with chloroquine revealed that the autophagic flux instigated cell death in 6-shogaol treated breast cancer cells in contrast to the autophagy inhibitor chloroquine. Furthermore, 6-shogaol-induced cell death got suppressed in the presence of chloroquine and a very low level of apoptosis was exhibited even after prolonged treatment of the compound, suggesting that autophagy is the major mode of cell death induced by 6-shogaol in breast cancer cells. 6-shogaol reduced the expression levels of Cleaved Notch1 and its target proteins Hes1 and Cyclin D1 in spheroids, and the reduction was further pronounced in the presence of a γ-secretase inhibitor. Secondary sphere formation in the presence of the inhibitor was also further reduced by 6-shogaol. Together, these results indicate that the inhibitory action of 6-shogaol on spheroid growth and sustainability is conferred through γ-secretase mediated down-regulation of Notch signaling. The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment.

 

 

A Cancer called Cricket

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Cancer called Cricket
Cancer called Cricket

Cancer cell? What is it? There is nothing like cancer cell. Body cells are your Annamaya footprints. Your own identity. There is nothing called cancer cell. Cancer cells – they are nothing but your normal body cells behaving cancerously.

Cancer is a behavior. Uncontrolled behavior to rebel against the self. Rebel because you being Pati (Protector) of the Ayodhya (Body) is not performing duties well.

Cancer can be treated. Suppressing cancer symptoms is not cancer treatment. Revive cellular confidence. Be happy. Be cheerful. Be more social. Live in the lap of mother nature.

Cricket is a societal cancer. So even if you are a great person but still associated with Cricket, you are responsible for cancer. I don’t see such persons with high respect.

I am long distance runner and despite crossing 30, I still can beat teen athletes in 100 m sprints. Occasionally, I play football. In my teen age, I played cricket too.

My yardstick to evaluate Cricket as cancer is because of my understanding of word क्रीडा.

Cricket is light years far to fit in word ‘क्रीडा’ (Cricket being hopelessly laggard entertainment cannot fit in my understanding of क्रीडा ) but it is very close to word ‘कीड़ा’ (insects – mafias, corrupts, criminals chewing this Nation) of the society. As a leader, as a political party with difference, as a youngster, I would never ever embrace it.

And someone doing it, it is fate of the Nation, party and an individual. God bless.

Here is the post about क्रीडा. Do read:

Sports: Bhagwad Gita perspective

Desi Cow Ghee, Omega-3 and Cancer protection

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Ghee to fight cancer
Ghee to fight cancer

If I say “Omega-3 Fatty Acids cures cancer”, our so called rational and educated mind will appreciate feat of the modern science and start googling about ‘Source for Omega-3″ 😀.

But if I say that “Ghee Prepared using manual churning method from the ethically procured milk of Desi Gau mata” can cure any disease, same arrogant educated mind will either make fun of the fact or ignore it as bigoted view! 😀

Tumors are called ‘Arbuda’ in Ayurveda. Desi Gau mata’s milk, ghee, mutra and gobar is primary treatment for any form of ‘Arbuda’. We don’t really need complex “Omega-3 Fatty Acids” complex science. Mother helps to cure is a common sense for those who live in the laps of the nature.

Take that! Respect your roots! Invest time and wealth in protecting Desi Gau. Have her prasad as medicine, be healthy forever (Y).

Thanks to Modern Medicine for fear mongering about ghee and modern dairy for looting wealth from villages, society’s intake of ghee is reduced drastically in past 30 years. This is the same period, cancer and heart cases have increased.


How exactly it works?

Gobar represents and is full of Apana Prana. It helps body to eliminate toxic waste/junk DNAs and cleanse Prana-flows.

Urine/Mutra is Ganga Jal. It has quality to balance tridosha. So further damage is paused.

Ghee is full of omega-3. As per below research, it improves quality and treatment of cancer patients. It actually helps in rejuvenation.


Research


Omega-3 Fatty Acids May Help Improve Treatment and Quality of Life in Cancer Patients

http://www.nutritioncare.org/Press_Room/2015/Omega-3_Fatty_Acids_May_Help_Improve_Treatment_and_Quality_of_Life_in_Cancer_Patients/

Adding omega-3 fatty acids to anti-tumor medications may improve treatment response and quality of life for cancer patients according to a new study by researchers at the University Hospitals of Leicester in the United Kingdom.

The study, published today in the OnlineFirst version of the Journal of Parenteral and Enteral Nutrition (JPEN), the research journal of the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), examined 50 patients with advanced pancreatic cancer.

Patients were given 1,000 mg of gemcitabine weekly followed by up to 100 g of omega-3 rich lipid emulsion for three weeks followed by a rest week. This was continued for up to six cycles, progression, unacceptable toxicity, patient request, or death.

The study found evidence of activity in response and disease stabilization rates, reduction in liver metastasis volume, and improved quality of life scores in this group of patients.

While this is the first study to use omega-3 fatty acids with a chemotherapy agent in a cancer setting, the researchers believe the results are encouraging enough to warrant further investigation in a randomized phase III trial.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061595/

Docosahexaenoic acid content is significantly higher in ghrita prepared by traditional Ayurvedic method

Background:

Ghee (clarified butter) also known as ghrita, has been utilized for thousands of years in Ayurveda. Ghee is mostly prepared by traditional method in Indian households or by direct cream method at industry level. Ayurvedic classics mention that ghrita made from cow milk is superior. However, there is no scientific comparison available on preparation methods and essential fatty acids content of ghrita.

Objective:

To investigate fatty acid composition of ghrita prepared by traditional/Ayurvedic method and commercial method (direct cream method).

Materials and Methods:

Fatty Acid Methyl Esters (FAME) extracted from ghrita samples were analysed on Gas Chromatography (GC) Shimadzu B using capillary column BPX70 (0.32 mm*60 m, ID of 0.25 mm). The fatty acids in the samples were identified by comparing peaks with the external standard 68A (Nu-Chek-Prep, Inc.USA). Significant differences between the experimental groups were assessed by analysis of variance.

Results:

Distribution of fatty acids was compared in ghrita samples prepared by traditional method and direct cream method which is commercially used. Saturated fatty acids were predominant in both the groups. Mono unsaturated fatty acids and poly unsaturated fatty acids were in the range of 17-18% and 3-6% respectively. DHA content was significantly higher in ghee prepared by traditional method using curd starter fermentation.

Conclusion:

The findings suggested that ghrita prepared by traditional ayurvedic methods contains higher amount of DHA; Omega-3 long-chain polyunsaturated fatty acids, which is a major component of retinal and brain tissues and remains important in prevention of various diseases.

Cow Milk, BAMLET and Cancer Prevention

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Cow Milk Cancer

We cut short feeding duration for petty things like career, beauty and money.
We also don’t have access to ethically procured A2 milk from lovable mother Gau.

Mother’s milk has HAMLET. Cow’s raw milk has BAMLET.

Both can control cancerous nature of the cell.

And we cry increasing numbers of cancer cases. 🙁

“Breast-feeding has also been reported to protect against development of immunological diseases, such as allergy (Ahmed & Fuchs, 1997; Saarinen & Kajosaari, 1995), infantile diabetes mellitus (Gerstein, 1994; Mayer et al., 1988) and inflammatory gastrointestinal disease (Koletzko et al., 1989). These results imply that factors in milk may help optimise the function of the immune system and regulate cell populations that results in les risk of tumor development and less risk for abberant immunity in the rapidly growing neonatal intestinal tract.”

 

“These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.”


Research


Breast-feeding, HAMLET, and cancer

http://www.acsu.buffalo.edu/~andersh/research/milkcancer.asp

HAMLETs effect against tumors in vivo

To date several studies have addressed the ability of HAMLET to kill tumor cells in vivo. Early attempts in mouse models were thwarted as we realized that serum (especially serum albumin) induces a partial inactivation of HAMLET based on binding to the fatty acid in HAMLET. The attempts that have since been done have addressed topical or mucosal administration of HAMLET.

Walter Fischer, then in Bergen, Norway, used HAMLET in a model where tumor tissue from patients with glioblastomas were transplanted under the skull of rats. In this model one dose of HAMLET was infused in the brain through a pump and tissue was tested for apoptosis induction and the rats were monitored for survival. HAMLET treatment delayed death of the rats and the most important finding was that when investigating the brain tissue they found that apoptosis was only induced in tumor cells, no healthy brain cells were affected (Fischer Cancer Res 2004). This indicated what we already know in vitro, that the protein only attacks tumor cells, and indicated that little side effects may be expected should this be used for treatment purposes. Walter, now in Copenhagen, Denmark, is currently planning a patient study in patients with glioblastomas.

In a second study, Lotta Gustafsson together with Irene Leijonhufvud conducted a study on benign papilloma virus warts. Papillomas are a benign tumor form where the skin cells are transformed by virus infection and the hypothesis was that this transformation may make them susceptible to HAMLET treatment. A population of individuals having a major problem with recurrent warts were treated topically with HAMLET and it was found that HAMLET was effective in eliminating warts and that this effect had a long lasting effect (Gustafsson NEJM 2004).

Recently, Anki Mossberg together with Bjorn Wullt performed a study on 9 patients with transitional bladder carcinomas (tumor of the urinary bladder) (Mossberg Int J Cancer 2007). They instilled HAMLET in the bladder of patients in the week preceding surgery and evaluated the tumor morphology by endoscopic photography and apoptosis-induction in biopsy tissue. They found that a reduction in tumor size was seen in 8 of 9 patients and that apoptosis was detected in the tumor tissue but not in the adjacent healthy tissue, indicating that HAMLET is specifically tumorigenic also in vivo. This study was followed up by a study in mice (Mossberg, J Urol, 2010) using the MB49 bladder carcinoma model. In this model they showed a delay in tumor development when HAMLET was instilled in the bladder.

In a study from 2014 Puthia et al (Gut January issue, 2014) it wa shown that HAMLET could be used to prevent and treat colon cancer in APC/Min-mice. HAMLET was given perorally and showed a reduced progression of tumor growth and an increased survival when given as a prophylaxis and reduction of established tumors when given as treatment. HAMLEt accumulated only in tumor tissue and only healthy cells were observed to be apoptotic.


BAMLET activates a lysosomal cell death program in cancer cells.

https://www.ncbi.nlm.nih.gov/pubmed/20053771

A complex of human alpha-lactalbumin and oleic acid (HAMLET) was originally isolated from human milk as a potent anticancer agent. It kills a wide range of transformed cells of various origins while leaving nontransformed healthy cells largely unaffected both in vitro and in vivo. Importantly, purified alpha-lactalbumins from other mammals form complexes with oleic acid that show biological activities similar to that of HAMLET. The mechanism by which these protein-lipid complexes kill tumor cells is, however, largely unknown. Here, we show that complex of bovine alpha-lactalbumin and oleic acid (BAMLET), the bovine counterpart of HAMLET, kills tumor cells via a mechanism involving lysosomal membrane permeabilization. BAMLET shows potent cytotoxic activity against eight cancer cell lines tested, whereas nontransformed NIH-3T3 murine embryonic fibroblasts are relatively resistant. BAMLET accumulates rapidly and specifically in the endolysosomal compartment of tumor cells and induces an early leakage of lysosomal cathepsins into the cytosol followed by the activation of the proapoptotic protein Bax. Ectopic expression of three proteins known to stabilize the lysosomal compartment, i.e. heat shock protein 70 (Hsp70), Hsp70-2, and lens epithelium-derived growth factor, confer significant protection against BAMLET-induced cell death, whereas the antiapoptotic protein Bcl-2, caspase inhibition, and autophagy inhibition fail to do so. These data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of alpha-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.


Raw Milk Fights Cancer? Who is Hamlet and Bamlet?

Raw Milk Fights Cancer? Who is Hamlet and Bamlet?

Milk Protein Kills Cancer Cells and Antibiotic-Resistant Bacteria

Milk Protein Kills Cancer Cells and Antibiotic-Resistant Bacteria

Chocolate to Cookies, Consumerist Obsession : Palm Oil Helps Spreading Cancer

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cancer

You might not cook with it, but you almost certainly eat or use palm oil.

Palm oil is the most widely consumed vegetable oil on the planet, and it is in about half of all packaged products sold in the supermarket. While palm oil is the most efficient source of vegetable oil, its rapid expansion threatens some of the planet’s most important and sensitive habitats.

palmoil

Many products that use palm oil aren’t clearly labeled. Palm oil and its derivatives can appear under many names, including:

 

INGREDIENTS: Vegetable Oil, Vegetable Fat, Palm Kernel, Palm Kernel Oil, Palm Fruit Oil, Palmate, Palmitate, Palmolein, Glyceryl, Stearate, Stearic Acid, Elaeis Guineensis, Palmitic Acid, Palm Stearine, Palmitoyl Oxostearamide, Palmitoyl Tetrapeptide-3, Sodium Laureth Sulfate, Sodium Lauryl Sulfate, Sodium Kernelate, Sodium Palm Kernelate, Sodium Lauryl Lactylate/Sulphate, Hyrated Palm Glycerides, Etyl Palmitate, Octyl Palmitate, Palmityl Alcohol

CONTAINS: Palm oil

Do we realize the havoc we invite @ Indonesia by increasing demand of palm oil?

The establishment of vast monoculture oil plam plantations has a number of environmental impacts.

The two most serious are:

large-scale forest conversion
loss of critical habitat for endangered species

Other impacts include:

soil erosion
air pollution
soil & water pollution
climate change

cancer

What can I do personally or at family level?

Reduce palm oil usage. Google and find out different use of palm oil.

This was about Environmental Cancer!

Recent study finds that it also helps spreading cancer in body!

indiaimport


Research


GROUND-BREAKING EVIDENCE THAT CANCER SPREAD IS INCREASED BY A HIGH FAT DIET AS RESEARCHERS DISCOVER NEW CANCER-SPREADING PROTEIN

Prana heals : UCLA research suggests that Gut Microbes Prevents Cancer

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But we eat mindless acidic food so that bacteria can hardly reach GUT via digestive track.
We kill mouth bacteria by using toothpaste.
We kill them by handwash and soaps.
We hardly spend physically active time under the sun.
Our food lack supporting nutrition so that bacteria can travel and stabilize at Gut.
Mindless usage of antibiotics.
 
And then we are shocked by sudden increase in cancer cases! 😉
 
As a society, unless we correct our priorities, we will celebrate Cancer hospitals as human success milestones. 😛 😀
Microbes = Prana
Prana is an ultimate healer.
mirror daily_b39500c1cb938cbba99dc02f3fed73fd
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Research
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UCLA research suggests that gut bacteria could help prevent cancer

https://www.uclahealth.org/news/ucla-research-suggests-that-gut-bacteria-could-help-prevent-cancer

“It is not invasive and rather easy to do,” he said.

Over millions of years, gut bacteria have evolved into both good and bad types: The good ones have anti-inflammatory properties and the bad ones promote inflammation. The human body typically contains about 10 trillion bacterial cells, compared with only 1 trillion human cells.

Schiestl and his colleagues isolated a bacterium called Lactobacillus johnsonii 456, which is the most abundant of the beneficial bacteria, and which has some pretty useful applications outside of medicine. “Since it is a Lactobacillus strain, it makes excellent yogurt, kefir, kombucha and sauerkraut.”

In the UCLA study the bacterium reduced gene damage and significantly reduced inflammation — a critical goal because inflammation plays a key role in many diseases, including cancer, neurodegenerative diseases, heart disease, arthritis and lupus, and in the aging process.

Previous research led by Schiestl presented the first evidence of a relationship between intestinal microbiota and the onset of lymphoma, a cancer that originates in the immune system. The new study explains how this microbiota might delay the onset of cancer, and suggests that probiotic supplements could help keep cancer from forming.

For both studies, Schiestl and his team used mice that had mutations in a gene called ATM, which made them susceptible to a neurologic disorder called ataxia telangiectasia. The disorder, which affects 1 in 100,000 people, is associated with a high incidence of leukemia, lymphomas and other cancers.

The mice were divided into two groups — one that was given only anti-inflammatory bacteria and the other that received a mix of inflammatory and anti-inflammatory microbes that typically co-exist in the intestines.

In the Cancer Research paper, Schiestl and his team showed that in the mice with more of the beneficial bacteria, the lymphoma took significantly longer to form.

In the new study, the researchers analyzed the metabolites — molecules produced by the gut’s natural metabolic action — in the mice’s urine and feces. The scientists were surprised to find that the mice that were receiving only the beneficial microbiota produced metabolites that are known to prevent cancer. Those mice also had more efficient fat and oxidative metabolism, which the researchers believe might also lower the risk for cancer.

Among the other results, in the mice receiving only the good bacteria, lymphoma formed only half as quickly as it did in the other mice. In addition, mice with the good bacteria lived four times longer and had less DNA damage and inflammation.

Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis

Abstract

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151190

Intestinal microbiota play a significant role in nutrient metabolism, modulation of the immune system, obesity, and possibly in carcinogenesis, although the underlying mechanisms resulting in disease or impacts on longevity caused by different intestinal microbiota are mostly unknown. Herein we use isogenic Atm-deficient and wild type mice as models to interrogate changes in the metabolic profiles of urine and feces of these mice, which are differing in their intestinal microbiota. Using high resolution mass spectrometry approach we show that the composition of intestinal microbiota modulates specific metabolic perturbations resulting in a possible alleviation of a glycolytic phenotype. Metabolites including 3-methylbutyrolactone, kyneurenic acid and 3-methyladenine known to be onco-protective are elevated in Atm-deficient and wild type mice with restricted intestinal microbiota. Thus our approach has broad applicability to study the direct influence of gut microbiome on host metabolism and resultant phenotype. These results for the first time suggest a possible correlation of metabolic alterations and carcinogenesis, modulated by intestinal microbiota in A-T mice.

Muladhara(मूलाधार) and Cancer : Prevent and Cure

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MicrobesCancer

Tvam muladhara sthitosi nityam |
त्वं मूलाधार स्थितोऽसि नित्यं।
Lord Ganesha! You always dwell in muladhara chakra!

मूलाधार : शक्ति Center near Gut & anus : Abode of मरुत गण (Microbes) and their leader गणपति

It does not only control microbes in GUT but of entire body.

He is the lord of muladhara chakra. In other words, he rules our microbial flora (मरुत गण) and make sure only body-friendly मरुत गण resides in the abode.

मरुत गण (Microbes) : गण पति (Ganesha) : गण (Citizens) & पति (Protector) live together @ Muladhara

Awakening गण पति शक्ति is critical for maintaining health (which is critical for self-realization). Only he can protect and act as gatekeeper of Muladhara (Gut) so that body is kept protected from pathogens & aasuri shakti.

Here are two interesting researchers focuses on Muladhara for cancer-cause and cancer recovery.


Research


Cleveland Clinic Researchers Find Link Between Bacterial Imbalances and Breast Cancer

In a newly published study, Cleveland Clinicresearchers have uncovered differences in the bacterial composition of breast tissue of healthy women vs. women with breast cancer. The research team has discovered for the first time that healthy breast tissue contains more of the bacterial species Methylobacterium, a finding which could offer a new perspective in the battle against breast cancer.

Bacteria that live in the body, known as the microbiome, influence many diseases.

Most research has been done on the “gut” microbiome, or bacteria in the digestive tract. Researchers have long suspected that a “microbiome” exists within breast tissue and plays a role in breast cancer but it has not yet been characterized. The research team has taken the first step toward understanding the composition of the bacteria in breast cancer by uncovering distinct microbial differences in healthy and cancerous breast tissue.

“To my knowledge, this is the first study to examine both breast tissue and distant sites of the body for bacterial differences in breast cancer,” said co-senior author Charis Eng, M.D., Ph.D., chair of Cleveland Clinic’s Genomic Medicine Institute and director of the Center for Personalized Genetic Healthcare. “Our hope is to find a biomarker that would help us diagnose breast cancer quickly and easily.  In our wildest dreams, we hope we can use microbiomics right before breast cancer forms and then prevent cancer with probiotics or antibiotics.”

Published online in Oncotarget on Oct. 5, 2017, the study examined the tissues of 78 patients who underwent mastectomy for invasive carcinoma or elective cosmetic breast surgery. In addition, they examined oral rinse and urine to determine the bacterial composition of these distant sites in the body.

newsroom.clevelandclinic.org/2017/10/05/cleveland-clinic-researchers-find-link-between-bacterial-imbalances-and-breast-cancer/

Good-guy bacteria helps in cancer therapies

Researchers found he had the beneficial gut bacteria and suspect this microbiome contributed to the outcome. As a group, patients who responded well to the immunotherapy had three specific bacteria:

  • Bacteroides thetaiotaomicron
  • Faecalibacterium prausnitzii
  • Holdemania filiformis

All three are common normal flora in the human intestinal tract.

After identifying the link, researchers looked for a potential reason for the association between the helper bacteria and immunotherapy effectiveness. “Is it something the bacteria are making? We examined metabolites in these subjects and found the strongest correlation between anacardic acid, present in cashews and mangoes, and the beneficial bacteria,” Dr. Koh said.

Researchers plan to follow up on the current research, which appears in the journal Neoplasia, with larger clinical studies.

http://www.utsouthwestern.edu/newsroom/articles/year-2017/bacteria-immunotherapy-koh.html

 

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