Organ Clocks: Modern Science confirms Ayurveda principles

Marut

Ayurveda, Circadian

Can your liver sense when you’re staring at a television screen or cellphone late at night? Apparently so, and when such activity is detected, the organ can throw your circadian rhythms out of whack, leaving you more susceptible to health problems.

Daily routine play critical role in Ayurveda. According to Ayurveda, our body is completely aligned with the times of day in regards to our vital organs.  Every hour is related to a specific organ(s), and therefore the organ will be at its most powerful energy at its respective times.  Further, the time each organ is spiking can reveal to us the best time for treatment, as well as the mostly likely time an imbalance may occur.  Knowing one’s internal body clock can help us align our daily activities in order to allow optimal functioning and therefore optimal health.

Now, this fact was ignored arrogantly by modern medical science for more than century now. Recently, they started focusing on the concept.

BodyClocks

OrganClock

https://svasthaayurveda.com/wp-content/uploads/2017/07/Ayurvedic-Body-Clock-Chart.pdf

Here is the interesting paper about it from modern medical science school:


Research

UCI research helps shed new light on circadian clocks


“For example, despite the shutdown of all other body clocks, including the central brain clock, the liver knew what time it was, responded to light changes as day shifted to night and maintained critical functions, such as preparing to digest food at mealtime and converting glucose to energy.

Somehow, the liver’s circadian clock was able to detect light, presumably via signals from other organs. Only when the mice were subjected to constant darkness did the liver’s clock stop functioning.”

Highlights

  • The liver clock oscillates in the absence of all other clocks in vivo
  • Only ∼20% of hepatic rhythms are autonomous despite recruitment of BMAL1 to chromatin
  • The liver clock is sufficient for oscillation of glycogen and NAD + salvage metabolism
  • These autonomous oscillations depend on the light-dark cycle

Summary

Mammals rely on a network of circadian clocks to control daily systemic metabolism and physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered hierarchically dominant over peripheral clocks, whose degree of independence, or tissue-level autonomy, has never been ascertained in vivo. Using arrhythmic Bmal1-null mice, we generated animals with reconstituted circadian expression of BMAL1 exclusively in the liver (Liver-RE). High-throughput transcriptomics and metabolomics show that the liver has independent circadian functions specific for metabolic processes such as the NAD + salvage pathway and glycogen turnover. However, although BMAL1 occupies chromatin at most genomic targets in Liver-RE mice, circadian expression is restricted to ∼10% of normally rhythmic transcripts. Finally, rhythmic clock gene expression is lost in Liver-RE mice under constant darkness. Hence, full circadian function in the liver depends on signals emanating from other clocks, and light contributes to tissue-autonomous clock function.
https://www.cell.com/cell/fulltext/S0092-8674(19)30444-1
news.uci.edu/2019/05/30/uci-research-helps-shed-new-light-on-circadian-clocks/

 

Leave a Comment

The Prachodayat.in covers various topics, including politics, entertainment, sports, and business.

Have a question?

Contact us