Epigenetics Explains How We Inherit Fear From Our Ancestors



Memories can be passed down to later generations through genetic switches that allow offspring to inherit the experience of their ancestors, year old research says.

We do pitru tarpan. Satisfying subtle presence of all ancestors. Through them, do we get messages to activate or deactivate specific genes so that we can leverage benefit of their experiences in same situations? I strongly believe in it.

Well, let the fools of modern science prove it. But we should not wait for them.


Prepare yourself for Shradha paksha of 2014. Learn your roots and try to follow them. Forget about material benefits. Help your ancestors in their spiritual journey. Help yourself in your spiritual journey.


Parental olfactory experience influences behavior and neural structure in subsequent generations


Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes. Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels.

The Family Tree Of Phobia: Epigenetics Explains How We Inherit Fear From Our Ancestors


Fear can modify our DNA and influence the behavior of future generations, researchers find. According to a Nature Neuroscience study, when an ancestor endured a terrifying experience – and managed to survive – their genetic machinery kept note of it, manifesting as a phobia that gets passed down to subsequent kin.

To show this, researchers exposed mice to the smell of cherry-blossom in a panic-inducing situation. The so-called odor fear conditioning makes the mouse associate the cherry-blossom smell with a traumatic event to the point that a fear response occurs when they encounter the odor on its own. When female mice acquired this form of PTSD (post-traumatic stress disorder) before conception, the next two generations of mice still exhibited “behavioral sensitivity” towards the cherry-blossom odor despite never being exposed to it before, the authors report.

The study verified that this automatic fearful behavior was inherited rather than taught by finding that mice that were conceived via artificial insemination and fostered by mice they weren’t related to still exhibited this sensitivity to the cherry-blossom odor.

“The fact that these changes persisted after IVF, cross-fostering and across two generations is indicative of biological inheritance,” Brian Dias and Dr Kerry Ressler, researchers at Emory University, Atlanta, conclude in their study. “The second generation mice that we tested are a full and complete generation removed from the environmental perturbation of their parent; as such, our observations suggest a transgenerational phenomenon.”

Sharad Ritu and Pitru Paksha: Ancient Viral Invaders in Our DNA Help Fight Today’s Infections


Ever wondered why श्राद्ध पक्ष fall in to शरद ऋतू?

Ever wondered how remembering and paying homage to our ancestors help us?

There are several reasons why we remember and worship our ancestors during this time of the year but I would like to focus on very gross reason.

Pitru Paksha
Pitru Paksha

Remember one thing: You and your body, is gift from last several generations. Your genetic imprints carry entire history of at least 7 generations. It has recording of environmental changes happened during 7 generations (from mother and father side). It also had instructions to tackle future.

Under the toxic influence of mass mediums like movies, newspapers and TV news, we now really don’t remember and respect our ancestors.

श्राद्ध & पितृ तर्पण (tarapana) – We do it every year and get invisible help from ancestors legacy. This season (Sharad) is season of epidemics. It is also season when our immunity is all time low for the year due to vata prakop of monsoon. It is also now known fact that our mind drives and shapes body. So remembering 7 generations also activates memories (yeah, gross living won’t give that sensitivity but do perform pitru tarpana with faith!)

“Roughly eight percent of our DNA comes from viruses that infected our ancestors millions of years ago. New research by geneticists shows that more than an oddity, the viral DNA switches on genes responsible for initiating an immune response. When removed, the innate immune system — a first-responder to infection by pathogens including viruses — does not function properly. The study shows that viral DNA functions in our body by helping us fight infections.”

To activate or deactivate these genes is really a mental task. And a weak mind cannot receive help from the past. Nor the future can help.



Ancient Viral Invaders in Our DNA Help Fight Today’s Infections

Ancestors in DNA IMAGE SOURCE: http://healthcare.utah.edu/publicaffairs/news/2016/03/DNA%20Invaders.v6.jpg
Ancestors in DNA
IMAGE SOURCE: http://healthcare.utah.edu/publicaffairs/news/2016/03/DNA%20Invaders.v6.jpg

The human innate immune system’s ability to defeat foreign invaders depends on a well-coordinated response. Upon infection, cells dispatch a silent alarm by releasing interferons, a molecular signal that triggers nearby cells to activate an arsenal of hundreds of genes that fight off intruders. By analyzing publicly available genomic datasets from human cells, the authors discovered thousands of endogenous retroviruses that appeared to be activated by interferons. However, because these retroviruses crash-landed into our genomes many millions of years ago, they have long lost the ability to produce infectious particles. One clue to a potential modern-day function of some of these interferon-inducible elements came from their location in the genome. Instead of being distributed randomly, they were enriched near genes with known functions in immunity.

“These were the first signs to us that some of these elements may be truly involved in switching on immunity genes,” says Feschotte who collaborated on the project with assistant professor of human genetics and co-senior author Nels Elde, Ph.D., and lead author Edward Chuong, Ph.D., a Jane Coffin Childs postdoctoral fellow.

To test whether the pieces of viral DNA were indeed important for immunity, the scientists used the gene-editing tool CRISPR/Cas9 in cell culture to remove one by one several of these viral sequences, each located near known immune genes.  In mutant cells lacking the foreign code the adjacent immune genes could not turn on properly in response to interferon, demonstrating that they act as virus-derived switches. Further, when cells lacking the viral DNA element near the AIM2 immune defense gene were infected with virus, their ability to execute an effective immune response was greatly reduced. Taken together, the results indicate that ancient viral DNA has become important for mounting a proper defense against today’s viral infections.

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

Regulatory use of endogenous retroviruses

Mammalian genomes contain many endogenous retroviruses (ERVs), which have a range of evolutionary ages. The propagation and maintenance of these genetic elements have been attributed to their ability to contribute to gene regulation. Chuong et al.demonstrate that some ERV families are enriched in regulatory elements, so that they act as independently evolved enhancers for immune genes in both humans and mice (see the Perspective by Lynch). The analysis revealed a primate-specific element that orchestrates the transcriptional response to interferons. Selection can therefore act on selfish genetic elements to generate novel gene networks.


Endogenous retroviruses (ERVs) are abundant in mammalian genomes and contain sequences modulating transcription. The impact of ERV propagation on the evolution of gene regulation remains poorly understood. We found that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN) response, a major branch of innate immunity, and that lineage-specific ERVs have dispersed numerous IFN-inducible enhancers independently in diverse mammalian genomes. CRISPR-Cas9 deletion of a subset of these ERV elements in the human genome impaired expression of adjacent IFN-induced genes and revealed their involvement in the regulation of essential immune functions, including activation of the AIM2 inflammasome. Although these regulatory sequences likely arose in ancient viruses, they now constitute a dynamic reservoir of IFN-inducible enhancers fueling genetic innovation in mammalian immune defenses.


Crow : Wavering Mind Legacy

Wavering Mind
Wavering Mind

Young friend asked: “Why only offer food to Crow in Shradhdh paksha?”

It is not fixed that you offer food to only crow. Crow represents the weaknesses you received in legacy. It is to tame the Crow-legacy received.

We do not only receive physical body as legacy but also other parts of body (Refer: Panchkoshiya Sharir) from maternal and paternal seeds.

Manomay Kosha of our ancestors may have imprints of wavering nature due to their limitations or circumstances (or any other mental disorder of varied degree). The crow or कौआ is your Manomay sharir’s legacy defect, which represents चलद्रष्टि (wavering mind) predominantly. Everyone suffers from चलद्रष्टि of different intensity. Vata + Tamas type suffer more.

This is the time to take care of this defect and overcome it.

Since we cannot imagine anything without reference, it is important to feed Crow during this time of the year so that we can be reminded about wavering nature of our mind and immediate control over it.

As long as offering is concerned, this is what Vayu Puran has to say:

After death, as per karmic account or गुप्तचित्र, we receive different गति. कोई देवता तो कोई पितर तो कोई प्रेत तो कोई प्राणी तो कोई वृक्ष बनता है.. कुछ न कुछ तो बनता ही है..या बनने के समयकी राह देख रहा होता है..(trapped in time).
So how really my tarpan reaches to my ancestors?
नाममंत्रास्तथा देशा भवान्तरगतानपि ।
प्राणिनः प्रीणयन्त्येते तदाहारत्वमागतान् ।।
देवो यदि पिता जातः शुभकर्मानुयोगतः ।
तस्यान्नममृतं भूत्वा देवत्वेऽप्युनुगच्छति ।।
मर्त्यत्वे ह्यन्नरूपेण पशुत्वे च तृणं भवेत् ।
श्राद्धान्नं वायुरूपेण नागत्वे ऽ प्युपतिष्ठति ।।
The food is not just physical form (अन्नमय). It is after ritual performed, layer of your मनोमय, प्राणमय, विज्ञानमय & आनंदमय शरीर. So based on the योनी where ancestor is right now, different form reaches to them by various cycles of transformation of पिंड offered.
यथा गोष्ठे प्रणष्टां वै वत्सो विन्देत मातरम् ।
तथा तं नयते मंत्रो जन्तुर्यत्रावतिष्ठते ।
नाम गोत्रं च मंत्रश्च दत्तमन्नं नयन्ति तम् ।
अपि योनिशतं प्राप्तांस्तृप्तिस्ताननुगच्छति ।।
The way calf finds out her mother out of 1000s of Gaiya(s), same way with proper नाम,गोत्र, श्रध्धा & मंत्र , whatever is offered, reaches to all different ancestors.



Ancient Viruses lurk in our DNA



We discussed this before. You and me are conglomeration of helping hands lent to us by mother’s obedient workers. Bacterias, Viruses, Energy footprints, minds.

This ancient legacy is what we received from our ancestors. For which we never thank them 🙂 So selfish.

Fear of viruses and bacteria is like having fear from self. Fear of self-kill?


More ancient viruses lurk in our DNA than we thought

One whole endogenous retrovirus genome — and bits of 17 others — were spotted in a study of 2,500 human genomes


Nineteen new pieces of DNA — left by viruses that first infected our ancestors hundreds of thousands of years ago — have just been found, lurking between our own genes.

And one stretch of newfound DNA, found in about 50 of the 2,500 people studied, contains an intact, full genetic recipe for an entire virus, say the scientists who published their findings today in the Proceedings of the National Academy of Sciences.

Whether or not it can replicate, or reproduce, it isn’t yet known. But other studies of ancient virus DNA have shown it can affect the humans who carry it.

In addition to finding these new stretches, the scientists also confirmed 17 other pieces of virus DNA found in human genomes by other scientists in recent years.

The study looked at the entire span of DNA, or genome, from people from around the world, including a large number from Africa — where the ancestors of modern humans originated before migrating around the world. The team used sophisticated techniques to compare key areas of each person’s genome to the “reference” human genome.

Working at Tufts University and the University of Michigan Medical School, the researchers made the findings with funding from the National Institutes of Health.

Discovery of unfixed endogenous retrovirus insertions in diverse human populations

The human endogenous retrovirus (HERV) group HERV-K contains nearly intact and insertionally polymorphic integrations among humans, many of which code for viral proteins. Expression of such HERV-K proviruses occurs in tissues associated with cancers and autoimmune diseases, and in HIV-infected individuals, suggesting possible pathogenic effects. Proper characterization of these elements necessitates the discrimination of individual HERV-K loci; such studies are hampered by our incomplete catalog of HERV-K insertions, motivating the identification of additional HERV-K copies in humans. By examining >2,500 sequenced genomes, we have discovered 19 previously unidentified HERV-K insertions, including an intact provirus without apparent substitutions that would alter viral function, only the second such provirus described. Our results provide a basis for future studies of HERV evolution and implication for disease.

श्राद्ध Saves you from toxin reactions


Toxins legacy

I read article titled “Biologist Michael Skinner has enraged the chemical community and shocked his peers with his breakthrough research”

What modern science call a breakthrough research, is known to my culture from ages as पितृ दोष, a ancestors legacy gifted to next generation. Modern science, due to its limitations, limit this legacy to genes only. We expand this limited knowledge to all layers of our sharir.

Not only genes but mental and pranic legacy too carry forward to next generation. For some, it is healthy legacy, for others it is unfortunate suffering. Most of us carry mixed bag – good and bad legacy of biological and mental markers.

Now, these markers are of epigenetic in nature. They remain dormant until a environmental or social condition triggers them.

To keep negative legacy under control and to thank for positive legacy, we celebrate श्राद्ध every year. Btw, it is performed on the death anniversary or collectively during the PitruPaksha or Shraaddha paksha (Fortnight of ancestors), right before Sharad Navaratri in autumn. And it is the season when you see proliferation of diseases.

There are important spiritual reasons to perform pitru tarpana but it also plays critical role in maintaining physical health. More research is needed to identify these bio-markers and perform related rituals. Till then, do perform श्राद्ध every year.

You live life, not for self but also for wellbeing of future generations. Your good or bad physical and mental legacy will either perish next generation or flourish them. Be good, always. Do not forget to pay homage to your ancestors.


The Toxins That Affected Your Great-Grandparents Could Be In Your Genes

His discoveries touch on the basic question of how biological instructions are transmitted from one generation to the next. For half a century it has been common knowledge that the genetic material DNA controls this process; the “letters” in the DNA strand spell out messages that are passed from parent to offspring and so on. The messages come in the form of genes, the molecular equivalent of sentences, but they are not permanent. A change in a letter, a result of a random mutation, for example, can alter a gene’s message. The altered message can then be transmitted instead.

“In essence,” Skinner explains, “what your great-grandmother was exposed to could cause disease in you and your grandchildren.”




About Interstellar and the Ancestral Help



न देवा दण्डमादाय रक्षन्ति पशुपालवत् |
यं तु रक्षितुमिच्छन्ति बुद्ध्या संयोजयन्ति तम् |
(- महाभारत)

God is not one who will walk behind guiding you like cows with a stick. But God gives intelligence (to solve problems by oneself) to one whom god wishes to protect.

(Thank you Aparna ji for sharing this quote)
Like how Murph was guided by her dad from fifth dimension (Gravity anomaly), all our forefathers too influence us, in positive or negative manner, based on their innate nature. Like Murph’s library (information) ghost, there is parental influence on our personality. I understand it as ‘Pitru Rina-पितृ रुण’ or relation with forefathers which influences our thoughts and actions.

Not only forefathers, singular consciousness or God guide us. All our thoughts, insights, inspirations, opportunities, situations in favor of societal transformation, selfless actions are sent to this universe from the other world. Who sent it? “They” as movie interstellar talks about.

Some of us use words like ‘Genetic imprints’ or ‘Heredity’ to explain forefathers influence. But in my understanding, this exchange of information does not happen just on physical plane, like it is shown in movie, but is a subject of mental plane. To receive potent hints, we must first clean and condition our minds so that we can receive the hints, decipher them (Like Murph did) and use the wise advises for the welfare of the family, society and the universe.

There are several rituals in the culture of this land (Not sure about other cultures, there may be similar rituals. Subject of research.), to purify mind. Most popular is Yoga. It helps in mind purification which can lead to life sustaining actions. Mind becomes more receptive for deciphering guidance sent from fifth dimension 🙂. It is different thing that rituals have become mechanical, devoid of real purpose.

I do not deny scientific way to explain interstellar. But this is also interesting aspect if you wish to ponder upon. Think about it. Even if you are non-believer or atheist, forefathers influence does impact. Think about it. Take care. (Y)

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