Microbes

Microbes

Pathogens shape your Behaviour: Immunity and Being Social

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They shape out social behaviour
They shape out social behaviour IMAGE SOURCE: https://www.mtyhd.org/wp-content/uploads/2014/11/immunity-against-diseases_Gk5Lduu_-GS.jpg

General understanding about immunity is very naive based on the memes spread by modern science custodians in last 100 years. So far, it used to be function preventing us from unforeseen illnesses. Protecting us from pathogens. That is it, right?

It is high time we understand the roots of immunity.

Sanskrit word मुनि means anyone who is moved by inward impulses. Someone who is self-inspired. Someone who is performing duties intuitively.

Now let us understand Latin: Latin word Munis (early *moinis, moenis) has as its principal meaning someone who discharges his office/duty, somebody accomplishing a tasks also contained is the connotation present, gift. Related to it are im-munis (with its derivative im-munitas {immunity}, that is, the exemption from charge or duty.

So in our body, all active cells are Muni(s) or मुनि ((S). They are working as per self-inspiration based on cellular intelligence they carry from birth. Immunity is the process of retiring cells from their duties. Why do we need it?

We need it because their job is over. To maintain the integrity of the body, it is necessary to give them good bye. This process of good bye is a Immune response. This is called Innate immunity. Sometimes, when external conditions are not good, cells die prematurely or their processing is affected severely. So they broadcast messages for help or to alert others in cell community. We call it Viruses. Viruses are dead information. They are not मुनि. They are born to get uprooted once message is conveyed to other cells. We call it viral infection. When severe condition persists for cells, they die prematurely. We call it bacterial infection.

In short, integrity of organism is essential for Muni(s) or Body cell to perform tasks. To help them immune system perform immunity process.

So-called immune system knows which part of the body is self, and what is not-self. A self-marker or a suimarker is endowed to each self-element, an advantage not denied to an alien unit or cell present at the time of thymic maturation.

So when immunity is compromised (मुनि characteristic of us), it is trauma and stress for each individual cell/bacteria/देव/पितर participating in our existence! Summation of it, emerges as anti-social behaviour! And that is what this paper talks about!

At the same time, it is our social interactions as a child, that shapes our immunity (our sense of identifying self from rest).  And as immunity is strengthen, we become and remain social.

SHOCKING NEW ROLE FOUND FOR THE IMMUNE SYSTEM: CONTROLLING SOCIAL INTERACTIONS

https://news.virginia.edu/content/shocking-new-role-found-immune-system-controlling-social-interactions?utm_source=VirginiaHome&utm_medium=referral&utm_campaign=news

“The brain and the adaptive immune system were thought to be isolated from each other, and any immune activity in the brain was perceived as sign of a pathology. And now, not only are we showing that they are closely interacting, but some of our behavior traits might have evolved because of our immune response to pathogens,” explained Jonathan Kipnis, chair of UVA’s Department of Neuroscience. “It’s crazy, but maybe we are just multicellular battlefields for two ancient forces: pathogens and the immune system. Part of our personality may actually be dictated by the immune system.”

The UVA researchers have shown that a specific immune molecule, interferon gamma, seems to be critical for social behavior and that a variety of creatures, such as flies, zebrafish, mice and rats, activate interferon gamma responses when they are social. Normally, this molecule is produced by the immune system in response to bacteria, viruses or parasites. Blocking the molecule in mice using genetic modification made regions of the brain hyperactive, causing the mice to become less social. Restoring the molecule restored the brain connectivity and behavior to normal. In a paper outlining their findings, the researchers note the immune molecule plays a “profound role in maintaining proper social function.”

 

“It’s extremely critical for an organism to be social for the survival of the species. It’s important for foraging, sexual reproduction, gathering, hunting,” said Anthony J. Filiano, Hartwell postdoctoral fellow in the Kipnis lab and lead author of the study. “So the hypothesis is that when organisms come together, you have a higher propensity to spread infection. So you need to be social, but [in doing so] you have a higher chance of spreading pathogens. The idea is that interferon gamma, in evolution, has been used as a more efficient way to both boost social behavior while boosting an anti-pathogen response.”

Now, we see viruses, bacteria and mosquitos as our enemies. Think about it. Are they our enemies? Or they are mother nature’s faithful workers shaping our immunity! (self-realization! Moksha! What not! It starts with the physical self!)

 

 

Ganesha, The protector of second brain

Ganesha
Ganesha

गणेश चतुर्थी to गणेश चतुर्दशी : Here is your yearly chance to contemplate on ageless doubt “Who am I?” and strengthen self-belief.

Happy Festival!Best wishes for your ultimate joyous conversation with self!

Season’s Rain has done his job.
Seeds for new beginning are already sprouted.
Welcome to lord of beginning in our heart. May we become live example of गणपति.

During monsoon, our digestive power remains very low and so there are high chances that GUT remains polluted. So just when the monsoon is on the verge of end, we worship गणेश for 10 days.

गणपति resides in GUT area . And to worship him, we generally keep fast. Fasting clean the GUT and transforms it from GUTTER into Heaven. So clean GUT means right decisions, right actions and in real sense गणेश acts as विध्नहर्ता.

The part of the alimentary canal between the stomach and the anus is known as GUT. This is reservoir of microbes. Critical digestive processes happen here.

Muladhara
Muladhara

In Ayurveda, this place is considered as मूलाधार चक्र.गणपति resides here. Ayurveda considers body beyond physical body and energy layer is one of such layer, प्राणमय कोष. Energy @ मूलाधार चक्र is responsible for person’s intelligence, valor and many other traits. And Ganapati resides here. He controls all activities.

Now, modern science says, GUT is our second brain. 🙂 🙂 We use this second brain as gutter. We eat anything and everything. Creating highly polluted environment. So second brain hardly works. 🙂 🙂 😉 😛

Moral of the post: Do not make fun of your rituals under the influence of media, TV, Bollywood and some so called rational authors. If you do not understand a bit, still follow your culture. There are ample hidden benefits.

When you meditate on मूलाधार by chanting ganapati atharvashirsha, unique mental and physical state emerge. In modern science language, you actually help your second brain to work well.

Antibiotics disturbs this area most. This is the reason I advocate alternative use of controlling bacterial infection and not antibiotics. As it directly affect our emotions and thinking capacity.

See all photos with post. Think about it. Read more:


Research


http://www.scientificamerican.com/article/gut-second-brain/

Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being

Gut - Second brain
Gut – Second brain

Technically known as the enteric nervous system, the second brain consists of sheaths of neurons embedded in the walls of the long tube of our gut, or alimentary canal, which measures about nine meters end to end from the esophagus to the anus. The second brain contains some 100 million neurons, more than in either the spinal cord or the peripheral nervous system, Gershon says.

This multitude of neurons in the enteric nervous system enables us to “feel” the inner world of our gut and its contents. Much of this neural firepower comes to bear in the elaborate daily grind of digestion. Breaking down food, absorbing nutrients, and expelling of waste requires chemical processing, mechanical mixing and rhythmic muscle contractions that move everything on down the line.

Thus equipped with its own reflexes and senses, the second brain can control gut behavior independently of the brain, Gershon says. We likely evolved this intricate web of nerves to perform digestion and excretion “on site,” rather than remotely from our brains through the middleman of the spinal cord. “The brain in the head doesn’t need to get its hands dirty with the messy business of digestion, which is delegated to the brain in the gut,” Gershon says. He and other researchers explain, however, that the second brain’s complexity likely cannot be interpreted through this process alone.

“The system is way too complicated to have evolved only to make sure things move out of your colon,” says Emeran Mayer, professor of physiology, psychiatry and biobehavioral sciences at the David Geffen School of Medicine at the University of California, Los Angeles (U.C.L.A.). For example, scientists were shocked to learn that about 90 percent of the fibers in the primary visceral nerve, the vagus, carry information from the gut to the brain and not the other way around. “Some of that info is decidedly unpleasant,” Gershon says.

The second brain informs our state of mind in other more obscure ways, as well. “A big part of our emotions are probably influenced by the nerves in our gut,” Mayer says. Butterflies in the stomach—signaling in the gut as part of our physiological stress response, Gershon says—is but one example. Although gastrointestinal (GI) turmoil can sour one’s moods, everyday emotional well-being may rely on messages from the brain below to the brain above. For example, electrical stimulation of the vagus nerve—a useful treatment for depression—may mimic these signals, Gershon says.

Given the two brains’ commonalities, other depression treatments that target the mind can unintentionally impact the gut. The enteric nervous system uses more than 30 neurotransmitters, just like the brain, and in fact 95 percent of the body’s serotonin is found in the bowels. Because antidepressant medications called selective serotonin reuptake inhibitors (SSRIs) increase serotonin levels, it’s little wonder that meds meant to cause chemical changes in the mind often provoke GI issues as a side effect. Irritable bowel syndrome—which afflicts more than two million Americans—also arises in part from too much serotonin in our entrails, and could perhaps be regarded as a “mental illness” of the second brain.

Gau Gavya and Gau-Raksha

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When someone represent गौ-रक्षक in negative image, my blood boils. As a leader, I should actually promote that every citizen should be गौ-रक्षक!

गाय & गव्य
गाय & गव्य

Gavya is a Sanskrit word. It has multiple meanings. It is actually a bridge between different forms of Gau.

Gau means Cow. Gau means senses. Gau means mother Earth. Gavya is their prasad. One produces and another consumes. Cycle goes on forever.

गौ रक्षक
गौ रक्षक

Panchgavya is elixir from Gau, for Gau (Human senses and Mother Earth). Result again is Gavya (Seva from Humans and produce from Mother earth) from gau, for Gau (Cow).

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Method of preparation
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Pancha-Gavya and Gau Raksha
Pancha-Gavya and Gau Raksha

Panchagavya, an organic product has the potential to play the role of promoting growth and providing immunity in plant system. Panchagavya consists of nine products viz. cow dung, cow urine, milk, curd, jaggery, ghee, banana, Tender coconut and water. When suitably mixed and used, these have miraculous effects.

Cow dung – 7 kg
Cow ghee – 1 kg
Mix the above two ingredients thoroughly both in morning and evening hours and keep it for 3 days

Cow Urine – 10 liters
Water – 10 liters
After 3 days mix cow urine and water and keep it for 15 days with regular mixing both in morning and evening hours. After 15 days mix the following and panchagavya will be ready after 30 days.

Cow milk – 3 liters
Cow curd – 2 liters
Tender coconut water – 3 liters
Jaggery – 3 kg
Well ripened poovan banana – 12 nos.

Read more: http://agritech.tnau.ac.in/org_farm/orgfarm_panchakavya.html

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We all have Vishnu seated in us. We must perform duties in his form. Being Gopati.

Cow Milk : Season driven changes

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Every other day, I have to explain young friends that we don’t love our mother based on how much she fed us the breast milk. Similarly, mother soil or mother gau, must not be judged based on the yield. It is utterly sick world view. Abnormal and clearly against the dharma.

Milk quantity and quality changes with breed, season, terrain and care you provide to mother.So , for once and all, get rid of this pervert mentality to see Gau as milk machine.

When you are blessed by authentic raw cow milk, don’t try to compare it with milk from professional dairies. In Dairy, milk is homogenized, so you will get same quality every day. When you procure milk from Gau shala, quality changes every day, in all seasons!

Since आत्म विद्या, प्राण विद्या are not part of education, and many of us are not even exposed to introduction, it becomes difficult to understand how microbes work (Not that I know everything. I am still learning. )

Ethical Gau Shala takes care of calf
Ethical Gau Shala takes care of calf

Effectiveness of butter milk depends upon many factors. Source of milk, time of churning, season! Even two cows from same Gau shala will different quality based on their lactation cycle! So if you avail milk from Gau shala, it is very much possible that there will be variation in milk quality! It is natural to doubt variation if for last 20-30 years, you have drank dairy based milk! On the contrary – if there is same quality milk from Gau shala, you should doubt! 🙂  Essential solution is trust between you and Gau shala and frequent visits to Gau shala so that we can connect with Gau mata!

It is not religious fanaticism when I claim that desi zebu cattle’s milk is best probiotic food source, it is easily verifiable by modern scientific standards.

In this post (Real Milk vs Factory milk vs Vegan Alternatives), I shared how and why milk source matters.

Please note. Now, modern dairy science realize season driven changes in milk. Our festivals and deeply rooted life understand this as common sense and restrict milk usage in several patches of the year (I have shared here time to time).

We reduce milk usage by the end of summer and again make it regular by onset of शरद ऋतू.

Milk was never a primary reason we revere and worship cows.

Modern dairy science also misled (at least by advertisements) common mass by saying that pasteurization kills all microbes. Not true. Read paper to know more. They also set wrong standards by comparing milk quality by FAT %. Real nectar is not FAT % but type of fat and other minerals! (Which are lost in high heat dairy process!)

This paper also talks about how modern processes of transporting and processing milk changes microbes and fermented food (I shared it here at least twice why butter milk (छास) from market is different from home-made and why fermentation must happen at home).

While this paper talks sensibly, their end goals are still not right. 🙂

Read it. realize it.

http://mbio.asm.org/content/7/4/e00836-16

The Core and Seasonal Microbiota of Raw Bovine Milk in Tanker Trucks and the Impact of Transfer to a Milk Processing Facility

“Raw milk harbors diverse bacteria that are crucial determinants of the quality and safety of fluid milk and (fermented) dairy products. These bacteria enter farm milk during transport, storage, and processing. Although pathogens are destroyed by pasteurization, not all bacteria and their associated enzymes are eliminated. Our comprehensive analyses of the bacterial composition of raw milk upon arrival and shortly after storage at major dairy processors showed that the communities of milk microbiota are highly diverse. Even with these differences, there was a core microbiota that exhibited distinct seasonal trends. Remarkably, the effects of the processing facility outweighed those of the raw milk microbiome and the microbial composition changed distinctly within some but not all silos within a short time after transfer. “

Seasonal variation in milk vitamin contents available for processing in Punjab, Pakistan

http://www.sciencedirect.com/science/article/pii/S1658077X12000033

Seasonal variation in milk composition has attained core attention for consistent quality of dairy products at a global scale. Due to escalating scientific awareness, consumers are tracking toward nutritionally enhanced milk based functional products that have elevated their market demand. The current research was planned to evaluate localities and seasonal variation in fat, protein, lactose and vitamins (A, E, C) in milk (mix cow and buffalo milk) available for processing. The seasonal duration ranged from April 2008 to March 2009. The fat, protein and lactose contents of milk from all zones significantly varied throughout the season. Moreover, fat (5.4%) & protein (3.22%) contents were high in February, while maximum lactose content (6.26%) was observed in January. Additionally, minimum fat (4.3%), protein (2.3%) and lactose (4.93%) contents were observed in summer months. Highest vitamin C content (6.68 mg/100 g) of milk was recorded in February, whereas vitamin A (264.5 IU/100) and vitamin E (0.226 mg/100 g) were obtained in August and June, respectively. It was noted that vitamin A and E contents were high in August and subsequently declined till March. Conclusively, the current exploration proved helpful to analyze seasonal variation in milk composition with special reference to vitamins for consistent quality end products.

Milk Components: Understanding the Causes and Importance of Milk Fat and Protein Variation in Your Dairy Herd

http://extension.psu.edu/animals/dairy/nutrition/nutrition-and-feeding/diet-formulation-and-evaluation/milk-components-understanding-the-causes-and-importance-of-milk-fat-and-protein-variation-in-your-dairy-herd

 

Season vs Milk Fat
Season vs Milk Fat
Level of fat and protein varies across herds and seasonally. Ranges represent one standard deviation above and below the average. The solid line in the center of each range indicates the average for that month. For the three years studied, milk fat% averaged 3.76 ± 0.32 (blue), and milk protein% averaged 3.05 ± 0.19 (orange). (Bailey et al., 2005).

Season dramatically affects milk fat and protein (refer to Figure 1). The hot, humid months (July and August in the northeast) depress fat and protein content. There is a gradual increase of protein and fat in milk through the fall and peak levels occur in the colder months of winter. As temperatures increase through the spring, component levels are gradually decreased. These changes may be indicative of feed intake patterns, which are lower in summer due to changes in weather and temperature.

Effect of season of birth on milk, fat, and protein production of Israeli Holsteins.

http://www.ncbi.nlm.nih.gov/pubmed/8827465

The effects of birth month on production of milk, fat, and protein and percentages of fat and protein were analyzed based on production records of 101,653 first parity, 77,541 second parity, and 51,856 third parity Israeli Holstein cows. Each parity was analyzed separately. The analysis model also included the effects of herd-year, DIM, calving age, and calving month. First parity Type III sums of squares for birth month were nearly as large as those for calving month but decreased for later parities. Similar results were obtained using multiplicative models in which the dependent variables were the logarithms of the production traits. The effects of calving month and birth month were not similar, but birth month had similar effects for milk, fat, and protein production. Production was lowest by cows born in the early spring and highest by cows born in the fall. Analyses of the log-transformed traits showed that the F values for calving month were greater than, and the F values for birth month were nearly identical to, the F values for the untransformed trait analyses. The physiological basis for these trends was not clear.

Desi cow is is कामधेनु! do you know what is the meaning of कामधेनु?

Kamdhenu
Kamdhenu

श्रियः प्रदुग्धे विपदो रुणद्धि
यशांसि सूते मलिनं प्रमार्ष्टि ।
संस्कारशौचेन परं पुनीते
शुद्धा हि वुद्धिः किल कामधेनुः ॥

शुद्ध बुद्धि सचमुच कामधेनु है, क्यों कि वह संपत्ति को दोहती है, विपत्ति को रुकाती है, यश दिलाती है, मलिनता धो देती है, और संस्काररुप पावित्र्य द्वारा अन्य को पावन करती है ।

Like knowledge, mother helps us by preventing difficult situations and purifying our environment (both internal body and external)

Think beyond FAT % while doing Gau seva and receiving Prasad (milk)

‘I’ is becoming obsolete

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Tree of Life Img Src: https://s-media-cache-ak0.pinimg.com/736x/ec/79/d2/ec79d24ccd98700a5a4b982f95d90744.jpg
Tree of Life
Img Src: https://s-media-cache-ak0.pinimg.com/736x/ec/79/d2/ec79d24ccd98700a5a4b982f95d90744.jpg

All Sanatana Dharma scriptures talks about dissolving false ego ‘I’ or अहंकार. There is nothing like ‘I’. It is your false ego. There is indeed thin line by which you can recognize end of you and start of environment.

And this life is never for self but to serve others. I tried example of microbes and their friendship with us several times to show this synergy and border-less body we have.

The real life starts when you dissolve this false arrogance of being ‘I’. I am something. I am doctor. i am engineer. I am Mr. XYZ 😀

Taking care of body is highest धर्म (duty). It is सेवा of all microbial societies forming your body. It is सेवा of all molecular bodies giving you luxury of false ego.

शरीर
शरीरमाद्यं खलु धर्मसाधनम् ।
शरीर धर्म पालन का पहला साधन है ।

Not eating food your body wants, not doing exercise, taking too much stress,taking mindless chemicals in form of medicines — All of these are Karmic crimes against lower worlds serving as your body!!

Now science is preaching same.


Reference


The pronoun ‘I’ is becoming obsolete

http://news.vanderbilt.edu/2015/08/the-pronoun-i-is-becoming-obsolete/

Recent microbiological research has shown that thinking of plants and animals, including humans, as autonomous individuals is a serious over-simplification.

A series of groundbreaking studies have revealed that what we have always thought of as individuals are actually “biomolecular networks” that consist of visible hosts plus millions of invisible microbes that have a significant effect on how the host develops, the diseases it catches, how it behaves and possibly even its social interactions.

It’s a case of the whole being greater than the sum of its parts,” said Seth Bordenstein, associate professor of biological sciences at Vanderbilt University, who has contributed to the body of scientific knowledge that is pointing to the conclusion that symbiotic microbes play a fundamental role in virtually all aspects of plant and animal biology, including the origin of new species.

Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002226

Groundbreaking research on the universality and diversity of microorganisms is now challenging the life sciences to upgrade fundamental theories that once seemed untouchable. To fully appreciate the change that the field is now undergoing, one has to place the epochs and foundational principles of Darwin, Mendel, and the modern synthesis in light of the current advances that are enabling a new vision for the central importance of microbiology. Animals and plants are no longer heralded as autonomous entities but rather as biomolecular networks composed of the host plus its associated microbes, i.e., “holobionts.” As such, their collective genomes forge a “hologenome,” and models of animal and plant biology that do not account for these intergenomic associations are incomplete. Here, we integrate these concepts into historical and contemporary visions of biology and summarize a predictive and refutable framework for their evaluation. Specifically, we present ten principles that clarify and append what these concepts are and are not, explain how they both support and extend existing theory in the life sciences, and discuss their potential ramifications for the multifaceted approaches of zoology and botany. We anticipate that the conceptual and evidence-based foundation provided in this essay will serve as a roadmap for hypothesis-driven, experimentally validated research on holobionts and their hologenomes, thereby catalyzing the continued fusion of biology’s subdisciplines. At a time when symbiotic microbes are recognized as fundamental to all aspects of animal and plant biology, the holobiont and hologenome concepts afford a holistic view of biological complexity that is consistent with the generally reductionist approaches of biology.

Ganesha’s favorite fruit and seasonal remedies

गणपति’s form महागणपति carries pomegranate in his hand. This is the season of worshiping him.

This is also season when many suffer from food infection and poisoning.

This is also season dental issues like gingivitis and pyorrhea.

Worshiping Ganesha during this month (भाद्रपद) and eating pomegranate after meals will save you from any type of bacterial infection and food poisoning. It will maintain optimum GUT microbes.

Season driven worship
Season driven worship

It also helps against aging related memory loss.

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Src: http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00260
Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease
Src: http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00260

What modern medicine shares are physical benefits of pomegranate. In my understanding, they are not complete unless we start worshiping Ganesha who represents Muladhara!


Reference for pomegranate


The antiplaque efficacy of pomegranate mouthrinse.

http://www.ncbi.nlm.nih.gov/pubmed/21206931

“these results indicate that the pomegranate mouthrinse has an antiplaque effect. Pomegranate extract is efficacious against A.a., P.g., and P.i. strains in vitro. Pomegranate mouthrinse should be explored as a long-term antiplaque rinse with prophylactic benefits.”

 

Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk.

“Four weeks of mouth rinsing, thrice daily, with the pomegranate extract dissolved in water, altered salivary measures pertinent to oral health, including gingivitis. The changes were: Decreased total protein (which can correlate with plaque forming bacteria readings), diminished activities of aspartate aminotransferase (a marker of cell injury), attenuated alpha-glucosidase activity (a sucrose degrading enzyme), enhanced activities of the antioxidant enzyme ceruloplasmin (affording superior protection against oral oxidant stress), and augmented radical scavenging capacity (however non-significant). Hence, the use of pomegranate extracts in oral health products such as toothpastes and mouthwashes could be a viable option.”

Punica granatum (pomegranate) extract is active against dental plaque.

In the present work, we studied the effect of the hydroalcoholic extract (HAE) from Punica granatum (pomegranate) fruits on dental plaque microorganisms. The study was conducted on 60 healthy patients (33 females and 27 males, with age ranging from 9 to 25 years) using fixed orthodontic appliances, and randomly distributed into 3 groups of 20 patients each. The first group (control) used distilled water, while the second and third groups used chlorhexidine (standard) and HAE as mouth-rinses, respectively. The dental plaque material was collected from each patient, before and after a 1-min mouth-rinse with 15 ml of either distilled water, chlorhexidine or HAE. In both dental plaque collections, the material was removed from patients without oral hygiene, for 24 h (no tooth brushing). Dental plaque samples were diluted in phosphate buffered saline (PBS) plated on Mueller-Hinton agar, and incubated for 48 h, at 37 degrees C. Results, expressed as the number of colony forming units per milliliter (CFU/mL), show that the HAE was very effective against dental plaque microorganisms, decreasing the CFU/ml by 84% (CFU x 10(5)), before mouth-rinse: 154.0 +/- 41.18; after mouthrinse: 25.4 +/- 7.76). While similar values were observed with chlorhexidine, used as standard and positive control (79% inhibition), only an 11% inhibition of CFU/ml was demonstrated in the distilled water group, negative control (CFU x 10(5)), before mouth-rinse: chlorhexidine, 208.7 +/- 58.81 and distilled water, 81.1 +/- 10.12; after mouth-rinse: chlorhexidine, 44.0 +/- 15.85 and distilled water, 71.9 +/- 8.68). The HAE presented also an antibacterial activity against selected microorganisms, and may be a possible alternative for the treatment of dental plaque bacteria.

Gut bacteria make pomegranate metabolites that may protect against Alzheimer’s disease

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00260

Pomegranate shows neuroprotective effects against Alzheimer’s disease (AD) in several reported animal studies. However, whether its constituent ellagitannins and/or their physiologically relevant gut microbiota-derived metabolites, namely, urolithins (6H-dibenzo[b,d]pyran-6-one derivatives), are the responsible bioactive constituents is unknown. Therefore, from a pomegranate extract (PE), previously reported by our group to have anti-AD effects in vivo, 21 constituents, which were primarily ellagitannins, were isolated and identified (by HPLC, NMR, and HRESIMS). In silico computational studies, used to predict blood-brain barrier permeability, revealed that none of the PE constituents, but the urolithins, fulfilled criteria required for penetration. Urolithins prevented β-amyloid fibrillation in vitro and methyl-urolithin B (3-methoxy-6H-dibenzo[b,d]pyran-6-one), but not PE or its predominant ellagitannins, had a protective effect in Caenorhabditis elegans post induction of amyloid β1–42 induced neurotoxicity and paralysis. Therefore, urolithins are the possible brain absorbable compounds which contribute to pomegranate’s anti-AD effects warranting further in vivo studies on these compounds.

Pomegranate finally reveals its powerful anti-aging secret

Intestinal bacteria transform a molecule contained in the fruit with spectacular results

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

http://www.nature.com/nm/journal/v22/n8/full/nm.4132.html

Are pomegranates really the superfood we’ve been led to believe will counteract the aging process? Up to now, scientific proof has been fairly weak. And some controversial marketing tactics have led to skepticism as well. A team of scientists from EPFL and the company Amazentis wanted to explore the issue by taking a closer look at the secrets of this plump pink fruit. They discovered that a molecule in pomegranates, transformed by microbes in the gut, enables muscle cells to protect themselves against one of the major causes of aging. In nematodes and rodents, the effect is nothing short of amazing. Human clinical trials are currently underway, but these initial findings have already been published in the journal Nature Medicine.

Ganesha Utsav, Center of body, Microbes And Health

In Sanatana dharma, one God has several forms described in scriptures. As per worshipper’s need, different form is prescribed for worship.

Mahaganapati
Mahaganapati
Vigneswara
Vigneswara

As per scriptures, देह-मध्य is where मूलाधार or abode of गणेश is. For humans, it is near GUT. For animals, in heart. For birds, in stomach. For trees, it is roots. For all living and non-living beings, देह-मध्य varies and so place of गणपति. Based on the place or the host, गणपति’s name, form, color, vehicle and decoration changes. So there are infinite forms of गणपति based on variations in प्राण combinations of each object (living or dead) has.

First and foremost thing we can do to Ganesh Pooja in human form is to maintain proper posture. 🙂 Right posture means stability of प्राण in देह-मध्य.

Second, we can keep our GUT clean. Modak made from Desi Cow ghee helps here in this season. 🙂

देह-मध्य शुचिता (cleansing of center of the body) is important.

Some of us worship Vinayaka, some worship Lambodara, some worship महागणपति.

महागणपति is depicted with pomegranate in hand. Like Modak, it is indicating vital food of the season.

Mahaganpati
Mahaganpati
Ucchistha Ganapati
Ucchistha Ganapati

There are three harvesting seasons for pomegranate in India.
1) November-March (Mrig bahar)
2) February-May (Hasta bahar)
3) June – August (Ambe Bahar – flowering happens along with Mango flowering)

In Maharashtra, farmers follow third harvest season. So when this time of the year they celebrate Ganesh Festival, pomegranate is vital part of food and life in all households.महागणपति form prescribes us to eat pomegranate in this season. It is no wonder that Maharashtra celebrates Ganesha with pomegranate.

Why?

All Sanatana Dharma symbols give hints related to three worlds 1) Physical body (आधि-भौतिक) 2) Internal working of body (आधि-दैविक) 3) Mental world (आध्यात्मिक)

It will take time understand meaning of pomegranate on आधि-दैविक and आध्यात्मिक plane but it is easy to understand its importance on आधि-भौतिक plane.

“१ अनार १०० बीमार” – “1 pomegranate for 100 diseases.”

pomegranate
pomegranate

This season is known for epidemics. pomegranate can help you keep Nation of trillion+ body cells healthy.

Google and search benefits of pomegranate.

As a part of our worship, we should study these symbols, decipher meanings and live life as per prescriptions.

Sugarcane is also part of महागणपति. It tropical region, this period is either planting or harvesting time for sugarcane.

Eating jaggery in this season is also important for health.


Reference:


Research on pomegranate drug to stem Alzheimer’s and Parkinson’s

https://www.hud.ac.uk/news/2014/august/researchonpomegranatedrugtostemalzheimersandparkinsons.php

Dr Olumayokun Olajide’s research will now look to produce compound derivatives of punicalagin for a drug that would treat neuro-inflammation

Dr Olumayokun Olajide ‌THE onset of Alzheimer’s disease can be slowed and some of its symptoms curbed by a natural compound that is found in pomegranate. Also, the painful inflammation that accompanies illnesses such as rheumatoid arthritis and Parkinson’s disease could be reduced, according to the findings of a two-year project headed by University of Huddersfield scientist Dr Olumayokun Olajide, who specialises in the anti-inflammatory properties of natural products.

 

Research underway to create pomegranate drug to stem Alzheimer’s and Parkinson’s.

Modern medicine is re-inventing wheel invented by Ayurveda.
Those who have studied भावप्रकाश निघंटु, knows this very well.

In fact, it is common sense in local culture: “१ अनार १०० बीमार” – “1 pomegranate for 100 diseases.”

PS 1: Observe the trend. Modern chemical based pharma is losing ability to cure sickness using fancy chemical compounds. They are now researching on plant based medicines. If you are wise, embrace your local traditions! Or pay high price later by buying nice fancy pomegranate based medicines 😀

PS 2: Your kids are under going schooling which alieanted them far away from local culture. So they will hardly know all these things 🙂. Solution? De-school them daily 🙂. Spend more time with them. Spend more time in mother nature. She loves all of us and gives potent hints

Yagnopavit, GUT Microbes, Vagus Nerve

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Gut, Vagus nerve and mind cotnrol
Gut, Vagus nerve and mind cotnrol

We discussed this last week. We are guest and they are host. They control our lives and we facilitate.

How could they send messages -> Using vagus nerve.

How do you control messages? By controlling vagus nerve.

What can help to control vagus nerve so that you are always in good mood? Yagnopavit (जनेऊ). When we encircle ear during urination or passing stool, we control Vagus nerve. And by that we control internal movement of GUT so no excess Apana Vayu is exchanged with environment.

Yagnopavit and Vagus nerve
Yagnopavit and Vagus nerve

“Microbes have the capacity to manipulate behavior and mood through altering the neural signals in the vagus nerve, changing taste receptors, producing toxins to make us feel bad, and releasing chemical rewards to make us feel good,”

=================
About VAgus nerve

=================

Gut controlled mind
Gut controlled mind

The vagus nerve supplies motor parasympathetic fibers to all the organs except the suprarenal (adrenal) glands, from the neck down to the second segment of the transverse colon. The vagus also controls a few skeletal muscles, notable ones being:

Cricothyroid muscle
Levator veli palatini muscle
Salpingopharyngeus muscle
Palatoglossus muscle
Palatopharyngeus muscle
Superior, middle and inferior pharyngeal constrictors
Muscles of the larynx (speech).

This means that the vagus nerve is responsible for such varied tasks as heart rate, gastrointestinal peristalsis, sweating, and quite a few muscle movements in the mouth, including speech (via the recurrent laryngeal nerve). It also has some afferent fibers that innervate the inner (canal) portion of the outer ear (via the auricular branch, also known as Alderman’s nerve) and part of the meninges. This explains why a person may cough when tickled on the ear, such as when trying to remove ear wax with a cotton swab.

Do Gut Bacteria Rule Our Minds?

http://www.ucsf.edu/news/2014/08/116526/do-gut-bacteria-rule-our-minds

In an Ecosystem Within Us, Microbes Evolved to Sway Food Choices

A Power Struggle Inside the Gut

Bacterial species vary in the nutrients they need. Some prefer fat, and others sugar, for instance. But they not only vie with each other for food and to retain a niche within their ecosystem – our digestive tracts – they also often have different aims than we do when it comes to our own actions, according to senior author Athena Aktipis, PhD, co-founder of the Center for Evolution and Cancer with the Helen Diller Family Comprehensive Cancer Center at UCSF.

 

Intestinal flora effects drug response

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Antibacterial drugs cause changes in the intestinal flora. These changes have an influence on the capacity of the liver and kidneys to detoxify and eliminate therapeutic drugs due to large changes in the metabolizing and transport proteins. Credit: Dr. Sumio Ohtsuki Src: http://www.eurekalert.org/multimedia/pub/121803.php
Antibacterial drugs cause changes in the intestinal flora. These changes have an influence on the capacity of the liver and kidneys to detoxify and eliminate therapeutic drugs due to large changes in the metabolizing and transport proteins.
Credit: Dr. Sumio Ohtsuki
Src: http://www.eurekalert.org/multimedia/pub/121803.php

 

This is interesting study. This supports my hypothesis that only scientific medicine we have is Ayurvedic.
 
It is only in Ayurveda, medicine is given based on individual prakriti, keeping in mind birth prakriti, season and age.
 
On the other hand, modern medicine has no such standard except change in dosage based on weight and age.
 
Microbial flora in our body changes with season, age and innate prakriti. Hence, one medicine for all will never work.
 
“Antibacterial drugs cause changes in the intestinal flora. These changes have an influence on the capacity of the liver and kidneys to detoxify and eliminate therapeutic drugs due to large changes in the metabolizing and transport proteins.”
———————-
Research http://www.eurekalert.org/pub_releases/2016-08/ku-ife081216.php
———————-

Intestinal flora effects drug response

KUMAMOTO UNIVERSITY

Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body’s response to drugs. Recent research from Kumamoto University in Japan strongly suggests that changes in the intestinal flora, caused by antibacterial and antibiotic drugs or individual differences between people, may have an effect on a person’s response to drugs including side effects. The research focused on the changes in proteins due to the condition of intestinal flora that affect the response to drugs in the liver and kidneys.

Antibacterial and antibiotic drugs are often prescribed for the treatment and prevention of bacterial infections and are often taken with therapeutic drugs to prevent recurrence of infection during treatment. Unfortunately, the drugs affect not only harmful bacteria, but also the naturally occurring bacteria within the intestine. To determine the effects of this influence on drug efficacy, Kumamoto University researchers investigated protein changes in the liver and kidney. Changes in these proteins have a great influence on drug efficacy and side effects since they are responsible for the metabolism and transport of many drugs, and are also affected by changes in the intestinal flora.

Season of Maruts

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Microbes
Microbes

This is season of Maruts. Microbes. Rain showers abundant of Prana. Originated from various corners of the sea. With infinite different forms and past memories and Sanskars. (Yes, water do carry memories and Sanskars of its travel and so do all elements).

Since it is season of Maruts. There are chances that weak humans get trapped under these new combinations of Prana, fell sick and blame microbes for all their fault! 😀

So this post for positive attitude towards Prana.

Microbial biomass exceeds the total animal biomass. I am = I + M = I + Maruts = I + Microbes.

So who is host and who is guest? Your textbook taught you that, you are host and microbes live at your mercy.

In reality, it is total reverse case. They are host and we are guest. In any infectious disease, problem is not with bacteria and virus but WE the ill-behaved guests.

If we ill-behave (use wifi, use mobile, use pesticides, use antibiotics etc), host (microbial biomass that hosts us i.e. Maruts) has all rights to kill us.

If we behave (live life as per mother Nature’s rules and by maintaining synergy with all organisms) well, they build our life with all pleasures.

Instead of killing rich sources of Prana, improve your immunity. Do fasting. Eat moderately. Do not it for taste. Fix meal timings. Fix sleep timings. During monsoon, do not take extra mental stress. Focus your mind by jap, tap, dhyana and Sadhna. Detoxify mind and body. See the magic. You will not fell sick for entire year! Maruts will take care of you! 🙂

Human microbiota: onset and shaping through life stages and perturbations.
Human microbiota: onset and shaping through life stages and perturbations.

Second image from this research paper:

The function of our microbiota: who is out there and what do they do?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417542/

Current meta-omics developments provide a portal into the functional potential and activity of the intestinal microbiota. The comparative and functional meta-omics approaches have made it possible to get a molecular snap shot of microbial function at a certain time and place. To this end, metagenomics is a DNA-based approach, metatranscriptomics studies the total transcribed RNA, metaproteomics focuses on protein levels and metabolomics describes metabolic profiles. Notably, the metagenomic toolbox is rapidly expanding and has been instrumental in the generation of draft genome sequences of over 1000 human associated microorganisms as well as an astonishing 3.3 million unique microbial genes derived from the intestinal tract of over 100 European adults. Remarkably, it appeared that there are at least 3 clusters of co-occurring microbial species, termed enterotypes, that characterize the intestinal microbiota throughout various continents. The human intestinal microbial metagenome further revealed unique functions carried out in the intestinal environment and provided the basis for newly discovered mechanisms for signaling, vitamin production and glycan, amino-acid and xenobiotic metabolism. The activity and composition of the microbiota is affected by genetic background, age, diet, and health status of the host. In its turn the microbiota composition and activity influence host metabolism and disease development. Exemplified by the differences in microbiota composition and activity between breast- as compared to formula-fed babies, healthy and malnourished infants, elderly and centenarians as compared to youngsters, humans that are either lean or obese and healthy or suffering of inflammatory bowel diseases (IBD). In this review we will focus on our current understanding of the functionality of the human intestinal microbiota based on all available metagenome, metatranscriptome, and metaproteome results

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