Epigenetics

Epigenetics

Relational Biology : Membranes Not Genes

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Biologists know this very well: “Embryo development (ontogeny) depends on developmental gene regulatory networks (dGRNs), but dGRNs depend on preexisting spatial anisotropies that are defined by early embryonic axes, and those axes are established long before the embryo’s dGRNs are put in place. DNA sequences do not specify the final functional forms of most membrane components. Still less does DNA specify the spatial arrangements of those components. Yet their spatial arrangements carry essential ontogenetic information. The fact that membrane patterns carry ontogenetic information that is not specified by DNA poses a problem for any theory of evolution (such as Neo-Darwinism) that attributes the origin of evolutionary novelties to changes in a genetic program—whether at the level of DNA sequences or dGRNs.”[1]

In short, development of new cells depends more on Membrane Patterns than genes at the center. Membrane Patterns are formed based on epigenetic factors and cell-cell communication.

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Every one of us completely regenerates our own skin every 7 days. A cut heals itself and disappears in a week or two. Every single cell in our skeleton is replaced every 7 years. And there are many such regeneration cycles going on right now at different layers of our physical body.

At each such new beginning constantly pushed in to our microcosm Universe, there is an opportunity to repair the damaged life codes (DNA in modern science language) and streamline irregular processes.

Sheer abundances of chances presented by mother nature to regain healthy state back.

Unfortunately, we are taught in Biology that genes control us ever since Watson and Crick proposed Genes dogma. So there is apathy and doubt related to epigenetic factors (Non-genetic factors controlling and shaping our lives) not limited to stress-free mind, stress-free social environment, natural habitat, pets, animals, plants – they all play a role in helping us regaining healthy state back.

Think about it. Take care.

[1] Membrane Patterns Carry Ontogenetic Information That Is Specified Independently of DNA

http://bio-complexity.org/ojs/index.php/main/article/viewArticle/BIO-C.2014.2

 

Epigenetics: You are what your Father did before birth

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Mindless Youth - Future parent?
Mindless Youth – Future parent?

But fathers believe in fun! Parties!

What is present married couple’s attitude before progeny planning?

हेल्लो मिस्टर . डी जे, मेरे गाने पिल्ज़ प्ले
आज नो वाइन, आज नो लागा, आज पियेंगे चाम्पपियेंन
बम बम बम बूजिंग डांसिंग एंड वी क्रुज़िंग
बौंसर पंगा लेता है तोह, गोटा कीप ईट मूविंग
चार बज गए लेकिन पार्टी अभी बाकी है
ब ब ब .., विथ द बजे ऐ

“I damn don’t care! Its a Friday night!”

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Damn the self-centered ignorance! You spoil not only your future but also future of the Earth by passing on weak and faulty legacy genes.

A father’s lifetime experiences can be transmitted to his offspring to affect health and development. The mechanisms underlying paternal epigenetic transmission are unclear. Unlike somatic cells, there are few nucleosomes in sperm and their function in epigenetic inheritance is unknown.

No matter who you are, human, horse, dog or donkey, the biological legacy will haunt you for entire life! Fated! Destined! You must live with them and find you way of living by adjustments.

So your life under the influence of addictions, rampant life style – you gift this to your kids.

Why so much ignorance? Do you really want to gift chaos to kids?

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My tips for newly married:

Unlike female egg that is renewed with every mensuration cycle, male sperm takes 72 days from inception to maturation. During this 72 days, whatever you eat, drink, how you act, what you think – they all play role in shaping biological and mental destiny of your child! Not only your child, 7 generations to come!

So before you plan for a child:

1) Regularize your routine. Same time to sleep, same time wake up. Right food always!
2) No mental stress of whatsoever!
3) No addictions
4) No junk food
5) Pious simple life

All (Sacrifices?) in the service of future generation!

Think about it! Take care!

(those of us like me, who are already parents, better late than never. Take care as a grand-father!)


Research


What your father did before you were born could influence your future health

http://www.sciencealert.com/what-your-father-did-before-you-were-born-could-influence-your-future

It might not just be expectant mothers who have to pay attention to their lifestyle. Now a new study published in Science could be relevant to a growing body of research looking at ways in which the lifestyle and environment of men before they become fathers could influence the lives of their children and grandchildren.

We know that many human traits, such as weight, height, susceptibility to disease, longevity or intelligence, can be partly inherited, but researchers have so far struggled to identify the precise genetic basis for this. This may partly be due to limitations in our understanding of how genetics works, but now there is growing interest in the potential for something called epigenetics to explain this heritability.

Epigenetics refers to the information in the genome over and above that contained in the DNA sequence. This information takes a number of forms, but the most popular ones scientists have studied relate to the chemical modification (known as methylation and acetylation) of DNA and the proteins called histones that together make up the human genome.

This epigenetic information – which influences which copies of the genes in our DNA are ‘expressed’, or used – may be passed from one generation to another during reproduction. It can even persist within a lifetime in a person’s tissues and organs, even as their cells are replenished.

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

http://science.sciencemag.org/content/early/2015/10/07/science.aab2006

A father’s lifetime experiences can be transmitted to his offspring to affect health and development. The mechanisms underlying paternal epigenetic transmission are unclear. Unlike somatic cells, there are few nucleosomes in sperm and their function in epigenetic inheritance is unknown. We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase LSD1/KDM1A during spermatogenesis reduced H3K4 dimethylation in sperm. KDM1A overexpression in one generation severely impaired development and survivability of offspring. These defects persisted transgenerationally in the absence of KDM1A germ line expression and were associated with altered RNA profiles in sperm and offspring. We show that epigenetic inheritance of aberrant development can be initiated by histone demethylase activity in developing sperm, without changes to DNA methylation at CpG-rich regions.

 

Fetus, Genes, Epigenetics and GM Crops

Do you use molecular structure report of your kid’s DNA to decide his/her upbringing?
Do you use his/her blood report to identify innate nature and then use it for personality development?
Do you hire geneticist to modify his/her DNA to get desired results?

No. And yet, efforts put in parenting do pay the yield, positively or negatively.

Then why do you need to change genes of the seeds? 🙂

Prakriti
Prakriti

For fetus growing in the womb, there are several influences that shape its future prakriti.

First, it is impact of शुक्र & शोणित (रज,वीर्य). Parental legacy. 7 layers of generational legacy. It is called शुक्रशोणित प्रकृति.

Second, it is timing of the conception and health of the womb that has impact on the growing fetus. For example, वर्षाषु मारुतो दुष्ट: | Conception during monsoon means influence of Vayu. It is called कालगर्भाशय प्रकृति|

Third, it is mother’s food intake. Mental state. Activities. क्षेत्र प्रकृति |

Fourth, it is महाभूतविकार प्रकृति | Past life karma and past life interaction with panch-mahabhut.

Now, all these forces together shaped you and me in womb. And they will go it forever. They will do it forever this way only! Sanatana! Nitya! Always this way!

Please note: Genes play mere 25% (or less) role ( शुक्रशोणित प्रकृति.). 75% is about environment.

It is epigenetics! Be the custodian of master senses and learn to decipher mother nature’s hints! She always wants you to receive in abundance! Lest we realize it! Be the bridge between soil and seeds. Be the instrumental! That’s it!

This is the reason why GMO is highly inefficient and random technology. 75% control is with mother nature.(In fact, it is 100% mother’s rule 🙂 ) Sometimes favorable results, sometimes not. Read the history. IR8 rice (Famous green revolution hero, is now zero) to btCotton : shining examples of failures.


Supporting Research


Shaping Variation in the Human Immune System

http://www.cell.com/trends/immunology/abstract/S1471-4906(16)30091-6

Genetic variation accounts for 20–40% of immune variation, with enrichment of gene variants associated with autoimmunity, inflammatory disease, and susceptibility to infections among the identified genetic drivers.

Among the identified intrinsic drivers of immune variation, age is the most potent, driving a shift from a precursor-biased immune status to an inflammation-biased immune status.

A strong environmental effect on immune variation is observed, as revealed by cohabitation studies, with the strongest individual driver identified to date being chronic viral infection.

 

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