Sleep

Sleep

Antioxidants : Billion Dollar Business vs Body’s Inherent Mechanism

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sleep

Antioxidants are molecule which inhibits the oxidation of other substance, thus reducing the damage that is caused due to oxygen. The effect of free radical is neutralized by them and prevent the oxidation reaction by oxidizing themselves. There are two types of antioxidants; natural and artificial antioxidant.

There is huge growing market of antioxidants and since it works on Gillette model (recurring purchase by consumers), intense marketing is being done in media. So much that even face-wash and shampoo(s) are also sold with antioxidants. 😀

Global Antioxidants (Natural and Synthetic) Market Poised to Surge From USD 2.25 Billion in 2014 to USD 3.25 Billion by 2020, Growing at 5.5% CAGR – Market Research Store [1]

Idea of slowing down aging is not just possible by food as modern medicine and pharma mafia proclaims. As per Ayurveda, it works based on three basic principles.

Food, Sleep and Brahmcharya.

त्रय उपस्तम्भा: आहार: स्वप्नो ब्रह्मचर्यमिति (चरक संहिता सूत्र. 11/35)

अर्थात् शरीर और स्वास्थ्य को स्थिर, सुदृढ़ और उत्तम बनाये रखने के लिए आहार, स्वप्न (निद्रा) और ब्रह्मचर्य – ये तीन उपस्तम्भ हैं। ‘उप’ यानी सहायक और ‘स्तम्भ’ यानी खम्भा। इन तीनों उप स्तम्भों का यथा विधि सेवन करने से ही शरीर और स्वास्थ्य की रक्षा होती है।

Three Pillars of Life

Food, full of preservatives. Late night movies and entertainment. And never-stopped sexual indulgence ever since you hit puberty. This is becoming norm in our teen age. Do you expect them to excel life with such life design?

We not only talk about sleep, timely and just enough sleep. If we sleep untimely or sleep more, it is not going to help!

निद्रा उचित समय पर उचित मात्रा में लेनी चाहिए। असमय तथा अधिक मात्रा में शयन करने से अथवा निद्रा का बिल्कुल त्याग कर देने से आरोग्य व आयुष्य का ह्रास होता है। दिन में शयन स्वास्थ्य के लिए अत्यन्त हानिकर है परंतु जो व्यक्ति अधिक अध्ययन, अत्यधिक श्रम करते हैं, धातु-क्षय से क्षीण हो गये हैं, रात्रि जागरण अथवा मुसाफिरी से थके हुए हैं वे बालक, वृद्ध, कृश, दुर्बल व्यक्ति दिन में शयन कर सकते हैं

दिन में सोने से होने वाली हानियाँ-

दिन में सोने से जठराग्नि मंद हो जाती है। अन्न का ठीक से पाचन न होकर अपाचित रस (आम) बन जाता है जिससे शरीर में भारीपन, शरीर टूटना, जी मिचलाना, सिरदर्द, हृदय में भारीपन, त्वचारोग आदि लक्षण उत्पन्न होते हैं। तमोगुण बढ़ने से स्मरणशक्ति व बुद्धि का नाश होता है।

अतिनिद्रा दूर करने के उपायः

उपवास, प्राणायाम व व्यायाम करने तथा तामसी आहार (लहसुन, प्याज, मूली, उड़द, बासी व तले हुए पदार्थ आदि) का त्याग करने से अतिनिद्रा का नाश होता है। [2]

Now, let us explore value of sleep as per modern research.


Research & References


A bidirectional relationship between sleep and oxidative stress in Drosophila

Most animals sleep; humans sleep nearly a third of their lives. Yet the fundamental functions of sleep remain unknown. Here, we used short-sleeping Drosophila mutants to uncover a role for sleep in resistance to oxidative stress. Oxidative stress is an imbalance of reactive oxygen species and antioxidant responses. Although these short-sleeping mutants have defects in diverse pathways, they all exhibit sensitivity to oxidative stress. Moreover, increasing sleep in wild-type flies increased resistance to oxidative stress. This suggests that one function of sleep is to defend against oxidative stress. Finally, reducing oxidative stress in neurons of wild-type flies reduces their sleep, suggesting that oxidative stress also regulates sleep. Taken together, our results support an intriguing hypothesis for a bidirectional relationship between sleep and oxidative stress: oxidative stress triggers sleep, which then acts as an antioxidant for both the body and the brain. These results have implications for human patients suffering from chronic sleep restriction and diseases associated with oxidative stress.

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005206

[1] https://www.cnbc.com/2016/01/19/globe-newswire-global-antioxidants-natural-and-synthetic-market-poised-to-surge-from-usd-225-billion-in-2014-to-usd-325-billion-by-2020.html

[2] http://www.ashram.org/Teachings/Healthy-Living/Ayurveda/ArtMID/2138/ArticleID/10468/%E0%A4%A8%E0%A4%BF%E0%A4%A6%E0%A5%8D%E0%A4%B0%E0%A4%BE

One night of poor sleep, 6 months of junk fat food

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Sleep

Sleep is very crucial aspect of our life. Yet, we compromise it knowingly or unknowingly.

Impact created by 6 months of high fat diet is experienced by body by just compromising sleep of one day!

No wonder why there is rise of viral infection (including vector based dengue and bacterial typhoid) post Navaratri in my city every year. People compromise sleep without taking proper rest, eat anything and everything, turning nine nights of Sadhana into extravaganza! Such activities are too early during Navaratri (are okay for Diwali).

Compromised sleep + Garrulous eating + garba – No SAdhana – No upavas = Typical post-Navaratri low immunity spell.

My personal observation: One of the major cause of viral infection in children is sleep deprivation. Sleep deprivation is an intense stressful event for body. Critical recovery process hampered.

When they body’s Vayu element is deranged, sleep is deprived or sleep reduces. If this happens in age below 60, it is actually a sign of rapid aging. Observe: Old age people’s sleep is very less. And that is due to derangement of Vayu is natural in old age.

Even if you have sleep disorder, take enough rest. Lie down on the bed and rest for at least 6 hrs.

When the body becomes less sensitive to insulin (i.e., “insulin resistant”), it needs to produce more insulin to keep blood sugar stable. This may eventually lead to Type 2 diabetes, a disease where the body’s insulin response doesn’t work properly and there is too much sugar in the blood. Diabetes is associated with a number of serious complications, including heart disease. Individuals with obesity are more likely to develop insulin resistance and subsequently, diabetes.

“Research has shown that sleep deficiency and a high-fat diet both lead to impaired insulin sensitivity, but it was previously unknown which leads to more severe insulin resistance,” said Dr. Broussard. “Our study suggests that one night of total sleep deprivation may be as detrimental to insulin sensitivity as six months on a high-fat diet. This research demonstrates the importance of adequate sleep in maintaining blood sugar levels and reducing risk for metabolic diseases like obesity and diabetes.”

Take care.


Research


One Night of Poor Sleep Could Equal Six Months on a High-Fat Diet, Study Shows

New study in canines examines the effect of sleep loss on insulin sensitivity

“Research has shown that sleep deficiency and a high-fat diet both lead to impaired insulin sensitivity, but it was previously unknown which leads to more severe insulin resistance,” said Dr. Broussard. “Our study suggests that one night of total sleep deprivation may be as detrimental to insulin sensitivity as six months on a high-fat diet. This research demonstrates the importance of adequate sleep in maintaining blood sugar levels and reducing risk for metabolic diseases like obesity and diabetes.”

http://www.newswise.com/articles/one-night-of-poor-sleep-could-equal-six-months-on-a-high-fat-diet-study-shows

Infants, Sleep and Samadhi

I never wake up / wake up someone before 100 minutes from sleeping time. Let there be at least 1 cycle completed.

People often feel amazed when leaders like Modi ji work tirelessly with less sleep. The reason being is efficient management of REM sleep. Or rather sleep slots of 90 minutes.

If you sleep for 3 hrs (2 90 minutes slots) and little more. You can be better regains and fresh compare to someone sleeping 8- 9 hours without managing 90 minutes slots (Deep sleep + Rem sleep cycles)

sleep

Many of us strives to realize the state of Samadhi while in awake state but all efforts are futile without following the regime.

Only possible for all type, Kaliyugi glimpse of being connected with the source, supreme consciousness, is sleep. Specific REM sleep. If you have sound sleep, if you know art of sleeping then REM slot is the period when you may have opportunity to realize the self. Provided you have good enough clean mind. If the mind is not clean from all types of lusts (greed, arrogance, fame the 12 mental stool -shared in past), it is difficult to achieve. Eventhough, REM is critical sleep period.

REM

Kids below 5 are God personified (until they develop Ego. Nowadays, it happens very early. Around 3) . They remain in REM state for longer during sleep. Since they have longer sleep span, they experience more REM states in one night compare to adults.

One suggestion I always give to fellow young parents of infants and toddler is: NEVER EVER COMPROMISE Child’s sleep! Sleep is their growth accelerating state. Sleep is their medicine. Since they are in rapid growth stage, maximum cellular changes happen. During sleep, this process is regularized. Sleep is when they form new memories. Sleep is when they learn new concepts. Sleep when they grow. So, zero tolerance for sleep.

Most of kid’s sleep is REM sleep. Rapid eye movement sleep (REM sleep, REMS) is a unique phase of mammalian sleep characterized by random movement of the eyes, low muscle tonethroughout the body, and the propensity of the sleeper to dream vividly.

A newborn baby spends more than 80% of total sleep time in REM. Infants spend more time in higher REM sleep than adults. The proportion of REM sleep then decreases significantly in childhood.

Usually, REM sleep happens 90 minutes after you fall asleep. The first period of REM typically lasts 10 minutes. Each of your later REM stages gets longer, and the final one may last up to an hour. Your heart rate and breathing quickens.
As per research [1],

“REM sleep acts like the chemical developer in old-fashioned photography to make traces of experience more permanent and focused in the brain,”
“Experience is fragile,” he said. “These traces tend to vanish without REM sleep and the brain basically forgets what it saw.”

SO REM sleep is CRITICAL.

Frank said young brains, including those of human children, go through critical periods of plasticity – or remodeling – when vision, speech, language, motor skills, social skills and other higher cognitive functions are developed.

The study suggests that during these periods, REM sleep helps growing brains adjust the strength or number of their neuronal connections to match the input they receive from their environment, he said.

My suggestions to parents (based on my parenting and sleep management experience so far)

1) SLEEP first. All your adult activities (TV, Mobile, Whatsapp, Work, Fun, Movies, Marriages) can wait, SLEEP cannot wait.
2) Avoid travelling as much as possible for first 5 years. Let kid enjoy sound sleep in his/her daily sleeping room. No frequent changes.
3) Try to reach home before Kid’s regular sleep time.
4) From age 0 to age 20 – Avoid all stimulants like antidepressant medicines, steroid, alcohol, smoking, high sugary diet (Imagine teens addicts! Critical REM compromise! )
5) Avoid brain stimulant medications for child
6) Sleep must accompanied by parent.


Research


REM sleep critical for young brains; medication interferes

REM sleep critical for young brains; medication interferes

Sleep and Rest : Critical Role

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SLEEP IS CRITICAL in child development. Sleep deprived children face difficulties in learning.

Babies and young children make giant developmental leaps all of the time. Sometimes, it seems, even overnight they figure out how to recognize certain shapes or what the word “no” means no matter who says it.


But wait! Our parents are selfish. They want their late night entertainment – cricket, movies and talks! So children too develop habit of sleeping at late night.

Result?

Sleep deprivation! And all unfortunate learning delays!

Take care of sleep!

baby_shiva-t3


Research


From Learning in Infancy to Planning Ahead in Adulthood: Sleep’s Vital Role for Memory

Babies and young children make giant developmental leaps all of the time. Sometimes, it seems, even overnight they figure out how to recognize certain shapes or what the word “no” means no matter who says it. It turns out that making those leaps could be a nap away: New research finds that infants who nap are better able to apply lessons learned to new skills, while preschoolers are better able to retain learned knowledge after napping.

“Sleep plays a crucial role in learning from early in development,” says Rebecca Gómez of the University of Arizona. She will be presenting her new work, which looks specifically at how sleep enables babies and young children to learn language over time, at the Cognitive Neuroscience Society (CNS) annual meeting in Boston today, as part of a symposium on sleep and memory.

“We want to show that sleep is not just a necessary evil for the organism to stay functional,” says Susanne Diekelmann of the University of Tübingen in Germany who is chairing the symposium. “Sleep is an active state that is essential for the formation of lasting memories.”

A growing body of research shows how memories become reactivated during sleep, and new work is shedding light on exactly when and how memories get stored and reactivated. “Sleep is a highly selective state that preferentially strengthens memories that are relevant for our future behavior,” Diekelmann says. “Sleep can also abstract general rules from single experiences, which helps us to deal more efficiently with similar situations in the future.”

Read more: https://www.cogneurosociety.org/sleep_memory_cns2014/

Compromised Sleep, Compromised Metabolics and Degeneration of Neurons

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Attention for friends working in shifts with nocturnal tendencies : Never compromise sleep
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Extended Wakefulness -> Compromised Metabolics -> Degeneration of Locus Ceruleus Neurons -> genetic and idiopathic Parkinson’s disease, progressive supranuclear palsy, Pick’s disease or Alzheimer’s disease.

Sleep

Btw, this was common sense in our culture until few generations back, shared between generations by sayings and folk-songs.

In fact, in Ayurveda, sleep is considered foster-mother(भूतधात्री)

रात्रिस्वभावप्रभवा मता याताँ भूतधत्रीं प्रवदन्ति निद्राम्॥

अर्थात्- रात्रि स्वभाव के कारण उत्पन्न होने वाली जो रात्रि की निद्रा होती है, विशेषज्ञ उसको भूतधात्री कहते हैं। भूतानि प्राणिनी दधाति पुष्णाति इसलि भूतधात्री (चक्रपाणि) अर्थात् रात्रि निद्रा में सर्वाधिक लाभ होने से भूतधात्री। धात्री जिस प्रकार बालकों का पालन-पोषण करती है, निद्रा भी ठीक इसी प्रकार प्राणियों का पोषण करती है।

It is different thing that, we have responded to this common sense wisdom with disgusting subnormal intelligence by carelessly ignoring importance of sleep.

Take care, at least when our pet modern science is accepting our culture’s common sense 🙂. And yes, grand-pa was not wrong when he advised to sleep early and wake up early


Research


Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons

http://www.jneurosci.org/content/34/12/4418

Abstract

Modern society enables a shortening of sleep times, yet long-term consequences of extended wakefulness on the brain are largely unknown. Essential for optimal alertness, locus ceruleus neurons (LCns) are metabolically active neurons that fire at increased rates across sustained wakefulness. We hypothesized that wakefulness is a metabolic stressor to LCns and that, with extended wakefulness, adaptive mitochondrial metabolic responses fail and injury ensues. The nicotinamide adenine dinucleotide-dependent deacetylase sirtuin type 3 (SirT3) coordinates mitochondrial energy production and redox homeostasis. We find that brief wakefulness upregulates SirT3 and antioxidants in LCns, protecting metabolic homeostasis. Strikingly, mice lacking SirT3 lose the adaptive antioxidant response and incur oxidative injury in LCns across brief wakefulness. When wakefulness is extended for longer durations in wild-type mice, SirT3 protein declines in LCns, while oxidative stress and acetylation of mitochondrial proteins, including electron transport chain complex I proteins, increase. In parallel with metabolic dyshomeostasis, apoptosis is activated and LCns are lost. This work identifies mitochondrial stress in LCns upon wakefulness, highlights an essential role for SirT3 activation in maintaining metabolic homeostasis in LCns across wakefulness, and demonstrates that extended wakefulness results in reduced SirT3 activity and, ultimately, degeneration of LCns.

 

Desi Cow Ghee, Omega 3, Smoking Addiction, Bipolar Disorder

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gheesmoking

It is vicious cycle. You abandon mother and her prasad and the vacuum will be filled by vices.

Smoking leads to mental disorders.

Omega-3 intake reduces smoking addiction.

We also notes on this forum that Omega-3 intake also reduces Bipolar disorder symptoms.

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गौ माता cures smoking addiction
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Omega 3 = Desi Cow Ghee is full of it.
Lack of Omega-3 = Striving for addictions?

“it was found that taking omega-3 capsules significantly reduces nicotine craving and the number of cigarettes that people smoke a day”


Research


A New Study Conducted at the University of Haifa Has Found Omega-3 Reduces Smoking

http://www.newswise.com/articles/a-new-study-conducted-at-the-university-of-haifa-has-found-omega-3-reduces-smoking

In a study performed by Dr. Sharon Rabinovitz Shenkar, head of the school of criminology department’s addiction program, it was found that taking omega-3 capsules significantly reduces nicotine craving and the number of cigarettes that people smoke a day

Taking omega-3 supplements reduces craving for nicotine and even reduces the number of cigarettes that people smoke a day, according to a new study conducted at the University of Haifa. “The substances and medications used currently to help people reduce and quit smoking are not very effective and cause adverse effects that are not easy to cope with. The findings of this study indicated that omega-3, an inexpensive and easily available dietary supplement with almost no side effects, reduces smoking significantly,” said Dr. Sharon Rabinovitz Shenkar, head of the addictions program at the University of Haifa’s school of criminology department and of the psychopharmacology laboratory at Bar-Ilan, who conducted this study.

Chronic exposure to smoke-derived toxicants is the primary cause of progressive pulmonary and immune dysfunctions, as well as carcinogenesis Cigarette smoking is connected not only to cardiovascular dysfunction, immune system dysfunction and cancer, it also reduces the levels of essential fatty acids in the brain, especially that of omega-3. A deficiency in omega-3 damages the cellular structure of nerve cells and interrupts neurotransmission in areas of the brain involved with feeling pleasure and satisfaction. These areas are essential in reward and decision-making, and are very important in the process of the development, maintenance and relapseof the addiction and to the inability to stop smoking. In simpler terms, omega-3 deficiency makes it harder for the smoker’s body to deal with its craving for another cigarette. “Earlier studies have proven that an imbalance in omega-3 is also related to mental health, depression and the ability to cope with pressure and stress. Pressure and stress, in turn, are associated with the urge to smoke. It is also known that stress and tension levels rise among people who quit smoking. Despite all this, the connection between all these factors had not been studied until now,” Dr. Rabinovitz Shenkar said.

Three Pillars of Life

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त्रय उपस्तम्भा: आहार: स्वप्नो ब्रह्मचर्यमिति (चरक संहिता सूत्र. 11/35)

threepillars
अर्थात् शरीर और स्वास्थ्य को स्थिर, सुदृढ़ और उत्तम बनाये रखने के लिए आहार, स्वप्न (निद्रा) और ब्रह्मचर्य – ये तीन उपस्तम्भ हैं। ‘उप’ यानी सहायक और ‘स्तम्भ’ यानी खम्भा। इन तीनों उप स्तम्भों का यथा विधि सेवन करने से ही शरीर और स्वास्थ्य की रक्षा होती है।

Are we not living terribly anti-life routine? Do you love your life? your family? If yes, act.

Isn’t it a heinous crime to waste human life? Yes, it is terrible crime. It is called प्रज्ञापराध.

धी धृति स्मृति विभ्रष्ट: कर्मयत् कुरुतऽशुभम्।
प्रज्ञापराधं तं विद्यातं सर्वदोष प्रकोपणम्।। — (चरक संहिता; शरीर. 1/102)

अर्थात् धी (बुद्धि), धृति (धैर्य) और स्मृति (स्मरण शक्ति) के भ्रष्ट हो जाने पर मनुष्य जब अशुभ कर्म करता है तब सभी शारीरिक और मानसिक दोष प्रकुपित हो जाते हैं। इन अशुभ कर्मों को प्रज्ञापराध कहा जाता है। जो प्रज्ञापराध करेगा उसके शरीर और स्वास्थ्य की हानि होगी और वह रोगग्रस्त हो ही जाएगा।

If there is sickness, man would jump between sleep and food, try to correct them, but will hardly pay attention to Brahmcharya :). Such is the shoddy state of our modern living. Think about it.

Psychological stress, Ama (Toxins) and Aging

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I receive many queries related to premature aging. Reduced appetite, reduced sleep, grey hair, arthritis – All these issues manifest after 40. But you now see them even in age below 20.

stress

In old age, we can understand, it is due to मन्दाग्नि (Mandagni – Low Fire) but how come they are now regular in young age?

Ama (आम) – Toxins – Something that is unripe. Unripe outcomes of biological process. it can be at the time of digestion, assimilation or purging. All three stages or any one of them, when not working as per laws of the body, accumulates toxins locally. That is आम.

These end products, being inadequately processed, have a macromolecular structure, which is bigger and grosser than those end products which might have produced if a complete processing would have taken place.

It happens naturally in old-age. It happens unnaturally in young age due to following habits:

Despite physically young and metabolically active, if you indulge in physical and mental activities just after having meal, you are disturbing active digestion process. This can result in Ama i.e. Toxins.

Irregular meal timings is another reason that disturbs fire-based processes in body.

Regular intake of food lacking hydration and fat (dry), cold food, stale food can also generate Ama.

Too many emotions out of balance. Extreme Kama, Krdha, Lobha, Moha, Irshya. Extreme lajja, shoka, abhimana, Udvega, Bhaya, Up-tapta (sad).

In many experimental studies, various types of physical and psychological stress are found to induce dysfunction of intestinal barrier, resulting in enhanced intake of potentially noxious material (e.g., antigens, toxins, and other proinflammatory molecule) from the gut lumen into the bloodstream [1] . This gives a very interesting proposition to see if these noxious materials play the role of ama as a progenitor to joint diseases as perceived in Ayurveda.

In short, Quality of the food + Intake method and timing + Mood + Compatibility with your nature and age play critical role in perfect digestion, assimilation and elimination.

Check your routine. Check life of avg urban teen-ager. You will realize reason behind early aging. If such habits continue for 3-4 generations, rapid aging becomes स्वभाव of the gene-pool.

Take care. Check your habits in mirror. Correct them. Whatever happened so far, cannot be reversed but you can certainly slow down further aging by eliminating toxins and not making their way again in the body.


Research


[1]

[1] Stress and intestinal barrier function

http://ajpgi.physiology.org/content/280/1/G7

The intestinal mucosa is continuously exposed to an immense load of antigens from ingested food, resident bacteria, invading viruses, etc. The single-cell epithelial layer lining the gut lumen (surface area ∼300 m2) has conflicting functions, playing a major role in the digestion and absorption of nutrients and at the same time constituting the organism’s most important barrier between the internal and external environments. Under normal circumstances, the epithelium allows only minute quantities of intact antigens to cross into the mucosa, where they interact with the mucosal immune system to downregulate inflammation (known as oral tolerance). On the other hand, it is necessary for enteric pathogens to activate immune cells and initiate the inflammatory response required to clear the infection. In some disease conditions, such as inflammatory bowel disease, excessive penetration of antigens through the epithelial layer may result in inappropriate immune stimulation, leading to chronic gastrointestinal inflammation. The ability of the epithelium to control uptake of molecules into the body is denoted as the intestinal barrier function.

 

Vitamin B12 Deficiency, GUT and Muladhara

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Yesterday was harsh day of this season. Heavy rain, humid, and extreme heat. My friend and I, working on critical task, felt exhausted. Dehydrated.

Friend suggested :”I think it is again Vitamin B12 deficiency! I think I will need injections again!”

I wondered. How a simple season driven exhaustion is turned into deficiency! 🙁

There were two things at play for both of us. 1) Stress induced non-healthy GUT 2) lack of healthy food for days.

Solution is to take rest. Worship Ganesha and eat healthy season driven food!

 

B12 Eyewash
B12 Eyewash

Modern medicine has reduced wholesome food into supplement status symbols.

Oh, B12 ? Take injections!
Oh Vit A? Take this supplement!

This is nothing but eyewash. Unless we correct our GUT, there is no hope for malnutrition.Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet.

Gut Health
Gut Health

One person might have stronger nerves than another because she has a better stock of vitamin B–producing bacteria. Another person might be able to deal easily with bit of bread mold eaten by mistake. Yet another might have a tendency to gain weight because the “chubby” bacteria in his gut feed him a bit too willingly. Science is just beginning to understand that each of us is an entire ecosystem.

You take all costly B-12 injections or Vitamin A supplement or Vitamin C but if your GUT is not healthy, they are garbage and will be purged within 72 hrs via urine and stool!

There is no shortcut for healthy life. Stop nonsensical torture on body first. Stop all processed acidic food so that bacteria have chance to get flourished in you GUT. Then stop stressful events in life. Late night parties, tongue-lust driven non-seasonal food – stop it if you really want your B12 injections to work.

Above all physical nutrition, health is all mental. To correct your mental stress and linked sick GUT, this is best season. गणपति is protector of GUT. As per Tantra-Shashtra, गणपति lives in Muladhara, an energy center near GUT. It is your mind that helps प्राणमय शरीर (cellular intelligence) to form health अन्नमय शरीर (physical body) (Do not ask proof. Modern proof-based science cannot swim in this sea of knowledge at this moment). Experiment! Does not matter if you are an atheist! Or follow any other religion. गणपति is eternal, beyond religious boundaries.

Worship and surrender to गणपति. That is the beginning of the yearly healthy GUT.

ॐ गणेशाय नमः |

Muladhara Protector
Muladhara Protector

Research


Bacteria as vitamin suppliers to their host: a gut microbiota perspective.

http://www.ncbi.nlm.nih.gov/pubmed/22940212

Food-related lactic acid bacteria (LAB) as well as human gut commensals such as bifidobacteria can de novo synthesize and supply vitamins. This is important since humans lack the biosynthetic capacity for most vitamins and these must thus be provided exogenously. Although vitamins are present in a variety of foods, deficiencies still occur, mainly due to malnutrition as a result of insufficient food intake and because of poor eating habits. Fermented milks with high levels of B-group vitamins (such as folate and riboflavin) can be produced by LAB-promoted and possibly bifidobacteria-promoted biosynthesis. Moreover, certain strains of LAB produce the complex vitamin cobalamin (or vitamin B12). In this review, fermented foods with elevated levels of B-group vitamins produced by LAB used as starter cultures will be covered. In addition, genetic abilities for vitamin biosynthesis by selected human gut commensals will be discussed.

Vitamin B12 synthesis by human small intestinal bacteria.

http://www.ncbi.nlm.nih.gov/pubmed/7354869

In man, physiological amounts of vitamin B12 (cyanocobalamin) are absorbed by the intrinsic factor mediated mechanism exclusively in the ileum. Human faeces contain appreciable quantities of vitamin B12 or vitamin B12-like material presumably produced by bacteria in the colon, but this is unavailable to the non-coprophagic individual. However, the human small intestine also often harbours a considerable microflora and this is even more extensive in apparently healthy southern Indian subjects. We now show that at least two groups of organisms in the small bowel, Pseudomonas and Klebsiella sp., may synthesise significant amounts of the vitamin.

Effects of Gut Microbes on Nutrient Absorption and Energy Regulation

Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet. The composition of the gut microbiota has been shown to differ between lean and obese humans and mice; however, the specific roles that individual gut microbes play in energy harvest remain uncertain. The gut microbiota may also influence the development of conditions characterized by chronic low-level inflammation, such as obesity, through systemic exposure to bacterial lipopolysaccharide derived from the gut microbiota. In this review, the role of the gut microbiota in energy harvest and fat storage is explored, as well as differences in the microbiota in obesity and undernutrition.

 

Research: Not just enough sleep, timely sleep!

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We have saying: Those who sleep early and wake up early, are Heroes. They receive strength, intellect, knowledge and wealth. Their body remains in bliss.

But our so called educated and rational flock make fun of it and says: If this is true, all milkmen and newspaper vendors should be wealthy!

Claps! Good joke! 😀

What you miss in this silly argument is noteworthy.

Shifting sleep cycle affects immune response, sleep quality

Late? Forever
Late? Forever

Ayurveda


ब्राह्मे मुहूर्ते बुध्येत स्वस्थो रक्षाऽथमायुषः|

तत्र सर्वाघशान्त्यर्थं स्मरेद्धि मधुसूदनम्||

अर्थात् स्वस्थ व्यक्ति को अपनी जीवन-रक्षा के लिए प्रातः काल ब्रह्ममुहूर्त में उठना चाहिए।

Those who want to protect life, should wake up in the early morning (4 AM) and spend time in self-realization.

ब्राह्मे मुहूर्त उत्तिष्ठेतस्वस्थो रक्षार्थमायुष : ।

Brahm muhurt = 96 minutes before sunrise. Adjust your routine accordingly.

ब्राह्मे मुहूर्ते बुध्येत धर्मार्थांचानुचिंतयेत।

कायक्लेषाँष्च तन्मूलान्वेदतत्तवार्थमेव च॥ (मनु. 4/92)

प्रत्येक मनुष्य को ब्रह्ममुहूर्त में उठकर धर्म और अर्थ का चिंतन करना तथा शरीर के रोग और उनके कारणों का विचार करना एवं वेद के रहस्यों का भी विचार-चिंतन करना चाहिए।

What do we have now?

Everyday different wake up time. Mostly after sunrise. 🙂 Job forces to alter sleep as per shift!

Dincharya
Dincharya

Read this research.


Research


Shifting sleep cycle affects sleep quality, immune response

Shifting sleep cycle affects sleep quality, immune response

Most sleep research focuses on the effects of sleep deprivation or the overall amount of sleep an animal needs. This is generally referred to as sleep’s homeostatic process, which is driven by sleepiness or “sleep pressure.”

The work by Karatsoreos and his colleagues – published in the journal Brain, Behavior and Immunity – is a rare look into the circadian process, a brain-driven clock that controls the rhythms of various biological processes, from digestion to blood pressure, heart rate to waking and sleeping. The cycle is found in most everything that lives more than 24 hours, including plants and single-celled organisms.

Research into the system has significant implications for modern living, write Karatsoreos and his coauthors, as “disruption of the circadian clock is nearly ubiquitous in our modern society” due to nighttime lighting, shift work, jet lag and even the blue-tinged light emitted by cell phones and tablets.

Typically, sleep researchers have a hard time studying sleep deprivation and the circadian cycle separately, as a change in one usually affects the other. However, Karatsoreos and his colleagues saw their model did not affect an animal’s total sleep, giving them a unique look into the effects on the timing of the sleeping-waking cycle.

The researchers used mice whose body clocks run at about 24 hours – much like our own – and housed them in a shorter 20-hour day. This forced their biological clocks out of sync with the light-dark cycle. After four weeks, the researchers injected the mice with lipopolysaccharide, a molecule found in bacteria that can make an animal sick without being contagious.

Environmental disruption of the circadian clock leads to altered sleep and immune responses in mouse

In mammals, one of the most salient outputs of the circadian (daily) clock is the timing of the sleep–wake cycle. Modern industrialized society has led to a fundamental breakdown in the relationship between our endogenous timekeeping systems and the solar day, disrupting normal circadian rhythms. We have argued that disrupted circadian rhythms could lead to changes in allostatic load, and the capacity of organisms to respond to other environmental challenges. In this set of studies, we apply a model of circadian disruption characterized in our lab in which mice are housed in a 20 h long day, with 10 h of light and 10 h of darkness. We explored the effects of this environmental disruption on sleep patterns, to establish if this model results in marked sleep deprivation. Given the interaction between circadian, sleep, and immune systems, we further probed if our model of circadian disruption also alters the innate immune response to peripheral bacterial endotoxin challenge. Our results demonstrate that this model of circadian disruption does not lead to marked sleep deprivation, but instead affects the timing and quality of sleep. We also show that while circadian disruption does not lead to basal changes in the immune markers we explored, the immune response is affected, both in the brain and the periphery. Together, our findings further strengthen the important role of the circadian timing system in sleep regulation and immune responses, and provide evidence that disrupting the circadian clock increases vulnerability to further environmental stressors, including immunological challenges.

http://www.sciencedirect.com/science/article/pii/S0889159114005716

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