Microbes

Microbes

Local Food, Mother’s diet and Infant’s milk microbes

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Local Food
Even closed door medical conferences across India cherish importance of local diet influence, society follow market and media and enjoy global diet. One of the fundamental error in selection of food is to select food for taste and urge to taste non-local food.
 
For example: It is perfectly ok to eat Idli-Sambhar in Kerala but having same every day in Gujarati home living in Gujarat?
 
It is perfectly ok to eat apple in Himachal but having same in hot and humid Gujarat summer?
My common sense suggest to prefer only local diet over non-local taste-lust food selection.
 
For would-be mothers, it is important to maintain local diet if they wish their breast-feeding. What you eat, decides GUT microbes and in turn pass on legacy to newborn babies via breast-milk!
Your local diet is the immunity for your kid. During and after breast-feeding. And not the packaged processed food!
Educate mothers around you and help building strong Nation via strong future geneations.
Here is the interesting study looking to localization of GUT microbes of breast-feeding mothers’ GUT. It supports the hypothesis that there is no alternative of local diet. All healthy diet fads are marketing gimmick or at best, suitable to local population where the diet is showing results. What is good for pregnant mother in China, may not work for same in India!
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Research
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Bacterial Composition and Diversity in Breast Milk Samples from Mothers Living in Taiwan and Mainland China

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447776/

Human breast milk is widely recognized as the best source of nutrients for healthy growth and development of infants; it contains a diverse microbiota. Here, we characterized the diversity of the microbiota in the breast milk of East Asian women and assessed whether delivery mode influenced the microbiota in the milk of healthy breast-feeding mothers. We profiled the microbiota in breast milk samples collected from 133 healthy mothers in Taiwan and in six regions of mainland China (Central, East, North, Northeast, South, and Southwest China) by using 16S rRNA pyrosequencing. Lactation stage (months postpartum when the milk sample was collected) and maternal body mass index did not influence the breast milk microbiota. Bacterial composition at the family level differed significantly among samples from the seven geographical regions. The five most predominant bacterial families were Streptococcaceae(mean relative abundance: 24.4%), Pseudomonadaceae (14.0%), Staphylococcaceae (12.2%), Lactobacillaceae (6.2%), and Oxalobacteraceae (4.8%). The microbial profiles were classified into three clusters, driven by Staphylococcaceae (abundance in Cluster 1: 42.1%), Streptococcaceae (Cluster 2: 48.5%), or Pseudomonadaceae (Cluster 3: 26.5%). Microbial network analysis at the genus level revealed that the abundances of the Gram-positive StaphylococcusStreptococcus, and Rothia were negatively correlated with those of the Gram-negative AcinetobacterBacteroidesHalomonasHerbaspirillum, and Pseudomonas. Milk from mothers who had undergone Caesarian section (C-section group) had a significantly higher abundance of Lactobacillus (P < 0.05) and a higher number of unique unclassified operational taxonomic units (OTUs) (P < 0.001) than that from mothers who had undergone vaginal delivery (vaginal group). These findings revealed that (i) geographic differences in the microbial profiles were found in breast milk from mothers living in Taiwan and mainland China, (ii) the predominant bacterial families StreptococcaceaeStaphylococcaceae, and Pseudomonadaceae were key components for forming three respective clusters, and (iii) a significantly greater number of unique OTUs was found in the breast milk from mothers who had undergone C-section than from those who had delivered vaginally.

Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations.

https://www.ncbi.nlm.nih.gov/pubmed/27790209

Conclusion

https://www.frontiersin.org/files/Articles/217349/fmicb-07-01619-HTML/image_m/fmicb-07-01619-g002.jpg
https://www.frontiersin.org/files/Articles/217349/fmicb-07-01619-HTML/image_m/fmicb-07-01619-g002.jpg

Our results demonstrate differences in the composition of lipids and microbiota in breast milk in different geographic regions and offer a new insight to the differences in development of gut microbiota in infants in different geographic areas. The impact of mode of delivery on milk microbiota composition appears to be even more important within all geographical regions. Furthermore, our study shows distinct association between fatty acid composition and individual microbiota in breast milk, suggesting important role of lipids in shaping the microbial profile which likely one important factor influencing the infant gut microbiota development.

Wound Healing : Thanks to wonder that is skin microbes!

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Few days back, I shared that I had a deep cut on hand and I applied Gau mutra on it. I followed it for a week. Along with Gau mutra, I also used to massage the wound with my early morning saliva. Wound is not only healed, skin color is also emerged back to normal color.

Who helped me?

Short answer: Skin microbes.

Long understanding: Gau mutra and Saliva controlled my skin friend microbes i.e. my प्राणमय कोष so that विकृत प्राण or प्राण against my prakruti does not assimilate at wound location.

Here is the paper supporting this theory:

Chronic wounds—cuts or lesions that just never seem to heal—are a significant health problem, particularly among elderly people. An estimated 1 in 20 elderly people live with a chronic wound, which often results from diabetes, poor blood circulation or being confined to bed or a wheelchair.
“These wounds can literally persist for years, and we simply have no good treatments to help a chronic wound heal,”

The trillions of bacteria that live on and in our bodies have attracted a great deal of scientific interest in recent years. Findings from studies of microbes in the gut have made it clear that although some bacteria cause disease, many other bacteria are highly beneficial for our health.

=====================
Gobar, mutra, saliva (GMS) are natural bio-healers. While modern medicine has no solution for chronic wounds in elder people with already depleted प्राणमय कोष, GMS can help greatly.


Research


Bacteria on the Skin: New Insights on Our Invisible Companions

Study examines how skin-dwelling bacteria influence wound healing; findings could help address chronic wounds, a common ailment in the elderly

http://www.newswise.com/articles/bacteria-on-the-skin-new-insights-on-our-invisible-companions

Chronic wounds—cuts or lesions that just never seem to heal—are a significant health problem, particularly among elderly people. An estimated 1 in 20 elderly people live with a chronic wound, which often results from diabetes, poor blood circulation or being confined to bed or a wheelchair.

“These wounds can literally persist for years, and we simply have no good treatments to help a chronic wound heal,” said Hardman, who added that doctors currently have no reliable way to tell whether a wound will heal or persist. “There’s a definite need for better ways to both predict how a wound is going to heal and develop new treatments to promote healing.”

In their recent study, Hardman and his colleagues compared the skin bacteria from people with chronic wounds that did or did not heal. The results showed markedly different bacterial communities, suggesting there may be a bacterial “signature” of a wound that refuses to heal.

“Our data clearly support the idea that one could swab a wound, profile the bacteria that are there and then be able to tell whether the wound is likely to heal quickly or persist, which could impact treatment decisions,” said Hardman.

Utter Nonsense called Darwinian competition

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For almost entire past century, modern science fooled us by sharing fancy numbers of genes we possess.

The count started with 100000 and now reduced to 19000. I am sure, it will further reduce.

Why am I damn sure?

Your body is composed of an estimated 30 trillion human cells, but it is host to more than 100 trillion bacterial and fungal cells, the friendly microbes that coevolved with our species. Think about that: right now in your body bacterial cells substantially outnumber your own human cells.
If you are host to 100 trillion microbes and each microbe is a tiny genetic machine, how many genes are cranking away within your resident microbes and what are those genes doing?

The shift of numbers is from our genes to microbial genes. In other words, 99 percent of the unique genes in your body are bacterial, and only about 1 percent are human.

We acquire microbial genes, not only from parents but from environment i.e. our foster mother, Mother Nature.

And for healthy life, it is critical to live in healthy environment.

Sheer presence[1] of microbial world in our Body proves one thing for sure that idea of ‘dog-eat-dog world of Darwinian competition’ is utter nonsense. Sadly, same survival of the fittest idea is so much ingrained in our psyche by modern education that we waste precious youth life in chasing false alarms and unnecessary competitions.

Life is about living for each other, helping each other. Darwinian illusion is catastrophic. Unlearn it..If we cannot unlearn, we are like those pathogens who make us feel sick selfish and self-centered.

[1] Your body is composed of an estimated 30 trillion human cells, but it is host to more than 100 trillion bacterial and fungal cells, the friendly microbes that coevolved with our species. Think about that: right now in your body bacterial cells substantially outnumber your own human cells.
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Multiple evidence strands suggest that there may be as few as 19 000 human protein-coding genes

https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/ddu309

Determining the full complement of protein-coding genes is a key goal of genome annotation. The most powerful approach for confirming protein-coding potential is the detection of cellular protein expression through peptide mass spectrometry (MS) experiments. Here, we mapped peptides detected in seven large-scale proteomics studies to almost 60% of the protein-coding genes in the GENCODE annotation of the human genome. We found a strong relationship between detection in proteomics experiments and both gene family age and cross-species conservation. Most of the genes for which we detected peptides were highly conserved. We found peptides for >96% of genes that evolved before bilateria. At the opposite end of the scale, we identified almost no peptides for genes that have appeared since primates, for genes that did not have any protein-like features or for genes with poor cross-species conservation. These results motivated us to describe a set of 2001 potential non-coding genes based on features such as weak conservation, a lack of protein features, or ambiguous annotations from major databases, all of which correlated with low peptide detection across the seven experiments. We identified peptides for just 3% of these genes. We show that many of these genes behave more like non-coding genes than protein-coding genes and suggest that most are unlikely to code for proteins under normal circumstances. We believe that their inclusion in the human protein-coding gene catalogue should be revised as part of the ongoing human genome annotation effort.

Shower Panel, Water particles in air and Infection

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Water is indeed a carrier for Prana. It can transport the prana. Microbes are nothing but manifestation of prana. Not only infection, water can also spread the positive prana.

In all Hindu rituals, sprinkling water is common ritual. Using water to spread the positive vibes, good prana and protecting the ritual/persons from the negative vibes/microbes.

On the other hand, Shower is where people spend significant time with water. Water particles in air. This is potent medium to spread the microbes. Most of the times, they are non-compatible prana or sickness causing microbes.

Shower is not the only place to get the infection. Toilet spray, Car-wash shops, paint shops are other places where water particles in air can affect the health of people with low immunity.


Research

Drexel and Arizona State Researchers Look at Risk of Infection From Water in the Air at Home

https://drexel.edu/now/archive/2019/January/indoor-breathing-water/


Researchers at Drexel and Arizona State created a framework for understanding risk of inhaling Legionella bacteria from the water spray of showers, faucets and toilets.

“Don’t drink the water” might be good enough advice to keep you from getting sick in some places, but according to researchers from Arizona State and Drexel University, the admonition should probably be expanded to “…try not to breathe the water either.” In research recently published in the journal Environmental Science & Technology, the group takes a closer look at how the spray from showers, sinks and toilets can expose us to the bacteria responsible for the most waterborne disease outbreaks in the country.

“Most people in the United States think we have a handle on our water quality problems and drinking water isn’t something we need to worry about anymore. If anything, the recent water crisis in Flint, Michigan, and frequent Legionnaires’ disease outbreaks across the nation have demonstrated that’s not the case,” said Kerry Hamilton, PhD, an assistant professor in the Ira A. Fulton Schools of Engineering at Arizona State University and former doctoral researcher at Drexel, who led the investigation into how the Legionella pneumophila bacteria can grow and spread in indoor water supplies.

Legionella, the bacteria that causes pneumonia-like Legionnaire’s disease, has been responsible for a  number of recent outbreaks and can be fatal in 10-25 percent of infections, according to the Centers for Disease Control and Prevention. While it is considered one of the deadliest waterborne diseases in the United States, it is actually contracted via inhalation or aspiration. This means to accurately understand environments that could increase one’s risk of exposure, researchers need to examine places where people are exposed to water in the air.

“To protect people from infections, we first need to understand the risks,” Hamilton said. “If we can better model and predict how water quality degrades under different circumstances, we can more efficiently target resources and prevent disease outbreaks.”

Gau Prasad (गौ प्रसाद – पंचगव्य – Microbes) can cure radiation-induced toxicity

Radiation

Problem with cow promoters in India is that they don’t talk the language of mass. And sometimes, become object of mockery.

One such case was when it was proclaimed that cow dung can protect against the radiation.

Yes, it does. How? Most of the times, we don’t have citations to support it.

Here is one research to help connect the dots.

Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice.


Remember one thing : Microbes are manifestation of Prana. Like how your body cells are. Life is interplay of different forms of Prana. Microbes, no exception.

If the faecal transplant can help protecting against radiation-induced toxicity, panchgavya (product made up of 5 prasad, rich in the form of microbes) can do wonder.

Faecal of an individual is not perfect but cow dung and urine of desi cow is perfect when cow is taken care well. (Well-fed, stress-free, grazing)


Research


Faecal microbiota transplantation protects against radiation‐induced toxicity

Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation‐induced toxicity. High‐throughput sequencing showed that gastrointestinal bacterial community composition differed between male and female mice and was associated with susceptibility to radiation toxicity. Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. FMT preserved the intestinal bacterial composition and retained mRNA and long non‐coding RNA expression profiles of host small intestines in a sex‐specific fashion. Despite promoting angiogenesis, sex‐matched FMT did not accelerate the proliferation of cancer cells in vivo. FMT might serve as a therapeutic to mitigate radiation‐induced toxicity and improve the prognosis of tumour patients after radiotherapy.

Faecal microbiota transplantation ameliorates radiation‐induced toxicity in irradiated mice by improving gastrointestinal tract function and epithelial integrity, preserving gut bacterial composition and maintaining the small intestine transcriptome.

  • Gut microbiota determines the radiosensitivity of hosts.

  • Faecal microbiota transplantation (FMT) fights against radiation‐induced gastrointestinal toxicity.

  • FMT preserves enteric bacterial composition and retains the RNA expression profile of irradiated hosts.

  • FMT might emerge as a therapeutic schedule in tumour radiotherapy to improve prognosis.

Read more: http://embomolmed.embopress.org/content/early/2017/02/27/emmm.201606932

Research : Obese Dog and Obese human share Gut Demography

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Guts of obese dogs look similar to those of obese people

Indeed! They are also like us. So do the bacteria causing obesity. And like us, they too have Prana and its physical manifestation i.e. microbes or Marut(s).

Same Prana constitution that makes us obese, act on their body.


Research


Guts of obese dogs look similar to those of obese people

http://www.sciencemag.org/news/2014/11/guts-obese-dogs-look-similar-those-obese-people

Obese people have a less diverse array of bacteria living in their guts than do thin people—and the same holds true for dogs. In a new study, researchers fed seven beagles unrestricted amounts of food for 6 months, during which each dog gained an average of 4.93 kilograms—about 67% of their initial average weight of 7.37 kilograms. The investigators fed another seven beagles controlled food portions, and, as expected, this group did not gain weight. When the researchers examined the fecal samples collected from both groups after 6 months, they found that the guts of obese beagles contained a smaller diversity of bacteria than those of the other dogs. What’s more, microbes from the phylum Firmicutes were the predominant group in the lean dogs, whereas Gram-negative bacteria called Proteobacteria were prevalent in the obese group, the team reported online this month in the Journal of Veterinary Internal Medicine. The researchers speculate that an abundance of Proteobacteria may lead to an increase in lipopolysaccharide, a major component of the cell wall of Gram-negative bacteria, which has been linked to weight gain in mice. More research is needed to examine what role gut bacteria may play in the development of obesity, however, the authors say.

 

Vitamin B12 Deficiency, GUT and Muladhara

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Yesterday was harsh day of this season. Heavy rain, humid, and extreme heat. My friend and I, working on critical task, felt exhausted. Dehydrated.

Friend suggested :”I think it is again Vitamin B12 deficiency! I think I will need injections again!”

I wondered. How a simple season driven exhaustion is turned into deficiency! 🙁

There were two things at play for both of us. 1) Stress induced non-healthy GUT 2) lack of healthy food for days.

Solution is to take rest. Worship Ganesha and eat healthy season driven food!

 

B12 Eyewash
B12 Eyewash

Modern medicine has reduced wholesome food into supplement status symbols.

Oh, B12 ? Take injections!
Oh Vit A? Take this supplement!

This is nothing but eyewash. Unless we correct our GUT, there is no hope for malnutrition.Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet.

Gut Health
Gut Health

One person might have stronger nerves than another because she has a better stock of vitamin B–producing bacteria. Another person might be able to deal easily with bit of bread mold eaten by mistake. Yet another might have a tendency to gain weight because the “chubby” bacteria in his gut feed him a bit too willingly. Science is just beginning to understand that each of us is an entire ecosystem.

You take all costly B-12 injections or Vitamin A supplement or Vitamin C but if your GUT is not healthy, they are garbage and will be purged within 72 hrs via urine and stool!

There is no shortcut for healthy life. Stop nonsensical torture on body first. Stop all processed acidic food so that bacteria have chance to get flourished in you GUT. Then stop stressful events in life. Late night parties, tongue-lust driven non-seasonal food – stop it if you really want your B12 injections to work.

Above all physical nutrition, health is all mental. To correct your mental stress and linked sick GUT, this is best season. गणपति is protector of GUT. As per Tantra-Shashtra, गणपति lives in Muladhara, an energy center near GUT. It is your mind that helps प्राणमय शरीर (cellular intelligence) to form health अन्नमय शरीर (physical body) (Do not ask proof. Modern proof-based science cannot swim in this sea of knowledge at this moment). Experiment! Does not matter if you are an atheist! Or follow any other religion. गणपति is eternal, beyond religious boundaries.

Worship and surrender to गणपति. That is the beginning of the yearly healthy GUT.

ॐ गणेशाय नमः |

Muladhara Protector
Muladhara Protector

Research


Bacteria as vitamin suppliers to their host: a gut microbiota perspective.

http://www.ncbi.nlm.nih.gov/pubmed/22940212

Food-related lactic acid bacteria (LAB) as well as human gut commensals such as bifidobacteria can de novo synthesize and supply vitamins. This is important since humans lack the biosynthetic capacity for most vitamins and these must thus be provided exogenously. Although vitamins are present in a variety of foods, deficiencies still occur, mainly due to malnutrition as a result of insufficient food intake and because of poor eating habits. Fermented milks with high levels of B-group vitamins (such as folate and riboflavin) can be produced by LAB-promoted and possibly bifidobacteria-promoted biosynthesis. Moreover, certain strains of LAB produce the complex vitamin cobalamin (or vitamin B12). In this review, fermented foods with elevated levels of B-group vitamins produced by LAB used as starter cultures will be covered. In addition, genetic abilities for vitamin biosynthesis by selected human gut commensals will be discussed.

Vitamin B12 synthesis by human small intestinal bacteria.

http://www.ncbi.nlm.nih.gov/pubmed/7354869

In man, physiological amounts of vitamin B12 (cyanocobalamin) are absorbed by the intrinsic factor mediated mechanism exclusively in the ileum. Human faeces contain appreciable quantities of vitamin B12 or vitamin B12-like material presumably produced by bacteria in the colon, but this is unavailable to the non-coprophagic individual. However, the human small intestine also often harbours a considerable microflora and this is even more extensive in apparently healthy southern Indian subjects. We now show that at least two groups of organisms in the small bowel, Pseudomonas and Klebsiella sp., may synthesise significant amounts of the vitamin.

Effects of Gut Microbes on Nutrient Absorption and Energy Regulation

Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet. The composition of the gut microbiota has been shown to differ between lean and obese humans and mice; however, the specific roles that individual gut microbes play in energy harvest remain uncertain. The gut microbiota may also influence the development of conditions characterized by chronic low-level inflammation, such as obesity, through systemic exposure to bacterial lipopolysaccharide derived from the gut microbiota. In this review, the role of the gut microbiota in energy harvest and fat storage is explored, as well as differences in the microbiota in obesity and undernutrition.

 

Pathogenicity (Ability to cause diseases) is not a rule

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We are brainwashed to believe that diseases are natural and they happen due to microbes and viruses.

In my several notes, I tried to represent alternate perspective.

Here is what Biologist Lewis Thomas said in 1974.

In real life, however, even in our worst circumstances we have always been a relatively minor interest of the vast microbial world. Pathogenicity is not the rule. Indeed, it occurs so infrequently and involves such a relatively small number of species, considering the huge population of bacteria on the earth, that it has a freakish aspect. Disease usually results from inconclusive negotiations for symbiosis, an overstepping of the line by one side or the other, a biologic misinterpretation of  borders.

So? Stop blaming microbes for all your failed communications with them! Instead of blaming them, cultivate your immunity! Learn to live in मुनि state! (More here about Muni and Immunity )

Some bacteria are only harmful to us when they make exotoxins, and they only do this when they are, in a sense, diseased themselves. The toxins of diphtheria bacilli and streptococci are produced when the organisms have been infected by bacteriophage; it is the virus that provides the code for toxin. Uninfected bacteria are uninformed. When we catch diphtheria it is a virus infection, but not of us. Our involvement is not that of an adversary in a straightforward game, but more like blundering into someone else’s accident.

Some claims it is diphtheria vaccine that has saved the children! I say, it is post-world war, improved environment that had reduced the cases of diphtheria. Environmental stress reduced, diphtheria not affected by stress-messengers i.e. viruses (bacteriophage) and hence no exotoxins so no diphtheria led deaths.

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Lewis Thomas further writes:

I can think of a few microorganisms, possibly the tubercle bacillus, thesyphilis spirochete, the malarial parasite, and a few others, that have a selective advantage in their ability to infect human beings, but there is nothing to be gained, in an evolutionary sense, by the capacity to cause illness or death. Pathogenicity may be something of a disadvantage for most microbes, carrying lethal risks more frightening to them than to us. The man who catches a meningococcus is in considerably less danger for his life, even without chemotherapy, than meningococci with the bad luck to catch a man. Most meningococci have the sense to stay out on the surface, in the rhinopharynx. During epidemics this is where they are to be found in the majority of the host population, and it generally goes well. It is only in the unaccountable minority, the “cases,” that the line is crossed, and then there is the devil to pay on both sides, but most of allfor the meningococci.

Think about it. We need radical new perspective about life. Then only we can see destruction of environment going around. If we don’t nurture environment, we will soon invite another series of epidemic like we did in 18th, 19th and 20th centuries. And no technology would save us!

 

Art of Surfing in Microbial Sea: Balance

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Infectious means easily spread. Many sicknesses are called Infectious. And we blame bacteria and viruses for it! 😉 🙂

Balance is the key
Balance is the key

In reality, you will be afflicted only when your body is not in balanced state. Read this view.

Skimboarding or Surfboarding is an interesting board-sports for those who live near sea.

Board is used to glide across the water’s surface to meet an incoming, breaking wave, and ride it back to shore. Never done it but must be thrilling and mind bending. To balance the self, we have only one alternative, to balance self as per pattern of the wave. We can not control the wave.

Our environment is ocean of bacteria and viruses. Mother nature does not like vaccum. Place your hand anywhere and you will be in contact with millions and billions bacteria and viruses. Infection is a vacuum filling activity by mother nature. Like a giant wave to face when you are doing Skimboarding. You cannot anyway kill all the bacteria like you cannot change the pattern of the wave. One wave will go and another will come (Modern medicine calls it resistant bacteria 🙂 ). Similarly, antibiotics will wipe out one set of microbes and another will take the place.

Like a Skimboarders @ sea, we must learn to balance self in this sea of bacteria. That is the essence of immunity. Killing bacteria is short-sighted solution. Those who cannot envision ocean can only try to control and bend wave. 🙂 My two years old son do it often 😉

Think about it. (Y)

Seat of the Prana: Heart Attack and Gut Microbes: Part 1

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A recent study point out that Microbial communities play significant role in make or break of heart by causing or avoiding heart attack.

Read the research abstract summary first[1]

The gut is a major reservoir of T cells and diverse resident microbes, microbiota, which can influence immune responses in sites distant from the mucosal surfaces. Complete sterilization of the gut has proven to be beneficial in some experimental models of T cell mediated diseases, whereas partial recolonization post sterilization leads to microbial perturbations, a process called dysbiosis, and, worsens the outcome. Gut dysbiosis is thus recently becoming associated with the pathogenesis of several diseases, in part, by mechanisms in which certain bacteria promote T cell activation and enhance disease progression in a vicious cycle. The complex syndrome of heart failure (HF), a leading cause of morbidity and mortality affecting more than 24 million people worldwide, is recently becoming associated with gut dysbiosis and T cell mediated systemic inflammation in patients, but the mechanisms regulating this emerging gut-heart axis, and whether T cell activation and heart infiltration play a role remains unclear. We have previously reported that T cells infiltrate the heart in patients with non-ischemic HF, and using the transverse aortic constriction (TAC) mouse model of HF, demonstrated that T cells are critical regulators of adverse cardiac remodeling and HF. We hypothesized that sterilization of the gut by microbiota depletion prevents adverse cardiac remodeling and HF in a T cell dependent manner. C57/BL6 mice were orally treated with a well-established cocktail of antibiotics and antifungal (ABX) and subjected to TAC or Sham surgery. ABX treatment started 1 week before TAC surgery and was terminated 4 weeks after TAC. In vivo transthoracic echocardiography and hemodynamics showed a preserved ejection fraction and fractional shortening in mice treated with ABX as compared to untreated mice. Furthermore, gut microbiota depletion with ABX resulted in decreased left ventricular interstitial and perivascular fibrosis, and decreased cardiac hypertrophy in response to TAC, as compared to non-ABX treated TAC mice. These changes correlated with significant reduction of CD4 T cell activation in the mediastinal lymph nodes (mLNs) draining the heart, determined by FACS, as well as in the number of CD4 T cells infiltrated in the heart in ABX treated mice. Our findings indicate that ABX treatment results in distal effects in T cell activation occurring during TAC and protects from adverse cardiac remodeling, supporting the potential importance of gut microbiota in pressure overload induced HF. Future studies will determine whether dysbiosis post ABX treatment contributes to pathological cardiac remodeling and the mechanisms regulating the gut-heart axis in non-ischemic HF.

Let us first understand few terms and entities.

What is Gut dysbiosis?

Gut dysbiosis, sometimes called bacterial dysbiosis, means you have a lack of beneficial bacteria in your gastrointestinal (GI) tract.

There are approximately over 400 species of bacteria in your system that make up your gut microbiome. You actually have more bacteria in your gut than you do cells in your body! These bacteria help you digest food, synthesize vitamins, and fight off harmful pathogens. In short, gut bacteria are a fundamental part of your health, and without them you wouldn’t be able to survive.

[2]

What are T-cells (T-Lymphocytes (T-Cells))?

A type of white blood cell. T-lymphocytes are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T cell and thymocyte.

When our body lacks life-enriching Prana, naturally, it is being captured by life-consuming prana. Life-consuming prana or Prana doing job of destruction, flows from GUt to heart and disturbs its working.

Inflammed GUT due to idiotic eating habits, will generate flood of T-cells. When these T-cells travel to Heart, they are responsible for heart failure as per research.


My understanding


Body is made up of srota or channels. Channel that transports Prana, is known as Pranavaha Srotas. It’s root is in heart (left chamber). Seat is in heart. It receives Prana from two places. Lungs and gastrointestinal tract. It is also connected to GUT/Colon. Clogged colon or inflamed GUT , not only disturbs Prana transport but also affect breathing, and vice a versa. If breathing is not proper, GUT/Colon will be disturbed.
 
Heart attack is easy to detect very early by person’s eating habits. Irregular meals, obsession for exotic food against age, gender, season and time of the day, obsession for specific rasa (sweet teeth) – all of them play role in destroying GUT and in turn disturbing Prana transportation by polluting heart the root of the Pranavaha channel.

More in next part…

[1] https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.287.3

[2] https://blog.kettleandfire.com/gut-dysbiosis/

 

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