See, I told you, modern science does not have that द्रष्टि (see my yesterday’s post. Shared again in comment).

In last post, I shared how fungi acts as helping hand in agriculture.

Now, read this: Genotoxins damage the genetic material in cells and can cause mutations and cancer. Some bacteria code for and produce genotoxins. A new study reports the surprising finding that one of them, typhoid toxin, actually increases survival of the infected host and promotes long-term colonization without causing disease in the host.

Now, damn modern medicine will try everything to get rid typhoid bacteria by very very heavy dosage of antibiotics. This leaves severe side effects marks. (I have seen 10 years old girl with white hairs. All thanks to typhoid treatment.)

I know, typhoid fever is risky. But I am also sure that early detection and proper fever management, can help body to re-program against genotoxins.

If you are afflicted by typhoid, it is to save you from more worse future of cancer!


The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection

Author Summary

Bacterial genotoxins cause DNA damage in the host cells, resulting in activation of the classical DNA damage response, similarly to other well-characterized genotoxic agents. Three types of bacterial genotoxins have been identified: the cytolethal distending toxin (CDTs) family, the typhoid toxin and the peptide-polyketide colibactin, all produced by Gram-negative bacteria. The presence of genetic mobile elements upstream and downstream of the genes encoding for some CDT members suggests horizontal transfer, and indicates that these effectors may play a key function in bacterial infection/colonization. However, it is not clear whether these effectors play a role as virulence factors. In this work, we have addressed the effect of one of these genotoxins, the typhoid toxin, in the context of a natural infection. We used Salmonella Typhimurium, a bacterium that can establish persistent asymptomatic infections in immunocompetent individuals. We provide evidence that the presence of the functional genotoxin promotes the survival of the infected hosts and favours long-term asymptomatic colonization. Our work contributes to highlight the role of these microbial toxins in the complex interplay between the host and pathogenic bacteria, and poses a semantic and biological question on whether these effectors can be defined as “toxins”.