Precision medicine is a buzz word in medical arena. Target medicines to specific cells by Genome sequencing and finding precise target.
The next step of precision medicine, as I envision , is open source conclusion that it is not one or two genes but set of genes that governs the decision.
What would it look like?
Well-established Ayurvedic System of Tridosha i.e. Kapha, Pitta, Vayu
Our body = Our genes + Bacterial genes
As per this report [1], our genes are broadly divided into three categories.
As per this report [2] , our bacteria are divided into three categories.
When you target genes and decide therapy, you actually decide medicine based on state of Individual’s prakriti.
So future of precision medicine is Ayurveda. Ultimately, it is not about genes but your prakriti (and Vikruti i.e. derangement of the dosha) that decides cure.
Research
[1] http://www.nature.com/articles/srep15786
Genome-wide analysis correlates Ayurveda Prakriti
The practice of Ayurveda, the traditional medicine of India, is based on the concept of three major constitutional types (Vata, Pitta and Kapha) defined as “Prakriti”. To the best of our knowledge, no study has convincingly correlated genomic variations with the classification of Prakriti. In the present study, we performed genome-wide SNP (single nucleotide polymorphism) analysis (Affymetrix, 6.0) of 262 well-classified male individuals (after screening 3416 subjects) belonging to three Prakritis. We found 52 SNPs (p ≤ 1 × 10−5) were significantly different between Prakritis, without any confounding effect of stratification, after 106 permutations. Principal component analysis (PCA) of these SNPs classified 262 individuals into their respective groups (Vata, Pitta and Kapha) irrespective of their ancestry, which represent its power in categorization. We further validated our finding with 297 Indian population samples with known ancestry. Subsequently, we found that PGM1 correlates with phenotype of Pitta as described in the ancient text of Caraka Samhita, suggesting that the phenotypic classification of India’s traditional medicine has a genetic basis; and its Prakriti-based practice in vogue for many centuries resonates with personalized medicine.
[2] http://www.nytimes.com/2011/04/21/science/21gut.html?_r=1
