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soil

6 months back, we published a note here that being rooted to soil, barefoot, will soon become primary heath prescription. We have already seen news reports where doctors across the world now prescribe spending time with nature as cure!

Soil has capacity to absorb our physical toxins, mental negativity, balancing our energy and revive the प्राण! In TB or Diabetes, the root cause is : Depleted प्राण (The subtle energy acting as cellular intelligence).

This paper may talk in language of antibiotics but essentially, it is all about re-balancing body with the help of mother earth and her प्राणमय कोष! Soil indeed play critical role in future cure!


Searching in soil, scientists find a new way to combat tuberculosis


Soil is a rich source of bacteria, some of which produce molecules that act as natural antibiotics.

For decades, doctors have been using antibiotics to fight tuberculosis (TB). And consistently, the microbe responsible for the disease, Mycobacterium tuberculosis, has been fighting back. When confronted with current drugs, such as the antibiotic rifamycin, the bacterium often mutates in ways that make it resistant to the treatment.

Rates of rifamycin resistance are steadily rising, which presents a major problem to doctors attempting to treat TB. But, according to a new study from a team of Rockefeller scientists, nature might have come up with a solution. The study, published in Nature Communications, suggests that an antibiotic found in dirt can destroy mutant mycobacteria.

Nature’s antibiotics

Rifamycin, or Rif, works by targeting RNA polymerase (RNAP), an enzyme crucial to bacteria’s survival. Resistance develops when the genes coding for RNAP mutate: Even a small genetic change can prevent Rif from binding to the enzyme and obstructing its function.

To circumvent resistance, researchers needed a drug that acted like Rif, but that could bind to RNAP, even in the presence of mutations. And while some scientists might turn to the lab to synthesize such a molecule, Sean F. Brady, the Evnin Professor, turned to the environment.

“Rifamycin is naturally produced by a bacterium,” he says. “So I wanted to find out whether nature had also made Rif analogs—molecules that look like rifamycin, but that have slight differences.”

To identify any such analogs, Brady’s lab sequenced the genes of microbes found in soil samples collected from locations across the country. They hoped to uncover antibiotics that were genetically related to Rif, but with small variations that allowed them to bind to mutated RNAPs.

That’s exactly what they found.

https://www.rockefeller.edu/news/24159-searching-soil-scientists-find-new-way-combat-tuberculosis/

 

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