SHARE

F4.large

A recent study point out that Microbial communities play significant role in make or break of heart by causing or avoiding heart attack.

Read the research abstract summary first[1]

The gut is a major reservoir of T cells and diverse resident microbes, microbiota, which can influence immune responses in sites distant from the mucosal surfaces. Complete sterilization of the gut has proven to be beneficial in some experimental models of T cell mediated diseases, whereas partial recolonization post sterilization leads to microbial perturbations, a process called dysbiosis, and, worsens the outcome. Gut dysbiosis is thus recently becoming associated with the pathogenesis of several diseases, in part, by mechanisms in which certain bacteria promote T cell activation and enhance disease progression in a vicious cycle. The complex syndrome of heart failure (HF), a leading cause of morbidity and mortality affecting more than 24 million people worldwide, is recently becoming associated with gut dysbiosis and T cell mediated systemic inflammation in patients, but the mechanisms regulating this emerging gut-heart axis, and whether T cell activation and heart infiltration play a role remains unclear. We have previously reported that T cells infiltrate the heart in patients with non-ischemic HF, and using the transverse aortic constriction (TAC) mouse model of HF, demonstrated that T cells are critical regulators of adverse cardiac remodeling and HF. We hypothesized that sterilization of the gut by microbiota depletion prevents adverse cardiac remodeling and HF in a T cell dependent manner. C57/BL6 mice were orally treated with a well-established cocktail of antibiotics and antifungal (ABX) and subjected to TAC or Sham surgery. ABX treatment started 1 week before TAC surgery and was terminated 4 weeks after TAC. In vivo transthoracic echocardiography and hemodynamics showed a preserved ejection fraction and fractional shortening in mice treated with ABX as compared to untreated mice. Furthermore, gut microbiota depletion with ABX resulted in decreased left ventricular interstitial and perivascular fibrosis, and decreased cardiac hypertrophy in response to TAC, as compared to non-ABX treated TAC mice. These changes correlated with significant reduction of CD4 T cell activation in the mediastinal lymph nodes (mLNs) draining the heart, determined by FACS, as well as in the number of CD4 T cells infiltrated in the heart in ABX treated mice. Our findings indicate that ABX treatment results in distal effects in T cell activation occurring during TAC and protects from adverse cardiac remodeling, supporting the potential importance of gut microbiota in pressure overload induced HF. Future studies will determine whether dysbiosis post ABX treatment contributes to pathological cardiac remodeling and the mechanisms regulating the gut-heart axis in non-ischemic HF.

Let us first understand few terms and entities.

What is Gut dysbiosis?

Gut dysbiosis, sometimes called bacterial dysbiosis, means you have a lack of beneficial bacteria in your gastrointestinal (GI) tract.

There are approximately over 400 species of bacteria in your system that make up your gut microbiome. You actually have more bacteria in your gut than you do cells in your body! These bacteria help you digest food, synthesize vitamins, and fight off harmful pathogens. In short, gut bacteria are a fundamental part of your health, and without them you wouldn’t be able to survive.

[2]

What are T-cells (T-Lymphocytes (T-Cells))?

A type of white blood cell. T-lymphocytes are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T cell and thymocyte.

When our body lacks life-enriching Prana, naturally, it is being captured by life-consuming prana. Life-consuming prana or Prana doing job of destruction, flows from GUt to heart and disturbs its working.

Inflammed GUT due to idiotic eating habits, will generate flood of T-cells. When these T-cells travel to Heart, they are responsible for heart failure as per research.


My understanding


Body is made up of srota or channels. Channel that transports Prana, is known as Pranavaha Srotas. It’s root is in heart (left chamber). Seat is in heart. It receives Prana from two places. Lungs and gastrointestinal tract. It is also connected to GUT/Colon. Clogged colon or inflamed GUT , not only disturbs Prana transport but also affect breathing, and vice a versa. If breathing is not proper, GUT/Colon will be disturbed.
 
Heart attack is easy to detect very early by person’s eating habits. Irregular meals, obsession for exotic food against age, gender, season and time of the day, obsession for specific rasa (sweet teeth) – all of them play role in destroying GUT and in turn disturbing Prana transportation by polluting heart the root of the Pranavaha channel.

More in next part…

[1] https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.287.3

[2] https://blog.kettleandfire.com/gut-dysbiosis/

 

LEAVE A REPLY