Blog Page 134

The Gut – Brain Axis and Roots of Inflamed brain

Gut Microbes - Depression
Gut Microbes – Depression
Gut Microbes - Depression
Gut Microbes – Depression

Inflammation is your body’s first line of defense against infection and injury. This process normally shuts down after healing occurs.
But trouble can arise when the inflammation process gets stuck “on” and doesn’t know when to stop.
Then inflammation can turn on your body, attacking healthy cells, blood vessels, and tissues instead of protecting them.
This is called chronic or systemic inflammation.
You can develop chronic inflammation anywhere in the body — including the brain.
Unlike the inflammation of an injury or arthritis, brain inflammation doesn’t cause pain since the brain has no pain receptors.
But that doesn’t mean it’s not there, causing hidden damage to your most vital organ.

As per this[1]  research, depression is linked to brain inflammation.

As per this[2] research, Gut microbes protects against brain inflammation.

Antibiotics, Highly acidic processed food, chemical ingredients – We are daily waging war against our friends. 🙁

And we complain about Alzheimer, Parkinson’s, Aggression, Autism, Asthma, Suicides, Dumb, Zombiness… 🙁 That is what we deserve.
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[1] http://archpsyc.jamanetwork.com/article.aspx?articleid=2091919

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

Elaine Setiawan, PhD1,2; Alan A. Wilson, PhD1,2,3; Romina Mizrahi, MD, PhD1,2,3,4; Pablo M. Rusjan, PhD1,2; Laura Miler, HBSc1,2; Grazyna Rajkowska, PhD5; Ivonne Suridjan, HBSc1,2,4; James L. Kennedy, MD1,2,3,4; P. Vivien Rekkas, PhD1,2; Sylvain Houle, MD, PhD1,2,3; Jeffrey H. Meyer, MD, PhD, FRCPC1,2,3,4

The neuroinflammatory hypothesis of major depressive disorder is supported by several main findings. First, in humans and animals, activation of the immune system causes sickness behaviors that present during a major depressive episode (MDE), such as low mood, anhedonia, anorexia, and weight loss. Second, peripheral markers of inflammation are frequently reported in major depressive disorder. Third, neuroinflammatory illnesses are associated with high rates of MDEs. However, a fundamental limitation of the neuroinflammatory hypothesis is a paucity of evidence of brain inflammation during MDE. Translocator protein density measured by distribution volume (TSPO VT) is increased in activated microglia, an important aspect of neuroinflammation.

[2] http://today.duke.edu/2015/07/wormsonthebrain

Gut Worms Protect Babies’ Brains From Inflammation

What’s in mom’s gut could help protect her baby’s brain

According to what scientists call the “Biome Depletion Theory,” some autoimmune and inflammation-related diseases may be the result of too few of the life forms that once lived in and on the body — particularly gut worms — rather than too many.

Tapeworms, roundworms and other wormy companions have inhabited the warm wet folds of animal intestines for more than 100 million years, bathing in a constant supply of food and nutrients.

Over millions of years of co-existence, the theory goes, the immune system learned to tolerate these live-in guests, and eventually adapted to work with worms in mind.

The theory is that now, with worms gone from our guts, the body’s natural defenses can spiral out of control.

“Our bodies are essentially an ecosystem,” said Duke immunologist and study co-author William Parker.

Gau Mutra And Free Radical Scavenging

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Cow urine : Effective free radical scavenging
Cow urine : Effective free radical scavenging

It is your self-denial that stops you embracing ageless local culture back in life routine and get benefits of health society. Self denial mode is a biggest road block created by modern education. Unfortunately for so called educated, anything out of text book is humbug and fake. For them, real experience and experiments don’t matter but staged lab results like fake clinical trials.

Break your comfort zone of self-denial and dare to live life as per local culture.

Free radicals are everywhere, in the air, our bodies, and the materials around us. They cause the deterioration of plastics, the fading of paint, the degradation of works of art, aging related illnesses, and can contribute to heart attacks, stroke and cancers.

Free radicals are molecules with unpaired electrons. In their quest to find another electron, they are very reactive and cause damage to surrounding molecules.

It is one of the reasons why we see rapid aging & imbecility in our youth.

Free of cost solution?

Gau seva and Gau Prasad

When Gau is revered like a mata and taken care like your own mother, she takes care of you like a son and bestows magical boons.

Gau mutra act as an agent of radical scavenging which captures free radicals and satiates there energy needs. A vast amount of circumstantial evidence implicates free radicals as the mediators of wide range of diseases including diabetes, ageing, cancer, etc. Gau mutra can cure all of them magically.

If we want to stop Cow slaughter, best way is not the Milk production but by establishing usage of all her various prasads including Gau mutra in our society.

Cow urine as antioxidant
Cow urine as antioxidant
Anti-oxidant
Cow urine Anti-oxidant

 

Medicinal use of cow urine has been in practice since time immemorial in India. It is one of the ingredients in “Panchgavya”. Several medicinal properties of cow urine have been mentioned and in Indian tradition it is believed to have therapeutic properties. In the present investigation antioxidant activity of cow urine (fresh) and its distillate was evaluated using two in vitro models i.e. Total antioxidant activity by ABTS method and DPPH radical scavenging activity. Both cow urine and its distillate exhibited the antioxidant activity. The IC50 value for ABTS radical scavenging activity of fresh urine was found to be 69.39 μl/ml and that of urine distillate was 86.91μl/ml. IC50 value for free radical scavenging activity of fresh urine and its distillate was found to be 5.25 μl/ml and 7.37 μl/ml respectively. Comparatively cow urine was found to be better antioxidant than its distillate. This supports the claim of traditional practitioners. The revealed antioxidant property of cow urine and its distillate may provide potential therapeutic intervention against oxidative threats, both in healthy and disease conditions.

http://directory.indianjournals.com/ijor.aspx?target=ijor:ic&volume=8&issue=30&article=004

 

 

Cowshed : Solution for Auto-immune diseases

Gau-mata-Pooja
Gau-mata-Pooja
Gau Shala
Gau Shala

Yes, cowshed is the solution. I often prescribe friends and relatives to visit गौ शाला. गौ शाला is more than temple and beyond modern hospitals. I also suggest to avail milk and other prasad ( urine/dung) from only those गौ शाला where mother is kept happy! Like a mother and not as milk machine.

Let your growing child get frequent exposure to गौ शाला!

Some harsh reality:

Food allergies have increased about 50% in children since 1997.

I see children with diet restrictions. I see toddlers with long list of ‘No to eat’ list. This is the price we pay for disrespecting microbes, our friends, philosophers and guides.

Microbes can save growing epedemic of allergies. Respect them. Take care of them. Eat GUT-friendly food. Do not treat your body as gutter by eating anything and everything at anytime.

Include microbe-rich ghee, honey, dahi, butter-milk in regular diet.

There are various theories explaining why. One is that the 21st century lifestyle, which includes a diet very different from our ancestors’, lots of antibiotic use, and even a rise in cesarean section deliveries, has profoundly changed the makeup of microbes in the gut of many people in developed countries. For example, the average child in the United States has taken three courses of antibiotics by the time he or she is 2 years old, says Martin Blaser, an infectious disease specialist and microbiologist at New York University in New York City.

Here, I share two important articles to support my claim and unshakable faith on mother.

A gut microbe that stops food allergies

A class of bacteria commonly found in the guts of people—and rodents—appears to keep mice safe from food allergies, a study suggests. The same bacteria are among those reduced by antibiotic use in early childhood. The research fits neatly into an emerging paradigm that helps explain a recent alarming increase in food allergies and other conditions, such as obesity and autoimmune disease, and hints at strategies to reverse the trend.

In one of the latest efforts, Nagler’s team first confirmed that mice given antibiotics early in life were far more susceptible to peanut sensitization, a model of human peanut allergy. Then, they introduced a solution containing Clostridia, a common class of bacteria that’s naturally found in the mammalian gut, into the rodents’ mouths and stomachs. The animals’ food allergen sensitization disappeared, the team reports online today in the Proceedings of the National Academy of Sciences. When the scientists instead introduced another common kind of healthy bacteria, called Bacteroides, into similarly allergy-prone mice, they didn’t see the same effect. Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream. “The bacteria are maintaining the integrity of the [intestinal] barrier,” Nagler says.

http://www.sciencemag.org/news/2014/08/gut-microbe-stops-food-allergies

So, conclusion?

A probiotic consisting of Clostridia could be a new allergy therapy. For your surprise, Clostridia bacteria are found in abundance in cowshed! In fact, in all rustic places where humans live with animals! In cowshed, you are exposed to all healthy bacteria along with Clostridia which are not present with other animals.

So by chance if your child is treated with antibiotics ( which we must avoid! ), the best way to recover is to visit nearby Gau shala!! And take blessings of Gau mata!

A Cure for the Allergy Epidemic?

WILL the cure for allergies come from the cowshed?

Allergies are often seen as an accident. Your immune system misinterprets a harmless protein like dust or peanuts as a threat, and when you encounter it, you pay the price with sneezing, wheezing, and in the worst cases, death.

The working hypothesis is that innocuous cowshed microbes, plant material and raw milk protect farming children by favorably stimulating their immune systems throughout life, particularly early on. That spring morning, Dr. Holbreich gave me a tour of the bonanza of immune stimuli under consideration.

This research suggests that farming mothers might benefit from a naturally occurring immunotherapy, one that preprograms the developing fetus against allergic disease. Yet how to apply that therapy deliberately remains unclear. Is “microbial pressure” what matters — a stiff microbial wind in our sails? Or do certain cowshed microbes actually colonize farmers, and favorably calibrate their immune function?

Which brings us to farm milk. In Europe, the consumption of unpasteurized milk has repeatedly correlated with protection against allergic disease. In America, 80 percent of the Amish studied by Dr. Holbreich consume raw milk. In a study published earlier this year, Dr. Schaub’s group showed that European children who consumed farm milk had more of those regulatory T-cells, irrespective of whether they lived on farms. The higher the quantity of those cells, the less likely these children were to be given diagnoses of asthma. Here, finally, is something concrete to take off the farm.

http://www.nytimes.com/2013/11/10/opinion/sunday/a-cure-for-the-allergy-epidemic.html?_r=1

Any doubt? Don’t waste time. If you cannot keep Gau mata at home, get connected with near by ethical Gau shala! Inspire farmers in nearby villages to start Gau shala!

Mother is the only cure!

Your child and You: Growth vs Chaos

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Chaos Img src: https://static01.nyt.com/images/2015/07/07/science/07BRODY-copy/07BRODY-master1050.jpg
Chaos
Img src: https://static01.nyt.com/images/2015/07/07/science/07BRODY-copy/07BRODY-master1050.jpg

Tremendous brain growth occurs in the first 7 years of life. In first two years, more dramatic than at any other age, overall brain size doubles in the first year, reaching about 70 percent of its adult size; it reaches 85 percent of adult size by age two.

During this time your baby’s brain is busily building structural and functional connectivity, creating the essential neuro-architecture to support life and learning.

Child brain demands maximum human interactions during this growth period. (Critical first 2 years and at least first 7 years).

father_child Img src: http://goo.gl/HKk4Q0
father_child
Img src: http://goo.gl/HKk4Q0

When you replace quality human interactions with technology, shortchanges a young child on the time and mix of experiences the sensorium (The areas of the brain that process and register incoming sensory information and make possible the conscious awareness of the world) needs for well-rounded development. Neurologically and psychologically, the tech effect becomes a wild card in your baby’s development.

Now a dear friends argues that: But child learns from TV (Even recent TATA TV ad also give this idea). Well, learning at the cost of growth? What TV can teach, you can easily demonstrate. When you demonstrate, you actually help brain in growth.

The brain is not machine, and is designed to develop in all the areas through natural human interactions and play, and by putting kids in front of screens we are changing their brains.

Take care or live in self-denial and compromise your kid’s growth. What I presented here are crude biological facts. Opposing them will invite nothing but a self-goal 🙂.

——–

“Look, the brain of the child is shaped by the interactions they have with parents—that’s just absolutely clear. We need to be in the physical and relational world before we reduce it down to screens.”

—DAN SIEGEL, CHILD PSYCHIATRIST
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You already spend 8 hrs in sleep. 10 hrs at work. 2 hrs in daily chores. You left with 4 hrs. From this 4 hrs, you give 2 hrs to your entertainment dosage (TV, Internet, Mobile).

Your kid gets only 2 hrs per day. Kids are not machines that you can take care on weekends. They need continuous interactions.

Election of King in Dharma-bound nation-state

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Varna based Democracy
Varna based Democracy

There are misconceptions propagated in our society that in ancient times of Bharat, Nation-states were always ruled by son of the King. This is not complete truth. Selection of successor was never exclusively birth based. As Kalidasa described precisely in this verse of raghuvaMsham.

अथेतरे सप्तरघुप्रवीरा ज्येष्ठम् पुरोजन्मतया गुणैश्च।
चक्रुः कुशम् रत्नविशेषभाजम् सौभ्रात्रमेषाम् हि कुलानुकारि ॥१६-१

“Then, the other seven brave princes of the Raghu family made Kusha – the eldest both by his being born first and by his possessing virtues…”

The king is honored because of his qualities. It is not birth that makes a king. He is not respected so much because of his ancestry, as for his prowess, strength and valor. There were of course instances where seat of king was claimed by mere birth. But we are not talking about failed states or average states. When we look at the history and learn the lesson from it, we must thrive for best of it. And the best is, selection of King by qualities.

To support Kalidasa’s words, we have Allahbad Pillar inscription which records that Samudra Gupta was chosen among other princes of the family who were rendered crestfallen.

Conclusion:

Segregation is Natural. Every individual is unique and unparalleled. Every individual must be recognized, provided nurture and respected.
Nature teaches co-operation and co-existence. Love n harmony.

It is half truth when someone says that only Qualities are important and not Varna. Similarly, it is also half truth when someone says that only birth is enough to decide Kingly qualities.

Best way to summarize: Out of all Kshtriya clans, the most powerful (full of Kingly traits) becomes the King with Praja’s (Citizen’s) consent.

Monsoon and Clothes

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Monsoon and clothes img src: http://goo.gl/YDrAeN
Monsoon and clothes
img src: http://goo.gl/YDrAeN

Clothes do not see Sun much often in monsoon so there are high chances that they will act as breeding ground of pathogens.

It is advisable to do fumigation of cow-dung dry cakes to control breeding of pathogens and hence any possible sickness due to them. If cow-dung dry cakes are not available, use Ajwain from your kitchen pharmacy.

Medicinal Smoke (Havan) Reduces Airborne Bacteria*

 

As per this research paper:

“This study represents a comprehensive analysis and scientific validation of our ancient knowledge about the effect of ethnopharmacological aspects of natural products’ smoke for therapy and health care on airborne bacterial composition and dynamics, using the Biolog microplate panels and Microlog database. We have observed that 1h treatment of medicinal smoke emanated by burning wood and a mixture of odoriferous and medicinal herbs (havan sámagri=material used in oblation to fire all over India), on aerial bacterial population caused over 94% reduction of bacterial counts by 60 min and the ability of the smoke to purify or disinfect the air and to make the environment cleaner was maintained up to 24h in the closed room. Absence of pathogenic bacteria Corynebacterium urealyticum, Curtobacterium flaccumfaciens, Enterobacter aerogenes (Klebsiella mobilis), Kocuria rosea, Pseudomonas syringae pv. persicae, Staphylococcus lentus, and Xanthomonas campestris pv. tardicrescens in the open room even after 30 days is indicative of the bactericidal potential of the medicinal smoke treatment. We have demonstrated that using medicinal smoke it is possible to completely eliminate diverse plant and human pathogenic bacteria of the air within confined space.”

http://asianagrihistory.org/research/Medicinal-smoke.pdf

Why respect and follow local food traditions?

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https://www.leonardooliveoil.com/blog/wp-content/uploads/2015/06/Indian-cooking-with-Olive-oil.jpg
https://www.leonardooliveoil.com/blog/wp-content/uploads/2015/06/Indian-cooking-with-Olive-oil.jpg

Ghee is a tradition here. Olive oil is a tradition in Europe. Soybean in china. All suitable for respective local environment. If you live in China, you should eat Soybean. But in India? Why? Food Tradition does not come up overnight from scientist’s lab like your Crosin tablet that works everywhere with same side effects 😀.

Traditions emerge from social labs, our homes, by live experiments over several generations, under the guidance of Rishi personalities (The one with sharp and blessed observation powers). Traditions exists because they have proved benefits to many. Fake traditions do not stand against the time. What is suitable here, may not work well in Canada. What is best in Canada, may not work here (For example Canola oil).

Trust and follow your local food habits passed to you by parents, and get benefited. Doubt and live in self-denial? Loss of all benefits. Pay the price.

Side note: One of the hidden benefits of respecting food traditions is reduced transport due to demand of exotic food. Think about it. You can make huge difference!

Superman of Facebook and Activism

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Online Activists
Online Activists

I repeat this message again to remind myself as well as my friends that, there is only one life where you can create real impact and it is outside your Facebook wall so it is not worth spending precious hours in petty online debates.

Human thoughts elaborate progress of individual’s intelligence when speech (Face to face verbal Communication) is the harvest of thought and relation between words and mouth that speak is observed carefully. And intellectuals (self-proclaimed) spend infinite time online on petty debates and discussions. Amount of time activists and young politicians spend in online debates is prime indicator of their walk in wrong direction.

How can that be possible in online discussions where face to face meeting is distant reality?

If you want remain true to your self, your conviction, go offline regularly, meet more and more new people and exchange your ideas with them. This is the only way to create critical mass against all our societal issues. Debates are mere intellectual feasts if they are not backed efforts in the field. Go and penetrate self in people, the real faces! Get real!

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उमान मान गति संहति सार वर्ण
स्नेह स्वर प्रकृति सत्व मनूकमादै|
क्षेवंमृजोच विधिवत कुशल-वबय
सामुद्रविदवति यात मनागतंवा ।

– वराहमिहिर

If you are clever observer, careful observation of man/woman for his/her height,weight,gait,compactness,strength,complexion,glossiness,voice,natural character,courage,impressions of previous birth,parts of body and natural lustre, reveals past and the future.

Microbes and Svadharma

===================================================
Relation between I and my bacterial friends (Bacteria residing on my body)
===================================================

Being धार्मिक = Promote symbiosis but respect differences

symbiotic-relationship
symbiotic-relationship

The term biologists use for our relations with Bacteria is ‘Amphibiosis’. A symbiotic relationship that under certain circumstances can be helpful and other circumstances can be harmful, with the helpful and harmful aspects referring to either host or symbiont.

The term we use for this “Dharmic Relation”. In dharmic relation, each participant is following own dharma. Own duty towards the integrity of the cellular complex called ‘Body’. Sometimes, cells forget their duty. When cells forget duty, it is important for rest of the dharmic*** body cells to purge them. Sometimes, bacteria(s) do not do their duty so immune system flush them from body. Sometimes, by accident or bad habits of ours, non-compatible life forms enter into body. For example, कृमि worms. Most of the times, such non-compatible disturbances happen when our ego “I” forgets to perform duties. For example, eat food anytime of the day. Now this disturbs the digestion cycle. So cells are are over-stressed. Some of them die prematurely. To purge them, bacteria play role. And we call it bacterial infection. Except us, with free will, everyone else in the nature has instinct driven will or in other words, mother nature drives them. So they always remain धार्मिक. It is our Ego who has to remain धार्मिक to maintain the optimum body state. We can do it by following local culture since it is evolved life routine to maintain symbiotic relation with others in same environment.

***Dharmic (धार्मिक) = The one who follows own dharma.

*** What is dharma?
Dharma has the Sanskrit root dhri, which means “that which upholds” or “that without which nothing can stand” or “that which maintains the stability and harmony of the universe.” Dharma encompasses the natural, innate behavior of things, duty, law, ethics, virtue, etc. Every entity in the cosmos has its particular dharma — from the electron, which has the dharma to move in a certain manner, to the clouds, galaxies, plants, insects, and of course, man.

Why food matters?

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Food matters img src: https://c.o0bg.com/rf/image_960w/Boston/2011-2020/2015/07/21/BostonGlobe.com/Lifestyle/Images/Pic.3A.jpg
Food matters
img src: https://c.o0bg.com/rf/image_960w/Boston/2011-2020/2015/07/21/BostonGlobe.com/Lifestyle/Images/Pic.3A.jpg

Apart from external environmental factors affecting mind space, it is our polluted food and water sources, that play major role in weakening our psyche and slip ourselves in the mode societal corruption.
When people talk about neurological disorders, they consider only those disorders which exhibit visible symptoms (Autism, Phobias etc). For me, lack of integrity or moral perversion is also a neurological disorder, albeit silent one. It is getting diagnosed, only during harvesting time of past deeds of individual. And in most cases, it is never diagnosed during life time.

Corruption in society is resultant of polluted food origins. While working on correcting political system, it is equally important to see that majority of us, get nutritional food, both physical and mental.
Mental food by disinfecting Education system, physical food by disinfecting agriculture.
If you think you are sane citizen, contribute, in your capacity possible, for politics, education and agriculture.

With corrupted and weak psyche and body of majority in us, it is difficult to penetrate sane reformative ideas in our minds.

You go and explain, ideal democracy but if the other person is devoid of pure food and water, it is difficult for him being receptive and understand sane ideas necessary to change the Nation’s destiny from current shoddy state. Even if he/she understands, he/she won’t do much in action due to weak body and mind. For survival, compromises happen and saga of personal involvement in corruption continues.

Food -> Education -> Political awareness -> Critical Mass for change -> Revolution

Any upheaval, out of reaction, would remain temporary since roots are corrupt and in hibernation. With favorable environment to flourish, weakness will sprout again and reforms will topple again towards nadir.

If roots are replaces by food and education, it is difficult for any external force to break strong National fabric.

Political awareness minus Food and Education -> Revolution minus prolonged stability.

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