Different levels of brain response to sham treatment could predict resilience in the face of depression, help lead to new treatments
When it comes to treating depression, how well a person responds to a fake medicine may determine how well they’ll respond to a real one, new research finds.
Those who can muster their brain’s own chemical forces against depression, it appears, have a head start in overcoming its symptoms with help from a medication. But those whose brain chemistry doesn’t react as much to a fake medicine, or placebo, struggle even after getting an active drug.
We are not mere physical body. There are layers. One of them is मनोमय कोष. Mind. Cure efficacy highly depends upon patient’s strong will to live life fully (जिजीविषा) and doctor’s pious heart to see patient healthy asap.
Association Between Placebo-Activated Neural Systems and Antidepressant ResponsesNeurochemistry of Placebo Effects in Major Depression
Main Outcomes and Measures Changes in depressive symptoms in response to active placebo and antidepressant. Baseline and activation measures of µ-opioid receptor binding.
Results Higher baseline µ-opioid receptor binding in the nucleus accumbens was associated with better response to antidepressant treatment (r = 0.48; P = .02). Reductions in depressive symptoms after 1 week of active placebo treatment, compared with the inactive, were associated with increased placebo-induced µ-opioid neurotransmission in a network of regions implicated in emotion, stress regulation, and the pathophysiology of MDD, namely, the subgenual anterior cingulate cortex, nucleus accumbens, midline thalamus, and amygdala (nucleus accumbens: r = 0.6; P < .001). Placebo-induced endogenous opioid release in these regions was associated with better antidepressant treatment response, predicting 43% of the variance in symptom improvement at the end of the antidepressant trial.
Conclusions and Relevance These data demonstrate that placebo-induced activation of the µ-opioid system is implicated in the formation of placebo antidepressant effects in patients with MDD and also participate in antidepressant responses, conferring illness resiliency, during open administration.
Autophagy is news for Nobel prize and suddenly there is world-focus on this word! This particular phenomenon is not new for us in India. This is well-understood concept in Ayurveda. Ojovisramsa is impairment in distribution of Ojas. Ojas is a immunological factor.
“Ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture.”
This post is about Ginger triggered Autophagy!
Ginger truly does top the list of effective natural home remedies.
Being used throughout history by different cultures around the world, ginger harnesses an incredible healing power proven for a host of ailments. The spice is packed with essential nutrients and rejuvenating compounds.
While ginger has been shown to help countless ‘minor’ problems such as an upset stomach, amazingly the health benefits of ginger also include combating cancer more effectively than pharmaceutical cancer drugs.
इमां खनाम्योषधिं वीरुधं बलवत्तमाम् । ऋग्वेद: सूक्तं १०.१४५
“What I dig is very potent herb to increase strength.”
Excuse my faulty translation but there are interesting dots to connect.
1) शारीरिक & प्राणिक बल are necessary to earn पुरुषार्थ (धर्म,अर्थ,काम,मोक्ष) and perform our duties towards the Universe with least errors.
2) In my understanding, when grown in soil nurtured and kindled with Prana(प्राण) by gobar, mutra and butter milk of Desi Gau, Vegetables from कंद वर्ग (the ones that we dig) grows in the epicenter of rich Pranic environment. And this Prana is not Raw Prana like other vegetables and fruits get from the Sun by photosynthesis and external environment. It is digested Prana or churned prana. Churning prana makes its potency manifold. So they are full of प्राणिक बल. Since they are the roots, they have most possible essence of all physical nutrients.
3) कंद वर्ग’s vegetables is main food for ऋषि पञ्चमी. That means, to nurture the ऋषि अंश settled at our subtle senses can realize their full potential with the help of कंद वर्ग.
4) In most cases, you dig them only when they plant completes its life cycle. For example, I dig my turmeric only when all its leaves are dried and gone.
Keep an eye on seasonal कंद वर्ग vegetables and include them in your meals. Of course, nothing worth without Gau mata.
जामवंत के बचन सुहाए। सुनि हनुमंत हृदय अति भाए॥
तब लगि मोहि परिखेहु तुम्ह भाई। सहि दुख कंद मूल फल खाई॥
Now read on about Ginger and Autophagy! 🙂
6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death
Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. The spheroids were generated from adherent breast cancer cells. 6-shogaol was effective in killing both breast cancer monolayer cells and spheroids at doses that were not toxic to noncancerous cells. The percentages of CD44+CD24–/low cells and the secondary sphere content were reduced drastically upon treatment with 6-shogaol confirming its action on CSCs. Treatment with 6-shogaol caused cytoplasmic vacuole formation and cleavage of microtubule associated protein Light Chain3 (LC3) in both monolayer and spheroid culture indicating that it induced autophagy. Kinetic analysis of the LC3 expression and a combination treatment with chloroquine revealed that the autophagic flux instigated cell death in 6-shogaol treated breast cancer cells in contrast to the autophagy inhibitor chloroquine. Furthermore, 6-shogaol-induced cell death got suppressed in the presence of chloroquine and a very low level of apoptosis was exhibited even after prolonged treatment of the compound, suggesting that autophagy is the major mode of cell death induced by 6-shogaol in breast cancer cells. 6-shogaol reduced the expression levels of Cleaved Notch1 and its target proteins Hes1 and Cyclin D1 in spheroids, and the reduction was further pronounced in the presence of a γ-secretase inhibitor. Secondary sphere formation in the presence of the inhibitor was also further reduced by 6-shogaol. Together, these results indicate that the inhibitory action of 6-shogaol on spheroid growth and sustainability is conferred through γ-secretase mediated down-regulation of Notch signaling. The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment.
Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.
Zerumbone, a natural monocyclic sesquiterpene, is the main component of the tropical plant Zingiber zerumbet Smith. Zerumbone induced antiproliferative and apoptotic effects against PC-3 and DU-145, two human hormone-refractory prostate cancer (HRPC) cell lines. Zerumbone inhibited microtubule assembly and induced an increase of MPM-2 expression (specific recognition of mitotic proteins). It also caused an increase of phosphorylation of Bcl-2 and Bcl-xL, two key events in tubulin-binding effect, indicating tubulin-binding capability and mitotic arrest to zerumbone action. Furthermore, zerumbone induced several cellular effects distinct from tubulin-binding properties. First, zerumbone significantly increased, while paclitaxel (as a tubulin-binding control) decreased, Mcl-1 protein expression. Second, paclitaxel but not zerumbone induced Cdk1 activity. Third, zerumbone other than paclitaxel induced Cdc25C downregulation. The data suggest that, in addition to targeting tubulin/microtubule, zerumbone may act on other targets for signaling transduction. Zerumbone induced mitochondrial damage and endoplasmic reticulum (ER) stress as evidenced by the loss of mitochondrial membrane potential and upregulation of GRP-78 and CHOP/GADD153 expression. Zerumbone induced an increase of intracellular Ca(2+) levels, a crosstalk marker between ER stress and mitochondrial insult, associated with the formation of active calpain I fragment. It induced apoptosis through a caspase-dependent way and caused autophagy as evidenced by dramatic LC3-II formation. In summary, the data suggest that zerumbone is a multiple targeting compound that inhibits tubulin assembly and induces a crosstalk between ER stress and mitochondrial insult, leading to apoptosis and autophagy in HRPCs.
Vaccines are not necessary, admits mainstream study.
It’s established dogma that the immune system develops a “memory” of a microbial pathogen, with a correspondingly enhanced readiness to combat that microbe, only upon exposure to it — or to its components though a vaccine. But a discovery by Stanford University School of Medicine researchers casts doubt on that dogma.
“Mark Davis and his colleagues found that key immune cells in our bodies have “memories” of microbes they‘ve never encountered.”
Damn! Entire vaccine industry is running on false Dogma!
And when we talk about पितृ legacy, different from genes, and suggest पितृ तर्पण, we are fanatic superstitious morons! 😀
Remember one thing: We inherit many forms of inheritance. Genes are just one of them. Apart from genes, we inherit – memories, minding process, social patterns, विकृति (s), संस्कार (s), प्रकृति and the list goes on
Immune systems of healthy adults ‘remember’ germs to which they’ve never been exposed, Stanford study finds
In a path-breaking study published online Feb. 7 in Immunity, the investigators found that over the course of our lives, CD4 cells — key players circulating in blood and lymph whose ability to kick-start the immune response to viral, bacterial, protozoan and fungal pathogens can spell the difference between life and death — somehow acquire memory of microbes that have never entered our bodies.
Several implications flow from this discovery, said the study’s senior author, Mark Davis, PhD, professor of microbiology and immunology and director of Stanford’s Institute for Immunity, Transplantation and Infection. In the study, newborns’ blood showed no signs of this enhanced memory, which could explain why young children are so much more vulnerable to infectious diseases than adults. Moreover, the findings suggest a possible reason why vaccination against a single pathogen, measles, appears to have reduced overall mortality among African children more than can be attributed to the drop in measles deaths alone. And researchers may have to rethink the relevance of experiments conducted in squeaky-clean facilities on mice that have never been exposed to a single germ in their lives.
“It may even provide an evolutionary clue about why kids eat dirt,” said Davis. “The pre-existing immune memory of dangerous pathogens our immune systems have never seen before might stem from our constant exposure to ubiquitous, mostly harmless micro-organisms in soil and food and on our skin, our doorknobs, our telephones and our iPod earbuds.”
CD4 cells are members of the immune club known as T cells. CD4 cells hang out in our circulatory system, on the lookout for micro-organisms that have found their way into the blood or lymph tissue.
In order to be able to recognize and then coordinate a response to a particular pathogen without inciting a Midas-touch overreaction to anything a CD4 cell bumps into (including our own tissues), our bodies have to host immensely diverse inventories of CD4 cells, each with its own narrow capacity to recognize one single pathogenic “body part” or, to be more scientific, epitope — and, it’s been believed, only that epitope. Contact with that epitope can cause a CD4 to whirr into action, replicating rapidly and performing the immunological equivalent of posting bulletins, passing out bullets and bellowing attack orders through a bullhorn to other immune cells. This hyperactivity is vital to the immune response. (It is CD4 cells that are targeted and ultimately destroyed by HIV, the virus responsible for AIDS.)
Even if bees want to help in pollination, they cannot. Why? Because we use diesel tractors everywhere for farming! And the fume that is being emitted alters scent that bees seek.
So half of the scents are lost. Forget honey, pollination is affected. Crop yield reduction.
“People rely on bees and pollinating insects for a large proportion of our food, yet humans have paid the bees back with habitat destruction, insecticides, climate change and air pollution.”
Is it not hara-kiri to promote self-destructing technologies @ farms ? Tractor is costly and destructive shortcut.
Only solution we have to become सात्विक अन्नबाहुल्य राष्ट्र is to worship and take help from गौ माता!
Mantra for being sattvik world power : अन्नबाहुल्य
We have all संभावना. गौ, गंगा (त्रिदोषहर water in abundance) & गौरी (जमीन) to help us. Better late than never. Revive Agriculture. If we produce सात्विक धान्य for all, we will actually transform corrupted world-psyche in to सत्त्व. It is actually a 7 generation process. We have to start somewhere. Anytime is a good time to start. Sooner the better.
But instead, what do we support as a society?
Male calf? Useless for milk , send him to slaughter!
SCENTS AND SENSE ABILITY: DIESELS FUMES ALTER HALF THE FLOWER SMELLS BEES NEED
In polluted environments, diesel fumes may be reducing the availability of almost half the most common flower odours that bees use to find their food, research has found.
The new findings suggest that toxic nitrous oxide (NOx) in diesel exhausts could be having an even greater effect on bees’ ability to smell out flowers than was previously thought.
NOx is a poisonous pollutant produced by diesel engines which is harmful to humans, and has also previously been shown to confuse bees’ sense of smell, which they rely on to sniff out their food.
Researchers from the University of Southampton and the University of Reading found that there is now evidence to show that, of the eleven most common single compounds in floral odours, five have can be chemically altered by exposure to NOx gases from exhaust fumes.
Lead author Dr Robbie Girling, from the University of Reading’s Centre for Agri-Environmental Research, said: “Bees are worth millions to the British economy alone, but we know they have been in decline worldwide.
“We don’t think that air pollution from diesel vehicles is the main reason for this decline, but our latest work suggests that it may have a worse effect on the flower odours needed by bees than we initially thought.
“People rely on bees and pollinating insects for a large proportion of our food, yet humans have paid the bees back with habitat destruction, insecticides, climate change and air pollution.
“This work highlights that pollution from dirty vehicles is not only dangerous to people’s health, but could also have an impact on our natural environment and the economy.”
Co-author Professor Guy Poppy, from Biological Sciences at the University of Southampton, said: “It is becoming clear that bees are at risk from a range of stresses from neonicitinoid insecticides through to varroa mites. Our research highlights that a further stress could be the increasing amounts of vehicle emissions affecting air quality. Whilst it is unlikely that these emissions by themselves could be affecting bee populations, combined with the other stresses, it could be the tipping point.”
This latest research is part of continuing studies into the effects of air pollution on bees. Previous work in 2013 found that bees in the lab could be confused by the effects of diesel pollution. Dr Girling and Dr Tracey Newman from the University of Southampton are currently studying how diesel fumes may have direct effects on the bees themselves.
The Effects of Diesel Exhaust Pollution on Floral Volatiles and the Consequences for Honey Bee Olfaction
There is growing evidence of a substantial decline in pollinators within Europe and North America, most likely caused by multiple factors such as diseases, poor nutrition, habitat loss, insecticides, and environmental pollution. Diesel exhaust could be a contributing factor to this decline, since we found that diesel exhaust rapidly degrades floral volatiles, which honey bees require for flower recognition. In this study, we exposed eight of the most common floral volatiles to diesel exhaust in order to investigate whether it can affect volatile mediated plant-pollinator interaction. Exposure to diesel exhaust altered the blend of common flower volatiles significantly: myrcene was considerably reduced, β-ocimene became undetectable, and β-caryophyllene was transformed into its cis-isomer isocaryophyllene. Proboscis extension response (PER) assays showed that the alterations of the blend reduced the ability of honey bees to recognize it. The chemically reactive nitrogen oxides fraction of diesel exhaust gas was identified as capable of causing degradation of floral volatiles.
We have become society that only appreciates visible benefits of everything. Long term and/or invisible benefits, we are least bothered.
Gau mata helps in curing both visible and invisible illnesses.
गव्यं पवित्रं च रसायनं च पथ्यं च हृद्यं बल बुद्धि स्यात |
आयुः प्रदं, रक्त विकार हारि, त्रिदोष, हृद्रोग, विषापहं स्यात |
“The five elements obtained from the Cow are sacred and are medicine for the heart. They enhance bodily strength and intellect. They give long life, purify the blood, balance the Vata Pitta and Kapha doshas. They cure all diseases and detoxify the body.”
‘Pancha’ means 5 and ‘Gavya’ means substance obtained from the Cow. Panchgavya is a blend of the 5 Gavyas obtained from the Cow namely Milk, Ghee, Curd, Urine & Dung. Glorified very highly in Vedic scriptures for its purity and curing Powers, its medical, nutritional, environmental and agricultural efficacies are accepted and respected by modern science, alike.
Detoxifying, Anti-Cancer, Bio-Enhancing, Immunomodulatory, Anti-Oxidant, Anti-Bacterial, Anti-Septic, Anti-Tuberculosis, Anti-Fungal are some of its properties in modern scientific terms. It has the capacity to control and balance all the three life forces (Tridoshas) namely Vat, Pitt & Kaphaas per Ayurveda. Scriptures declare.
Both independently and in combination with abundantly available natural ingredients, the Gavyashelp to produce wonderful medicines, food, pest-repellents and fertilizer apart from hundreds of daily use items as tooth-powder, soaps, shampoos, hair-oil, massage oil, after-shave lotions and various types of creams, dhoop (incense), phenyle, face-powder, mosquito-coils, hand-wash, etc. Each one has its own unique powers.
Should we now appreciate Maa’s blessings? Protecting her from slaughter houses is very critical. Spread the awareness. Force govt to implement strict laws.
Those who are in sync with their external environment i.e. season change, they alter their life routine based on seasons.
Exercise is one such aspect. Since now many of us prefer isolated insulation called ‘Gym’ for exercise, we do same exercise 365 days! Even those who perform exercise on ground, don’t vary the intensity and type of exercise.
Ideally, we should. Winter is at doorstep. Best season to do heavy exercise, Akhada and oil massage!
Indian Calendar runs on moon’s movements. Soon we will observe first day (प्रतिपदा) of कार्तिक month (In western India – those who begin month with shukla paksha प्रतिपदा). Soon, Deva(s) will awake from 4 months hibernation. Active 6 months of the year to begin soon!
Since calendar is governed by Mother Nature, rituals too are governed based on season. From this month onwards, winter is officially started.
Sesame (तिल/તલ) becomes part of diet and routine. Oil massage in this season plays important role in maintaining Vayu movement in body. Those who do daily oil massage followed by exercise and running during winter, stores energy and health for entire year.
If your child is above age 7, this is ideal time to enroll him/her in near by Akhada (If you are lucky to have one in vicinity 🙂 ). If there is no Akhada, play with her/him in the morning so that good muscle toning happens. If there is newborn or infant or toddler at home, do not forget oil massage followed by innocent masti/play with him/her.
Oil massage from Today until end of winter, will keep heart attack, flu, muscle pain, ALS (Yes! It is great preventive care for ALS type symptoms) away.
When someone is admitted to hospital, do you question protocols and procedures followed?
When someone enrolls in Army, is there any room for careless conduct?
When someone is preparing for Marathon, can non-discipline help?
Then why carelessness and pathetic ignorance about Yogic Practices?
Yoga is not exercise. If you are doing just Asana(s) or teaching Asana(s), call it aerobic exercise. Don’t call it Yoga. Yoga demands much more than mere exercise. Self-control & discipline in life are essential to begin Yogic Sadhana.
What do we do?
We eat junk in the evening and do Asanas in the morning! 😀
We suffocate self while sleeping under AC close rooms and do Pranayama in the morning 😀
This will never help but on the other hand, it may work as contraindicated!
Self-proclaimed routine and life won’t work!
If you really want fruits of Yoga, learn and follow all prescriptions.
In brief the eight limbs, or steps to yoga, are as follows:
Yama : Universal morality
Niyama : Personal observances
Asanas : Body postures
Pranayama : Breathing exercises, and control of prana
Pratyahara : Control of the senses
Dharana : Concentration and cultivating inner perceptual awareness
Dhyana : Devotion, Meditation on the Divine
Samadhi : Union with the Divine
Consider it as westernization of eastern philosophy when philosophy is converted into catalog.
Yoga for men, Yoga for women, Yoga for morning, Yoga for night, Yoga for Chakra ….well save yourself from delusion!
मिताहारं विना यस्तु योगारम्भः तु कारयेत्।
नानारोगो भवेत्तस्य किञ्चिद्योगो न सिध्यति ॥१६॥He who practices Yogic exercises without moderation of diet, incurs various diseases, and obtains no success of any kind.
Moderation of diet is very important in Yogic exercises, dhyana or in any type of sadhana. If this is missed, success of any kind is not possible.
When Yogic exercises are performed as just another way of aerobic exercise, we not only incur any benefit but also damage body severely.
Our culture has highest morals set as long as food management is concerned. Because we consider food as sacred as our God. Without food, there is no life. Without food, there is no civilization. This land was known as land of abundance. We used to serve food to entire world.
ऋग्वेद के इस मंत्र में तो यहां तक कहा गया है कि धन-सम्पदा का अकेले भोग करने वाला व्यक्ति पाप का ही भोग करता है। अकेले भोग करने वाला व्यक्ति तो व्यर्थ ही अन्न, धन आदि सामग्रियों को प्राप्त करता है क्योंकि ऐसे व्यक्ति के लिए उसकी अपनी सम्पत्तियां ही मृत्यु का कारण बन जाती हैं। ऐसे व्यक्तियों का धन न तो सत्यवादी विद्वानों का पोषण करता है और न ही उसके आपत्तिग्रस्त सम्बन्धियों का। वैदिक काल से इस मंत्र का उच्चारण सामूहिक भोज के बाद किया जाता रहा है।
(English Summary: Your wealth is useless trash if you earn just for own sake. All your such wealth becomes reason for your premature death. Such wealth never helps the society in despair and hence useless. We chant this mantra after serving free food to needy)
Before planning for own meal, we plan for cow’s food, dog’s food, birds’ food. We arrange food for them before we eat.
Now, cows eat leftover food from dustbins. Street dogs also fight for sanitary napkins in trash. Birds still get it because someone told our selfish junta that if you feed the birds, you get good fortune! 🙂 You know…greedy give and take! 🙂. No ulterior motive!
We have hoarders who sale staple food at unimaginable prices! Our milk comes from torture cycle setup by dairy.
Society was never in such food mess before as we are currently. God bless our kids. (Y)
Our body is a clock. In fact, several billion clocks together, each in individual cell, each for community of cells i.e. organs. Unfortunately, they are not like mechanical clocks.
Organ level clocks have varied sunrise point (time when it is active most for designated activity). Morning time is the lung time. Midday is stomach time, when we feel hungry. Afternoon is liver time, and late afternoon is when the colon and kidneys operate at their peak.
Not only organs, our vital energy (Prana) also work on its own sunrise time. Our constitution also has different sunrise time. For example, 6 A.M.–10 A.M. is kapha time, 10 A.M.–2 P.M. is pitta time and so on.
Based on these clocks, one should design daily routine i.e. दिनचर्या. Daily routine helps us to maintian harmony among all vital forces working to keep our identity alive (cells, prana, swabhav, ahmkara etc).
Student life is dedicated to learn all of this by self-realization so that one can live Grihasthi jivan with minimal struggles.
Do our schools teach this? Oh no, our schools teach how to help NGOs. How to take care of patients and such after-shock care plans. Prevention is not in syllabus.