Blog Page 126

InterStellar and Tripura Rahasya

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The terms time warp, space warp, and time-space warp are commonly used in science fiction. They sometimes refer to Einstein’s theory that time and space form a continuum that bends, folds, or warps from the observer’s point of view, relative to such factors as movement or gravitation. They are also used in reference to more fantastic notions of discontinuities or other irregularities in spacetime not based on real-world science. It shown beautifully in movie InterStellar

The Tripura Rahasya (Devanagari: त्रिपुरा रहस्य, Tripurā Rahasya) meaning The Mystery beyond the Trinity, is an ancient literary work in Sanskrit believed to have been narrated by Dattatreya to Parashurama.It is an ancient prime text is one of the treatise on Advaita school of classical Indian Metaphysics.

This is must read for all who really are interested in understanding true nature of the Universe. It is complex text. Very very complex. Mind bending.
One part of this text is about nature of the cosmos. It explained HOW WAKEFULNESS AND DREAM ARE SIMILAR IN NATURE AND OBJECTS ARE ONLY MENTAL IMAGES

Watch movie Interstellar after reading this text (it is bit lengthy too). You will enjoy movie thoroughly.

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Excerpt from Tripura Rahasya, Chapter 13
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1-2. The sage’s son made the king sleep, united his subtle body with the gross one left in the hole, and then woke him up.

3. On regaining his senses, Mahasena found the whole world changed. The people, the river courses, the trees, the tanks, etc., were all different.

4-30. He was bewildered and asked the saint:

“O great one! How long have we spent seeing your world? This world looks different from the one I was accustomed to! “Thus asked, the sage’s son said to Mahasena: ‘Listen King, this is the world which we were in and left to see that within the hill. The same has undergone enormous changes owing to the long interval of time. We spent only one day looking round the hill region; the same interval counts for twelve thousand years in this land; and it has accordingly changed enormously. Look at the difference in the manners of the people and their languages. Such changes are natural. I have often noticed similar changes before. Look here! This is the Lord, my father in Samadhi. Here you stood before, praising my father and praying to him. There you see the hill in front of you.

“By this time, your brother’s progeny has increased to thousands. What was Vanga, your country, with Sundara, your capital, is now a jungle infested with jackals and wild animals. There is now one Virabahu in your brother’s line who has his capital Visala on the banks of the Kshipra in the country of Malwa; in your line, there is Susarma whose capital is Vardhana in the country of the Dravidas, on the banks of the Tambrabharani. Such is the course of the world which cannot remain the same even for a short time. For in this period, the hills, rivers, lakes, and the contour of the earth have altered. Mountains subside; plains heave high; deserts become fertile; plateaus change to sandy tracts; rocks decompose and become silt; clay hardens sometimes; cultivated farms become barren and barren lands are brought under tillage; precious stones become valueless and trinkets become invaluable; salt water becomes sweet and potable waters become brackish; some lands contain more people than cattle, others are infested with wild beasts; and yet others are invaded by venomous reptiles, insects and vermin. Such are some of the changes that happen on the earth in course of time. But there is no doubt that this is the same earth as we were in before.”

You can read Tripura Rahasya translation here:

http://scriptures.ru/tripura1.htm

Circadian Disturbances and Turmeric as Saviour

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Admit it – We indeed are having cognitive problems in youth now at epidemic level. Erratic behavior, psycho activities, memory loss, irresponsible responses etc.

Major cause is: Irregular bio-rhythms and irregular life routine. Irregular life is either forced by social norms (night shift job, late night family parties) or self-earned.

Solution is to amend the routine as early as possible and start cure for damage done so far.

Turmeric is Mother Nature’s greatest of boons. Start taking 1 table spoon of turmeric every morning with empty stomach (followed by water from copper vessel if you need it). And then do not consume anything for 2 hrs. Keep this routine for at least 90 days.

Turmeric available in market is not pure. Try to avail organically grown farm fresh turmeric (which can have full of curcumin oil) and grind it at home.

Start it before it is too late. Turmeric is also good for slowing down aging and fighting against cancer and other immune system disorders.

Necessity is mother of invention. Post-industrialization, mankind has disturbed human body’s circadian rhythms (A daily cycle of activity observed in many living organisms which depends on Sunrise and Sunset) severely by including post-sunset activities under artificial lights. There is 24×7 work culture now. Effects are inevitable. You see many among us with memory loss in young age. So it became necessity to invent memory supporting tools (From To Do list to modern smartphones)

Result? Slow but gradual degradation human mind’s strength like memory.

1) Keep low light at home after sunset
2) Avoid artificial lights at work (I know this is difficult but critical )
3) At least spend time in nature during sunrise and sunset
4) Make sure your kids sleep early (so that they avoid artificial lights for long)

How artificial light is wrecking your sleep, and what to do about it

Blue light and melatonin suppression

It is well established that short-wavelength or “blue” light is the most melatonin-suppressive; this is the type of light typically emitted by devices such as televisions, computer screens, and cellphones. (14, 15) To produce white light, these electronic devices must emit light at short wavelengths, close to the peak sensitivity of melatonin suppression. (16) This means that products such as tablets, smartphones, and other devices with self-luminous electronic displays are major sources for suppressing melatonin at night, thereby reducing sleep duration and disrupting sleep. (Figure credit: Wood et al, 2013)

How artificial light is wrecking your sleep, and what to do about it

Spice up your memory

http://www.monash.edu/news/articles/spice-up-your-memory

Adding just one gram of turmeric to breakfast could help improve the memory of people who are in the very early stages of diabetes and at risk of cognitive impairment.

The finding has particular significance given that the world’s ageing population means a rising incidence of conditions that predispose people to diabetes, which in turn is connected to dementia.

Early intervention could help to reduce the burden, whether by halting the disease or reducing its impact, said Emeritus Professor Mark Wahlqvist, from the Monash Asia Institute at Monash University.

Professor Wahlqvist recently led a study in Taiwan that tested the working memory of men and women aged 60 or older who had recently been diagnosed with untreated pre-diabetes.

“Working memory is widely thought to be one of the most important mental faculties, critical for cognitive abilities such as planning, problem solving and reasoning,” he said.

“Assessment of working memory is simple and convenient, but it is also very useful in the appraisal of cognition and in predicting future impairment and dementia.”

In the placebo-controlled study, subjects were given one gram of turmeric with an otherwise nutritionally bland breakfast of white bread. Their working memory was tested before and some hours after the meal.

“We found that this modest addition to breakfast improved working memory over six hours in older people with pre-diabetes,” Professor Wahlqvist said.

Turmeric is widely used in cooking, particularly in Asia. Its characteristic yellow colour is due to curcumin, which accounts for 3 to 6 per cent of turmeric and has been shown by experimental studies to reduce the risk of dementia.

“Our findings with turmeric are consistent with these observations, insofar as they appear to influence cognitive function where there is disordered energy metabolism and insulin resistance,” Professor Wahlqvist said.

The study, which was published in the Asia Pacific Journal of Clinical Nutrition, also involved a number of research institutes in Taiwan.

Post-Industrial Age Circadian Disturbances and Mass Zombieness

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Necessity is mother of invention. Post-industrialization, mankind has disturbed human body’s circadian rhythms (A daily cycle of activity observed in many living organisms which depends on Sunrise and Sunset) severely by including post-sunset activities under artificial lights. There is 24×7 work culture now. Effects are inevitable. You see many among us with memory loss in young age. So it became necessity to invent memory supporting tools (From To Do list to modern smartphones)

Result? Slow but gradual degradation human mind’s strength like memory.

Some suggestions to keep self fit against odds.

1) Keep low light at home after sunset
2) Avoid artificial lights at work (I know this is difficult but critical 🙁 )
3) At least spend time in nature during sunrise and sunset
4) Make sure your kids sleep early (so that they avoid artificial lights for long)


Research


 

Stanford biologists explore link between memory deficit and misfiring circadian clock

http://news.stanford.edu/pr/2014/pr-memory-circadian-rhythm-111714.html

By disrupting Siberian hamsters’ circadian rhythms, Stanford scientists have identified a part of the brain that, when misfiring, inhibits memory. The work could lead to therapies for neurodegenerative diseases in humans.

 

“When that clock doesn’t work well, memory deficits show up.”

 

Anyone who has struggled with a foggy brain while adjusting to daylight saving time knows first-hand how an out-of-sync circadian clock can impair brain function.

Now, by manipulating the circadian clocks of Siberian hamsters, Stanford scientists may have identified a brain structure that disrupts memory when circadian rhythms fall apart, as they often do in patients with neurodegenerative diseases such as Alzheimer’s.

“What we’ve been able to show is that the part of the brain that we absolutely know contains the circadian clock, the suprachiasmatic nucleus (SCN), also has an important role in learning and memory,” said Norman Ruby, a senior research scientist of biology at Stanford and senior author on the study. “When that clock doesn’t work well, memory deficits show up.”

Importantly, the researchers found that a broken clock impairs memory, but when they surgically removed the SCN from the hamsters, their memory abilities returned in full force, creating the possibility for new therapies.

Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing

http://science.sciencemag.org/content/346/6211/854.full

Bacteria: Our friends

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Bacteria our friends, really?

Bacteria are our friends. Viruses are our messengers.
When we kill both the friends and their messengers, we are doomed.
It is high time we look at science of health with new fresh holistic perspective.

We may think of ourselves as just human, but we’re really a mass of microorganisms housed in a human shell. Every person alive is host to about 100 trillion bacterial cells. They outnumber human cells 10 to one and account for 99.9 percent of the unique genes in the body.
Our collection of microbiota, known as the microbiome, is the human equivalent of an environmental ecosystem. Although the bacteria together weigh a mere three pounds, their composition determines much about how the body functions and, alas, sometimes malfunctions.
In short, what we are boast as body, is nothing but gift of our friends i.e.Bacteria. What we call ‘I’ is nothing but summation of Ego of all bacterial communities we host. Our habits, our responses are governed by them. As per one research, our cravings for specific food taste is also governed by these tiny little friends living in our body. Newborn’s body is sterile in womb. When it passes through mother’s vagina, bacteria in vagina adopts new body. These bacteria gives newborn sense and direction for breastfeeding. This is the reason why majority C-section delivered infants do not have immediate sense to suck mother’s nipple. Their essential friends from vagina are missing! We are protected from bad bacteria because good friends are present. As soon as we live in stress (lack of nutrition or mental stress), good friends start dying. Once they die, our body is exposed to all so called bad bacteria (actually they are not bad. They are doing their job to clean the dead bacteria and body cells).

If I start writing all good things bacteria do for us, this note will become book 🙂.

Amazing ecology host we are. We are caretakers of all tillion+ bacteria friends. In return, they provide us healthy life.

What changes in life style are needed?

1) Take healthy food so that you always remain healthy and provide enough food to bacteria friends. Fresh Air, fresh water and organic food – must strive for it.
2) Routine should be regular so that body is never under stress and so bacteria friends are never under stress.
3) Do not take mental stress at work, at home, in family relations.
4) Do not be so ambitious that you take a toll of body.
5) If you follow point 1-4, you will never need antibiotics. Avoid them
6) Stop usage of cleaning agents at home and gradually adopt natural cleaning agents like

Take care.

Side note: Antibiotics are like Tsunami of chemicals. Total destruction by highest level of cellular depression. They cannot differentiate good vs bad bacteria. They purge all. Once they purge all, body is again sterile. You never know, what all new bacteria will come back. So better to remain healthy and avoid them.


Research


We Are Our Bacteria

We may think of ourselves as just human, but we’re really a mass of microorganisms housed in a human shell. Every person alive is host to about 100 trillion bacterial cells. They outnumber human cells 10 to one and account for 99.9 percent of the unique genes in the body.

Our collection of microbiota, known as the microbiome, is the human equivalent of an environmental ecosystem. Although the bacteria together weigh a mere three pounds, their composition determines much about how the body functions and, alas, sometimes malfunctions.

Like ecosystems the world over, the human microbiome is losing its diversity, to the potential detriment of the health of those it inhabits.

Dr. Martin J. Blaser, a specialist in infectious diseases at the New York University School of Medicine and the director of the Human Microbiome Program, has studied the role of bacteria in disease for more than three decades. His research extends well beyond infectious diseases to  autoimmune conditions and other ailments that have been increasing sharply worldwide.

In his new book, “Missing Microbes,” Dr. Blaser links the declining variety within the microbiome to our increased susceptibility to serious, often chronic conditions,  from allergies and celiac disease to Type 1 diabetes and obesity. He and others primarily blame antibiotics for the connection.

The damaging effect of antibiotics on microbial diversity starts early, Dr. Blaser said. The average American child is given nearly three courses of antibiotics in the first two years of life, and eight more  during the next eight years. Even a short course of antibiotics like the widely prescribed  Z-pack (azithromycin, taken for five days), can result in long-term shifts in the body’s microbial environment.

But antibiotics are not the only way the balance within us can be disrupted. Cesarean deliveries, which  have soared  in recent decades, encourage the growth of microbes from the mother’s skin, instead of from the birth canal, in the baby’s gut, Dr. Blaser said in an interview.

This change in microbiota can reshape an infant’s metabolism and immune system. A recent review of 15 studies involving 163,796 births found that, compared with  babies delivered vaginally, those born by cesarean section were 26 percent more likely to be overweight and 22 percent more likely to be obese as adults.

The placenta has a microbiome of its own, researchers have discovered, which may also contribute to the infant’s gut health and help mitigate the microbial losses caused by cesarean sections.

Read more:

East India Company and Education

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East India Company was not interested, interfering in local Indian’s education affairs. They ignored it until 19th century. When British government first made proposal to East India Company, to introduce school masters and missionaries in Indian Society as their humble Duty, Board of directors of East India Company replied:

“India has her own system of education which had been in existence from time immemorial. The Hindus have as good a system of faith as most people and that it would be madness to attempt their conversion or to give them any more learning or any description of learning than what they already have”

Three people came on state during 1820s and 1830s. William Bentinck as Governor General. Macaulay as Legislative member of supreme council and William Adam as Education system surveyor.

William Bentinck was appointed to take decision whether to promote conversion via education or not. William Adam was in favor of continuing with native education. Macaulay was in favor of introducing English education and missionaries.

Bentinck liked Macaulay’s idea and on the 7th march, 1835, passed a resolution in favor of promotion of European education among Native India and diverted all education funds for English education. This exclusive proposal sealed the fate of Sanskrit based education in her own land. Adam’s proposal was later rejected stating it as ‘Impracticable’ and thus western education got the monopoly in India and a splendid opportunity was lost to introduce unified education system based on Sanskrit.

Why Bentinck approved Macaulay’s plan instead Adam’s when he himself appointed Adam to do Survey of Native education system?

Conditioned citizens are better obedient slaves than free thinking individuals.

Eligibility for receiving Gau Prasad

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I call गौमूत्र,गौमय (गोबर) & गौदुग्ध as प्रसाद.

प्रसादस्तु प्रसन्नता |

प्रसाद = That which brings जीव in state of प्रसन्नता. प्रसन्नता = Lack of illness.

गौसेवा से उत्पन्न प्रसन्नता को प्रसाद माना गया हैं and Not all dung, mutra, milk are प्रसाद.

If you want to see magical cure by गौमूत्र,गौमय (गोबर) & गौदुग्ध, begin गौसेवा.

Without selfless गौसेवा, गौमूत्र,गौमय (गोबर) & गौदुग्ध can not act like a प्रसाद. They may be full of physical benefits but can not be called प्रसाद.

Who is potent enough to receive प्रसादम्?
रागद्वेषवियुक्तैस्तु विषयानिन्द्रियैश्चरन् ।
आत्मवश्यैर्विधेयात्मा प्रसादमधिगच्छति ।।
परंतु अपने अधीन किये हुए अन्त:करणवाला साधक अपने वश में की हुई, राग द्वेष से रहित इन्द्रियों द्वारा विषयों में विचरण करता हुआ अन्त:करण की प्रसन्नता को प्राप्त होता है ।।
But the self-controlled practicant, while enjoying the various sense-objects through his senses, which are disciplined and free from likes and dislikes, attains placidity of mind.

गौ माँ से मशीन बन गयी…पर भक्तजन सोते रहे..मशीनसे मॉस बनी…फिर भी..सोते रहे…and they expect magical cure 🙁

 

Joint Family Living and Immunity

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Joint family living is extinct custom in most Indian lineages. Due to this extinct idea, upcoming generations will miss, not only cultural inheritance but also biological inheritance.

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Cultural inheritance – easy to understand. Common sense. Google

In classroom biology, we are taught about DNA based biological inheritance from paternal and maternal lines but story does not end there.

Exposure-sensitive periods in childhood and sex-specific transmissions are features that support biological rather than cultural transmission. Story begins with grand-parents exposure to children during exposure-sensitive growth periods. Grand-father and grand-mother – both plays critical role of transmitting surrogate biological instructions to growing children. Surrogate instructions are those gene expression, which are not transmitted by parents in their DNA. These gene-expressions, provide extra protection against most possible generational immunity buildup. Modern science has just started investigating this link. [Some studies are shared at the end of this note. This studies also suggest that why it is important for you to discard bad habits and develop good habits.]

And what do we do with our grandparents? We send them to old age home! What a stupid generation! Crime against civilization! If you love your children (which is possible if they are not product of your sex instinct and are not accidently delivered due to one night mistake i.e. Not so planned parenting) Think twice before you decide to live separate from your parents.

Parents, grand-parents, siblings, cousins – they all play role in child development [1]. I know many parents, sacrificing career opportunities to focus on child development. Results are amazing. Take care in national interest. Your child is future citizen. Do not produce weak generation. Fight against modern societal perils. Encourage joint family living.


Research


[1] Family structure, neonatal infection, and hay fever in adolescence.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1511536/

OBJECTIVE: To determine whether increased numbers of siblings and infection in early life protect against allergic sensitisation. DESIGN: Historical cohort study. SETTING: Sheffield, UK. SUBJECTS: 11,765 children aged 11-16 years for whom a history of neonatal infectious illness had been recorded systematically at 1 month of age. METHODS: A history of hay fever and family structure was obtained by postal questionnaire; neonatal illness history was ascertained from health visitor records; 723 children underwent skin prick testing with mixed grass pollen extract. RESULTS: The prevalence of hay fever was reduced (p < 0.0001) among children of younger mothers, and those from larger families. The number of older siblings exerted a stronger independent effect than the number of younger siblings (p < 0.001). Infants breast fed exclusively during the first month were at higher risk (p < 0.05) of subsequent hay fever, independent of demographic factors. Adolescents at high risk of hay fever by virtue of their family structure were more likely to be sensitised to grass pollen (p < 0.002). No significant relations emerged between hay fever and infection in the first month of life, even among children born in June. CONCLUSIONS: The association of hay fever with family structure is not due to reporting bias and reflects an environmental influence on allergic sensitisation. The effects of sibship size, birth order, and infant feeding are consistent with a protective influence of postnatal infection. The first month of life and the first postnatal exposure to allergen are not the critical periods during which this protective effect is determined.

Grandma’s Experiences Leave a Mark on Your Genes

Your ancestors’ lousy childhoods or excellent adventures might change your personality, bequeathing anxiety or resilience by altering the epigenetic expressions of genes in the brain.

http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes

Your Diet Affects Your Grandchildren’s DNA, Scientists Say

http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes

You are what you eat, the saying goes. And, according to two new genetic studies, you are what your mother, father, grandparents and great-grandparents ate, too.

Diet, be it poor or healthy, can so alter the nature of one’s DNA that those changes can be passed on to the progeny. While this much has been speculated for years, researchers in two independent studies have found ways in which this likely is happening.

The findings, which involve epigenetics, may help explain the increased genetic risk that children face compared to their parents for diseases such as obesity and diabetes.

Time to take epigenetic inheritance seriously

http://www.nature.com/ejhg/journal/v10/n11/full/5200901a.html

Whilst one striking result relates to the grandfather’s food availability, epigenetic transmission from just father to child would be sufficient to set up a cascade of metabolic responses down the generations.

 

Products expectant mothers should avoid during first trimester

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Toxic urban life style is killing our future 🙁

When you ask newly wedded couples to take care of these things, they often show their arrogance of foolishness and say: “I don’t care. My life, my style!”

🙁

For last decade, I suggest all married young couple to take care of life before it is conceptualized. From diet, sleep to utilities, married life demands critical care. But hardly anyone listen. 🙁

Everyone is in cloud 9 of modernity. 🙁

Expectant mothers in their first trimester should avoid certain cosmetics, cleaning agents and medicines, to protect the developing fetal brain from chemicals that can trigger autism, York U health researchers have found.

The list is long: cleaning solvents, pesticides, nonsteroidal anti-inflammatory drugs such as acetylsalicylic acid; misoprostol (a drug used for inducing labor); polychlorinated bisphenyls used as industrial lubricants; polybrominated diphenyl ethers found in wood and textiles; phthalates in PVC flooring, children’s toys, and cosmetics and lotions.


Research


York U researchers list products expectant mothers should avoid during first trimester

York U researchers list products expectant mothers should avoid during first trimester

Use it or Lose it: Study Shows Stopping Exercise Decreases Brain Blood Flow

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We all know that we can quickly lose cardiovascular endurance if we stop exercising for a few weeks, but what impact does the cessation of exercise have on our brains? New research led by University of Maryland School of Public Health researchers examined cerebral blood flow in healthy, physically fit older adults (ages 50-80 years) before and after a 10-day period during which they stopped all exercise. Using MRI brain imaging techniques, they found a significant decrease in blood flow to several brain regions, including the hippocampus, after they stopped their exercise routines.

“We know that the hippocampus plays an important role in learning and memory and is one of the first brain regions to shrink in people with Alzheimer’s disease,” says Dr. J. Carson Smith, associate professor of kinesiology and lead author of the study, which is published in Frontiers in Aging Neuroscience in August 2016. “In rodents, the hippocampus responds to exercise training by increasing the growth of new blood vessels and new neurons, and in older people, exercise can help protect the hippocampus from shrinking. So, it is significant that people who stopped exercising for only 10 days showed a decrease in blood flow to brain regions that are important for maintaining cognitive health.”


Research


http://journal.frontiersin.org/article/10.3389/fnagi.2016.00184/full

Hippocampal and Cerebral Blood Flow after Exercise Cessation in Master Athletes

While endurance exercise training improves cerebrovascular health and has neurotrophic effects within the hippocampus, the effects of stopping this exercise on the brain remain unclear. Our aim was to measure the effects of 10 days of detraining on resting cerebral blood flow (rCBF) in gray matter and the hippocampus in healthy and physically fit older adults. We hypothesized that rCBF would decrease in the hippocampus after a 10-day cessation of exercise training. Twelve master athletes, defined as older adults (age ≥ 50 years) with long-term endurance training histories (≥15 years), were recruited from local running clubs. After screening, eligible participants were asked to cease all training and vigorous physical activity for 10 consecutive days. Before and immediately after the exercise cessation period, rCBF was measured with perfusion-weighted MRI. A voxel-wise analysis was used in gray matter, and the hippocampus was selected a priori as a structurally defined region of interest (ROI), to detect rCBF changes over time. Resting CBF significantly decreased in eight gray matter brain regions. These regions included: (L) inferior temporal gyrus, fusiform gyrus, inferior parietal lobule, (R) cerebellar tonsil, lingual gyrus, precuneus, and bilateral cerebellum (FWE p < 0.05). Additionally, rCBF within the left and right hippocampus significantly decreased after 10 days of no exercise training. These findings suggest that the cerebrovascular system, including the regulation of resting hippocampal blood flow, is responsive to short-term decreases in exercise training among master athletes. Cessation of exercise training among physically fit individuals may provide a novel method to assess the effects of acute exercise and exercise training on brain function in older adults.

 

When you eat matters, not just what you eat

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Life routine of Sanatani/ following Ayurveda, is highly specialized / individualized.

Timinings are fixed. Sleeping time, wake up time, meal time, pooja time, exercise time, break time – all fixed.

Not following means stress for cellular processes, organ processes and body processes. Chaos. Mleccha. 🙂

Observe youth and teens around. You can easily forecast their biological future. Chaos and rapid aging. Mleccha 🙂

“Every organ has a clock,” That means there are times that our livers, intestines, muscles, and other organs will work at peak efficiency and other times when they are–more or less–sleeping.

Those metabolic cycles are critical for processes from cholesterol breakdown to glucose production, and they should be primed to turn on when we eat and back off when we don’t, or vice versa.

“When we eat randomly, those genes aren’t on completely or off completely,” Panda said. The principle is just like it is with sleep and waking, he explained. If we don’t sleep well at night, we aren’t completely awake during the day, and we work less efficiently as a consequence.

First thing first:
Have fixed meal timings.
Have proper gaps between two meals.
Don’t eat 8-10 times a day as modern dietitians suggest.
Last meal and sleep : 4 hrs gap.
Exercise and meal : 45 mins gap.
Bath and meal : 30 mins gap.
No breakfast but full meal to begin the day.


Research


Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

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While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes’ expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.

http://www.sciencedirect.com/science/article/pii/S1550413112001891

When you eat matters, not just what you eat

https://www.eurekalert.org/pub_releases/2012-05/cp-wye051112.php

When it comes to weight gain, when you eat might be at least as important as what you eat. That’s the conclusion of a study reported in the Cell Press journal Cell Metabolism published early online on May 17th.

When mice on a high-fat diet are restricted to eating for eight hours per day, they eat just as much as those who can eat around the clock, yet they are protected against obesity and other metabolic ills, the new study shows. The discovery suggests that the health consequences of a poor diet might result in part from a mismatch between our body clocks and our eating schedules.

“Every organ has a clock,” said lead author of the study Satchidananda Panda of the Salk Institute for Biological Studies. That means there are times that our livers, intestines, muscles, and other organs will work at peak efficiency and other times when they are–more or less–sleeping.

Those metabolic cycles are critical for processes from cholesterol breakdown to glucose production, and they should be primed to turn on when we eat and back off when we don’t, or vice versa. When mice or people eat frequently throughout the day and night, it can throw off those normal metabolic cycles.

“When we eat randomly, those genes aren’t on completely or off completely,” Panda said. The principle is just like it is with sleep and waking, he explained. If we don’t sleep well at night, we aren’t completely awake during the day, and we work less efficiently as a consequence.

To find out whether restricted feeding alone–without a change in calorie intake–could prevent metabolic disease, Panda’s team fed mice either a standard or high-fat diet with one of two types of food access: ad lib feeding or restricted access.

The time-restricted mice on a high-fat diet were protected from the adverse effects of a high-fat diet and showed improvements in their metabolic and physiological rhythms. They gained less weight and suffered less liver damage. The mice also had lower levels of inflammation, among other benefits.

Panda says there is reason to think our eating patterns have changed in recent years, as many people have greater access to food and reasons to stay up into the night, even if just to watch TV. And when people are awake, they tend to snack.

The findings suggest that restricted meal times might be an underappreciated lifestyle change to help people keep off the pounds. At the very least, the new evidence suggests that this is a factor in the obesity epidemic that should be given more careful consideration.

“The focus has been on what people eat,” Panda said. “We don’t collect data on when people eat.”

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