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GUT bacteria and Heart failure
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Heart Ganesh

I am not microbiologist but हनुमान & गणेश भक्त. And they give enough hints about the गण they protect for me within this body-universe.

I repeat almost daily and urge friends to take care of GUT by proper diet, surya Namaskar.

Area from GUT to Navel – very critical for existence. Protect it.

गणपति resides in GUT area . And to worship him, we generally keep fast. Fasting clean the GUT and transforms it from GUTTER into Heaven. So clean GUT means right decisions, right actions and in real sense गणेश acts as विध्नहर्ता.

During monsoon, our digestive power remains very low and so there are high chances that GUT remains polluted. So just when the monsoon is on the verge of end, we worship गणेश for 10 days.


Research


Heart failure is associated with loss of important gut bacteria

https://dzhk.de/en/news/latest-news/article/heart-failure-is-associated-with-loss-of-important-gut-bacteria/

“In the gut of patients with heart failure, important groups of bacteria are found less frequently and the gut flora is not as diverse as in healthy individuals. Data obtained by scientists of the German Centre for Cardiovascular Research (DZHK) provide valuable points of departure for understanding how gut colonisation is associated with the development and progress of heart failure.”

Influential factors: diet, medication, smoking

“Of course, other factors also affect the composition of our gut bacteria. We know that the gut flora of a vegan who starts eating meat changes within three days”, explains associate professor Dr. Mark Lüdde of the University Hospital Schleswig-Holstein, Campus Kiel. For this reason, we asked the Kiel-based researchers of dietary habits beforehand. Individuals with an extreme diet, such as a vegan diet, were not allowed to participate in their study. Instead, they chose individuals with a standard diet comprising both meat and vegetables for both groups.

In addition to diet, medication also affect the gut flora. It was, therefore, important that the control group also took medicinal products that patients with heart failure must take routinely. Antibiotics could not have been administered for at least three months prior. Smokers were also included in both groups. All participants were from the same region and were the same age; gender distribution and BMI were equal in both groups.

Consequence or cause of the disease?

The observed pattern of the reduced genera and families of bacteria seems very characteristic of heart failure, which is why these results may be new points of departure for therapies. The differences between healthy individuals and those with heart failure, thus, came about mainly through the loss of bacteria of the genera Blautia and Collinsella, as well as two previously unknown genera that belong to the families Erysipelotrichaceae and Ruminococcaceae. 

The Gut, the Heart, and TMAO

Here’s how it works: When people ingest certain nutrients, such as choline (abundant in red meat, egg yolks, and dairy products) and L-carnitine (found in red meat as well as some energy drinks and supplements), the gut bacteria that break it down produce a compound called trimethylamine (TMA). The liver then converts TMA into the compound, trimethylene N-oxide (TMAO).

The trouble with TMAO is that data show high levels contribute to a heightened risk for clot-related events such as heart attack and stroke—even after researchers take into account the presence of conventional risk factors and markers of inflammation that might skew the results. In their most recent analysis, scientists showed that high blood levels of TMAO were associated with higher rates of premature death in a group of 2235 patients with stable coronary artery disease. Those found to have higher blood levels of TMAO had a four-fold greater risk of dying from any cause over the subsequent five years.

The implications are intriguing. Taken together, the new studies suggest that positively altering the gut microbiota may help to reduce damage to blood vessels, resulting in a stronger cardiovascular system, and they point to targets for potential new heart disease therapies.

The Gut, the Heart, and TMAO

 

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