Modern research is suggestion personalized obesity treatment. Hmmm! That is what Ayurveda too prescribes! It is not always an exercise that works as an solution. Focus should be on different forms of fire and transformation processes in body! अग्नि play critical role in managing and curing obesity! And there is nothing as such related to genes!
Fat is predominantly water and earth element. Meda or Fat acts a fuel when it is digested properly. (Obesity is all about anticipation of body to store more and more fuel?) but not the Excess fat. Excess fat is raw and unprocessed due to dhatvagni. It is raw material that could not be transformed into either fat or subsequent sapta dhatu in sequence of transformation.
When your diet is too high compare to your digestive fire and dhatu-transformation fire (Hint GUT microbes), body fails to transform the food eaten into different layers of dhatu forms. And they are stored as excess fat, unprocessed, toxins. Protein and carbohydrates turn into excess fat.
Modern Ayurvedacharya do consider digestive enzymes as Pitta or Agni that can transform raw food into nutrients. Think through the lens of GUT microbes as they do the same job. They also represent a form of dhatu-agni, helping in transformation process.
The fat instead of being distributed across the skin, in obese person, fire remains accumulated in GUT. Food is turned into Meda but the process of transforming meda into further dhatu(s) is hampered.
When meda-dhatu-agni is low, excess fat is passed in stool. Stool will float on the water. Excess fat intake against digestive fire so liver is not able to process it and fatty stool is passed.
Lets us see what new research has to convey.
Processes in the gut that drive fat build-up around the waist
This means that important changes can be made to the way an individual’s gut processes and distributes fat by altering both their diet and microbial interactions in their gut.
On the back of the study researchers have built a gut metabolome bank that can help other scientists engineer bespoke and ideal gut environments that efficiently process and distribute fat. The study has also generated the first comprehensive database of which microbes are associated with which chemical metabolites in the gut. This can help other scientists to understand how bacteria in the gut affect human health.
‘This exciting work in our twins shows the importance to our health and weight of the thousands of chemicals that gut microbes produce in response to food. Knowing that they are largely controlled by what we eat rather than our genes is great news, and opens up many ways to use food as medicine. In the future these chemicals could even be used in smart toilets or as smart toilet paper.’
The human gut microbiome plays a key role in human health1, but 16S characterization lacks quantitative functional annotation2. The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype mediating host–microbiome interactions3. In this comprehensive description of the fecal metabolome, examining 1,116 metabolites from 786 individuals from a population-based twin study (TwinsUK), the fecal metabolome was found to be only modestly influenced by host genetics (heritability (H2) = 17.9%). One replicated locus at the NAT2 gene was associated with fecal metabolic traits. The fecal metabolome largely reflects gut microbial composition, explaining on average 67.7% (±18.8%) of its variance. It is strongly associated with visceral-fat mass, thereby illustrating potential mechanisms underlying the well-established microbial influence on abdominal obesity. Fecal metabolic profiling thus is a novel tool to explore links among microbiome composition, host phenotypes, and heritable complex traits.