Microbes

Microbes

Psychological Stress and INTESTINAL leak

Impact on intestine wall
Impact on intestine wall.Potential impact of stress-induced intestinal barrier dysfunction on health. Stress, via signals from the central nervous system, leads to altered release or response to neuroendocrine factors [such as corticotropin-releasing hormone (CRH)] in the intestinal mucosa. Such factors may act directly or indirectly on the epithelium, inducing barrier dysfunction and uptake of proinflammatory material (e.g., antigens, toxins, infectious agents, and their products) from the gut lumen. The resultant inflammation causes disability and increases stress, which further amplifies the defect.
I receive many queries related to premature aging. Reduced appetite, reduced sleep, grey hair, arthritis – All these issues manifest after 40. But you now see them even in age below 20.

In old age, we can understand, it is due to मन्दाग्नि (Mandagni – Low Fire) but how come they are now regular in young age?

Ama (आम) – Toxins – Something that is unripe. Unripe outcomes of biological process. it can be at the time of digestion, assimilation or purging. All three stages or any one of them, when not working as per laws of the body, accumulates toxins locally. That is आम.

These end products, being inadequately processed, have a macromolecular structure, which is bigger and grosser than those end products which might have produced if a complete processing would have taken place.

It happens naturally in old-age. It happens unnaturally in young age due to following habits:

Despite physically young and metabolically active, if you indulge in physical and mental activities just after having meal, you are disturbing active digestion process. This can result in Ama i.e. Toxins.

Irregular meal timings is another reason that disturbs fire-based processes in body.

Regular intake of food lacking hydration and fat (dry), cold food, stale food can also generate Ama.

Too many emotions out of balance. Extreme Kama, Krdha, Lobha, Moha, Irshya. Extreme lajja, shoka, abhimana, Udvega, Bhaya, Up-tapta (sad).

In many experimental studies, various types of physical and psychological stress are found to induce dysfunction of intestinal barrier, resulting in enhanced intake of potentially noxious material (e.g., antigens, toxins, and other proinflammatory molecule) from the gut lumen into the bloodstream [1] . This gives a very interesting proposition to see if these noxious materials play the role of ama as a progenitor to joint diseases as perceived in Ayurveda.

In short, Quality of the food + Intake method and timing + Mood + Compatibility with your nature and age play critical role in perfect digestion, assimilation and elimination.

Check your routine. Check life of avg urban teen-ager. You will realize reason behind early aging. If such habits continue for 3-4 generations, rapid aging becomes स्वभाव of the gene-pool.

Take care. Check your habits in mirror. Correct them. Whatever happened so far, cannot be reversed but you can certainly slow down further aging by eliminating toxins and not making their way again in the body.


Stress and intestinal barrier function


Potential impact of stress-induced intestinal barrier dysfunction on health.
Potential impact of stress-induced intestinal barrier dysfunction on health.

The intestinal mucosa is continuously exposed to an immense load of antigens from ingested food, resident bacteria, invading viruses, etc. The single-cell epithelial layer lining the gut lumen (surface area ∼300 m2) has conflicting functions, playing a major role in the digestion and absorption of nutrients and at the same time constituting the organism’s most important barrier between the internal and external environments. Under normal circumstances, the epithelium allows only minute quantities of intact antigens to cross into the mucosa, where they interact with the mucosal immune system to downregulate inflammation (known as oral tolerance). On the other hand, it is necessary for enteric pathogens to activate immune cells and initiate the inflammatory response required to clear the infection. In some disease conditions, such as inflammatory bowel disease, excessive penetration of antigens through the epithelial layer may result in inappropriate immune stimulation, leading to chronic gastrointestinal inflammation. The ability of the epithelium to control uptake of molecules into the body is denoted as the intestinal barrier function.

http://ajpgi.physiology.org/content/280/1/G7.figures-only

Why home-based fermented food? Link to Acidity

The Pink Acidity Medicine Src: http://goo.gl/ycnG8x
The Pink Acidity Medicine
Src: http://goo.gl/ycnG8x

In last post, I talked about importance of bacteria in controlling our mood/mental state.

This[1] interesting article supports the hypothesis I presented about eating ONLY home-made dahi/butter milk/yogurt (to avoid alien bacteria of alien environment i.e. shop/factory where dahi is prepared in mass). It also suggests another hypothesis of having Panchmrit prepared from all unrefined, unprocessed raw milk, jaggery, sugar and honey.

More processed food you eat, more alien food you eat (Food prepared in alien environment i.e. restaurants), frequent travelling you do (so eating outside food frequently) and more acidity you suffer from.

The researchers found that scavengers, or species that eat food at high risk of microbial contamination, have more acidic stomachs. This acidity allows the stomach to act as a filter, effectively controlling which microbes can pass through the stomach to the gut.

Passing stomach acidity is very essential for probiotic food. Most probiotic food available in market fail here. It only helps in increasing acidity of the stomach.

An analysis of data on stomach acidity and diet in birds and mammals suggests that high levels of stomach acidity developed not to help animals break down food, but to defend animals against food poisoning. The work raises interesting questions about the evolution of stomach acidity in humans, and how modern life may be affecting both our stomach acidity and the microbial communities that live in our guts.

Antacids is not a solution. It is actually counter-health solution. Right solution is to avoid eating at unknown food-joints, at unknown places. Avoid highly processed food full of chemicals.

Pathology-Low-Acid-Level-Diseases
Pathology-Low-Acid-Level-Diseases

1) If you start cooking for self, you will never need acidity regulators!acidity regulators are against the innate nature of stomach! Never take them! They worsen the stomach working.
2) Take good care of selecting and preparing probiotic food.
3) Avoid outside food and travelling as much as possible
4) Avoid non-veg diet if you are living in terrain where plant based diet is available.

Take care. Never seek easy short-sighted solutions.

The Evolutionary Link Between Diet and Stomach Acidity

[1] Reference: https://news.ncsu.edu/2015/07/beasley-acid-2015/

Diet and Stomach Acidity
Diet and Stomach Acidity

Gastric acidity is likely a key factor shaping the diversity and composition of microbial communities found in the vertebrate gut. We conducted a systematic review to test the hypothesis that a key role of the vertebrate stomach is to maintain the gut microbial community by filtering out novel microbial taxa before they pass into the intestines. We propose that species feeding either on carrion or on organisms that are close phylogenetic relatives should require the most restrictive filter (measured as high stomach acidity) as protection from foreign microbes. Conversely, species feeding on a lower trophic level or on food that is distantly related to them (e.g. herbivores) should require the least restrictive filter, as the risk of pathogen exposure is lower. Comparisons of stomach acidity across trophic groups in mammal and bird taxa show that scavengers and carnivores have significantly higher stomach acidities compared to herbivores or carnivores feeding on phylogenetically distant prey such as insects or fish. In addition, we find when stomach acidity varies within species either naturally (with age) or in treatments such as bariatric surgery, the effects on gut bacterial pathogens and communities are in line with our hypothesis that the stomach acts as an ecological filter. Together these results highlight the importance of including measurements of gastric pH when investigating gut microbial dynamics within and across species

Microbes, Mood Changer, Dahi

Panchamrut Img src: http://goo.gl/a9VKlP
Panchamrut
Img src: http://goo.gl/a9VKlP

No ritual of this land ends without Prasad. No Prasad without Panchamrita (पञ्चामृत). It is a mixture of five foods used in Hindu worship and puja, usually honey, sugar, milk, yogurt, and ghee. I remember, how my mother used to stop me every time I start from home for exam. She would feed a spoon full of misti dahi (dahi and/or jaggery/sugar) as a शुकन token and my success in exams. In marriage ritual, पञ्चामृत is used profusely as it is major emotional event for both families. Mighty God Krishna is never seen without probiotic food.

Amazing science behind it! As I shared in last post about connection of CAT and अपशुकन in last post, here is the connection of पञ्चामृत and शुकन (Well-being or well-execution of future immediate actions). All thanks to tiny little microbes whom we are ready to kill everyday using anti-microbes weapons. 🙂

Fermentation And Life Img src: https://goo.gl/b8ec5Z
Fermentation And Life
Img src: https://goo.gl/b8ec5Z

Lactobacilli bacteria in dahi reduces anxiety, chronic fatigue and depression. That is the magic of just one type of bacteria. Generally when dahi is fermented at home, it can have all beneficial bacteria. In पञ्चामृत, ghee and honey are potent probiotic food, increasing potency of altering our mood.

There is another bacteria in probiotic food: Bifidobacterium infantis. Probiotic treatment with B. infantis in a rat maternal separation model of depression resulted in a normal immune response, normal behavior, and normal levels of stress hormone in the brainstem compared to untreated rats. (As I’ve stated many times here, gut function affects all body parts, including the brain.)
So your mother or grandmother was more scientific than you and me who were laughing on them for blind rituals.

Things to take care for availing full benefits of probiotic Dahi

1) Fermentation must happen at home. Factory made Dahi will have bacteria from factory environment (other than Lactobacilli). Our home is full of bacteria suited for our body. So prepare dahi at home.

2) For probiotics to survive beyond acidic stomach pathway and establish themselves in GUT, milk, honey, jiggery used should be full of nutrition which bacteria can use for survival in harsh stomach conditions. Find Raw Desi Gay milk for it. Find chemical-free unprocessed honey and jiggery. Find unrefined non-white sugar.

3) Consume fresh Dahi. Do not refrigerate.

4) Prepare Panchamrit. Not exclusive dahi. Take in small quantity. For large quantity, prepare butter milk.

5) Avoid during monsoon due to unstable environment crowded so many different pathogens.

Humans as Superorganisms: How Microbes, Viruses, Imprinted Genes shapes Our Behavior

You will be assimilated. Resistance is futile.
—The Borg, Star Trek: The Next Generation

For entire last century and till now, we were groomed with a high human EGO. We are educated to see illusion of our body separate from the world. This delusion did not just went against our health but also developed destructive ideas which are right now creating havoc on earth.

What is the way ahead?

Break the illusion and develop new insight about our existence i.e. Human as a super-organism complex.

To understand better, consider beehive as super-organism. Anthill as super-organism. They do share their social decisions. They do work like one entity.

Img src: http://darwinian-medicine.com/wp-content/uploads/2015/07/modern-lifestyle-microbiome.jpg
Img src: http://darwinian-medicine.com/wp-content/uploads/2015/07/modern-lifestyle-microbiome.jpg

Unbeknownst to many people, our emotions, cognition, behavior, and mental health are influenced by a large number of entities that reside in our bodies while pursuing their own interests, which need not coincide with ours. Such entities include microbes, viruses, foreign human cells, and imprinted genes regulated by virus like elements. This article provides a broad overview, aimed at a wide readership, of the consequences of our coexistence with these entities. Its aim is to show that we are not unitary individuals in control of ourselves but rather “holobionts” or superorganisms—meant here as collections of human and nonhuman elements that are to varying degrees integrated and, in an incessant struggle, jointly define who we are.

Read this[1] research paper and learn to self with different outlook. I bet, if you alter your outlook towards self and others, we will have far better life than what we have right now. Take care.
If I take opportunity to connect the dots, as per Ayurveda, this body is nothing but infinite rhythms (नाड़ी) working together based on Pranic Intelligence (प्राणमय शरीर). Many of such rhythms form cells-complex and organs and many remain as separate organisms like microbes, viruses etc. Ultimately, it is प्राण that is controlling the physical body.

[1] Do read this: http://www.psy.unipd.it/~kramer/files/KramerBressan2015.pdf

In computer engineering, I learned bottom up approach. Just like that, we emerge as 1 single universe. 1 Mind divided into many…and that goes on to the infinity level. 🙂

Our body is just one state in between. 🙂 (Y)

So you and me, we all, are related. Are actually one super-organism like how trillions+ microbes and worms are part of each one of us.

And when some of the microbes forget their duty towards super-organism i.e. our body, we get sickness, same way, when some of us forget duties towards the universe,yet another state of super-organism, we get pollution, wars, weapons etc.

http://dailynous.com/2015/07/24/we-are-not-human-individuals/

 

Cat-love, Vegetarian diet vs Meat-diet, Brain Microbes, Infection

2
CAT love?
CAT love?

Toxoplasma gondii is a microbe. Toxoplasma starts its life cycle as an egg inside the intestines of a cat (or another feline); rats and mice habitually feed on the cat’s excrements and may ingest the eggs. Mammals, birds, and fish that consume infected animals or ingest contaminated water get infected too. Eating their meat undercooked is by far the most typical, though not the only (for a review, see Tenteret al., 2000), way of contracting the parasite for us.

Toxoplasma gondii
Toxoplasma gondii

Close proximity with Cat or mice may increase chances of getting this infection. It is common infection in 50% of developed nations and less common in vegetarian nations like India.

This microbes from Cat infects our brain. It results into workplace and traffic accidents (possibly because it renders one less careful and slows down reaction time), depression, suicides,changes in personality, and various mental and neurological diseases, including bipolar and obsessive-compulsive disorders.

In particular, Toxoplasma infection raises the probability of developing schizophrenia 2.7 times, and is thereby the largest known single risk factor of the disorder—larger than any of the currently known genetic and environmental ones (for a meta-analysis, see Torrey,Bartko, Lun, & Yolken, 2007)

Toxoplasma gondii life cycle
Toxoplasma gondii life cycle

Now visit the old कहावत : “काली बिल्ली रास्ता काटे तो अपशकुन होता है।” What is अपशकुन ? Failure in desired mental/physical actions.

Was this instruction given to save us from possible Toxoplasma gondii infection so that we do not suffer from mental disorders which can hamper success of our duties? 🙂

Sayings are not always blind beliefs. They are societal conclusions based on several generations observations. Not a worth to reject straight away with our shallow educated rational minds. 😉

PS: This does not mean we start hating cats. It is just that, we must take care of washing hands and legs when the local area is full of stray dogs and cats. (Nowadays, we don’t have such setup. Our bathrooms and washrooms are way behind the curtains of bedroom! 😀 . In ideal home setup, entrance must have wash-area )

Read more:

http://www.theatlantic.com/magazine/archive/2012/03/how-your-cat-is-making-you-crazy/308873/

The parasite, which is excreted by cats in their feces, is called Toxoplasma gondii(T. gondii or Toxo for short) and is the microbe that causes toxoplasmosis—the reason pregnant women are told to avoid cats’ litter boxes. Since the 1920s, doctors have recognized that a woman who becomes infected during pregnancy can transmit the disease to the fetus, in some cases resulting in severe brain damage or death. T. gondii is also a major threat to people with weakened immunity: in the early days of the AIDS epidemic, before good antiretroviral drugs were developed, it was to blame for the dementia that afflicted many patients at the disease’s end stage. Healthy children and adults, however, usually experience nothing worse than brief flu-like symptoms before quickly fighting off the protozoan, which thereafter lies dormant inside brain cells—or at least that’s the standard medical wisdom.

Toxoplasma Gondii, Parasite In Cat Feces, Linked To Schizophrenia And Other Mental Illness

Cats — especially stray or outdoor ones — may carry a parasite known as Toxoplasma gondii (T. gondii) in their feces. This parasite is able to infect any warm-blooded animal, including humans; the CDC estimates that some 60 million Americans have it. Most people don’t show any symptoms of the infection, but people with a weaker immune system could get sick with toxoplasmosis, which has been linked to miscarriage, fetal developmental disorders, blindness, and flu-like symptoms.

http://www.medicaldaily.com/toxoplasma-gondii-parasite-cat-feces-linked-schizophrenia-and-other-mental-illness-337030

Microbes and Svadharma

===================================================
Relation between I and my bacterial friends (Bacteria residing on my body)
===================================================

Being धार्मिक = Promote symbiosis but respect differences

symbiotic-relationship
symbiotic-relationship

The term biologists use for our relations with Bacteria is ‘Amphibiosis’. A symbiotic relationship that under certain circumstances can be helpful and other circumstances can be harmful, with the helpful and harmful aspects referring to either host or symbiont.

The term we use for this “Dharmic Relation”. In dharmic relation, each participant is following own dharma. Own duty towards the integrity of the cellular complex called ‘Body’. Sometimes, cells forget their duty. When cells forget duty, it is important for rest of the dharmic*** body cells to purge them. Sometimes, bacteria(s) do not do their duty so immune system flush them from body. Sometimes, by accident or bad habits of ours, non-compatible life forms enter into body. For example, कृमि worms. Most of the times, such non-compatible disturbances happen when our ego “I” forgets to perform duties. For example, eat food anytime of the day. Now this disturbs the digestion cycle. So cells are are over-stressed. Some of them die prematurely. To purge them, bacteria play role. And we call it bacterial infection. Except us, with free will, everyone else in the nature has instinct driven will or in other words, mother nature drives them. So they always remain धार्मिक. It is our Ego who has to remain धार्मिक to maintain the optimum body state. We can do it by following local culture since it is evolved life routine to maintain symbiotic relation with others in same environment.

***Dharmic (धार्मिक) = The one who follows own dharma.

*** What is dharma?
Dharma has the Sanskrit root dhri, which means “that which upholds” or “that without which nothing can stand” or “that which maintains the stability and harmony of the universe.” Dharma encompasses the natural, innate behavior of things, duty, law, ethics, virtue, etc. Every entity in the cosmos has its particular dharma — from the electron, which has the dharma to move in a certain manner, to the clouds, galaxies, plants, insects, and of course, man.

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