Microbes

Microbes

Gut Bacteria (Pranic Footprint-प्राणमय कोष) controls speed of tumor growth

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I have shared it many times that the ultimate way of cancer prevention is to restore Prana in body. It is lack of prana/blockage of Nadi, that causes cancer.

Gut Bacteria, like any other body organ, is manifestation of Prana. And they being non-organ self of body, play critical role in well-being of body organs.

We can prevent cancer easily. Even cancer management is also less painful compare to modern chemo and radiation torture.

Three fundamental source of Prana for restoration

  1. Raw Prana from the Sun
  2. Churned Prana from Desi cow’s milk and ghee
  3. Food grown on the soil replenished by raw and churned prana (Sun light, cow dung, urine, milk, butter milk)

GUTBacteria


Research


Gut Bacteria Determine Speed of Tumor Growth in Pancreatic Cancer

https://nyulangone.org/press-releases/gut-bacteria-determine-speed-of-tumor-growth-in-pancreatic-cancer

The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells.

These are the findings of a study conducted in mice and in patients with pancreatic ductal adenocarcinoma (PDA), a form of cancer that is usually fatal within two years. Led by researchers at NYU School of Medicine, Perlmutter Cancer Center, and NYU College of Dentistry, the study published online March 22 in Cancer Discovery, a journal of the American Association for Cancer Research (AACR).

Specifically, the study found that removing bacteria from the gut and pancreas by treating mice with antibiotics slowed cancer growth and reprogrammed immune cells to again “take notice” of cancer cells. Oral antibiotics also increased roughly threefold the efficacy of checkpoint inhibitors, a form of immunotherapy that had previously failed in pancreatic cancer clinical trials, to bring about a strong anti-tumor shift in immunity.

Experiments found that in patients with PDA, pathogenic gut bacteria migrate to the pancreas through the pancreatic duct, a tube that normally drains digestive juices from the pancreas into the intestines. Once in the pancreas, this abnormal bacterial mix (microbiome) gives off cellular components that shut down the immune system to promote cancer growth, say the authors.

Soil Health Card is useless without गौ आधारित खेती (Cow-based farming)

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SoilMicrobesCarbon

American university proclaims:

“With more than 7 billion microorganisms in the soil, it’s no surprise we still have a lot to learn about them and their impact on the environment. “Consequently, the activity of microorganisms in soil has the potential to alleviate or worsen climate change, so we need to form predictions regarding their activities.”

Do you think without Gau mata, one can achieve this?

Remember, I often share here that

Gau out = Desert In
Desert In = Desert Religion In (Islam/Christianity)

Soil health card may be good way to track soil nutrients but it is useless if you cannot understand value of cow in maintaining soil health. Soil health does not only mean NPK! Or Organic matter. It mean Prana! and only Gau mata can provide Prana!!

Not only carbon cycle, Gau mata has potential to stabilize all natural cycles!! She is medium via which we should embrace primordial prana i.e. Sun


Research


WVU researcher uncovers influence of microorganisms on soil carbon storage

With more than 7 billion microorganisms in the soil, it’s no surprise we still have a lot to learn about them and their impact on the environment. A West Virginia University researcher is uncovering critical information about these tiny organisms under our feet, which although small, can have a huge impact on the environment.

Ember Morrissey, assistant professor of environmental microbiology in the Davis College of Agriculture, Natural Resources and Design, received a $150,000 grant from National Science Foundation’s Division of Environmental Biology’s Early-concept Grants for Exploratory Research program, known as EAGER, to increase understanding of the behavior of microorganisms in the soil to provide descriptions of microbial function that currently aren’t available.

Morrissey’s research will lay the groundwork needed to figure out how soil can be managed to address environment-related processes and issues, including global warming and climate change.

Of particular interest for Morrissey and other researchers is the ability to formulate more precise predictions of microorganisms’ carbon cycling, or how they use and create carbon, a key to combatting climate change.

“Soil stores a large fraction of the earth’s carbon – actually more carbon than the atmosphere and biosphere combined,” Morrissey explained. “Microorganisms break down and consume this carbon as they live and grow, converting it into the greenhouse gas carbon dioxide.

“Consequently, the activity of microorganisms in soil has the potential to alleviate or worsen climate change, so we need to form predictions regarding their activities.”

https://wvutoday.wvu.edu/stories/2017/01/17/wvu-researcher-uncovers-influence-of-microorganisms-on-soil-carbon-storage

 

Local Food, Mother’s diet and Infant’s milk microbes

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Local Food
Even closed door medical conferences across India cherish importance of local diet influence, society follow market and media and enjoy global diet. One of the fundamental error in selection of food is to select food for taste and urge to taste non-local food.
 
For example: It is perfectly ok to eat Idli-Sambhar in Kerala but having same every day in Gujarati home living in Gujarat?
 
It is perfectly ok to eat apple in Himachal but having same in hot and humid Gujarat summer?
My common sense suggest to prefer only local diet over non-local taste-lust food selection.
 
For would-be mothers, it is important to maintain local diet if they wish their breast-feeding. What you eat, decides GUT microbes and in turn pass on legacy to newborn babies via breast-milk!
Your local diet is the immunity for your kid. During and after breast-feeding. And not the packaged processed food!
Educate mothers around you and help building strong Nation via strong future geneations.
Here is the interesting study looking to localization of GUT microbes of breast-feeding mothers’ GUT. It supports the hypothesis that there is no alternative of local diet. All healthy diet fads are marketing gimmick or at best, suitable to local population where the diet is showing results. What is good for pregnant mother in China, may not work for same in India!
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Research
——–

Bacterial Composition and Diversity in Breast Milk Samples from Mothers Living in Taiwan and Mainland China

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447776/

Human breast milk is widely recognized as the best source of nutrients for healthy growth and development of infants; it contains a diverse microbiota. Here, we characterized the diversity of the microbiota in the breast milk of East Asian women and assessed whether delivery mode influenced the microbiota in the milk of healthy breast-feeding mothers. We profiled the microbiota in breast milk samples collected from 133 healthy mothers in Taiwan and in six regions of mainland China (Central, East, North, Northeast, South, and Southwest China) by using 16S rRNA pyrosequencing. Lactation stage (months postpartum when the milk sample was collected) and maternal body mass index did not influence the breast milk microbiota. Bacterial composition at the family level differed significantly among samples from the seven geographical regions. The five most predominant bacterial families were Streptococcaceae(mean relative abundance: 24.4%), Pseudomonadaceae (14.0%), Staphylococcaceae (12.2%), Lactobacillaceae (6.2%), and Oxalobacteraceae (4.8%). The microbial profiles were classified into three clusters, driven by Staphylococcaceae (abundance in Cluster 1: 42.1%), Streptococcaceae (Cluster 2: 48.5%), or Pseudomonadaceae (Cluster 3: 26.5%). Microbial network analysis at the genus level revealed that the abundances of the Gram-positive StaphylococcusStreptococcus, and Rothia were negatively correlated with those of the Gram-negative AcinetobacterBacteroidesHalomonasHerbaspirillum, and Pseudomonas. Milk from mothers who had undergone Caesarian section (C-section group) had a significantly higher abundance of Lactobacillus (P < 0.05) and a higher number of unique unclassified operational taxonomic units (OTUs) (P < 0.001) than that from mothers who had undergone vaginal delivery (vaginal group). These findings revealed that (i) geographic differences in the microbial profiles were found in breast milk from mothers living in Taiwan and mainland China, (ii) the predominant bacterial families StreptococcaceaeStaphylococcaceae, and Pseudomonadaceae were key components for forming three respective clusters, and (iii) a significantly greater number of unique OTUs was found in the breast milk from mothers who had undergone C-section than from those who had delivered vaginally.

Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations.

https://www.ncbi.nlm.nih.gov/pubmed/27790209

Conclusion

https://www.frontiersin.org/files/Articles/217349/fmicb-07-01619-HTML/image_m/fmicb-07-01619-g002.jpg
https://www.frontiersin.org/files/Articles/217349/fmicb-07-01619-HTML/image_m/fmicb-07-01619-g002.jpg

Our results demonstrate differences in the composition of lipids and microbiota in breast milk in different geographic regions and offer a new insight to the differences in development of gut microbiota in infants in different geographic areas. The impact of mode of delivery on milk microbiota composition appears to be even more important within all geographical regions. Furthermore, our study shows distinct association between fatty acid composition and individual microbiota in breast milk, suggesting important role of lipids in shaping the microbial profile which likely one important factor influencing the infant gut microbiota development.

Microbial Community(प्राणमय कोष) controls Gene expression : Not genes, epigenetic!

http://www.cell.com/cms/attachment/2079859016/2071400130/fx1.jpg
http://www.cell.com/cms/attachment/2079859016/2071400130/fx1.jpg

Instead of medicine, why I suggest all friends to worship Surya and Hanuman! 🙂 It is the need of the hour as our Prana is being consumed daily rapidly by toxic environment, physical and mental.

So many dots can be connected by reading this research paper.

This is wonderful morning as I read this research. One more confirmation proof for my theory that it is प्राणमय कोष that actually influences body and not the genes!!

Entire Genome project is pseudo-science of last century! And so GMO crops! Yes, this is tall claim and against the waves but it is the reality! 🙂

प्राणमय कोष is our immunity. It is our cellular intelligence. It is the one that manifests and govern cell-formation. It is the one that manifests cells with individual identity i.e. microbes rather than collective identity i.e. Body organ cell like skill cell, liver cell or neuron.

It is not just me! I know couple of researchers confirming the same fact and working hard to find more and more epigenetic links!

Our food, our thoughts – all influence our well-being. Genes are actually controlled by them!!

It is not genes, it is epigenetic!

In our guts, and in the guts of all animals, resides a robust ecosystem of microbes known as the microbiome. Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance.

Now, in a study comparing mice raised in a “germ free” environment and mice raised under more typical lab conditions, scientists have identified yet another key role of the microbes that live within us: mediator of host gene expression through the epigenome, the chemical information that regulates which genes in cells are active.

Writing online Nov. 23 in the journal Molecular Cell, a team of researchers from the University of Wisconsin–Madison describes new research helping tease out the mechanics of how the gut microbiome communicates with the cells of its host to switch genes on and off. The upshot of the study, another indictment of the so-called Western diet (high in saturated fats, sugar and red meat), reveals how the metabolites produced by the bacteria in the stomach chemically communicate with cells, including cells far beyond the colon, to dictate gene expression and health in its host.


Research


Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

http://dx.doi.org/10.1016/j.molcel.2016.10.025

Highlights

  • Gut microbiota alter host histone acetylation and methylation in multiple tissues
  • Western diet suppresses microbiota-driven SCFA production and chromatin effects
  • SCFAs recapitulate microbiota-driven chromatin and transcriptional effects

Summary

Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous small-molecule metabolites, allowing chromatin to respond to changes in environment. The gut microbiota produces a myriad of metabolites that affect host physiology and susceptibility to disease; however, the underlying molecular events remain largely unknown. Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner: consumption of a “Western-type” diet prevents many of the microbiota-dependent chromatin changes that occur in a polysaccharide-rich diet. Finally, we demonstrate that supplementation of germ-free mice with short-chain fatty acids, major products of gut bacterial fermentation, is sufficient to recapitulate chromatin modification states and transcriptional responses associated with colonization. These findings have profound implications for understanding the complex functional interactions between diet, gut microbiota, and host health.

Increasing Eye diseases? High fat-High Sugar diet and Microbes

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==================
HIGH fat diet => Eye degeneration
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csm_20161114_intestin-bacteries_f4d9dbc3c1

Most critical organ of the body besides Heart is GUT and not brain! Sadly, we treat it like a gutter!

In past 5 years, I have shared almost 100 researches connecting GUT microbes with different bodily phenomenons.

This research is addition to it.

GUT Microbes affects major Eye diseases!

In Hindu Dharma, we worship two God(s) daily. Hanuman and Ganesh. They are always there in any temples.

They represent Muladhara. The Gut Protectors.


Research


Microbes in your gut influence major eye disease

Bacteria in your intestines may play an important role in determining if you will develop blinding wet Age-related Macular Degeneration (AMD).

http://nouvelles.umontreal.ca/en/article/2016/11/15/microbes-in-your-gut-influence-major-eye-disease/
“Our study suggests that diets rich in fat alter the gut microbiome in a way that aggravates wet AMD, a vascular disease of the aging eye. Influencing the types of microbes that reside in your gut either through diet or by other means may thus affect the chances of developing AMD and progression of this blinding disease”, says Dr Sapieha. Professor Sapieha holds the Wolfe Professorship in Translational Vision Research and a Canada Research Chair in retinal cell biology. The study was funded by the Foundation Fighting Blindness, the Canadian Institutes of Health Research, and thr Fond de Recherche en Ophthalmologie de l’Université de Montreal.

Cospeciation : Coevolution, Gut Microbes and role of Prana

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Conspeciation
This science paper confirms eternity of प्राण | Bacteria are manifestation of वैश्विक प्राण | So, not all Gut bacteria are acquired at birth! Some of them followed eternal journey with us!! And they depend upon host lineages!
 
“Gut bacteria therefore are not simply acquired from the environment, but have coevolved for millions of years with hominids to help shape our immune systems and development.”
 
Like how Prana drives growth of body from conception to birth to the youth, same Prana manifest microbial bacteria in GUT as per the need !
 
Our gutter-satisfying eating habits, medications ruin the legacy received from lineages!
 
“The evolutionary origins of the bacterial lineages that populate the human gut are unknown. Here we show that multiple lineages of the predominant bacterial taxa in the gut arose via cospeciation with humans, chimpanzees, bonobos, and gorillas over the past 15 million years. Analyses of strain-level bacterial diversity within hominid gut microbiomes revealed that clades of Bacteroidaceae and Bifidobacteriaceae have been maintained exclusively within host lineages across hundreds of thousands of host generations. Divergence times of these cospeciating gut bacteria are congruent with those of hominids, indicating that nuclear, mitochondrial, and gut bacterial genomes diversified in concert during hominid evolution. This study identifies human gut bacteria descended from ancient symbionts that speciated simultaneously with humans and the African apes.”
 

Cospeciation of gut microbiota with hominids

http://science.sciencemag.org/content/353/6297/380

Human-microbiota coevolution

The bacteria that make their home in the intestines of modern apes and humans arose from ancient bacteria that colonized the guts of our common ancestors. Moeller et al. have developed a method to compare rapidly evolving gyrB gene sequences in fecal samples from humans and wild chimpanzees, bonobos, and gorillas (see the Perspective by Segre and Salafsky). Comparison of the gyrB phylogenies of major bacterial lineages reveals that they mostly match the apehominid phylogeny, except for some rare symbiont transfers between primate species. Gut bacteria therefore are not simply acquired from the environment, but have coevolved for millions of years with hominids to help shape our immune systems and development.

Muladhara(मूलाधार) and Cancer : Prevent and Cure

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MicrobesCancer

Tvam muladhara sthitosi nityam |
त्वं मूलाधार स्थितोऽसि नित्यं।
Lord Ganesha! You always dwell in muladhara chakra!

मूलाधार : शक्ति Center near Gut & anus : Abode of मरुत गण (Microbes) and their leader गणपति

It does not only control microbes in GUT but of entire body.

He is the lord of muladhara chakra. In other words, he rules our microbial flora (मरुत गण) and make sure only body-friendly मरुत गण resides in the abode.

मरुत गण (Microbes) : गण पति (Ganesha) : गण (Citizens) & पति (Protector) live together @ Muladhara

Awakening गण पति शक्ति is critical for maintaining health (which is critical for self-realization). Only he can protect and act as gatekeeper of Muladhara (Gut) so that body is kept protected from pathogens & aasuri shakti.

Here are two interesting researchers focuses on Muladhara for cancer-cause and cancer recovery.


Research


Cleveland Clinic Researchers Find Link Between Bacterial Imbalances and Breast Cancer

In a newly published study, Cleveland Clinicresearchers have uncovered differences in the bacterial composition of breast tissue of healthy women vs. women with breast cancer. The research team has discovered for the first time that healthy breast tissue contains more of the bacterial species Methylobacterium, a finding which could offer a new perspective in the battle against breast cancer.

Bacteria that live in the body, known as the microbiome, influence many diseases.

Most research has been done on the “gut” microbiome, or bacteria in the digestive tract. Researchers have long suspected that a “microbiome” exists within breast tissue and plays a role in breast cancer but it has not yet been characterized. The research team has taken the first step toward understanding the composition of the bacteria in breast cancer by uncovering distinct microbial differences in healthy and cancerous breast tissue.

“To my knowledge, this is the first study to examine both breast tissue and distant sites of the body for bacterial differences in breast cancer,” said co-senior author Charis Eng, M.D., Ph.D., chair of Cleveland Clinic’s Genomic Medicine Institute and director of the Center for Personalized Genetic Healthcare. “Our hope is to find a biomarker that would help us diagnose breast cancer quickly and easily.  In our wildest dreams, we hope we can use microbiomics right before breast cancer forms and then prevent cancer with probiotics or antibiotics.”

Published online in Oncotarget on Oct. 5, 2017, the study examined the tissues of 78 patients who underwent mastectomy for invasive carcinoma or elective cosmetic breast surgery. In addition, they examined oral rinse and urine to determine the bacterial composition of these distant sites in the body.

newsroom.clevelandclinic.org/2017/10/05/cleveland-clinic-researchers-find-link-between-bacterial-imbalances-and-breast-cancer/

Good-guy bacteria helps in cancer therapies

Researchers found he had the beneficial gut bacteria and suspect this microbiome contributed to the outcome. As a group, patients who responded well to the immunotherapy had three specific bacteria:

  • Bacteroides thetaiotaomicron
  • Faecalibacterium prausnitzii
  • Holdemania filiformis

All three are common normal flora in the human intestinal tract.

After identifying the link, researchers looked for a potential reason for the association between the helper bacteria and immunotherapy effectiveness. “Is it something the bacteria are making? We examined metabolites in these subjects and found the strongest correlation between anacardic acid, present in cashews and mangoes, and the beneficial bacteria,” Dr. Koh said.

Researchers plan to follow up on the current research, which appears in the journal Neoplasia, with larger clinical studies.

http://www.utsouthwestern.edu/newsroom/articles/year-2017/bacteria-immunotherapy-koh.html

 

Your household and Family shape Salivary microbes and Oral immunity and not genes

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Genetics Saliva

“The Human Salivary Microbiome Is Shaped by Shared Environment Rather than Genetics”

This is very interesting study in support of my hypothesis that microbes are nothing but form of Prana with special purpose. Body cells without identity of known organ classification. They are bridge between us and environment. They are translator of environmental impact on body. They are reflection of bodily health state. In short, this form of prana is never an enemy! Just a faithful servant of mother nature, at our service until we ignore them and try to get rid of them by modern practices.

This study testifies importance of two things which Sanatana Dharma based living openly prescribes:

  1. Living in joint family is natural immunity booster
  2. Household plays critical role in shaping our prana hence our health. Vastu Vidya plays invisible role in maintaining your health.
  3. Home surrounded by mother nature helps a lot
  4. The most significant impact on salivary microbes is by the food we eat and medium used for cleaning the teeth and mouth. If you are using toothpaste and chemical cocktail to gargle, you are at significant loss of healthy prana i.e. good bacteria in oral cavity.
  5. Oral health had direct connection to heart. This way, your home environment, both physical, mental, play role in your health!

Old notes on Saliva

  1. 1. How to drink water, do we really know?

    2. Wound Healing : Thanks to wonder that is skin microbes!


Research


HOUSEHOLD ENVIRONMENT—NOT GENETICS—SHAPES SALIVARY MICROBES

https://www.asm.org/index.php/newsroom/item/6799-household-environment-not-genetics-shapes-salivary-microbes

“It’s generally becoming known that there’s a link between our microbiomes and our health and that’s reason enough to find out what’s in there, how they arrived there, and what they are doing,”

“The oral cavity is naturally colonized by hundreds of bacterial species, which stop external pathogens from establishing a foothold, but they also can themselves cause oral disease.”

Spouses and parents and children younger than 10 living in a household together had the most similar saliva microbiomes. “The contact doesn’t even have to be intimate, like kissing,” says Roberts. “Individuals’ hands are covered in saliva and they are touching everything in the house.”  Children younger than 10 had more similar bacteria to their parents than older children, perhaps reflecting that older children are becoming “more independent individuals,” says Roberts.

The Human Salivary Microbiome Is Shaped by Shared Environment Rather than Genetics: Evidence from a Large Family of Closely Related Individuals

http://mbio.asm.org/content/8/5/e01237-17

The human microbiome is affected by multiple factors, including the environment and host genetics. In this study, we analyzed the salivary microbiomes of an extended family of Ashkenazi Jewish individuals living in several cities and investigated associations with both shared household and host genetic similarities. We found that environmental effects dominated over genetic effects. While there was weak evidence of geographical structuring at the level of cities, we observed a large and significant effect of shared household on microbiome composition, supporting the role of the immediate shared environment in dictating the presence or absence of taxa. This effect was also seen when including adults who had grown up in the same household but moved out prior to the time of sampling, suggesting that the establishment of the salivary microbiome earlier in life may affect its long-term composition. We found weak associations between host genetic relatedness and microbiome dissimilarity when using family pedigrees as proxies for genetic similarity. However, this association disappeared when using more-accurate measures of kinship based on genome-wide genetic markers, indicating that the environment rather than host genetics is the dominant factor affecting the composition of the salivary microbiome in closely related individuals. Our results support the concept that there is a consistent core microbiome conserved across global scales but that small-scale effects due to a shared living environment significantly affect microbial community composition.

 

 

Heart Failure starts with Gut (मूलाधार) : Worship गणेश

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GUT bacteria and Heart failure
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Heart Ganesh

I am not microbiologist but हनुमान & गणेश भक्त. And they give enough hints about the गण they protect for me within this body-universe.

I repeat almost daily and urge friends to take care of GUT by proper diet, surya Namaskar.

Area from GUT to Navel – very critical for existence. Protect it.

गणपति resides in GUT area . And to worship him, we generally keep fast. Fasting clean the GUT and transforms it from GUTTER into Heaven. So clean GUT means right decisions, right actions and in real sense गणेश acts as विध्नहर्ता.

During monsoon, our digestive power remains very low and so there are high chances that GUT remains polluted. So just when the monsoon is on the verge of end, we worship गणेश for 10 days.


Research


Heart failure is associated with loss of important gut bacteria

https://dzhk.de/en/news/latest-news/article/heart-failure-is-associated-with-loss-of-important-gut-bacteria/

“In the gut of patients with heart failure, important groups of bacteria are found less frequently and the gut flora is not as diverse as in healthy individuals. Data obtained by scientists of the German Centre for Cardiovascular Research (DZHK) provide valuable points of departure for understanding how gut colonisation is associated with the development and progress of heart failure.”

Influential factors: diet, medication, smoking

“Of course, other factors also affect the composition of our gut bacteria. We know that the gut flora of a vegan who starts eating meat changes within three days”, explains associate professor Dr. Mark Lüdde of the University Hospital Schleswig-Holstein, Campus Kiel. For this reason, we asked the Kiel-based researchers of dietary habits beforehand. Individuals with an extreme diet, such as a vegan diet, were not allowed to participate in their study. Instead, they chose individuals with a standard diet comprising both meat and vegetables for both groups.

In addition to diet, medication also affect the gut flora. It was, therefore, important that the control group also took medicinal products that patients with heart failure must take routinely. Antibiotics could not have been administered for at least three months prior. Smokers were also included in both groups. All participants were from the same region and were the same age; gender distribution and BMI were equal in both groups.

Consequence or cause of the disease?

The observed pattern of the reduced genera and families of bacteria seems very characteristic of heart failure, which is why these results may be new points of departure for therapies. The differences between healthy individuals and those with heart failure, thus, came about mainly through the loss of bacteria of the genera Blautia and Collinsella, as well as two previously unknown genera that belong to the families Erysipelotrichaceae and Ruminococcaceae. 

The Gut, the Heart, and TMAO

Here’s how it works: When people ingest certain nutrients, such as choline (abundant in red meat, egg yolks, and dairy products) and L-carnitine (found in red meat as well as some energy drinks and supplements), the gut bacteria that break it down produce a compound called trimethylamine (TMA). The liver then converts TMA into the compound, trimethylene N-oxide (TMAO).

The trouble with TMAO is that data show high levels contribute to a heightened risk for clot-related events such as heart attack and stroke—even after researchers take into account the presence of conventional risk factors and markers of inflammation that might skew the results. In their most recent analysis, scientists showed that high blood levels of TMAO were associated with higher rates of premature death in a group of 2235 patients with stable coronary artery disease. Those found to have higher blood levels of TMAO had a four-fold greater risk of dying from any cause over the subsequent five years.

The implications are intriguing. Taken together, the new studies suggest that positively altering the gut microbiota may help to reduce damage to blood vessels, resulting in a stronger cardiovascular system, and they point to targets for potential new heart disease therapies.

The Gut, the Heart, and TMAO

 

Urban Forests : Must to maintain healthy microbial communities

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http://allswalls.com/images/central-park-nyc-wallpaper-3.jpg
http://allswalls.com/images/central-park-nyc-wallpaper-3.jpg

I discussed here several times how your local architecture/landscape shape microbial communities. And why Vastu-Vidhya revival is urgent need of the hour. Adding real smartness to the cities and villages. In my city, in name smart city, local civic body is converting Green plots into vertical slums for petty short-sighted vote-bank politics!


Research


Urban greenness influences airborne bacterial community composition

linkhttp://www.sciencedirect.com/science/article/pii/S0048969716314826

“Urban green space provides health benefits for city dwellers, and new evidence suggests that microorganisms associated with soil and vegetation could play a role. While airborne microorganisms are ubiquitous in urban areas, the influence of nearby vegetation on airborne microbial communities remains poorly understood. We examined airborne microbial communities in parks and parking lots in Eugene, Oregon, using high-throughput sequencing of the bacterial 16S rRNA gene on the Illumina MiSeq platform to identify bacterial taxa, and GIS to measure vegetation cover in buffer zones of different diameters. Our goal was to explore variation among highly vegetated (parks) versus non-vegetated (parking lots) urban environments. A secondary objective was to evaluate passive versus active collection methods for outdoor airborne microbial sampling. Airborne bacterial communities from five parks were different from those of five parking lots (p = 0.023), although alpha diversity was similar. Direct gradient analysis showed that the proportion of vegetated area within a 50 m radius of the sampling station explained 15% of the variation in bacterial community composition. A number of key taxa, including several Acidobacteriaceae were substantially more abundant in parks, while parking lots had higher relative abundance of Acetobacteraceae. Parks had greater beta diversity than parking lots, i.e. individual parks were characterized by unique bacterial signatures, whereas parking lot communities tended to be similar to each other. Although parks and parking lots were selected to form pairs of nearby sites, spatial proximity did not appear to affect compositional similarity. Our results also showed that passive and active collection methods gave comparable results, indicating the “settling dish” method is effective for outdoor airborne sampling. This work sets a foundation for understanding how urban vegetation may impact microbial communities, with potential implications for designing neighborhoods and open space systems that foster better human health.”

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