Microbes

Microbes

Immune System Fosters Good Bacteria

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We have been taught that immune system means Army. Immune System is defense system. But we were never taught that the immune system does more than mere purging non-body particles out of body.

Here is the interesting finding which supports what we discussed on this subject recently:
“When the immune system functions properly (MyD88 is active, green), IgA antibodies bind multiple species of bacteria, keeping the numbers and types of ‘good’ bacteria that inhabit the gut under control. (Right) When the immune system is disrupted (MyD88 is inactive, gray), IgA binds bacteria less effectively, and the bacterial community becomes imbalanced, jeopardizing digestive health.”

If bacteria are enemy, why would immune system help them grow? 🙂

There is no enmity with Mother Nature as most brainwashing media tell you. There is no war against bacteria or Virus going on. Purpose of immune system is to maintain your existence. That is it.

The ability of the human body to live in peace with 10 microbes per every human cell is a state of genuine immunity, wherein the body exercises a holy indifference to the resident microbes, to gain therefrom freedom from any reactivity against the obviously non-self microbes.

This is ability to realize self and non-self can be best developed when a child is exposed more often to mother nature.

Stop this delusion of war against the nature and see the magic. Your life will be much more healthier then the past! Try it! (Y)

Tulsi, Turmeric, Ghee (Desi Gau’s), Honey (Pure jungle based), Milk (Desi gau’s raw) – they all help you too strengthen immune system i.e. your own identity so that your body can identify self from non-self! 🙂


Research


http://healthcare.utah.edu/publicaffairs/news/2015/01/01-22-15_Immune_System_Fosters_Good_Bacteria.php

Immune System Promotes Digestive Health by Fostering Community of “Good” Gut Bacteria

As many as 1.4 million Americans suffer from uncomfortable abdominal cramping and diarrhea that come with ulcerative colitis and Crohn’s disease. These conditions, collectively known as inflammatory bowel disease (IBD), are associated with an imbalance among the thousands of species of “good” bacteria that inhabit the gut. A University of Utah study published on Jan. 22, 2015, in Cell Host and Microbe demonstrates that mice deficient for a component of the immune system, a protein called MyD88, have an imbalanced gut bacterial community – with some species dominating over others – and are more susceptible to contracting a severe IBD-like illness. Further, fecal transplants from healthy donors alleviate IBD symptoms in these mice.

The results show that the immune system encourages growth of a healthy community of “good” bacteria that is important for digestive health. This perspective on immune system function is in contrast to it’s best-known role as the first line of defense in the fight against pathogens, including invasive bacteria.

“Our work highlights that the immune system shapes the composition of bacterial communities in the intestine,” says senior author June Round, Ph.D., assistant professor of pathology at the University of Utah School of Medicine. “This interaction is important because it’s becoming more and more clear that resident microbes are very important for our health.”

Considering that some people with IBD have mutations in genes that are part of a MyD88-controlled pathway, fecal transplantation – which involves collecting and processing stool from a healthy donor, and delivering it into a recipient’s gut – might help to ameliorate disease in these people, according to Round.

Loss of MyD88 disturbs the microbial community because it disrupts production of IgA. This class of antibody works like a gatekeeper that controls which types of bacteria, and how many, are allowed to inhabit the gut. By performing inventories of total gut bacteria compared to species that bind IgA, the scientists determined that without MyD88, IgA failed to recognize species that it can otherwise.

Type 1 Diabetes, Microbes and Ganapati

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Bacteria diabetes

The part of the alimentary canal between the stomach and the anus is known as GUT. This is reservoir of microbes. Critical digestive processes happen here.

In Ayurveda, this place is considered as मूलाधार चक्र.गणपति resides here. Ayurveda considers body beyond physical body and energy layer is one of such layer, प्राणमय कोष. Energy @ मूलाधार चक्र is responsible for person’s intelligence, valor and many other traits. And Ganapati resides here. He controls all activities.

Tvam muladhara sthitosi nityam |
त्वं मूलाधार स्थितोऽसि नित्यं।
Lord Ganesha! You always dwell in muladhara chakra!

मूलाधार : शक्ति Center near Gut & anus : Abode of मरुत गण (Microbes) and their leader गणपति

He is the lord of muladhara chakra. In other words, he rules our microbial flora (मरुत गण) and make sure only body-friendly मरुत गण resides in the abode.

मरुत गण (Microbes) : गण पति (Ganesha) : गण (Citizens) & पति (Protector) live together @ Muladhara

Awakening गण पति शक्ति is critical for maintaining health (which is critical for self-realization). Only he can protect and act as gatekeeper of Muladhara (Gut) so that body is kept protected from pathogens & aasuri shakti.

Now, let us come to diabetes!

Type 1 diabetes (T1D) is an autoimmune disease in which a person’s pancreas stops producing insulin, a hormone that enables people to get energy from food. It occurs when the body’s immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells. While its causes are not yet entirely understood, scientists believe that both genetic factors and environmental triggers are involved. Its onset has nothing to do with diet or lifestyle. There is nothing you can do to prevent T1D, and—at present—nothing you can do to get rid of it.

Statistics

  • 1.25M Americans are living with T1D including about 200,000 youth (less than 20 years old) and over a million adults (20 years old and older)1,2,5
  • 40,000 people are diagnosed each year in the U.S.1, 2
  • 5 million people in the U.S. are expected to have T1D by 2050, including nearly 600,000 youth.2,3
  • Between 2001 and 2009 there was a 21% increase in the prevalence of T1D in people under age 20.3
  • $14B T1D-associated annual healthcare costs in the U.S.
  • Less than one-third of people with T1D in the U.S. are achieving target blood glucose control levels6
  • T1D is associated with an estimated loss of life-expectancy of up to 13 years7

As per latest research, microbes is the cure!!


Bacteria that Prevents Type 1 Diabetes

http://presse.inserm.fr/en/bacteria-that-prevents-type-1-diabetes/20118/


A pancreatic islet of Langerhans expressing the immunoregulator antimicrobial peptide CRAM (in red). The insulin-producting beta-cells are in green and the glucagon-producting alpha-cells are in blue. © Julien Diana
A pancreatic islet of Langerhans expressing the immunoregulator antimicrobial peptide CRAM (in red). The insulin-producting beta-cells are in green and the glucagon-producting alpha-cells are in blue. © Julien Diana

 

To combat pathogens, the immune system has developed various mechanisms to detect, defend against and even destroy micro-organisms that are harmful to the body. This includes antimicrobial peptides and natural proteins that destroy pathogenic bacteria by disrupting their cellular membrane. Not only are they produced by immune cells, they are also produced by cells whose functions are not immune-related.

A research team coordinated by Julien Diana, an Inserm Research Fellow at Inserm Unit 1151 “Institut Necker-Enfant Malades” [Necker Institute for Sick Children] (Inserm/CNRS/Université Paris Descartes), is focussing on a category of antimicrobial peptides, i.e.cathelicidins. Apart from their protective function, these peptides have also exhibited immunoregulatory abilities against several autoimmune diseases. As such, scientists hypothesise that cathelicidins may be involved in the control of type 1 diabetes, an autoimmune disease where certain cells in the immune system attack beta cells in the pancreas which secrete insulin.

Firstly, they observed that beta pancreatic cells in non-diseased mice produce cathelicidins and that, interestingly, this production is impaired in diabetic mice.

To test this hypothesis, they are injecting diabetic mice with cathelicidins where production is defective.

“Injecting cathelicidins inhibits the development of pancreatic inflammation and, as such, suppresses the development of autoimmune disease in these mice” states Julien Diana.

Microbes or Bacteria as popularly known, are our best friends. They save us from Type 1 diabetes! 🙂
 
But we will keep blind eyes towards these facts and apply antibiotics! create situations where antibiotics become unavoidable! 🙁
 
From Asthma to cancer to diabetes to irregular bowels to allergies to intellect to memory – we are at microbes’ mercy!
 
And who is there leader? गणपति! Worship him!! It is great psychological treatment (I know, this is very lowly reason for worship 🙂 )! After all, majority treatments are placebo! 🙂 

Gau Gavya and Gau-Raksha

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When someone represent गौ-रक्षक in negative image, my blood boils. As a leader, I should actually promote that every citizen should be गौ-रक्षक!

गाय & गव्य
गाय & गव्य

Gavya is a Sanskrit word. It has multiple meanings. It is actually a bridge between different forms of Gau.

Gau means Cow. Gau means senses. Gau means mother Earth. Gavya is their prasad. One produces and another consumes. Cycle goes on forever.

गौ रक्षक
गौ रक्षक

Panchgavya is elixir from Gau, for Gau (Human senses and Mother Earth). Result again is Gavya (Seva from Humans and produce from Mother earth) from gau, for Gau (Cow).

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Method of preparation
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Pancha-Gavya and Gau Raksha
Pancha-Gavya and Gau Raksha

Panchagavya, an organic product has the potential to play the role of promoting growth and providing immunity in plant system. Panchagavya consists of nine products viz. cow dung, cow urine, milk, curd, jaggery, ghee, banana, Tender coconut and water. When suitably mixed and used, these have miraculous effects.

Cow dung – 7 kg
Cow ghee – 1 kg
Mix the above two ingredients thoroughly both in morning and evening hours and keep it for 3 days

Cow Urine – 10 liters
Water – 10 liters
After 3 days mix cow urine and water and keep it for 15 days with regular mixing both in morning and evening hours. After 15 days mix the following and panchagavya will be ready after 30 days.

Cow milk – 3 liters
Cow curd – 2 liters
Tender coconut water – 3 liters
Jaggery – 3 kg
Well ripened poovan banana – 12 nos.

Read more: http://agritech.tnau.ac.in/org_farm/orgfarm_panchakavya.html

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We all have Vishnu seated in us. We must perform duties in his form. Being Gopati.

Maa Lakshmi and Microbial Wealth

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Real wealthy human carries rich microbial colonies in his Gut (The part of the alimentary canal between the stomach and the anus).

Rich in variety of healthy bacteria in Gut, healthier life, healthy brain -> healthy mind -> affirmative actions.

Health is wealth. 🙂

What do we do? We kill carriers of Maa Lakshmi at our door step.

How?

Smoking, alcohol, drugs, antibiotics.

प्राण, microbes and obesity

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bac

This land is land of मरुत/मारुति/हनुमान/गणेश worshiper. If not 100%, 80% of Indians worship one of them (Hanuman and/or Ganesh).

We do this because, we know the value of मूलाधार (GUT in modern medical science terms). We also know impact of focused mind on the well-being of Body.

Microbes are nothing but loosely-coupled manifestation of प्राण (here प्राण@मूलाधार ) in contrast to body-cells who are tightly coupled as organs.

One more study praising importance of microbes (i.e. प्राण => हनुमान, गणेश, मारुति i.e. driving force behind microbes population protection and control )

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“Obesity is linked to changes in our gut microbes — the trillions of tiny organisms that inhabit our intestines.

“Taken together these experiments demonstrate a causal link between alterations in the gut microbiota in response to changes in the diet and increased acetate production,” said Shulman. The increased acetate in turn leads to increased food intake, setting off a positive feedback loop that drives obesity and insulin resistance, he explained.

The study authors suggest that this positive feedback loop may have served an important role in evolution, by prompting animals to fatten up when they stumbled across calorically dense food in times of food scarcity.


Research


Study reveals how altered gut microbes cause obesity

http://news.yale.edu/2016/06/08/study-reveals-how-altered-gut-microbes-cause-obesity

“Alterations in the gut microbiota are associated with obesity and the metabolic syndrome in both humans and rodents,” Shulman noted. “In this study we provide a novel mechanism to explain this biological phenomenon in rodents, and we are now examining whether this mechanism translates to humans.”

Research : GUT Microbes controls circadian clocks

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GutMicrobesClocks

While selfish mankind is focusing more and investing more in understanding internal circadian rhythms, we are utter foolish in recording every day disturbed circadian rhythms in outer environment. If someone notices, they are called climate hoax creators, conspiracy theorists etc.

“5 elements outside. 5 elements inside. No difference. If the outside is disturbed, such disturbances can occur on the inside too. The reverse also becomes true if done so deeply that we’re all the zombies who destroy everything for no good reason (okay, our current “good reason” is to make money) and will ultimately turn into cannibal zombies to end the feeding frenzy.” – Suraj Kumar

It is vicious cycle. You eat junk, disturb GUT bacteria and your circadian rhythms are disturbed (body clocks).

On the other hand, disturb rhythms by shift jobs, late night movies, parties, irregular life routine – all results into disturbed GUT.


Research


http://harvardmagazine.com/2015/06/engineering-circadian-clock

Engineering an Internal Clock

Gut microbes affect circadian rhythms in mice, study says

http://www.anl.gov/articles/gut-microbes-affect-circadian-rhythms-mice-study-says

A study including researchers from the U.S. Department of Energy’s Argonne National Laboratory and the University of Chicago found evidence that gut microbes affect circadian rhythms and metabolism in mice.

We know from studies on jet lag and night shifts that metabolism—how bodies use energy from food—is linked to the body’s circadian rhythms. These rhythms, regular daily fluctuations in mental and bodily functions, are communicated and carried out via signals sent from the brain and liver. Light and dark signals guide circadian rhythms, but it appears that microbes have a role to play as well.

All humans have a set of bacteria, viruses and fungi living in our guts, called the gut microbiome, which helps us digest food—and also interacts with the body in a number of other ways: there is evidence they affect allergies, mental health, weight and other metabolic conditions.

Researchers found that mice with a normal set of gut microbes showed evidence of a regular daily microbial cycle, with different species flourishing in different parts of the day and producing different compounds as a result. These compounds appear to act on the liver—they affected how circadian clock genes were expressed in the liver.

A high-fat diet reduced the variation in the microbial cycle; the circadian clock genes were disrupted, and the mice gained weight.

Meanwhile, “germ-free” mice raised without a normal gut microbiome showed evidence of a disrupted circadian clock cycle, but did not gain weight even on a high-fat diet.

The researchers hypothesize that high-fat diets change the compounds that microbes produce, thus disrupting the liver’s circadian clock signaling.

“The earlier explanation for microbiome-related weight gain was that some bacteria make calories from food more available to your body, but this is a fundamental alternative explanation,” said Jack Gilbert, an Argonne microbial ecologist who co-authored the study.

Story of Cordyceps fungi and our food, microbes and GUT

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I often talk about importance of microbes in our physical well-being or in sickness. What I am going to share is very about impact on our mind.

Cordyceps is a fungus. Organism with large work to do for nature than microbes. Photos shared with this posts shows ants infected by this fungi. Once infected by Cordyceps, an ant becomes a zombie. It ignores its usual duties with its colony on the forest floor, and succumbs to the urge to climb a tree. Yes, that is how this fungi can control the ant’s mind. Some 100 cm or more above the forest floor, this ant is forced by fungi to bites down leaf vein and killing self. This is known as the ‘death grip’, as shortly afterwards, the fungus takes the ant’s life. Fungus grows and infect more ants on the forest floor.

The Cordyceps has changed the ant’s behavior, controlling it in an incredibly specific way, to help it give rise to the next generation of fungi.

Example I gave is about fungus but it is not just fungus but microbes, viruses and all living and dead organisms control our behavior. This is because all of them are manifestation of प्राण. Specific combination of प्राण which is programmed to alter your behavior.

Microbes in out Gut also do the same thing. First they take the place. And then control our behavior. You may eat some fast food for taste once but when they microbes loving fast food grows in the GUT, they will force you to eat more and more fast food. That is how food addictions are working in humans. Microbes controlling your habits.

If we understand this, many mental disorders treatment will become easy. Alter the Prana of the environment and see the magic. Same goes with Autistic children.

Only way to control Prana is Mind. मनोमय कोष had higher control over disturb or polluted प्राणमय कोष. But our mind is engaged in worldly pleasures and addictions. TV, News, Gossips, stress of daily life makes mind dull. Pollution by burning fossil fuels, cutting forest, cement cities reduces our pranic intelligence. In short, we all slowly become zombies like the ant becomes after fungus infection. Easy to control like slaves.

Ant has no choice but to succumb to fungus control due to limited mind but we have unlimited mind. Use it.

What you eat is important. Where you eat is equally important. How you eat is too. Eat = Physical food, mental food. Where you live is important. How clean you keep your home is also important. Ultimately how good you are at controlling प्राणिक & मानसिक exchange with environment will decide well-being of your life.

Microbes, CO2 Fixation and Synergy

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cow

Photo on the left : This colorized microscopy image hints at the complexity of microbial life. It shows two bacterial cells in soil. The bacteria glue clay particles together and protect themselves from predators. This also stabilizes soil and stores carbon that could otherwise enter the atmosphere.

Imagine the havoc we create by chemical industries. Fertilizers, pesticides, antibiotics and other medicines, waste from chemical industries. They instantly disturbs soil microbes.

Lack of microbes => Lack of nutrition in crops, Lack of प्राण , Mutated genes, more carbon in air than in soil, soil degradation, desertification, depleted ground water, more toxins in drinking water

This is going on for last 50 years in major regions of India. We are at tipping point of collapse. If we don’t wake up now and force farmers/industries/govt to get rid of chemicals in air, water and food, future is worse than our imagination of dooms day.

Solutions?

Indigenous cows have 20 times more microbes than any living organism’s dung can have. She gives dung that can stabilize carbon, water and other nutrients from air.

Soil with her help can sustain droughts (expect them frequently due to climate changes)

Sooner the better.

Ganesha, The protector of second brain

Ganesha
Ganesha

गणेश चतुर्थी to गणेश चतुर्दशी : Here is your yearly chance to contemplate on ageless doubt “Who am I?” and strengthen self-belief.

Happy Festival!Best wishes for your ultimate joyous conversation with self!

Season’s Rain has done his job.
Seeds for new beginning are already sprouted.
Welcome to lord of beginning in our heart. May we become live example of गणपति.

During monsoon, our digestive power remains very low and so there are high chances that GUT remains polluted. So just when the monsoon is on the verge of end, we worship गणेश for 10 days.

गणपति resides in GUT area . And to worship him, we generally keep fast. Fasting clean the GUT and transforms it from GUTTER into Heaven. So clean GUT means right decisions, right actions and in real sense गणेश acts as विध्नहर्ता.

The part of the alimentary canal between the stomach and the anus is known as GUT. This is reservoir of microbes. Critical digestive processes happen here.

Muladhara
Muladhara

In Ayurveda, this place is considered as मूलाधार चक्र.गणपति resides here. Ayurveda considers body beyond physical body and energy layer is one of such layer, प्राणमय कोष. Energy @ मूलाधार चक्र is responsible for person’s intelligence, valor and many other traits. And Ganapati resides here. He controls all activities.

Now, modern science says, GUT is our second brain. 🙂 🙂 We use this second brain as gutter. We eat anything and everything. Creating highly polluted environment. So second brain hardly works. 🙂 🙂 😉 😛

Moral of the post: Do not make fun of your rituals under the influence of media, TV, Bollywood and some so called rational authors. If you do not understand a bit, still follow your culture. There are ample hidden benefits.

When you meditate on मूलाधार by chanting ganapati atharvashirsha, unique mental and physical state emerge. In modern science language, you actually help your second brain to work well.

Antibiotics disturbs this area most. This is the reason I advocate alternative use of controlling bacterial infection and not antibiotics. As it directly affect our emotions and thinking capacity.

See all photos with post. Think about it. Read more:


Research


http://www.scientificamerican.com/article/gut-second-brain/

Think Twice: How the Gut’s “Second Brain” Influences Mood and Well-Being

Gut - Second brain
Gut – Second brain

Technically known as the enteric nervous system, the second brain consists of sheaths of neurons embedded in the walls of the long tube of our gut, or alimentary canal, which measures about nine meters end to end from the esophagus to the anus. The second brain contains some 100 million neurons, more than in either the spinal cord or the peripheral nervous system, Gershon says.

This multitude of neurons in the enteric nervous system enables us to “feel” the inner world of our gut and its contents. Much of this neural firepower comes to bear in the elaborate daily grind of digestion. Breaking down food, absorbing nutrients, and expelling of waste requires chemical processing, mechanical mixing and rhythmic muscle contractions that move everything on down the line.

Thus equipped with its own reflexes and senses, the second brain can control gut behavior independently of the brain, Gershon says. We likely evolved this intricate web of nerves to perform digestion and excretion “on site,” rather than remotely from our brains through the middleman of the spinal cord. “The brain in the head doesn’t need to get its hands dirty with the messy business of digestion, which is delegated to the brain in the gut,” Gershon says. He and other researchers explain, however, that the second brain’s complexity likely cannot be interpreted through this process alone.

“The system is way too complicated to have evolved only to make sure things move out of your colon,” says Emeran Mayer, professor of physiology, psychiatry and biobehavioral sciences at the David Geffen School of Medicine at the University of California, Los Angeles (U.C.L.A.). For example, scientists were shocked to learn that about 90 percent of the fibers in the primary visceral nerve, the vagus, carry information from the gut to the brain and not the other way around. “Some of that info is decidedly unpleasant,” Gershon says.

The second brain informs our state of mind in other more obscure ways, as well. “A big part of our emotions are probably influenced by the nerves in our gut,” Mayer says. Butterflies in the stomach—signaling in the gut as part of our physiological stress response, Gershon says—is but one example. Although gastrointestinal (GI) turmoil can sour one’s moods, everyday emotional well-being may rely on messages from the brain below to the brain above. For example, electrical stimulation of the vagus nerve—a useful treatment for depression—may mimic these signals, Gershon says.

Given the two brains’ commonalities, other depression treatments that target the mind can unintentionally impact the gut. The enteric nervous system uses more than 30 neurotransmitters, just like the brain, and in fact 95 percent of the body’s serotonin is found in the bowels. Because antidepressant medications called selective serotonin reuptake inhibitors (SSRIs) increase serotonin levels, it’s little wonder that meds meant to cause chemical changes in the mind often provoke GI issues as a side effect. Irritable bowel syndrome—which afflicts more than two million Americans—also arises in part from too much serotonin in our entrails, and could perhaps be regarded as a “mental illness” of the second brain.

Research : Bacteria Communicates Like Neurons

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the-electrical-communication-of-microbiota
the-electrical-communication-of-microbiota

Some interesting discoveries are happening in main stream science. This was our primary concept of Ayurveda. 72000 (नाड़ी) energy flow going on to keep the human body alive.

Imagine the havoc we create by bombarding chemicals in form of food, medicines and luxury items.

These under-currents giving us life also give life to other forms. Respect them.

Damn, it is all interplay of energy! Who are we? Nothing but inter-play of energies!Virus, bacteria, neuron – all are respecting interplay of Prana! 🙂

Bacteria communicate like neurons, study finds

http://www.sandiegouniontribune.com/business/biotech/sdut-bacteria-communicate-suel-2015oct21-story.html

“All of our senses, behavior and intelligence emerge from electrical communications among neurons in the brain mediated by ion channels. Now we find that bacteria use similar ion channels to communicate and resolve metabolic stress. Our discovery suggests that neurological disorders that are triggered by metabolic stress may have ancient bacterial origins, and could thus provide a new perspective on how to treat such conditions.”

 

Ion channels enable electrical communication in bacterial communities

http://www.nature.com/nature/journal/v527/n7576/full/nature15709.html

 

The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially propagating waves of potassium. These waves result from a positive feedback loop, in which a metabolic trigger induces release of intracellular potassium, which in turn depolarizes neighbouring cells. Propagating through the biofilm, this wave of depolarization coordinates metabolic states among cells in the interior and periphery of the biofilm. Deletion of the potassium channel abolishes this response. As predicted by a mathematical model, we further show that spatial propagation can be hindered by specific genetic perturbations to potassium channel gating. Together, these results demonstrate a function for ion channels in bacterial biofilms, and provide a prokaryotic paradigm for active, long-range electrical signalling in cellular communities.

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