Microbes

Microbes

Man’s comfort, Mother’s broken cycles

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Nitrogen

Fritz Haber (left, 1.0 Nobel prizes in 1918) and Carl Bosch (right, 0.5 Nobels in 1931) have probably had a greater impact than anyone in the past 100 years, including Hitler, Gandhi, Einstein, etc.

Yes, they invented a method to bypass soil microbes and provide nitrogen in terms of urea. One of the worse future of mankind was written by this process implementation.

Biological nitrogen fixation – essential natural cycle was disturbed. And many future generations will pay high price for it.

Today, essential nitrogen for your body does not come from soil microbes but Haber-Bosch process! 😀 प्राणविहीन Nitrogen and nitrates! 🙁

Urban Childhood : Loss of essential microbes, Loss of Prana

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Microbes

I was discussing growing cases of organ impairment in urban area. Like Kidney failure, liver damage and so on. And my friend Paramptap brought very critical point into discussion about importance of Vastu of the place!

In his own words:

Despite lot of people doing Yoga as activity, there particular diseases on rise, there is nothing wrong with Yoga but there is something off about how and where we live. In simple words “Not only you are what you do repeatedly, you are also where you live and breath repeatedly.”

Prana of local place play critical role. Not all infants born in same hospital are same forever! As they shift to their home, local environment play critical role in shaping their life.

GUT-Microbes are not only decided based on what you eat but also where you live!! Forest is the ideal place for child-development. No wonder why Gurukul were always in forest! Wild forest! For age 7 to 16, kids used to live in forest! Making of mighty population!


Research


Microbiome differences between urban and rural populations start soon after birth

“We’ve always assumed that the microbiomes of  were the same everywhere, and that differences came later in life,” says senior author Silvia Turroni of the Department of Pharmacy and Biotechnology at the University of Bologna in Italy. “We were surprised to find that the microbiomes of infants living in rural areas were missing components that we have long believed were standard to all infant populations—especially that they were essentially devoid of Bifidobacterium.” Bifidobacterium dominates the microbiomes of Western infants and has been considered a key element to healthy growth and development.

Previous studies that have analyzed the microbiomes of rural, hunter-gatherer societies have generally compared them to distant urban populations in Europe or the United States. This study was unique in that it looked at rural and urban African people in the same geographic area. Urban populations in the study were drawn from four state capital cities in Nigeria and the national capital, Abuja.

“This research was specifically designed to fill in gaps of knowledge about the variation of the human gut , as well as the metabolome, in relation to subsistence patterns in geographically close populations,” says first author Funmilola Ayeni of the Department of Pharmaceutical Microbiology at the University of Ibadan in Nigeria.

This study was also unique because it looked at both infant and adult microbiomes. For the purposes of this study, infants were defined as children up to age three. Unexpectedly, the investigators found that infants living in  had microbiome profiles that were overall more diverse and more like those of adults.

The rural people included in the study, an agricultural society called the Bassa, consume a diet consisting of tubers, grains, and leafy soups, as well as untreated water. The urban diet contained processed foods and treated water but had more elements of a traditional Nigerian diet than what is seen in Western countries. Rural infants were given foods other than breast milk at a younger age than urban infants were.

Although it is only one factor, diet is an important component affecting the makeup of the intestinal microbiota. The researchers found that the rural  had a higher level of certain bacterial species that are important for digesting fiber. In addition, when metabolites in the samples were analyzed, rural populations had lower levels of amino acids and biogenic amines, suggesting a lower consumption of protein.

https://medicalxpress.com/news/2018-06-microbiome-differences-urban-rural-populations.html

 

Body as Ecology, Gut as Forest and Restoration as Cure

Ecology

Body is not only ecology system. Like our mother earth, it also has self-healing attribute!

If we talk about Svabhavaparam-स्वभावोपरम principle of Ayurveda, educated arrogant Indians see it as DESI and inferior guess-work. But when a western university scientist talk about it with modern terminology, it is cool, trendy and perfect!

Probiotic food, Rama, Ravana and Dussehra

स्वभावोपरम : Principle of Self-healing

To return to stable state is not only nature of the human body but our mother earth and all her children. What we need to administer is nothing but a support for speedy recovery.

Chronic diseases of modern times are result of torture, be it mental or physical. We see body as machine and ignore it for first 30 years. And when it is in aging route, we start feeling different issues! Body also tries to restore normal state but since aging and torture, both are at work, we often see premature deaths.

Here is the interesting paper and perspective. Hope we learn from it.


Research


OSU biologist advocates ecological approach to improving human health

Chronic diseases like cancer, autoimmune disorders and obesity may ultimately vanquish the efforts of medical intervention unless people change their diet, an Oregon State University biologist argues in a paper published this week.

http://today.oregonstate.edu/news/osu-biologist-advocates-ecological-approach-improving-human-health

“I was diagnosed with Crohn’s disease and put on a monoclonal antibody inhibitor for life,” he said. “Except that I cleaned up my diet, stopped getting the gut irritation, cut out the monoclonal antibody inhibitor, and my symptoms are gone. Two doctors overturned the Crohn’s diagnosis in writing.

“All of that inspired me to think about ways that my knowledge of restoration ecology might help to guide physicians away from treating and misdiagnosing other people the way that they had treated and misdiagnosed me.”

Gut microbes perform a wide range of beneficial functions. Among other things, they produce nutrients in the form of short-chain fatty acids and vitamins, control blood sugar and weight, reduce inflammation and even improve mental health and psychological well-being.

And as with natural habitats, where successful restoration techniques will vary from year to year and place to place depending on individual circumstances, gut restoration requires a similar approach – one toward personalized medicine given that no two gut sets of gut microbiota are identical.

Except for that they’re all essential to the person’s health and all subject to disturbances, including the food people eat and the medicine they take.

“Nineteenth-century research identified microbes as agents of disease and set the stage for 20th-century breakthroughs in antibiotic therapies,” Orr said. “But antibiotic resistance is now a global crisis, and we’re also now aware that antimicrobials can harm beneficial species too.”

Skin Bacteria Heals Wounds: Are you suffering from Germ-Phobia?

GermWoundHEaling

This is for Lifebuoy and Dettol lovers. Entire generation is made to believe by fancy Ads that Bacterias are our enemies.

Research like this should held us back and force us to rethink our hygiene strategy.

A Boy in Ad is ridiculed because he does not use Lifebuoy, the germ killer. On the other hand, this boy was right. We don’t need any chemical soap.


http://www.newswise.com/articles/bacteria-on-the-skin-new-insights-on-our-invisible-companions

Bacteria on the Skin: New Insights on Our Invisible Companions

Study examines how skin-dwelling bacteria influence wound healing; findings could help address chronic wounds, a common ailment in the elderly

“These wounds can literally persist for years, and we simply have no good treatments to help a chronic wound heal,” said Hardman, who added that doctors currently have no reliable way to tell whether a wound will heal or persist. “There’s a definite need for better ways to both predict how a wound is going to heal and develop new treatments to promote healing.”

The trillions of bacteria that live on and in our bodies have attracted a great deal of scientific interest in recent years. Findings from studies of microbes in the gut have made it clear that although some bacteria cause disease, many other bacteria are highly beneficial for our health.

In their recent study, Hardman and his colleagues compared the skin bacteria from people with chronic wounds that did or did not heal. The results showed markedly different bacterial communities, suggesting there may be a bacterial “signature” of a wound that refuses to heal.

“Our data clearly support the idea that one could swab a wound, profile the bacteria that are there and then be able to tell whether the wound is likely to heal quickly or persist, which could impact treatment decisions,” said Hardman.

The team also conducted a series of studies in mice to shed light on the reasons why some wounds heal while others do not. They found that mice lacking a single gene had a different array of skin microbiota—including more harmful bacteria—and healed much more slowly than mice with a normal copy of the gene.

The gene, which has been linked to Chrohn’s disease, is known to help cells recognize and respond to bacteria. Hardman said the findings suggest that genetic factors influence the makeup of bacteria on a person’s skin, which in turn influences how they heal.

Seat of the Prana: Heart Attack and Gut Microbes: Part 1

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F4.large

A recent study point out that Microbial communities play significant role in make or break of heart by causing or avoiding heart attack.

Read the research abstract summary first[1]

The gut is a major reservoir of T cells and diverse resident microbes, microbiota, which can influence immune responses in sites distant from the mucosal surfaces. Complete sterilization of the gut has proven to be beneficial in some experimental models of T cell mediated diseases, whereas partial recolonization post sterilization leads to microbial perturbations, a process called dysbiosis, and, worsens the outcome. Gut dysbiosis is thus recently becoming associated with the pathogenesis of several diseases, in part, by mechanisms in which certain bacteria promote T cell activation and enhance disease progression in a vicious cycle. The complex syndrome of heart failure (HF), a leading cause of morbidity and mortality affecting more than 24 million people worldwide, is recently becoming associated with gut dysbiosis and T cell mediated systemic inflammation in patients, but the mechanisms regulating this emerging gut-heart axis, and whether T cell activation and heart infiltration play a role remains unclear. We have previously reported that T cells infiltrate the heart in patients with non-ischemic HF, and using the transverse aortic constriction (TAC) mouse model of HF, demonstrated that T cells are critical regulators of adverse cardiac remodeling and HF. We hypothesized that sterilization of the gut by microbiota depletion prevents adverse cardiac remodeling and HF in a T cell dependent manner. C57/BL6 mice were orally treated with a well-established cocktail of antibiotics and antifungal (ABX) and subjected to TAC or Sham surgery. ABX treatment started 1 week before TAC surgery and was terminated 4 weeks after TAC. In vivo transthoracic echocardiography and hemodynamics showed a preserved ejection fraction and fractional shortening in mice treated with ABX as compared to untreated mice. Furthermore, gut microbiota depletion with ABX resulted in decreased left ventricular interstitial and perivascular fibrosis, and decreased cardiac hypertrophy in response to TAC, as compared to non-ABX treated TAC mice. These changes correlated with significant reduction of CD4 T cell activation in the mediastinal lymph nodes (mLNs) draining the heart, determined by FACS, as well as in the number of CD4 T cells infiltrated in the heart in ABX treated mice. Our findings indicate that ABX treatment results in distal effects in T cell activation occurring during TAC and protects from adverse cardiac remodeling, supporting the potential importance of gut microbiota in pressure overload induced HF. Future studies will determine whether dysbiosis post ABX treatment contributes to pathological cardiac remodeling and the mechanisms regulating the gut-heart axis in non-ischemic HF.

Let us first understand few terms and entities.

What is Gut dysbiosis?

Gut dysbiosis, sometimes called bacterial dysbiosis, means you have a lack of beneficial bacteria in your gastrointestinal (GI) tract.

There are approximately over 400 species of bacteria in your system that make up your gut microbiome. You actually have more bacteria in your gut than you do cells in your body! These bacteria help you digest food, synthesize vitamins, and fight off harmful pathogens. In short, gut bacteria are a fundamental part of your health, and without them you wouldn’t be able to survive.

[2]

What are T-cells (T-Lymphocytes (T-Cells))?

A type of white blood cell. T-lymphocytes are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T cell and thymocyte.

When our body lacks life-enriching Prana, naturally, it is being captured by life-consuming prana. Life-consuming prana or Prana doing job of destruction, flows from GUt to heart and disturbs its working.

Inflammed GUT due to idiotic eating habits, will generate flood of T-cells. When these T-cells travel to Heart, they are responsible for heart failure as per research.


My understanding


Body is made up of srota or channels. Channel that transports Prana, is known as Pranavaha Srotas. It’s root is in heart (left chamber). Seat is in heart. It receives Prana from two places. Lungs and gastrointestinal tract. It is also connected to GUT/Colon. Clogged colon or inflamed GUT , not only disturbs Prana transport but also affect breathing, and vice a versa. If breathing is not proper, GUT/Colon will be disturbed.
 
Heart attack is easy to detect very early by person’s eating habits. Irregular meals, obsession for exotic food against age, gender, season and time of the day, obsession for specific rasa (sweet teeth) – all of them play role in destroying GUT and in turn disturbing Prana transportation by polluting heart the root of the Pranavaha channel.

More in next part…

[1] https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.287.3

[2] https://blog.kettleandfire.com/gut-dysbiosis/

 

Milk is not product or supplement, but प्रसाद(prasad) & प्रेम(love)!

MilkMicrobes

Since we are now brainwashed to see packaging and standard factory finishing as quality measure, we also see naturally available food with same lens. I often receive complaint from my family and friends that Gau shala milk is not of same quality every day! It is not possible! You are underrating grand design principles of महाप्राण!

During pregnancy, grand-mother always prescribes some work until 7th month.

But our modern moms don’t like this advice. They love chatting on whatsapp. They love watching TV.

Results into?

More Weight gain than expected.

The heavier the mother, the fewer the bacteria in the breastfeeding.

The study also reveals that the milk of overweight mothers or those who put on more weight than recommended during pregnancy contains a lesser diversity of species.

Spanish researchers have traced the bacterial microbiota map in breast milk, which is often the main source of nourishment for newborns. The study has revealed a larger microbial diversity than originally thought: more than 700 species.

Breast milk is recognized as the most important postpartum element in metabolic and immunologic programming of health of neonates. The factors influencing the milk microbiome and the potential impact of microbes on infant health have not yet been uncovered.

Imagine the vaccum of good bacteria when the breast-fed is replaced by formula feeding?

Similar pro-life prana (bacteria) is present in Gau mata’s milk. But we pasteurize it! 🙁

Reason why lean and freely grazing cows give more nutritious milk than cows kept in curfew?

Games of MahaPrana!

Ghor KaliyugA! 🙁


Research


The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery

Background: Breast milk is recognized as the most important postpartum element in metabolic and immunologic programming of health of neonates. The factors influencing the milk microbiome and the potential impact of microbes on infant health have not yet been uncovered.

Objective: Our objective was to identify pre- and postnatal factors that can potentially influence the bacterial communities inhabiting human milk.

Design: We characterized the milk microbial community at 3 different time points by pyrosequencing and quantitative polymerase chain reaction in mothers (n = 18) who varied in BMI, weight gain, and mode of delivery.

Results: We found that the human milk microbiome changes over lactation. Weisella, LeuconostocStaphylococcusStreptococcus, and Lactococcus were predominant in colostrum samples, whereas in 1- and 6-mo milk samples the typical inhabitants of the oral cavity (eg, VeillonellaLeptotrichia, and Prevotella) increased significantly. Milk from obese mothers tended to contain a different and less diverse bacterial community compared with milk from normal-weight mothers. Milk samples from elective but not from nonelective mothers who underwent cesarean delivery contained a different bacterial community than did milk samples from individuals giving birth by vaginal delivery, suggesting that it is not the operation per se but rather the absence of physiological stress or hormonal signals that could influence the microbial transmission process to milk.

Conclusions: Our results indicate that milk bacteria are not contaminants and suggest that the milk microbiome is influenced by several factors that significantly skew its composition. Because bacteria present in breast milk are among the very first microbes entering the human body, our data emphasize the necessity to understand the biological role that the milk microbiome could potentially play for human health.

https://academic.oup.com/ajcn/article/96/3/544/4576808

 

महाप्राण (MahaPrana), Bacteria and Oxygen Generation by plants

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Cynobacteria

Sometime back I shared how Mitochondria – the power house of the cell resembles to bacterial functions. And scientists even debate to call them bacteria! (https://www.youtube.com/watch?v=durqRtrN700)

Now, another link speaks the same about cyanobacteria and photosynthesis !

One more study that helps us realize value of महाप्राण!!

Ultimately, it is महाप्राण and its different forms that drives the living organisms!

Old note:

One friend asked me:

“Why do you call bacteria as just another form of Prana that is not manifested as any multi-cellular organism like human body? And they are no enemies!”

Me: “Because, at the end, we all are manifestation of Prana. Like our body cells, bacteria too are manifestation of Prana.”

Friend: “I am not convinced.”

Me: “Do you know Mitochondria?”

Friend: “No”

Me: “Mitochondria is an organelle found in large numbers in most cells, in which the biochemical processes of respiration and energy production occur. So basically it helps cell in energy production. And for your surprise, they are structurally same as bacteria! A Bacteria within cell! Just like how Prana’s manifestation within cell i.e. Mitochondria is helping cells, they also help outside cell, as a bacteria. Basically, they, like other cells, perform their duties. All living organisms are alive to perform their duties!”

What we really need to realize is that immunity is not war but process of self-realization. Stronger the self-realization, better you can cope up with non-compatible prana manifestation in form of viruses, bacteria, toxins. Think about it 🙂

Listen this for more understanding! 🙂 (y)


Research


How do Plants Make Oxygen? Ask Cyanobacteria

“The ability to generate oxygen through photosynthesis—that helpful service performed by plants and algae, making life possible for humans and animals on Earth—evolved just once, roughly 2.3 billion years ago, in certain types of cyanobacteria. This planet-changing biological invention has never been duplicated, as far as anyone can tell. Instead, according to endosymbiotic theory, all the “green” oxygen-producing organisms (plants and algae) simply subsumed cyanobacteria as organelles in their cells at some point during their evolution.”

http://science.sciencemag.org/content/355/6332/1436

Gut Bacteria (Pranic Footprint-प्राणमय कोष) controls speed of tumor growth

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I have shared it many times that the ultimate way of cancer prevention is to restore Prana in body. It is lack of prana/blockage of Nadi, that causes cancer.

Gut Bacteria, like any other body organ, is manifestation of Prana. And they being non-organ self of body, play critical role in well-being of body organs.

We can prevent cancer easily. Even cancer management is also less painful compare to modern chemo and radiation torture.

Three fundamental source of Prana for restoration

  1. Raw Prana from the Sun
  2. Churned Prana from Desi cow’s milk and ghee
  3. Food grown on the soil replenished by raw and churned prana (Sun light, cow dung, urine, milk, butter milk)

GUTBacteria


Research


Gut Bacteria Determine Speed of Tumor Growth in Pancreatic Cancer

https://nyulangone.org/press-releases/gut-bacteria-determine-speed-of-tumor-growth-in-pancreatic-cancer

The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells.

These are the findings of a study conducted in mice and in patients with pancreatic ductal adenocarcinoma (PDA), a form of cancer that is usually fatal within two years. Led by researchers at NYU School of Medicine, Perlmutter Cancer Center, and NYU College of Dentistry, the study published online March 22 in Cancer Discovery, a journal of the American Association for Cancer Research (AACR).

Specifically, the study found that removing bacteria from the gut and pancreas by treating mice with antibiotics slowed cancer growth and reprogrammed immune cells to again “take notice” of cancer cells. Oral antibiotics also increased roughly threefold the efficacy of checkpoint inhibitors, a form of immunotherapy that had previously failed in pancreatic cancer clinical trials, to bring about a strong anti-tumor shift in immunity.

Experiments found that in patients with PDA, pathogenic gut bacteria migrate to the pancreas through the pancreatic duct, a tube that normally drains digestive juices from the pancreas into the intestines. Once in the pancreas, this abnormal bacterial mix (microbiome) gives off cellular components that shut down the immune system to promote cancer growth, say the authors.

Soil Health Card is useless without गौ आधारित खेती (Cow-based farming)

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SoilMicrobesCarbon

American university proclaims:

“With more than 7 billion microorganisms in the soil, it’s no surprise we still have a lot to learn about them and their impact on the environment. “Consequently, the activity of microorganisms in soil has the potential to alleviate or worsen climate change, so we need to form predictions regarding their activities.”

Do you think without Gau mata, one can achieve this?

Remember, I often share here that

Gau out = Desert In
Desert In = Desert Religion In (Islam/Christianity)

Soil health card may be good way to track soil nutrients but it is useless if you cannot understand value of cow in maintaining soil health. Soil health does not only mean NPK! Or Organic matter. It mean Prana! and only Gau mata can provide Prana!!

Not only carbon cycle, Gau mata has potential to stabilize all natural cycles!! She is medium via which we should embrace primordial prana i.e. Sun


Research


WVU researcher uncovers influence of microorganisms on soil carbon storage

With more than 7 billion microorganisms in the soil, it’s no surprise we still have a lot to learn about them and their impact on the environment. A West Virginia University researcher is uncovering critical information about these tiny organisms under our feet, which although small, can have a huge impact on the environment.

Ember Morrissey, assistant professor of environmental microbiology in the Davis College of Agriculture, Natural Resources and Design, received a $150,000 grant from National Science Foundation’s Division of Environmental Biology’s Early-concept Grants for Exploratory Research program, known as EAGER, to increase understanding of the behavior of microorganisms in the soil to provide descriptions of microbial function that currently aren’t available.

Morrissey’s research will lay the groundwork needed to figure out how soil can be managed to address environment-related processes and issues, including global warming and climate change.

Of particular interest for Morrissey and other researchers is the ability to formulate more precise predictions of microorganisms’ carbon cycling, or how they use and create carbon, a key to combatting climate change.

“Soil stores a large fraction of the earth’s carbon – actually more carbon than the atmosphere and biosphere combined,” Morrissey explained. “Microorganisms break down and consume this carbon as they live and grow, converting it into the greenhouse gas carbon dioxide.

“Consequently, the activity of microorganisms in soil has the potential to alleviate or worsen climate change, so we need to form predictions regarding their activities.”

https://wvutoday.wvu.edu/stories/2017/01/17/wvu-researcher-uncovers-influence-of-microorganisms-on-soil-carbon-storage

 

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