Microbial Community(प्राणमय कोष) controls Gene expression : Not genes, epigenetic!

Instead of medicine, why I suggest all friends to worship Surya and Hanuman! 🙂 It is the need of the hour as our Prana is being consumed daily rapidly by toxic environment, physical and mental.

So many dots can be connected by reading this research paper.

This is wonderful morning as I read this research. One more confirmation proof for my theory that it is प्राणमय कोष that actually influences body and not the genes!!

Entire Genome project is pseudo-science of last century! And so GMO crops! Yes, this is tall claim and against the waves but it is the reality! 🙂

प्राणमय कोष is our immunity. It is our cellular intelligence. It is the one that manifests and govern cell-formation. It is the one that manifests cells with individual identity i.e. microbes rather than collective identity i.e. Body organ cell like skill cell, liver cell or neuron.

It is not just me! I know couple of researchers confirming the same fact and working hard to find more and more epigenetic links!

Our food, our thoughts – all influence our well-being. Genes are actually controlled by them!!

It is not genes, it is epigenetic!

In our guts, and in the guts of all animals, resides a robust ecosystem of microbes known as the microbiome. Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance.

Now, in a study comparing mice raised in a “germ free” environment and mice raised under more typical lab conditions, scientists have identified yet another key role of the microbes that live within us: mediator of host gene expression through the epigenome, the chemical information that regulates which genes in cells are active.

Writing online Nov. 23 in the journal Molecular Cell, a team of researchers from the University of Wisconsin–Madison describes new research helping tease out the mechanics of how the gut microbiome communicates with the cells of its host to switch genes on and off. The upshot of the study, another indictment of the so-called Western diet (high in saturated fats, sugar and red meat), reveals how the metabolites produced by the bacteria in the stomach chemically communicate with cells, including cells far beyond the colon, to dictate gene expression and health in its host.


Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues


  • Gut microbiota alter host histone acetylation and methylation in multiple tissues
  • Western diet suppresses microbiota-driven SCFA production and chromatin effects
  • SCFAs recapitulate microbiota-driven chromatin and transcriptional effects


Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous small-molecule metabolites, allowing chromatin to respond to changes in environment. The gut microbiota produces a myriad of metabolites that affect host physiology and susceptibility to disease; however, the underlying molecular events remain largely unknown. Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner: consumption of a “Western-type” diet prevents many of the microbiota-dependent chromatin changes that occur in a polysaccharide-rich diet. Finally, we demonstrate that supplementation of germ-free mice with short-chain fatty acids, major products of gut bacterial fermentation, is sufficient to recapitulate chromatin modification states and transcriptional responses associated with colonization. These findings have profound implications for understanding the complex functional interactions between diet, gut microbiota, and host health.

Disordered Eating : Invite long-term neg­at­ive health ef­fects



We have discussed this many times. Not following strict routine is nothing but rape of body and torture that will pop as negative health impacts, sooner or later. If you are parent of toddler, make sure you groom your kids for regular meal habits. If you are parent of teen, share this paper with them and ask them to follow regular routine. And if they fail to follow out of ignorance or arrogance, be ready for negative consequences.

Help your family and friends realize that MediClaim and FiveStar hospital is not the cure! Prevention is the ONLY Cure if you don’t wish to suffer and let your family suffer while you are in bed.

What is solution?

Sit with your grandparents.They know local eating habits best. Learn from them. Have meals with them! Be rooted. Follow traditions.

Learn and implement rules about

  1. Meal timing
  2. Season driven diet
  3. Age driven diet
  4. Food compatibiltiy
  5. Food staleness
  6. Day time driven food


Dis­ordered eat­ing among young adults found to have long-term neg­at­ive health ef­fects

According to a recent University of Helsinki study, disordered eating among young adults has long-term effects on their health. Disordered eating among 24-year-old women and men was an indicator of higher body weight, larger waist circumference and lower psychological wellbeing as well as a lower self-evaluation of general health both at age 24 and ten years later.

“Disordered eating is often seen as harmless as it is so common. However, it seems that disordered eating may have far-reaching negative effects on the general health and wellbeing of young adults,” says researcher Ulla Kärkkäinen, authorised nutritionist. “Even if the symptoms do not constitute a clinical eating disorder, early recognition and treatment is important, also for men.”

Published in the European Eating Disorders Review, the study is part of the extensive FinnTwin 16 study, and included more than 4,900 young Finnish men and women. The research participants answered questionnaires on eating behaviour, weight, health and psychological wellbeing at age 24 and again, ten years later at age 34.

When all variables were considered, disordered eating at age 24 was a predictor of lower psychological wellbeing among both women and men as well as a lower self-evaluation of health among men ten years later.

“These results prove that disordered eating is detrimental to the physical and mental health of young adults both in the short and long term. Previous research has established that low psychological wellbeing and a poor self-evaluation of health are predictors of higher susceptibility to physical illness and mortality. To mitigate these long-term negative effects, we must recognise disordered eating early and direct sufferers to treatment,” says Kärkkäinen.

Eating is disordered when a person arbitrarily decides when they are hungry or full, regardless of how they are feeling; weighs themselves constantly; or drinks non-caloric drinks to keep from feeling hungry. Eating can also be considered disordered if a person meticulously plans each meal long into the future, counts calories and weighs foods, follows an excessively strict diet or cuts certain foods from their diet claiming health or ethical reasons, when the real motivation is weight loss, describes Kärkkäinen.

“Even though disordered eating is common in the population, it is not harmless. Disordered eating among both women and men should be taken seriously,” states Kärkkäinen.

The study was headed by Associate Professor Anna Keski-Rahkonen from the University of Helsinki.

Do Disordered Eating Behaviours Have Long-term Health-related Consequences?;jsessionid=A3E6035625AE122844743F72E5DA1567.f03t01


In crude models, disordered eating behaviours at age 24 were associated cross-sectionally and prospectively with poor self-rated health, higher BMI, larger waist circumference and psychological distress in both sexes. In models adjusted for baseline BMI and potential confounders, disordered eating behaviours predicted increased psychological distress in both sexes and poor self-rated health in men.


Among young adults, disordered eating behaviours are associated with long-term health-related consequences, particularly psychological distress. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

Universal diet is a myth


Universal diets don’t work because ‘healthy’ foods differ by individual

Globalization is a deepest myth propagated in last 100 years.
Modern medicine is flavor of it.

Even Today, Indian doctors quote British Journal, American Journal and treat patients! What a slavery!

From food to medicine, everything is local in reality. Not only local, personal! Individual!

This is the base on Ayurveda and they call it primitive guess work! What a foolish arrogance modern doctors have!

If two persons with fever visit genuine Ayurvedacharya, both gets different treatment! Unlike idiotic modern medicine! One pill for everyone!

Not only that, food choices changes based on person’s mental state, biological age, season, time of the day, terrain, region and community!

What do we have now?

Pizza for Navratri! Pizza for Diwali! Pizza for Uttrayan! 😀

Replace pizza with any global choice!

We now don’t decide food based on mental state, biological age, season, time of the day, terrain, region and community but what the market bombard on us! Pity!


Personalized Nutrition by Prediction of Glycemic Responses

“Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility. We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.”

Why only selective few develop Life-threatening Dengue?



We modern humans often play petty blame game. It has become our habit to blame insects for our faulty life style!

It is true that Dengue is vector borne sickness. It is also true that certain protein in specific mosquito flag off the onset of dengue and other post-monsoon sicknesses. It is also reality that not all are afflicted by fever when mosquito bites!

What we see as Dengue epidemic, used to be Plague epidemic half a century back. Epidemics are natural and will happen time to time. It is natural way of population control.

During this sensitive time, it is our job to change diet as per season! Increase intake of certain diet and decrease/stop other as per season!

How do you feel when you see pictures from artificial famine of 1940s Bengal?

Disgusting right? Undercurrent of anger pass through entire body, resulted in shivering.

Our body cells go through similar famine trauma when we eat food (fast food, junk food, pesticide food) like morons, when we take unnecessary mental stress, when we indulge in sensual habits like animals. And that too during monsoon!

We are Churchill (who planned artificial famine in Bengal) for our body. On one hand we oppose subjugation by British and on the other hand, we blissfully enjoy same subjugation with own body! Worse breed of hypocrites? Yes, अनार्य, म्लेच्छा.

Roots of dengue or any viral infections are sown way back when we hamper our digestion. When we eat mindlessly against our prakriti, season and capacity of digestive fire (जठराग्नि).

It is actually a पित्त प्रकोप.

Here is the interesting research discussion why only selective few develop life-threatening dengue? It shows that the root is in the blood (पित्त) and not the vector transferred by mosquito!


Discovery helps explain why only some people develop life-threatening dengue infections

Discovery helps explain why only some people develop life-threatening dengue infections


IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

A rare ability to enhance dengue virus disease

In some cases, secondary infections of dengue virus can be extremely serious and result in plasma leakage, thrombocytopenia, and hemorrhagic disease. This phenomenon has been attributed to antibody-dependent enhancement. Wang et al. show that a specific subclass of antibody, IgG1, which lacks fucosyl residues on the Fc segment of the heavy chain of the immunoglobulin, is elevated in patients with severe secondary dengue disease. These non-neutralizing antibodies bind activating Fc receptors and appear to cross-react with platelet antigens to cause platelet depletion, contributing to thrombocytopenia.


Dengue virus (DENV) infection in the presence of reactive, non-neutralizing immunoglobulin G (IgG) (RNNIg) is the greatest risk factor for dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Progression to DHF/DSS is attributed to antibody-dependent enhancement (ADE); however, because only a fraction of infections occurring in the presence of RNNIg advance to DHF/DSS, the presence of RNNIg alone cannot account for disease severity. We discovered that DHF/DSS patients respond to infection by producing IgGs with enhanced affinity for the activating Fc receptor FcγRIIIA due to afucosylated Fc glycans and IgG1 subclass. RNNIg enriched for afucosylated IgG1 triggered platelet reduction in vivo and was a significant risk factor for thrombocytopenia. Thus, therapeutics and vaccines restricting production of afucosylated, IgG1 RNNIg during infection may prevent ADE of DENV disease.

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