Red Blood Cells and Case of Epigenetics


If you are from medical field, this is not new fact (I hope so! 😉 ) but sharing for general mass living under Genetics dogma.
You and me, are groomed by Watson-Crick Structure of DNA. Very powerful concept. Right? Even so many discoveries based on it. Every other day, we discover a gene responsible something!
Let me share two simple facts.
1) Red blood cells (RBC) are the most common type of blood cell and the vertebrate’s principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.[1] RBCs take up oxygen in the lungs, or gills of fish, and release it into tissues while squeezing through the body’s capillaries.
These red blood cells naturally throw away their nuclei , containing all of their genes, during maturation process, yet they continue to live for around 120 days after purging genes containing nuclei!
What cell biologist Bruce lipton has to say?
The notion that the nucleus and its genes are the “brain” of the cell is an untenable and illogical hypothesis. If the brain is removed from an animal, disruption of physiologic integration would immediately lead to the organism’s death. If the nucleus truly represented the brain of the cell, then removal of the nucleus would result in the cessation of cell functions and immediate cell death. However, experimentally enucleated cells may survive for two or more months with out genes, and yet are capable of effecting complex responses to environmental and cytoplasmic stimuli (Lipton, et al., Differentiation 1991, 46:117-133). Logic reveals that the nucleus can not be the brain of the cell![1]
2) On the other side, A cell that kept its genes but lost the function of its proteins would be dead within seconds. Yes! Within seconds!
This is where we must break the dogma that genes are command center of our body! It is environment within cell, outside cell, outside organism, that is responsible for protein movements which in turn decode the genes and help cell survive beyond 120 days like RBCs!
What is the benefit of breaking this gene-centered dogma?
Too many benefits! You will start understanding value of microbes! Energy fields. Prana. Indra (electrical fields). Internal wind (Vayu/Vata) channels, external environment! You will start caring about your life habits, food, your local environment, water, air! Healthy life will be easy to achieve and we can shift so many doctors for more constructive work like combating natural epidemics (certain natural cycles we cannot avoid and their impact on local population) than exploiting gullible patients! We can truly achieve preventive care!
[1] https://www.brucelipton.com/resource/article/insight-cellular-consciousness

Good conduct (सदाचार) as preventive care



Herbs needs to be nurtured for extremely rare sicknesses manifested despite good conduct (सदाचार) but due to past life karma that needs to be exhausted now! (Herbs helps in speedy recovery from these mandatory karma execution)

Do we really need to do Tulasi and other herb farming? Is it worth? Are we not inviting bad karma by supporting it? Land of वृन्दावन promoting तुलसी farming so that we can sell तुलसी अर्क? 

Try to understand सदाचार and stick to it. It is the dharma way! And not the way we live by exploiting body and seeking help from codified herbs!!

सदाचार is the root of healthy life!

सदाचारमें रत नहीं रहना पर त्रिफलाके गुण गाते रहना है! 😀


We recognize Ayurveda in very selective manner. Whatever is aligned with my present life, I will implement. Rest, I don’t care! 😀

देवगोब्राह्मणगुरुवृद्धसिद्धाचार्यानर्चयेत् | – चरक

देवता, गौ, ब्राह्मण, गुरु, वृद्ध, सिद्ध, आचार्योका पूजन करना चाहिए |

सदाचार is the root of healthy life!

सदाचारमें रत नहीं रहना पर त्रिफलाके गुण गाते रहना है! 😀


We recognize Ayurveda in very selective manner. Whatever is aligned with my present life, I will implement. Rest, I don’t care! 😀

देवगोब्राह्मणगुरुवृद्धसिद्धाचार्यानर्चयेत् | – चरक

देवता, गौ, ब्राह्मण, गुरु, वृद्ध, सिद्ध, आचार्योका पूजन करना चाहिए |

नातिसमयं जह्यात्, न नियमं भिन्द्यात्, न नक्तं नादेशे चरेत्, न सन्ध्यास्वभ्यवहाराध्ययनस्त्रीस्वप्नसेवी स्यात्, नबालवृद्धलुब्धमूर्खक्लिष्टक्लीबैः सह सख्यं कुर्यात्, न मद्यद्यूतवेश्याप्रसङ्गरुचिः स्यात्, न गुह्यं विवृणुयात्, नकञ्चिदवजानीयात्, नाहम्मानी स्यान्नादक्षो नादक्षिणो नासूयकः, न ब्राह्मणान् [१] परिवदेत्, न गवां दण्डमुद्यच्छेत्, नवृद्धान्न गुरून्न गणान्न नृपान् वाऽधिक्षिपेत्, न चातिब्रूयात्, न बान्धवानुरक्तकृच्छ्रद्वितीयगुह्यज्ञान् बहिष्कुर्यात्||२५||

One should not deviate from generally approved social practices & should not break any code of conduct .
One should not move in the night or in an appropriate place . One should not indulge in taking food , studies, sexual relations or sleep during the dawn or dusk .
One should not make friendship with children , the old, the greedy, the fools, the persons under affliction and the eunuchs.
One should not have interest in taking wine , gambling & making physical relationship with prostitutes.
One should not disclose secrets & should not insult any body . one should not be conceited, unskilled, unfavourite and envious. One should not insult the Brahmins nor should beat the cow with sticks. One should not abuse the old, the preceptors, the administrative class and the king .
One should not speak too much nor should turn out the kins ,persons attached, that who stood along in difficult times and the persons who know the secrets . ||25||

न कार्यकालमतिपातयेत्, नापरीक्षितमभिनिविशेत्, नेन्द्रियवशगः स्यात्, न चञ्चलं मनोऽनुभ्रामयेत्, न बुद्धीन्द्रियाणामतिभारमादध्यात्, न चातिदीर्घसूत्री स्यात्, न क्रोधहर्षावनुविदध्यात्, न शोकमनुवसेत्, न सिद्धावुत्सेकं [११] यच्छेन्नासिद्धौ दैन्यं, प्रकृतिमभीक्ष्णं स्मरेत्, हेतुप्रभावनिश्चितः स्याद्धेत्वारम्भनित्यश्च, न कृतमित्याश्वसेत्, न वीर्यं जह्यात्, नापवादमनुस्मरेत्||

One should not postpone things at the time of action nor should one take up anything without examining it; one should not be submissive to his sense organs nor should one turn his unstable mind round; one should not over burden the sense organs, one should not be too much dilatory; one should not act under the emotions of anger or exhilaration. One should not live under continued grief. One should not feel exhilarated in success and depressed in failure; one should always keep his constitution in mind. One should be confident of the effect of a cause and as such should always initiate the cause, one should not assume that now nothing is to be done, one should not give up courage nor should one remember his scandals.

Strive for सदाचार |

Indian Pioneer in Plastic Surgery in 19th Century



 Dr. Tribhovandas Motichand Shah (1850-1904)
Assistant Surgeon, Cheif Medical Officer of Junagarh State
Fellow of Bombay university

The tradition of rebuilding the nose was reimported from Europe into India following the establishment of the Raj. Within the Westernized tradition of India surgery in the 19th century there was a further development of this reception. Indian surgeons did indeed stress the idea of the “nose job” as an “original” Indian contribution to surgery. They read these origins quite differently from the way Europeans did .

Tribhovandas Motichand Shah (1850-1904), writing in Junagadh in 1889, rationalized his clinical account of a hundred cases of rhinoplasty by labeling the Indian patients the victims of criminal activity: “The Makrani outlaws, who carried out depredations against the Jungadh State for a period of nearly three years, had not infrequently indulged in mutilating the noses of undefended and unarmed ryots [peasants] of villages.”

Such activities are criminal. Unsanctioned by the state. It is true that there is a tradition of vendettas in India, Motichand Shah continues, in which the nose is cut off, in contrast to the (much worse, he implies) Western tradition of vendettas in which the chief modes of mortal revenge are homicide, either by poisoning, shooting, or wounding.

It is true, of course, that the West, too, has a problem with lost noses: In these countries loss of the nose is only a consequence of disease- chiefly syphilis. The rationale for the rebuilding of the Indian nose, on the other hand, is the reconstitution of delicate feelings of honour and the overcoming of “feelings of the greatest humiliation.”

• Remember Tribhovandas Motichand Shah as first known modern plastic surgery surgeon!
• Europe was brutal and barbaric as far as vendettas and revenges are concerned.
• Europe of 19th century was suffering from infectious diseases like syphilis.

[1] http://journals.lww.com/plasreconsurg/Citation/1970/02000/RHINOPLASTY__A_Short_Description_of_One_Hundred.11.aspx
His paper was accessible online till last week when I first accessed. Now it shows access denied.

Tridosha vs Enterotypes of the human gut microbiome


Gut Microbes

An enterotype is a classification of living organisms based on its bacteriological ecosystem in the gut microbiome. So far, scientists identified three robust clusters (enterotypes hereafter) that are not nation or continent-specific (In 2011). They confirmed the enterotypes also in two published, larger cohorts suggesting that intestinal microbiota variation is generally stratified, not continuous. Bacteroides (enterotype 1), Prevotella (enterotype 2) and Ruminococcus (enterotype 3).[1]

In Ayurveda, our Prakriti is important for treatment. Each individual has different Prakriti. Kapha Prakriti, Pitta Prakriti, Vata Prakriti and mix.

3 clusters of microbiome. 3 Types of human nature (Physical Prakriti/Constitution/Mental Constitution)

No wonder, soon we will see missing link.

Points to note here:

1) Gut bacteria are related to your nature/Prakriti/Constitution
2) Gut bacteria changes with age and so your prakriti also change(Children – Kapha, Adult – Pitta, Old age – Vata)

Interesting time ahead



[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728647/

Enterotypes of the human gut microbiome


Our knowledge on species and function composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about their variation across the world. Combining 22 newly sequenced fecal metagenomes of individuals from 4 countries with previously published datasets, we identified three robust clusters (enterotypes hereafter) that are not nation or continent-specific. We confirmed the enterotypes also in two published, larger cohorts suggesting that intestinal microbiota variation is generally stratified, not continuous. This further indicates the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis for a community understanding. While individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers

Exercise and Tridosha Prakriti



Natural predominance of Vata over other dosha happen after we crosses 60. (Age 0 to 14 : Kapha, 14 to 60 : Pitta).

However, there are seasonal variations which stays forever with youth due to mindless habits. Hence, we see rapid aging, sudden infant deaths etc.

Vata! Shani Maharaj! Hahuman!

It is mentioned in classical Ayurvedic texts and proven in modern experiments that Vata type individuals will have maximum propensity for chronic diseases.

Natural predominance of Vata over other dosha happen after we crosses 60. (Age 0 to 14 : Kapha, 14 to 60 : Pitta).

Unfortunately, due to life style, Vata becomes predominance in young age. So we see many in early 30s with VP Prakriti i.e. Vata heavy and PItta as secondary.VP Prakriti individuals have greater degree of Vata dosha so the individuals are more reactive to any kind of stimuli and prone to develop chronic stress leading to different kind of psychosomatic disorders.The reason for this could be that Pitta is responsible for intelligence and Vata is responsible for initiation and enthusiasm.
So to save our youth from diabetes, blood pressure and further complications, it is mandatory to engage them in exercise. It is very well defined in Ayurvedic text books that in advanced stage Prameha, exercises like physical exercise, wrestling, sports, riding elephant, horse and chariot, travelling on foot and moving around and also feats of archery are to be practiced. And since high calorie fiet with no exercise is routine for many, they are prone to madhuprameha (Advance stage of prameha).


Effect of walking (aerobic isotonic exercise) on physiological variants with special reference to Prameha (diabetes mellitus) as per Prakriti


Walking is an isotonic aerobic exercise and has been associated with reduced blood sugar level in diabetic patients and other physiological changes in observational studies. A study was conducted to determine the effect of isotonic aerobic exercise (walking) on blood sugar level and other important physiological parameters as per Prakriti. This study was carried out in Department of Kriya Sharira and Kayachikita, S. S. Hospital; Faculty of Ayurveda, IMS, BHU and some cases were enrolled from Kashi Mumukshu Bhawan, Assi, Varanasi. A total 83 (32 diabetic control and 51 diabetic exercise) diabetic cases were included with age ranging from 35 to 65 years during January 2009 to January 2011. Control cases enrolled in this study had not performed any exercise. The results of the study revealed that, there is a strong association in between Prakriti, Blood pressure and certain other Biochemical parameters.


Grabbing Ayurvedic Formulas : New low from Pharma-cartel


BattleTurmericThis is alarming.

Since ayurveda is able to cure ailments for which modern medicine has not been able to offer solutions, pharma giants are buying up rights for “traditional practices”, said P. Murali Krishna, professor, Sri Venkateswara Ayurvedic College and Hospital.

He said a U.S.-based pharma giant had purchased rights for a traditional ayurvedic practice for 15 years. More such transactions were on the cards, he said.

Two points

1) This should be eye opener for my allopath friends who still live in denial mode and not ready to accept power of Ayurveda

2) Does not matter much if they buy rights of procedures. With reductionist attitude, it is not possible to receive wholesome benefits of Ayurvedic procedures.

Pharma giants buying up rights for Ayurvedic practices: expert

Since ayurveda is able to cure ailments for which modern medicine has not been able to offer solutions, pharma giants are buying up rights for “traditional practices”, said P. Murali Krishna, professor, Sri Venkateswara Ayurvedic College and Hospital.

Dr. Krishna delivered the keynote address on “Management of skin disorders” at a national-level seminar organised by Kerala-based Vaidyaratnam Oushadha Sala here on Thursday.

He said a U.S.-based pharma giant had purchased rights for a traditional ayurvedic practice for 15 years. More such transactions were on the cards, he said.

Dr Krishna said several ailments, particularly skin, for which modern medicine offered no sustainable remedies, had cures in ayurveda.

The three-pronged approach of ayurveda — diet, drugs and life style — had a cure for chronic skin aliments like psoriasis and eczema which were suppressed only temporarily by antibiotics and steroids.

That Arrow that is not yet shot


Once you shoot arrow, there’s no going back. Similarly, when Purusha(Jiva/Self) within is afflicted,hurt, there is no going back. Sooner or later, now or in next birth, symptoms will appear on Kaya surface. That’s where it is important to learn Kaya-Chikitsa. Care before open fire. If you can not due to ignorance or Ahmakara or bodily-passions or mental-passions, seek and surrender to advice of Kaya-chikitsa and reduce possible pain.

Kaya-Chikitsa is God’s love for his ignorant children. Treatment of diseases pertaining to Kaya. Kaya takes in food(different layers of Kaya takes in food of their plane[1].), digests,absorbs and metabolize it. When this is disturbed, purusha within is afflicted.


(1) The physical Consciousness (Annamaya Kos) which is manifested in the activities of hormones and enzymes etc.
(2) The Awakened Consciousness (Pranmaya Kos) which is active in the form of bioelectricity
(3) The Psychic Consciousness (Manomaya Kos) which gives rise to biomagnetism.
(4) The intuitive Consciousness (Vigyanmaya Kos)
(5) The beatitudinous consciousness (Anandmaya Kos) which subtly exists in the reticular Activating System in the Cortical Nuclei.Arrow

Superiority of Ayurvedic Nephrology & Kidney regeneration

Superiority of Ayurveda & Nephrology
Many modern doctor friends consider my posts bigoted and fanatic as I am firm on my stand that Ayurveda in its purest form is the supreme science of life. 🙂
Contrary to long-held beliefs, a new study shows that kidneys have the capacity to regenerate themselves.

One more example from Nephrology (The branch of medicine concerned with the kidney) .
May 16, 2014 : One year old news from Standford’s Stem cell institute says that adult kidneys constantly grow and remodel themselves, and how they do it. 
“The kidney, incredibly, rejuvenates itself and continues to generate specialized kidney cells all the time.”
What they call this? “These are basic findings that have direct implications for kidney disease and kidney regeneration”
So this is just a basic from modern science.
On the other hand, vivid description of Kidney regeneration is well documented in ancient Ayurvedic texts. Not only that, there are herbs and procedures mentioned to accelerate Kidney regeneration in acute conditions. Without side effects :). It is popularly known as PUNARNAVA. (Unlike modern nephrologists who will prescribe you all unnecessary side effects!)
For more details, you can read below paper where sample drug is discussed.
1) Mishra J, Singh R. The effect of indigenous drug Boerhaavia diffusa on kidney regeneration. Indian J Pharmacol.
2) Book : The Kidney & Its Regeneration Singh, R.H. & Udupa, K.N.
All those who doubt Ayurveda and its efficacy, must read this book too:

Adult kidneys constantly grow, remodel themselves, study finds


“These are basic findings that have direct implications for kidney disease and kidney regeneration,” said Yuval Rinkevich, PhD, the lead author of the paper and a postdoctoral scholar at the institute.

The findings were published online May 15 in Cell Reports.

It has long been thought that kidney cells didn’t reproduce much once the organ was fully formed. The new research shows that the kidneys are regenerating and repairing themselves throughout life.

“This research tells us that the kidney is in no way a static organ,” said Benjamin Dekel, MD, PhD, a senior author of the paper and associate professor of pediatrics at Sackler, as well as head of the Pediatric Stem Cell Research Institute at the Sheba Medical Center in Israel. “The kidney, incredibly, rejuvenates itself and continues to generate specialized kidney cells all the time.”

Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus

Microalbuminuria is the strong predictor of diabetic nephropathy, which is the main cause of morbidity and mortality in patients with diabetes mellitus (DM). Microalbuminuria is also characterized by increased prevalence of arterial hypertension, proliferative retinopathy, and peripheral neuropathy. The study was planned to evaluate the effect of Gokshura-Punarnava Basti in the management of microalbuminuria in DM (Madhumeha). Eligible diabetic patients with urine albumin excretion between 30 and 300 mg in 24 h were randomly divided into two groups. Asthapana Basti (decoction enema) of Gokshura and Punarnava Kwatha (decoction), Kalka (paste), Taila (medicated oil), Madhu (honey), and Saindhava (rock salt) for 6 consecutive days and Anuvasana (unctuous enema) of Gokshura-Punarnava Taila on 1st and 8th day by traditional Basti Putaka method was given in study group. Tablet Enalapril 5 mg, twice daily for 30 days was given to the patients in control group. The primary outcome measures were percentage change in the presenting complaints of diabetes, urine microalbumin, Blood Sugar Level (BSL), and Blood Pressure (BP). Enalapril showed 33.33% improvement, where as Gokshura-Punarnava Basti showed 79.59% improvement in the presenting complaints of diabetes, urine microalbumin, BSL and BP. Gokshura-Punarnava Basti has shown superior results in the management of microalbuminuria in DM as compared to control drug.


Role of प्रत्यक्ष प्रमाण – Direct visible evidences in Ayurveda



प्रत्यक्ष प्रमाण – Direct visible evidences are more trusted by Ayurveda. What microscope can decipher, Man’s mighty brain too can process and decipher, more precisely.

For example:

Do you really need a scientific calculator to calculate parabolic path of the ball hit by a batsman, for a caught and bowled wicket?

No. With practice, we fine-tune our judgement and it become rock solid one day.

Same is the case of clinical observations. Due to over-use of technology, doctors are losing this vital skill.

Genuine Ayurvedic Doctor still rely on own intuition. He or she will follow standard 8 point examination carefully. Those are:
1) pulse,
2) feces,
3) urine,
4) various auscultatory findings,
5) palpation,
6) skin,
7) eyes, and
8) body strength.

Try it. Out of all doctors you know, observe who examines above 8 points. Irrespective of their branch. Be it Allopath or Homeopath or Ayurvedic or any local healthcare system of the world. Those doctors treatment will be more precise who trust their own senses and conclude.

In fact, with practice, everyone can become own doctor. That is real open source system.

Myth Busting: Ayurveda is Evidence Based



Every time I talk about superiority of Ayurveda, friends from other branches of healthcare start talking and asking for EBM in Ayurveda! 😀

Ha! EBM or Evidence-based medicine! 🙂 Ayurveda is actually real EBM if you consider textbook definition. Follow the post for detail.

I am thinking to write entire series of posts based on it to make them realize that how really western science is slowly learning Ayurvedic principles of EBM. Stay tuned. (Y)

This is post#1 #EBM #AyurVedaEBM #Ayurveda

EBM, which has become a buzz word concerning medical decision making, refers to a three aspects of information that the physician should use to determine the best treatment for a particular patient:
1. Best available relevant scientific evidence concerning the effectiveness and efficacy of the proposed treatment
2. Physician knowledge based on practice experience
3. Patient’s own preferences for treatment modalities if they do not contradict 1 or 2 above

Now, if you compare modern medicine and Ayurveda (As a layman, I have exposure to both medicine and their practitioners.) , Modern medicine is coming closer to a holistic treatment approach, closer to the parameters of treatment in Ayurvedic practice. What is considered as EBM, is already followed by
Ayurveda for 5000+ years!

We will explore this subject in subsequent posts. Stay tuned.
Meanwhile, read this pdf to know what exactly is EBM:

“Good doctors use both individual clinical expertise and the best available external evidence, and neither alone is enough. Without clinical expertise, practice risks becoming tyrannised by evidence, for even excellent external evidence may be inapplicable to or inappropriate for an individual patient. Without current best evidence, practice risks becoming rapidly out of date, to the detriment of patients.”

Do we really have such good doctors?Introspection needed for doctor community. Most modern medicine doctors consider patients dumb. Forget about considering patient’s values and preferences! So high ego! (this is very well taken care by Ayurvedic doctors! So humble they are!)

Evidence based medicine: what it is and what it isn’t

It’s about integrating individual clinical expertise and the best external evidence

Evidence based medicine, whose philosophical origins extend back to mid-19th century Paris and earlier, remains a hot topic for clinicians, public health practitioners, purchasers, planners, and the public. There are now frequent workshops in how to practice and teach it (one sponsored by the BMJ will be held in London on 24 April); undergraduate1 and postgraduate2 training programmes are incorporating it3 (or pondering how to do so); British centres for evidence based practice have been established or planned in adult medicine, child health, surgery, pathology, pharmacotherapy, nursing, general practice, and dentistry; the Cochrane Collaboration and Britain’s Centre for Review and Dissemination in York are providing systematic reviews of the effects of health care; new evidence based practice journals are being launched; and it has become a common topic in the lay media. But enthusiasm has been mixed with some negative reaction.4 5 6 Criticism has ranged from evidence based medicine being old hat to it being a dangerous innovation, perpetrated by the arrogant to serve cost cutters and suppress clinical freedom. As evidence based medicine continues to evolve and adapt, now is a useful time to refine the discussion of what it is and what it is not.


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